Facteurs de Risque, Epidémiologie et Prise en Charge de la Grossesse Extra-utérine Rompue (GEUR) au Service de Gynécologie et d’Obstétrique de l’Hôpital National Ignace Deen du CHU de Conakry en 2022

Introduction : urgence gynécologique fréquente, découverte fortuite aux urgences médicales et ou chirurgicales dans un tableau d’anémie. L’objectif de ce travail était d’étudier les facteurs de risque, épidémiologie, et prise en charge de la grossesse extra-utérine rompue au service de gynécologie et d’obstétrique de l’hôpital national Ignace Deen du CHU de Conakry en 2022. Méthodes : il s’agissait d’une étude descriptive transversale à recrutement rétrospectif. Elle a été menée au service de gynécologie et d’obstétrique de l’hôpital national Ignace Deen du CHU de Conakry du 1er janvier  2019 au 31 Décembre 2022 soit une période de trois ans. Ont été étudiées les variables se rapportant aux facteurs de risque, épidémiologie, et la prise en charge de la GEUR dans notre contexte de travail. Nous avons utilisé le logiciel Excel pour l’analyse des données. Résultats : fréquence de la GEUR dans notre étude était 1,26 % sur l’ensemble des interventions gynécologiques, les tranches d’âge les plus représentées étaient celles de 20-24 ans et 30-34 ans dans 32,69%, plus de la moitié était célibataire 69,23%, sans profession, non scolarisé respectivement 64,23% et 42,31%, primipares dans 49,04%.  Parmi les facteurs de risque (FDR) retrouvés dans notre série, figuraient les antécédents de :  l’infection génitale 46,15%, les fausses couches spontanées 10,58%, la contraception par microprogestatif 16,34%. La prise en charge a été exclusivement chirurgicale (100%), associée à la transfusion sanguine comme moyen de réanimation dans 95,16%. Conclusion : la grossesse extra-utérine rompue est une urgence médicochirurgicale fréquente, le diagnostic précoce traine les pas dans les pays à faibles ressources.   Introduction : a frequent gynecological emergency, discovered incidentally in medical and/or surgical emergencies in the setting of anemia. The aim of this study was to investigate the risk factors and management of ectopic pregnancy in the gynecology and obstetrics department of the Ignace Deen National Hospital of Conakry University Hospital in 2022. Methods : This was a descriptive study with retrospective recruitment. It was conducted at the gynecology and obstetrics department of the CHU Ignace Deen national hospital in Conakry from January 1, 2019 to December 31, 2022, a three-year period. Variables relating to risk factors, epidemiology and management of GEUR in our working context were studied. We used Excel software for data analysis. Results : The frequency of GEUR in our study was 1.26% of all gynaecological procedures, the most represented age groups were 20-24 and 30-34 years with 32.69%, more than half were single 69.23%, without profession, not in school respectively 64.23% and 42.31%, primiparous in 49.04%.  Among the risk factors found in our series were a history of : genital infection 46,15%, spontaneous miscarriage 10.58%, microprogestogen contraception 16.34%. Management was exclusively surgical (100%), associated with blood transfusion as a means of resuscitation in 95.16% Conclusion : Ruptured ectopic pregnancy is a frequent medico-surgical emergency, early diagnosis is lagging behind in low-resource countries

Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c <i>In Vitro</i>

Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin. This represents a specialised form of regulated membrane trafficking. Intracellular membrane traffic is subject to multiple levels of regulation by conserved families of proteins in all eukaryotic cells. Notably, all intracellular fusion events require SNARE proteins and Sec1p/Munc18 family members. Fusion of GLUT4-containing vesicles with the plasma membrane of insulin-sensitive cells involves the SM protein Munc18c, and is regulated by the formation of syntaxin 4/SNAP23/VAMP2 SNARE complexes. Methodology/Principal Findings Here we have used biochemical approaches to characterise the interaction(s) of Munc18c with its cognate SNARE proteins and to examine the role of Munc18c in regulating liposome fusion catalysed by syntaxin 4/SNAP23/VAMP2 SNARE complex formation. We demonstrate that Munc18c makes contacts with both t- and v-SNARE proteins of this complex, and directly inhibits bilayer fusion mediated by the syntaxin 4/SNAP23/VAMP2 SNARE complex. Conclusion/Significance Our reductionist approach has enabled us to ascertain a direct inhibitory role for Munc18c in regulating membrane fusion mediated by syntaxin 4/SNAP23/VAMP2 SNARE complex formation. It is important to note that two different SM proteins have recently been shown to stimulate liposome fusion mediated by their cognate SNARE complexes. Given the structural similarities between SM proteins, it seems unlikely that different members of this family perform opposing regulatory functions. Hence, our findings indicate that Munc18c requires a further level of regulation in order to stimulate SNARE-mediated membrane fusion

Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications

T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-beta, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the correct stratification of patients into appropriate therapeutic regimens and to identify novel targets for the development of specific, less detrimental therapies for T-ALL

Rare B Decays with a HyperCP Particle of Spin One

In light of recent experimental information from the CLEO, BaBar, KTeV, and Belle collaborations, we investigate some consequences of the possibility that a light spin-one particle is responsible for the three Sigma^+ -> p mu^+ mu^- events observed by the HyperCP experiment. In particular, allowing the new particle to have both vector and axial-vector couplings to ordinary fermions, we systematically study its contributions to various processes involving b-flavored mesons, including B-Bbar mixing as well as leptonic, inclusive, and exclusive B decays. Using the latest experimental data, we extract bounds on its couplings and subsequently estimate upper limits for the branching ratios of a number of B decays with the new particle. This can serve to guide experimental searches for the particle in order to help confirm or refute its existence.Comment: 17 pages, 3 figures; discussion on spin-0 case modified, few errors corrected, main conclusions unchange

Chern-Simons black holes: scalar perturbations, mass and area spectrum and greybody factors

We study the Chern-Simons black holes in d-dimensions and we calculate analytically the quasi-normal modes of the scalar perturbations and we show that they depend on the highest power of curvature present in the Chern-Simons theory. We obtain the mass and area spectrum of these black holes and we show that they have a strong dependence on the topology of the transverse space and they are not evenly spaced. We also calculate analytically the reflection and transmission coefficients and the absorption cross section and we show that at low frequency limit there is a range of modes which contributes to the absorption cross section.Comment: 19 pages, 18 figures, the title has been changed to reflect the addition of an another section on the reflection, transmission coefficients and absorption cross sections of the Chern-Simons black holes. Version to be published in JHE

Phytochemicals as antibiotic alternatives to promote growth and enhance host health

There are heightened concerns globally on emerging drug-resistant superbugs and the lack of new antibiotics for treating human and animal diseases. For the agricultural industry, there is an urgent need to develop strategies to replace antibiotics for food-producing animals, especially poultry and livestock. The 2nd International Symposium on Alternatives to Antibiotics was held at the World Organization for Animal Health in Paris, France, December 12-15, 2016 to discuss recent scientific developments on strategic antibiotic-free management plans, to evaluate regional differences in policies regarding the reduction of antibiotics in animal agriculture and to develop antibiotic alternatives to combat the global increase in antibiotic resistance. More than 270 participants from academia, government research institutions, regulatory agencies, and private animal industries from >25 different countries came together to discuss recent research and promising novel technologies that could provide alternatives to antibiotics for use in animal health and production; assess challenges associated with their commercialization; and devise actionable strategies to facilitate the development of alternatives to antibiotic growth promoters (AGPs) without hampering animal production. The 3-day meeting consisted of four scientific sessions including vaccines, microbial products, phytochemicals, immune-related products, and innovative drugs, chemicals and enzymes, followed by the last session on regulation and funding. Each session was followed by an expert panel discussion that included industry representatives and session speakers. The session on phytochemicals included talks describing recent research achievements, with examples of successful agricultural use of various phytochemicals as antibiotic alternatives and their mode of action in major agricultural animals (poultry, swine and ruminants). Scientists from industry and academia and government research institutes shared their experience in developing and applying potential antibiotic-alternative phytochemicals commercially to reduce AGPs and to develop a sustainable animal production system in the absence of antibiotics.Fil: Lillehoj, Hyun. United States Department of Agriculture. Agricultural Research Service; ArgentinaFil: Liu, Yanhong. University of California; Estados UnidosFil: Calsamiglia, Sergio. Universitat Autònoma de Barcelona; EspañaFil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; ArgentinaFil: Chi, Fang. Amlan International; Estados UnidosFil: Cravens, Ron L.. Amlan International; Estados UnidosFil: Oh, Sungtaek. United States Department of Agriculture. Agricultural Research Service; ArgentinaFil: Gay, Cyril G.. United States Department of Agriculture. Agricultural Research Service; Argentin

Twisted fallopian tube in pregnancy: a case report

BACKGROUND: Isolated twisted fallopian tube is an uncommon event, isolated twisted fallopian tube in pregnancy is also very rare. The diagnosis is often difficult and established during the operation. The right fallopian tube is most common affected. CASE PRESENTATION: We report an uncommon twisted left fallopian tube in pregnancy. A 34-year-old G(3)P(2) 28 weeks pregnant woman presented with acute left lower abdominal pain. The clinical and ultrasonographic findings led to diagnosis of twisted left ovarian cyst. Emergency exploratory laparotomy was performed. A twisted left fallopian tube and paratubal cyst was noted and left salpingectomy was performed. The postoperative course was uneventful and the pregnancy continued until term without complication. CONCLUSIONS: Although isolated twisted fallopian tube during pregnancy is very rare, it should be included in the differential diagnosis of acute abdomen in pregnancy. Early surgical intervention will decrease obstetric morbidity and may allow preservation of the fallopian tube