6,942 research outputs found
Observation of contemporaneous optical radiation from a gamma-ray burst
The origin of gamma-ray bursts (GRBs) has been enigmatic since their
discovery. The situation improved dramatically in 1997, when the rapid
availability of precise coordinates for the bursts allowed the detection of
faint optical and radio afterglows - optical spectra thus obtained have
demonstrated conclusively that the bursts occur at cosmological distances. But,
despite efforts by several groups, optical detection has not hitherto been
achieved during the brief duration of a burst. Here we report the detection of
bright optical emission from GRB990123 while the burst was still in progress.
Our observations begin 22 seconds after the onset of the burst and show an
increase in brightness by a factor of 14 during the first 25 seconds; the
brightness then declines by a factor of 100, at which point (700 seconds after
the burst onset) it falls below our detection threshold. The redshift of this
burst, approximately 1.6, implies a peak optical luminosity of 5 times 10^{49}
erg per second. Optical emission from gamma-ray bursts has been generally
thought to take place at the shock fronts generated by interaction of the
primary energy source with the surrounding medium, where the gamma-rays might
also be produced. The lack of a significant change in the gamma-ray light curve
when the optical emission develops suggests that the gamma-rays are not
produced at the shock front, but closer to the site of the original explosion.Comment: 10 pages, 2 figures. Accepted for publication in Nature. For
additional information see http://www.umich.edu/~rotse
Decision Making for Inconsistent Expert Judgments Using Negative Probabilities
In this paper we provide a simple random-variable example of inconsistent
information, and analyze it using three different approaches: Bayesian,
quantum-like, and negative probabilities. We then show that, at least for this
particular example, both the Bayesian and the quantum-like approaches have less
normative power than the negative probabilities one.Comment: 14 pages, revised version to appear in the Proceedings of the QI2013
(Quantum Interactions) conferenc
Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering
Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering. Multilayered constructs were formed by depositing the polyelectrolytes chitosan (CHT) and chondroitin sulphate (CS) on either bidimensional glass surfaces or 3D packet of paraffin spheres. 2D CHT/CS multi-layered constructs proved to support the attachment and proliferation of bovine chondrocytes (BCH). The technology was transposed to 3D level and CHT/CS multi-layered hierarchical scaffolds were retrieved after paraffin leaching. The obtained nanostructured 3D constructs had a high porosity and water uptake capacity of about 300%. Dynamical mechanical analysis (DMA) showed the viscoelastic nature of the scaffolds. Cellular tests were performed with the culture of BCH and multipotent bone marrow derived stromal cells (hMSCs) up to 21 days in chondrogenic differentiation media. Together with scanning electronic microscopy analysis, viability tests and DNA quantification, our results clearly showed that cells attached, proliferated and were metabolically active over the entire scaffold. Cartilaginous extracellular matrix (ECM) formation was further assessed and results showed that GAG secretion occurred indicating the maintenance of the chondrogenic phenotype and the chondrogenic differentiation of hMSCs
Tactical Voting in Plurality Elections
How often will elections end in landslides? What is the probability for a
head-to-head race? Analyzing ballot results from several large countries rather
anomalous and yet unexplained distributions have been observed. We identify
tactical voting as the driving ingredient for the anomalies and introduce a
model to study its effect on plurality elections, characterized by the relative
strength of the feedback from polls and the pairwise interaction between
individuals in the society. With this model it becomes possible to explain the
polarization of votes between two candidates, understand the small margin of
victories frequently observed for different elections, and analyze the polls'
impact in American, Canadian, and Brazilian ballots. Moreover, the model
reproduces, quantitatively, the distribution of votes obtained in the Brazilian
mayor elections with two, three, and four candidates.Comment: 7 pages, 4 figure
Critical evaluation of proteomic protocols for passion fruit (Passiflora edulis Sims) leaves, a crop with juice market benefits
Passion fruit grows practically all over Brazilian territory; its production is largely destined to juice industry and expanding to overseas markets. The suitability of four protein extraction protocols for plant proteome was investigated to determine the best choice for studies concerning passion fruit leaf proteins. Trichloroacetic acid (TCA)/acetone extraction; isoelectric focusing (IEF) buffer extraction; phenol (Phe) extraction and Phe-SDS extraction were tested. The Phe method produced the best results, showing higher reproducibility of resolved protein spots and clearer 2D gel background staining. In comparison, the Phe-SDS method presented fewer spots and lower reproducibility. The TCA/acetone method produced the fewest identifiable spots and the IEF buffer produced the poorest results,displaying fewer reproducibly detected spots, more vertical streaks and darker 2D staining. Selected spots, obtained with Phe method, were identified by spectrometric analysis (MALDI-TOF-TOF) to exemplify the viability to perform more comprehensive proteomic studies with passion fruit leaves and, therefore increase information about stress-related and developmental responses in this fruit crop.Key words: Passion fruit, proteomic, protein extraction, juice industry
An exploratory study of a NoSQL database for a clinical data repository
The need to implement a distributed Clinical Data Repository (CDR) at a healthcare facility, rose in large part due to the high volume of data and the discrepancy of their sources. Over the years, Relational Database Management Systems (RDBMS) began to present difficulties in responding to the needs of various organizations when it comes to manipulating a large amount of data and to its scalability. Therefore, it was necessary to explore other techniques to choose the appropriate technology to build the CDR. In this way, NoSQL emerged as a new type of database that is quite useful to work with multiple and different types of data. In addition, NoSQL introduces a number of user-friendly features such as a distributed, scalable, elastic and also fault tolerant system. In this way, Oracle NoSQL Database was the NoSQL solution chosen to develop this case study, using the key-value storage. This article was motivated to propose a CDR architecture based on Oracle NoSQL Database functionalities. A one-single node database was deployed for better comprehension, in order to enhance their features for future implementation.The work has been supported by FCT – Fundação para a Ciência e Tecnologia within the Project Scope UID/CEC/00319/2019 and DSAIPA/DS/0084/2018
Retinal nerve fibre layer thickness profile in normal eyes using third-generation optical coherence tomography
Aims To establish four normal retinal nerve fibre layer (RNFL) thickness radial profiles based on third-generation optical coherence tomography (OCT) and to compare them with previously reported histologic measurements.Methods A total of 20 normal eyes were studied. A circular scan was adjusted to the size of the optic disc and three scans were performed with this radius and every 200 mu m thereafter, up to a distance of 1400 mu m. Four different radial sections (superotemporal, superonasal, inferonasal, and inferotemporal) were studied to establish RNFL thickness OCT profiles. Additionally, two radial scans orientated at 45 and 1351 crossing the optic disc centre were performed in six of 20 eyes, and RNFL thickness was measured at disc margin.Results Quadrant location and distance from disc margin interaction in RNFL thickness was statistically significant (P < 0.001). the RNFL thickness decreased (P < 0.001) as the distance from the disc margin increased for all sections. the measurements automatically generated by the OCT built-in software were thinner (P < 0.001) than histologic ones close to the disc margin.Conclusions Four normal OCT RNFL profiles were established and compared with histological data obtained from the same area. RNFL measurements assessed by OCT 3 were significantly thinner close to the optic disc margin.Hosp Olhos Araraquara, Glaucoma Sect, BR-14802530 Araraquara, SP, BrazilHosp Olhos Araraquara, Retina Diagnost & Treatment Div, BR-14802530 Araraquara, SP, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilUSP, Inst Fis Sao Carlos, Sao Carlos, SP, BrazilUniv So Calif, Doheny Eye Inst, Dept Ophthalmol, Los Angeles, CA USAUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc
Prevalence and predictors of video game addiction: a study based on a national representative sample of gamers
Video gaming has become a popular leisure activity in many parts of the world, and an increasing number of empirical studies examine the small minority that appears to develop problems as a result of excessive gaming. This study investigated prevalence rates and predictors of video game addiction in a sample of gamers, randomly selected from the National Population Registry of Norway (N =3389). Results showed there were 1.4 % addicted gamers, 7.3 % problem gamers, 3.9 % engaged gamers, and 87.4 % normal gamers. Gender (being male) and age group (being young) were positively associated with addicted-, problem-, and engaged gamers. Place of birth (Africa, Asia, South- and Middle America) were positively associated with addicted- and problem gamers. Video game addiction was negatively associated with conscientiousness and positively associated with neuroticism. Poor psychosomatic health was positively associated with problem- and engaged gaming. These factors provide insight into the field of video game addiction, and may help to provide guidance as to how individuals that are at risk of becoming addicted gamers can be identified
- …