Duality Versus Supersymmetry and Compactification

We study the interplay between T-duality, compactification and supersymmetry. We prove that when the original configuration has unbroken space-time supersymmetries, the dual configuration also does if a special condition is met: the Killing spinors of the original configuration have to be independent on the coordinate which corresponds to the isometry direction of the bosonic fields used for duality. Examples of ``losers" (T-duals are not supersymmetric) and ``winners" (T-duals are supersymmetric) are given.Comment: LaTeX file, 19 pages, U. of Groningen Report UG-8/94, Stanford U. Report SU-ITP-94-19, QMW College Report QMW-PH-94-1

GraphStep: A System Architecture for Sparse-Graph Algorithms

Many important applications are organized around long-lived, irregular sparse graphs (e.g., data and knowledge bases, CAD optimization, numerical problems, simulations). The graph structures are large, and the applications need regular access to a large, data-dependent portion of the graph for each operation (e.g., the algorithm may need to walk the graph, visiting all nodes, or propagate changes through many nodes in the graph). On conventional microprocessors, the graph structures exceed on-chip cache capacities, making main-memory bandwidth and latency the key performance limiters. To avoid this “memory wall,” we introduce a concurrent system architecture for sparse graph algorithms that places graph nodes in small distributed memories paired with specialized graph processing nodes interconnected by a lightweight network. This gives us a scalable way to map these applications so that they can exploit the high-bandwidth and low-latency capabilities of embedded memories (e.g., FPGA Block RAMs). On typical spreading activation queries on the ConceptNet Knowledge Base, a sample application, this translates into an order of magnitude speedup per FPGA compared to a state-of-the-art Pentium processor

Exact SU(2)*U(1) Stringy Black Holes

Extreme magnetic dilaton black holes are promoted to exact solutions of heterotic string theory with unbroken supersymmetry. With account taken of alpha' corrections this is accomplished by supplementing the known solutions with SU(2) Yang-Mills vectors and scalars in addition to the already existing Abelian U(1) vector field. The solution has a simple analytic form and includes multi-black-holes. The issue of exactness of other black-hole-type solutions, including extreme dilaton electrically charged black holes and Taub-NUT solutions is discussed.Comment: 10 pages, SU-ITP-94-27 and QMW-PH-94-34 (version accepted for publication in Phys. Rev., contains a discussion of (4.1) supersymmetry of the black hole sigma model

Solution--Generating Transformations and the String Effective Action

We study exhaustively the solution-generating transformations (dualities) that occur in the context of the low-energy effective action of superstring theory. We first consider target-space duality (``T duality'') transformations in absence of vector fields. We find that for one isometry the full duality group is (SO^{\uparrow}(1,1))^{3} x D_{4}, the discrete part (D_{4}) being non-Abelian. We, then, include non-Abelian Yang--Mills fields and find the corresponding generalization of the T duality transformations. We study the \alpha^{\prime} corrections to these transformations and show that the T duality rules considerably simplify if the gauge group is embedded in the holonomy group. Next, in the case in which there are Abelian vector fields, we consider the duality group that includes the transformation introduced by Sen that rotates among themselves components of the metric, axion and vector field. Finally we list the duality symmetries of the Type II theories with one isometry.Comment: latex file, 42 pages (less if you use optional commands) No changes at all. Resubmited due to mailer problem

Kihon Checklist to assess frailty in older adults: Some evidence on the internal consistency and validity of the Spanish version

Aim: The aim of this study was to assess the internal consistency, hypothesis testing and criterion-related validity of the Spanish versions of the Kihon Checklist (KCL) - the original 25-item and reduced 15-item versions - for screening frailty in community-dwelling older adults. Methods: A cross-sectional study was carried out between March and September 2018 in Valencia province (Spain). A sample of 251 participants was recruited. Construct validity was assessed using four different frailty instruments, and alternative measures corresponding to the KCL domains (handgrip strength, gait speed, the Short Physical Performance Battery, skeletal muscle mass index, physical activity level, functional status, cognitive function, depressive mood, health-related quality of life and nutritional status). Fried's Frailty Phenotype was used to evaluate criterion validity. Results: Internal consistency assessed with Kuder-Richardson Formula had a value of 0.69 for the 25-item version, slightly lower than the usual 0.7 for considering good reliability, and 0.71 for the 15-item version. There were significant correlations between KCL versions and Fried's Frailty Phenotype, Edmonton Scale, Tilburg Indicator and FRAIL Scale. Consistent significant correlations were also obtained with all frailty measurements and instrumental activities of daily living, physical strength, eating, socialization, and mood domains of the KCL. The KCL closely correlated with other standardized measurements of physical function, cognitive function, depressive mood, and health-related quality of life. The KCL also showed satisfactory diagnostic accuracy for frailty (area under the curve 0.891 for KCL-25; area under the curve 0.857 for KCL-15). The optimal cut-off points were 5/6 and 3/4, respectively. Conclusions: The findings suggest that both versions of the KCL, especially KCL-15, showed adequate evidence of validity and internal consistency as a preliminary screening of frailty among community-dwelling older adults in Spain

GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo

© The Author(s).[Background]: Insulin secretion from the pancreatic β-cell is finely modulated by different signals to allow an adequate control of glucose homeostasis. Incretin hormones such as glucagon-like peptide-1 (GLP-1) act as key physiological potentiators of insulin release through binding to the G protein-coupled receptor GLP-1R. Another key regulator of insulin signaling is the Ser/Thr kinase G protein-coupled receptor kinase 2 (GRK2). However, whether GRK2 affects insulin secretion or if GRK2 can control incretin actions in vivo remains to be analyzed. [Results]: Using GRK2 hemizygous mice, isolated pancreatic islets, and model β-cell lines, we have uncovered a relevant physiological role for GRK2 as a regulator of incretin-mediated insulin secretion in vivo. Feeding, oral glucose gavage, or administration of GLP-1R agonists in animals with reduced GRK2 levels (GRK2+/− mice) resulted in enhanced early phase insulin release without affecting late phase secretion. In contrast, intraperitoneal glucose-induced insulin release was not affected. This effect was recapitulated in isolated islets and correlated with the increased size or priming efficacy of the readily releasable pool (RRP) of insulin granules that was observed in GRK2+/− mice. Using nanoBRET in β-cell lines, we found that stimulation of GLP-1R promoted GRK2 association to this receptor and that GRK2 protein and kinase activity were required for subsequent β-arrestin recruitment. [Conclusions]: Overall, our data suggest that GRK2 is an important negative modulator of GLP-1R-mediated insulin secretion and that GRK2-interfering strategies may favor β-cell insulin secretion specifically during the early phase, an effect that may carry interesting therapeutic applications.We acknowledge support by Ministerio de Economía y Competitividad (MINECO/FEDER), Spain (grant SAF2017-84125-R to FM and CM and BFU2017-89336-R to MV); CIBER de Enfermedades Cardiovasculares (CIBERCV). Instituto de Salud Carlos III, Spain (grant CB16/11/00278 to F.M., co-funded with European FEDER contribution); CIBER de Diabetes y Enfermedades Metabólicas Asociadas (Ciberdem), Instituto de Salud Carlos III (CB07/08/0029 to MV); and Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FM; Medical Research Council to AT and BJ

Vibration reduction for vision systems on board unmanned aerial vehicles using a neuro-fuzzy controller

In this paper, an intelligent control approach based on neuro-fuzzy systems performance is presented, with the objective of counteracting the vibrations that affect the low-cost vision platform onboard an unmanned aerial system of rotating nature. A scaled dynamical model of a helicopter is used to simulate vibrations on its fuselage. The impact of these vibrations on the low-cost vision system will be assessed and an intelligent control approach will be derived in order to reduce its detrimental influence. Different trials that consider a neuro-fuzzy approach as a fundamental part of an intelligent semi-active control strategy have been carried out. Satisfactory results have been achieved compared to those obtained by means of vibration reduction passive techniques

Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes

Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the natural product prodigiosin, a tripyrrolic molecule produced by microorganisms such as Streptomyces and Serratia, facilitates chloride/bicarbonate exchange (antiport) across liposomal membranes. Higher concentrations of simple synthetic molecules based on a 4,6-dihydroxyisophthalamide core are also shown to facilitate this antiport process. Although it is well known that proteins regulate Cl-/HCO3- exchange in cells, these results suggest that small molecules may also be able to regulate the concentration of these anions in biological systems

The Cinematic Daydream as a Tool of Political Emancipation: Plus-de-Jouir, Aufhebung and the Parallax

In this research, we will start by expo- sing the paradox of ‘surplus enjoyment’ (the Lacanian plus-de-jouir), showing that its parallax structure of lack and excess is also applicable to the pheno- menon of (surplus) repression. Linking his concept with the Hegelian Aufhebung, understood as a ‘failed negation of negation’ or a ‘negation of negation’ as failure, we will focus in detail on the central example illustrating our theoretical positions, which is Iciar Bollain’s film Tambien la Lluvia (Even the Rain). In analyzing its narrative structures that address the neocolonial reality, we will tend to approach indirectly, by reading the medium of cinematic narration, the ‘neocolonial question.

Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study.

Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors. Past research has determined that stress experienced in adulthood is associated with shorter telomere length, but is limited to mostly cross-sectional reports. We test whether repeated reports of chronic psychosocial and financial burden is associated with telomere length change over a 5-year period (years 15 and 20) from 969 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a longitudinal, population-based cohort, ages 18-30 at time of recruitment in 1985. We further examine whether multisystem resiliency, comprised of social connections, health-maintaining behaviors, and psychological resources, mitigates the effects of repeated burden on telomere attrition over 5 years. Our results indicate that adults with high chronic burden do not show decreased telomere length over the 5-year period. However, these effects do vary by level of resiliency, as regression results revealed a significant interaction between chronic burden and multisystem resiliency. For individuals with high repeated chronic burden and low multisystem resiliency (1 SD below the mean), there was a significant 5-year shortening in telomere length, whereas no significant relationships between chronic burden and attrition were evident for those at moderate and higher levels of resiliency. These effects apply similarly across the three components of resiliency. Results imply that interventions should focus on establishing strong social connections, psychological resources, and health-maintaining behaviors when attempting to ameliorate stress-related decline in telomere length among at-risk individuals