126 research outputs found
The relationship of bottle feeding and other sucking behaviors with speech disorder in Patagonian preschoolers
- Author
- A Lindner
- A Olguin
- Annette L Fitzpatrick
- AP Verrastro
- AV Fox
- B Ogaard
- B Svedmyr
- Bizu Gelaye
- Chanaye Jackson
- Clarita Barbosa
- D Ingram
- D Stampe
- D Viggiano
- D Zadik
- FC Neiva
- FE Broad
- FE Broad
- GMM Pavez
- JJ Warren
- JJ Warren
- Juan Carlos Velez Gonzalez
- K Duncan
- M Ferguson
- M Maggiolo
- Mary A Parada
- N David Yanez
- NE Tomita
- P Agurto
- Sandra Vasquez
- VV Degan
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Previous studies have shown that children's nonnutritive sucking habits may lead to delayed development of their oral anatomy and functioning. However, these findings were inconsistent. We investigated associations between use of bottles, pacifiers, and other sucking behaviors with speech disorders in children attending three preschools in Punta Arenas (Patagonia), Chile.</p> <p>Methods</p> <p>Information on infant feeding and sucking behaviors, age starting and stopping breast- and bottle-feeding, pacifier use, and other sucking behaviors, was collected from self-administered questionnaires completed by parents. Evaluation of speech problems was conducted at preschools with subsequent scoring by a licensed speech pathologist using age-normative standards.</p> <p>Results</p> <p>A total of 128 three- to five-year olds were assessed, 46% girls and 54% boys. Children were breastfed for an average of 25.2 (SD 9.6) months and used a bottle 24.4 (SD 15.2) months. Fifty-three children (41.7%) had or currently used a pacifier for an average of 11.4 (SD 17.3) months; 23 children (18.3%) were reported to have sucked their fingers. Delayed use of a bottle until after 9 months appeared to be protective for subsequent speech disorders. There was less than a one-third lower relative odds of subsequent speech disorders for children with a delayed use of a bottle compared to children without a delayed use of a bottle (OR: 0.32, 95% CI: 0.10-0.98). A three-fold increase in relative odds of speech disorder was found for finger-sucking behavior (OR: 2.99, 95% CI: 1.10-8.00) and for use of a pacifier for 3 or more years (OR: 3.42, 95% CI: 1.08-10.81).</p> <p>Conclusion</p> <p>The results suggest extended use of sucking outside of breastfeeding may have detrimental effects on speech development in young children.</p
The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease
- Author
- A Banerjee
- A Caccamo
- A Calastretti
- A Edström
- A Mathie
- A Sali
- A Shimada
- AD Cash
- AI Bush
- AI Bush
- AM Grabrucker
- BM Riederer
- BN Ames
- C Gonzalez-Billaut
- C Lafay-Chebassier
- C SĂĄnchez
- CC Hoogenraad
- Cheng-Xin Gong
- CJ Frederickson
- CJ Frederickson
- CL Allan
- D Sept
- D Sept
- Deepak Chopra
- E Nogales
- E Thies
- E Unger
- EA Van der Zee
- EM Sigurdsson
- F Gaskin
- F Gaskin
- F Wandosell
- F Wang
- FC Bernstein
- FD Wang
- G Lian
- GR Eagle
- H Li
- H Li
- HX Liu
- I Kim
- J Cronly-Dillon
- J Löwe
- J Nunez
- JA Tuszynski
- JA Tuszynski
- Jack A. Tuszynski
- JC Ebert
- JC Phillips
- JE Hesketh
- JE Hesketh
- JE Hesketh
- JF DĂaz
- JF Loring
- JH Weiss
- JJ Pei
- JJ Pei
- JL Ross
- JW Ashford
- JY Koh
- K Fukunaga
- K Hsiao
- K Prus
- KM Haskins
- L Dehmelt
- LA Roberts
- Lee E. Goldstein
- LS Goldstein
- M Bianchi
- M Ester
- M Godert
- M Paula-Barbosa
- M Zervas
- N Hirokawa
- N Shu
- NA Baker
- NG Faux
- NJ Woolf
- NJ Woolf
- NJ Woolf
- NJ Woolf
- NJ Woolf
- Noel Casey
- PA Adlard
- PA Adlard
- PA Adlard
- PI Oteiza
- PI Oteiza
- R Dixit
- R Melki
- R Sabaté
- RE Tanzi
- RP Chi
- Rudolph E. Tanzi
- S Cavallaro
- S Hagan
- S Halpain
- S Hameroff
- S Hameroff
- S Kar
- S Sahu
- SR Hameroff
- SR Hameroff
- SS Yoo
- Stuart R. Hameroff
- TJ Dolinsky
- TJ Dolinsky
- TJ Nelson
- TJA Craddock
- TJA Craddock
- Travis J. A. Craddock
- V Meske
- W DeLano
- W Vater
- WL An
- WL An
- Y Kress
- Y Tufail
- YP Pang
- YP Pang
- YP Pang
- Z Khuchua
- ZY Mo
- Publication venue
- Public Library of Science
- Publication date
- 23/03/2012
- Field of study
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Hallmark AD neuropathology includes extracellular amyloid plaques composed largely of the amyloid-ÎČ protein (AÎČ), intracellular neurofibrillary tangles (NFTs) composed of hyper-phosphorylated microtubule-associated protein tau (MAP-tau), and microtubule destabilization. Early-onset autosomal dominant AD genes are associated with excessive AÎČ accumulation, however cognitive impairment best correlates with NFTs and disrupted microtubules. The mechanisms linking AÎČ and NFT pathologies in AD are unknown. Here, we propose that sequestration of zinc by AÎČ-amyloid deposits (AÎČ oligomers and plaques) not only drives AÎČ aggregation, but also disrupts zinc homeostasis in zinc-enriched brain regions important for memory and vulnerable to AD pathology, resulting in intra-neuronal zinc levels, which are either too low, or excessively high. To evaluate this hypothesis, we 1) used molecular modeling of zinc binding to the microtubule component protein tubulin, identifying specific, high-affinity zinc binding sites that influence side-to-side tubulin interaction, the sensitive link in microtubule polymerization and stability. We also 2) performed kinetic modeling showing zinc distribution in extra-neuronal AÎČ deposits can reduce intra-neuronal zinc binding to microtubules, destabilizing microtubules. Finally, we 3) used metallomic imaging mass spectrometry (MIMS) to show anatomically-localized and age-dependent zinc dyshomeostasis in specific brain regions of Tg2576 transgenic, mice, a model for AD. We found excess zinc in brain regions associated with memory processing and NFT pathology. Overall, we present a theoretical framework and support for a new theory of AD linking extra-neuronal AÎČ amyloid to intra-neuronal NFTs and cognitive dysfunction. The connection, we propose, is based on ÎČ-amyloid-induced alterations in zinc ion concentration inside neurons affecting stability of polymerized microtubules, their binding to MAP-tau, and molecular dynamics involved in cognition. Further, our theory supports novel AD therapeutic strategies targeting intra-neuronal zinc homeostasis and microtubule dynamics to prevent neurodegeneration and cognitive decline
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
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- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström PÄ
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
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- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
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- Burley T
- Burova N
- Burris H
- Burton C
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- Burtt D
- Busak L
- Busic N
- Byars W
- BĂžen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
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- Collier D
- Collins R
- Coloma G
- Colquhoun D
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- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
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- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
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- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
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- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
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- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
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- Dodds G
- Doesborg L
- Doggett J
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- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
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- Dudarev M
- Dudhatra N
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- Dunhurst F
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- Erickson B
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- Feitosa G
- Felario Junior Ga
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- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
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- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
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- Flezar M
- Fliesser-Goerzer E
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- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
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- Fruchter G
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- Fucak E
- Fuchs R
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- Fukuike C
- Fullerton D
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- Gilley J
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- Glancy R
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- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
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- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
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- Hecht J
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- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- HernĂĄndez N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
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- Hodnett P
- Hoffman M
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- Holmes Z
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- Holscher A
- Hominal M
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- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- HĂ€rstedt N
- HĂživik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- JuliĂŁo K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
- Koba M
- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
- Koldas N
- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- KopczyĆska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
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- Landzberg J
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- Langdon J
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- Lappo M
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- Lembo G
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- Lennard M
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- Lepor N
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- Lester F
- Levin P
- Levine D
- Lewis D
- Li W
- Li X
- Li Y
- Li Y
- Li Y
- Li Yh
- Li Z
- Libby P
- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
- Lindholm Cj
- Lindner C
- Liniado G
- Lino E
- Lipchenko A
- Liu B
- Liu B
- Liu Hm
- Liu P
- Liu S
- Liu Y
- Liviu C
- Lock E
- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
- Mody F
- Moehring B
- Moen S
- Moffat J
- Mohan K
- Molina Di
- Molk B
- Molter D
- Monroe T
- Montana O
- Montenegro E
- Montenegro P
- Montero H
- Montgomery R
- Monti L
- Moodh J
- Mooe T
- Mookherjee D
- Moon K
- Moraes J Jr
- Moran J
- Moreira L
- Morell Y
- Moriarty P
- Morii I
- Morinaga Y
- Morisawa T
- Morozov E
- Morrison J
- Morton D
- Mos L
- Moshayedi P
- Mosley J
- Motiejuniene R
- Muehlhaus J
- Mueller S
- Muenter Kc
- Muenzel T
- Mulder R
- Munoz N
- Munoz R
- Munshi K
- Muntaner J
- Mureddu V
- Murphy G
- Murray A
- Mustafa J
- Musumeci Mb
- Muñoz W
- Myslyaeva L
- Nadar V
- Nagai Y
- Nagele-Luse I
- Nagy Ac
- Naidu R
- Naka T
- Nakamura S
- Nakamura Y
- Nakayoshi K
- Nalley J
- Nanas J
- Nandy P
- Naumann R
- Navarrete S
- Navy S
- Nebel J
- Neil L
- Nema D
- Neumann J
- Neutel Jm
- Niblack P
- Nicely V
- Nicolai M
- Nicolau J
- Nijmeh G
- Nikas A
- Nikoletta P
- Nikolic L
- Nikyar A
- Nilsen V
- Ning M
- Nishibe A
- Nixon S
- Nociar J
- Noori E
- Norin V
- Norkiene S
- Norkute-Macijauske U
- Norman L
- Noto G
- Nour K
- Novo S
- Nuding S
- Nugent A
- Nugteren Skz
- Ocman B
- Odegard A
- Ogawa H
- Ogawa M
- Okada Y
- Okawa M
- Okeefe D
- Olenchock B
- Olmedo M
- Olofsson M
- Olsen S
- Olsson Gh
- Olympios Cd
- Ondrasik J
- Onuchina E
- Oomman A
- Ord M
- Ortiz-Carrasquillo R
- Ossino N
- Otasevic P
- Otava M
- Otis R
- Otterstad Je
- Ouimet F
- Overhoff U
- Ozcan It
- OâNeil G
- P Pais
- P Peters
- P Piatti
- P Poliacik
- P Povolny
- P Purnell
- Pacora Ff
- Paez H
- Paganini M
- Page A
- Pagett K
- Pagnan M
- Pai R
- Pai V
- Palaniswami N
- Palatkina T
- Palchick B
- Pales J
- Paliwal Y
- Palka J Jr
- Palubova L
- Pande R
- Pandey S
- Paniagua A
- Pannell R
- Panov A
- Pansheriya A
- Panzarino C
- Papke B
- Parekh N
- Parente A
- Parepa I
- Parfait V
- Park B
- Park C
- Parmon E
- Partridge J
- Patel B
- Patel J
- Patel M
- Patel R
- Patel R
- Patel S
- Patino Jm
- Patole T
- Patsilinakos S
- Paulweber B
- Pavlickova L
- Paysor C
- Paz S
- Peck C
- Pella D
- Pena A
- Pencz I
- Peng L
- Penzes J
- Pereira S
- Perez Manghi F
- Perez A
- Perez M
- Perkins H
- Perkins L
- Perlstein T
- Perotti M
- Perperis A
- Perry B
- Pesce F
- Petelina T
- Peter Y
- Peterka M
- Petrauskiene B
- Petrescu L
- Petrillo C
- Petrov D
- Petrova I
- Petrusheva T
- Pettersen Ki
- Peukert Am
- Phillippi C
- Phillips A
- Phillips A
- Piacente R
- Pieretti Hb
- Pinheiro L
- Pintado M
- Pirenne B
- Pish R
- Piskorz D
- Pitt W
- Planinc I
- Ploechl A
- Plotz M
- Podoleanu C
- Pogson A
- Pokorna B
- Polato C
- Poling T
- Pomposini D
- Ponce T
- Poock J
- Pool T
- Poor F
- Pop Cf
- Popa V
- Popescu E
- Popovic Z
- Potts J
- Poudrier R
- Poulimenos L
- Pradhan A
- Pramatarova I
- Praveen M
- Prenner A
- Price D
- Price R
- Prior J
- Priori S
- Pritchard C
- Procter K
- Pupic L
- Purighalla R
- Pye M
- Qing L
- Quddusi K
- Quinones J
- Quinton D
- R Rauch
- R Recoaro
- R Reyes
- R Roettges
- R Rummel
- Racca V
- Radde I
- Radeljic V
- Radhakrishnan V
- Radin M
- Radoi M
- Radojcsics B
- Radvan M
- Raev D
- Ragghianti B
- Raghu C
- Rajan B A
- Rajasekhar D
- Rajput B
- Raju Ss
- Rama B
- Ramdas S
- Ramos G
- Ramos M
- Rancane G
- Randvee L
- Ranjith N
- Rao M
- Rao Mb
- Rao Nm
- Rassi S
- Rathnavel S
- Rathore A
- Rathore Srs
- Ratnik E
- Rau T
- Rawat S
- Raynes K
- Reber Am
- Reddy J
- Reddy Nc
- Redfearn H
- Rees Dh
- Reeves M
- Regner S
- Reichenbach D
- Reilly K
- Reimand M
- Reimer D
- Reinmets S
- Reis G
- Reis H
- Ren L
- Renaud K
- Renda G
- Repin A
- Resende I
- Resnick H
- Rewbury J
- Reznakova S
- Reznik I
- Rhudy Jm
- Richardson M
- Richert L
- Rickova Z
- Ridker Pm
- Riethof M
- Righini V
- Rinke A
- Risberg K
- Risenfors M
- Riser J
- Rivis L
- Robbins K
- Roberts-Thomson P
- Robinson S
- Rodero M
- Rodriguez Araya E
- Rodriguez A
- Rodriguez D
- Rodriguez J
- Rodriguez Lm
- Rodriguez Sm
- Roel A
- Romano A
- Romanski A
- Roos J
- Roper L
- Ross B
- Rossi Prf
- Rost N
- Roszkowska P
- Rotreklova M
- Roy A
- Roy C
- Roy M
- Rozeman P
- Ruder D
- Rudys A
- Ruffini L
- Rugo H
- Runev N
- Runquist L
- Rupka D
- Ruschel K
- Ryding A
- Rönndahl M
- RĂžnnevik P
- RĂžnnevik Td
- S Sarah
- S Sasaki
- S Sathe
- S Seki
- S Sharma
- S Shayani
- S Shetty
- S Shustov
- S Srivastava
- S Stadelmeier
- S Stoltz
- S Strand
- S Strugatsky
- S Such
- Sabo L
- Sack G
- Sahin M
- Sahin T
- Saini R
- Saint-Jacques H
- Saka B
- Sakamoto Y
- Sakurada M
- Salfity M
- Salinger M
- Salko T
- Sall N
- Saloustros I
- Salvador L
- Sam K
- Samal A
- Samer H
- Samkova D
- Sanchez Vallejo G
- Sanchez A
- Sanchez D
- Sang X
- Santiago J Jr
- Santosh Mj
- Sanuri M
- Saporito W
- Saraiva Jf
- Saravia Ma
- Sarbu I
- Sarcone M
- Sarjanovich R
- Sarma R
- Sarnighausen He
- Sarszegi Z
- Sattar N
- Saunders K
- Savard D
- Savignano C
- Saylor R
- Sazonova E
- Scaro G
- Scheffel M
- Scheibner T
- Schermaul Kh
- Schiavi Lb
- Schifferdecker B
- Schindler A
- Schindler A
- Schindler E
- Schlundt C
- Schmidt E
- Schmidt K
- Schnabel A
- Schneider P
- Schneider R
- Schnitzler R
- Schoen N
- Schorn K
- Schrager B
- Schroeder T
- Schulenburg D
- Schultz C
- Schulz M
- Schulze J
- Schulze U
- Schumacher M
- Schwartz A
- Schwerin G
- Schwerin M
- SchÀfer B
- Sciborski R
- Scott J
- Scott R
- Seals A
- Senni M
- Sergienko T
- Seroqui M
- Servaes V
- Sesto I
- Seung Kb
- Shah A
- Shah Av
- Shah J
- Shaikh P
- Shanahan T
- Shaposhnik I
- Shapovalova Y
- Sharma K
- Sharma T
- Sharp A
- Shatsky K
- Shaw P
- Shealy N
- Sheets L
- Shelley J
- Shepard P
- Shetty P
- Shimokawa H
- Shimomura H
- Shinozaki T
- Shvarts Y
- Sidhu G
- Siemann M
- Sigurdadottir E
- Sigurdsson A
- Silva R
- Silver K
- Simay A
- Sime I
- Simon J
- Simon M
- Simons N
- Simpson H
- Singerling M
- Singh K
- Singh N
- Singh V
- Singhal A
- Sinnaeve P
- Siostrzonek P
- Sirakova-Taseva A
- Sirnes Pa
- Sizemore Bc
- Skalicka H
- Skatrud L
- Skjelvan G
- Skopets I
- Skubova K
- Skuladottir F
- Skuratova M
- Slanina M
- Slapikas R
- Slayton C
- Slechticka A
- Slimak V
- Sloane G
- Smallwood B
- Smeele F
- Smik R
- Smith B
- Smith G
- Smith J
- Smith J
- Smith M
- Smith M
- Smith P
- Smith T
- Smith W
- Smith W
- Smolenskaya O
- Soca Y
- Socoteanu E
- Socoteanu G
- Sofley C
- Sohi Gs
- Solares A
- Soler J
- Solovev O
- Song M
- Sopko K
- Soro E
- Sorodoc L
- Sosa-Padilla M
- Sotolongo R
- Sotomayor A
- Soucy D
- Spiridon M
- Sprinkle B
- Squire I
- Srdos V
- Srinath Vs
- St Amour E
- Stahl A
- Stahl Hd
- Stanciulescu G
- Starzec M
- Stefanescu M
- Steinhoff J
- Stelly L
- Steringer-Mascherbauer R
- Stern M
- Sternthal P
- Stinson J
- Stitova M
- Stockhausen G
- Stockhausen J
- Stoddard M
- Stoessel J
- Stofkova D
- Stokuca-Korac N
- Stolze K
- Stone B
- Stonkute K
- Storey R
- Stover T
- Strain J
- Stratmann M
- Strazdiene D
- Strbova J
- Stroes E
- Strohner-Kaestenbauer H
- Stys T
- Sugimoto N
- Suleman A
- Sullivan P
- Sun Z
- Sundelin R
- Suorra I
- Sutalo K
- Suzuki A
- Swart Hp
- Szacinski G
- Szakal I
- Szatmarine V
- Szocs A
- Szpajer M
- Szymanowski N
- T Tase
- T Tekten
- T Thuren
- T Tjaden
- Taguchi S
- Tahk S
- Tahon S
- Takahashi J
- Takase S
- Talliard C
- Tamburrini P
- Tamesby G
- Tamez W
- Tan M
- Tan R
- Tanabe K
- Tanaka A
- Tanaseanu C
- Tandon N
- Tani S
- Taqueti V
- Taran A
- Taverner P
- Tawfik R
- Teenan M
- Telekes P
- Teltser M
- Ten Holt W
- Terry K
- Terry Ps
- Tesak M
- Teschner Ab
- Teske A
- Tessmar C
- Thakkar B
- Thekkoott D
- Theunissen E
- Thiessen S
- Thomas D
- Thomas Dm
- Thomas H
- Thompson E
- Thompson J
- Thornton A
- Tijuneliene E
- Tinnirello V
- Tisheva-Gospodinova S
- Tobias C
- Todorova A
- Tomassi A
- Tomioka J
- Toom M
- Topper J
- Torgersruud M
- Torstensson I
- Torun A
- Toth P
- Townend J
- Tran A
- Treasure C
- Trenkamp P
- Trevelyan J
- Trevino M
- Trofimov V
- Troquay Rpt
- Tsai Mc
- Tsao Hm
- Tsioufis K
- Tsorbatzoglou K
- Tsou L
- Tsuboi H
- Tsuji M
- Tsujita K
- Tsujiyama S
- Tudoran M
- Tuholske C
- Turner F
- Tusek S
- Tzekova M
- Tzong L
- Ucar N
- Uecker C
- Ueng Kc
- Umesu A
- Unterkircher B
- Urbonas G
- Uresin S
- Urgeova L
- Urina M
- Urina-Triana M
- Uy W
- V Vahula
- V Vijan
- V Vora
- Vahtel M
- Vaid B
- Valenzuela M
- Valle M
- Vallejo Ma
- Vallone L
- Van Der Wal M
- Van Der Zwaan C
- Van Genechten G
- Van Kempen Ww
- Van Maarseveen M
- Van Stein I
- Vanagiene S
- Vance A
- Vandam J
- Vanhecke T
- Vanness WC Iii
- Vardas P
- Vargas R
- Varigos J
- Vasiliev M
- Vaz S
- Vazquez Tanus J
- Veerina K
- Vega J
- VegsundvÄg J
- Veit S
- Velusamy K
- Vento A
- Venturini C
- Vertes G
- Vervoort G
- Vesely J
- Vesely P
- Vesga B
- Vettus R
- Veze I
- Vezikova N
- Vezina M
- Vibert J
- Vicente C
- Vico Ml
- Vida-Simiti L
- Vieira N
- Viergever Ep
- Viezelis M
- Vijay N
- Villani Gq
- Vinanska D
- Vincelli G
- Vins P
- Viola Hg
- Visseren Flj
- Vissers C
- Vitovec M
- Vodnansky P
- Voelker F
- Voeller H
- Vogel M
- Vogt E
- Vold D
- Volpe M
- Voors C
- Vora K
- Vorster M
- Voyzey Ej
- Vozzhaev A
- Vranckx P
- Vrolix M
- Vuriya Ak
- W Wu
- Wade Rd
- Wadell C
- Wakeling J
- Waksman R
- Walker K
- Walker K
- Wallace K
- Walter I
- Walter J
- Walther I
- Walukiewicz P
- Wanderley Ff
- Wang Cp
- Wang Hc
- Wang J
- Wang Y
- Wang Yl
- Warren M
- Washam M
- Watson B
- Webel R
- Weber Hg
- Wei J
- Wei N
- Weimer J
- Weisnagel Sj
- Wells T
- West M
- Westberg Jc
- Whitaker J
- White A
- White A
- White C
- White J
- Wichterich K
- Wiebusch A
- Wilhoit G
- Wilkins M
- Wilkinson S
- William M
- Willingham K
- Willmerdinger M
- Willner C
- Wilson S
- Wilson V
- Winkelmann B
- Winkler J
- Wise J
- Wistuba T
- Woehrle J
- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1ÎČ, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1ÎČ innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
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- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- AbellĂĄn Am
- AbellĂĄn Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
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- Afshar S
- Agresta F
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- Ahel J
- Ahern Dp
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- Ainsworth P
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- Ais G
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- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
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- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
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- Shanmugarajah K
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- Shingler G
- Shiwani Mh
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- Shurlock J
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- Siddiqui Mn
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- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16â45âyears presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which twoâthirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; Pâ<â0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cutâoff score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cutâoff score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decisionâmaking by identifying adults in the UK at low risk of appendicitis were identified
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- Author
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- Ăzçelik Ă
- Publication venue
- Elsevier
- Publication date
- 26/02/2023
- Field of study
A preprint version of this article is available at arXiv:2210.00043v2 [hep-ex], https://arxiv.org/abs/2210.00043v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-009 (CMS Public Pages). Report number: CMS-B2G-20-009, CERN-EP-2022-152.Data availability: see: https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-009 .A search for new heavy resonances decaying to WW, WZ, ZZ, WH, or ZH boson pairs in the all-jets final state is presented. The analysis is based on proton-proton collision data recorded by the CMS detector in 2016-2018 at a centre-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 138 fb^{-1}. The search is sensitive to resonances with masses between 1.3 and 6 TeV, decaying to bosons that are highly Lorentz-boosted such that each of the bosons forms a single large-radius jet. Machine learning techniques are employed to identify such jets. No significant excess over the estimated standard model background is observed. A maximum local significance of 3.6 standard deviations, corresponding to a global significance of 2.3 standard deviations, is observed at masses of 2.1 and 2.9 TeV. In a heavy vector triplet model, spin-1 Z' and W' resonances with masses below 4.8 TeV are excluded at the 95% confidence level (CL). These limits are the most stringent to date. In a bulk graviton model, spin-2 gravitons and spin-0 radions with masses below 1.4 and 2.7 TeV, respectively, are excluded at 95% CL. Production of heavy resonances through vector boson fusion is constrained with upper cross section limits at 95% CL as low as 0.1 fb.SCOAP3
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Measurement of the Higgs boson production via vector boson fusion and its decay into bottom quarks in proton-proton collisions at sâ = 13 TeV
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/01/2024
- Field of study
A preprint version of the article is available at arXiv:2308.01253v2 [hep-ex], https://arxiv.org/abs/2308.01253v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-22-009 (CMS Public Pages). Report number: CMS-HIG-22-009, CERN-EP-2023-110.A measurement of the Higgs boson (H) production via vector boson fusion (VBF) and its decay into a bottom quark-antiquark pair (bbÂŻ) is presented using proton-proton collision data recorded by the CMS experiment at sâ = 13 TeV and corresponding to an integrated luminosity of 90.8 fbâ1. Treating the gluon-gluon fusion process as a background and constraining its rate to the value expected in the standard model (SM) within uncertainties, the signal strength of the VBF process, defined as the ratio of the observed signal rate to that predicted by the SM, is measured to be ÎŒqqHHbbÂŻ = 1.01 +0.55â0.46. The VBF signal is observed with a significance of 2.4 standard deviations relative to the background prediction, while the expected significance is 2.7 standard deviations. Considering inclusive Higgs boson production and decay into bottom quarks, the signal strength is measured to be ÎŒincl.HbbÂŻ = 0.99 +0.48â0.41, corresponding to an observed (expected) significance of 2.6 (2.9) standard deviations.SCOAP3, STFC; Marie-Curie program and the European Research Council and Horizon 2020 Gran
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Evidence for tWZ production in proton-proton collisions at âs=13 TeV in multilepton final states
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- Zoi I
- Zolkapli Z
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- Zuolo D
- Zygala L
- Publication venue
- Elsevier BV
- Publication date
- 21/06/2024
- Field of study
Data availability - https://www.sciencedirect.com/science/article/pii/S0370269324003733?via%3Dihub#dav0001 [Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open access policy (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2)]The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016â2018 in proton-proton collisions at âs=13 TeV, and correspond to an integrated luminosity of 138 fbâ1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.SCOAP
Recommended from our members
Measurement of inclusive and differential cross sections for single top quark production in association with a W boson in proton-proton collisions at sâ = 13 TeV
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- Publication venue
- Springer Nature
- Publication date
- 06/11/2022
- Field of study
A preprint version of the article is available at arXiv:2208.00924v2 [hep-ex], https://arxiv.org/abs/2208.00924v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-21-010 (CMS Public Pages). Report number: CMS-TOP-21-010, CERN-EP-2022-158.Measurements of the inclusive and normalised differential cross sections are presented for the production of single top quarks in association with a W boson in proton-proton collisions at a centre-of-mass energy of 13 TeV. The data used were recorded with the CMS detector at the LHC during 2016-2018, and correspond to an integrated luminosity of 138 fb^{â1}. Events containing one electron and one muon in the final state are analysed. For the inclusive measurement, a multivariate discriminant, exploiting the kinematic properties of the events is used to separate the signal from the dominant ttÂŻ background. A cross section of 79.2 ± 0.9 (stat) +7.7â8.0 (syst) ± 1.2 (lumi) pb is obtained, consistent with the predictions of the standard model. For the differential measurements, a fiducial region is defined according to the detector acceptance, and the requirement of exactly one jet coming from the fragmentation of a bottom quark. The resulting distributions are unfolded to particle level and agree with the predictions at next-to-leading order in perturbative quantum chromodynamics.SCOAP3
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Measurements of the Higgs boson production cross section and couplings in the W boson pair decay channel in proton-proton collisions at sâ = 13 TeV
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- Ăzçelik Ă
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 09/10/2022
- Field of study
A preprint version of the article is available at arXiv:2206.09466v2 [hep-ex], https://arxiv.org/abs/2206.09466v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at httpS://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-20-013 (CMS Public Pages). Report number: CMS-HIG-20-013, CERN-EP-2022-120.Production cross sections of the standard model Higgs boson decaying to a pair of W bosons are measured in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis targets Higgs bosons produced via gluon fusion, vector boson fusion, and in association with a W or Z boson. Candidate events are required to have at least two charged leptons and moderate missing transverse momentum, targeting events with at least one leptonically decaying W boson originating from the Higgs boson. Results are presented in the form of inclusive and differential cross sections in the simplified template cross section framework, as well as couplings of the Higgs boson to vector bosons and fermions. The data set collected by the CMS detector during 2016-2018 is used, corresponding to an integrated luminosity of 138 fb^â1. The signal strength modifier ÎŒ, defined as the ratio of the observed production rate in a given decay channel to the standard model expectation, is measured to be ÎŒ = 0.95 +0.10â0.09. All results are found to be compatible with the standard model within the uncertainties.SCOAP3
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