1,647 research outputs found
R-parity Violation and Semileptonic Decays of B-meson
We investigate the effects of R-parity violation on the semileptonic decays
of B-meson in the minimal supersymmetric standard model with explicit R-parity
violation and discuss its physical implications. We find that the semileptonic
decays of B-meson can be largely affected by the R-parity violation.Comment: 10 pages, LaTex file, no figure. References and a table are added.
Tables are improve
New Insulin Delivery Recommendations
Many primary care professionals manage injection or infusion therapies in patients with diabetes. Few published guidelines have been available to help such professionals and their patients manage these therapies. Herein, we present new, practical, and comprehensive recommendations for diabetes injections and infusions. These recommendations were informed by a large international survey of current practice and were written and vetted by 183 diabetes experts from 54 countries at the Forum for Injection Technique and Therapy: Expert Recommendations (FITTER) workshop held in Rome, Italy, in 2015. Recommendations are organized around the themes of anatomy, physiology, pathology, psychology, and technology. Key among the recommendations are that the shortest needles (currently the 4-mm pen and 6-mm syringe needles) are safe, effective, and less painful and should be the first-line choice in all patient categories; intramuscular injections should be avoided, especially with long-acting insulins, because severe hypoglycemia may result; lipohypertrophy is a frequent complication of therapy that distorts insulin absorption, and, therefore, injections and infusions should not be given into these lesions and correct site rotation will help prevent them; effective long-term therapy with insulin is critically dependent on addressing psychological hurdles upstream, even before insulin has been started; inappropriate disposal of used sharps poses a risk of infection with blood-borne pathogens; and mitigation is possible with proper training, effective disposal strategies, and the use of safety devices. Adherence to these new recommendations should lead to more effective therapies, improved outcomes, and lower costs for patients with diabetes. (C) 2016 Mayo Foundation for Medical Education and Research.BD, a manufacturer of injecting devicesSCI(E)[email protected]
Constraints on the R-parity- and Lepton-Flavor-Violating Couplings from B0 Decats to Two Charged Leptons
We derive the upper bounds on certain products of R-parity- and
lepton-flavor-violating couplings from the decays of the neutral meson into
two charged leptons. These modes of decays can constrain the product
combinations of the couplings with one or more heavy generation indices. We
find that most of these bounds are stronger than the previous ones.Comment: Table is changed; version to appear in Phys. Rev.
Direct electronic measurement of the spin Hall effect
The generation, manipulation and detection of spin-polarized electrons in
nanostructures define the main challenges of spin-based electronics[1]. Amongst
the different approaches for spin generation and manipulation, spin-orbit
coupling, which couples the spin of an electron to its momentum, is attracting
considerable interest. In a spin-orbit-coupled system, a nonzero spin-current
is predicted in a direction perpendicular to the applied electric field, giving
rise to a "spin Hall effect"[2-4]. Consistent with this effect,
electrically-induced spin polarization was recently detected by optical
techniques at the edges of a semiconductor channel[5] and in two-dimensional
electron gases in semiconductor heterostructures[6,7]. Here we report
electrical measurements of the spin-Hall effect in a diffusive metallic
conductor, using a ferromagnetic electrode in combination with a tunnel barrier
to inject a spin-polarized current. In our devices, we observe an induced
voltage that results exclusively from the conversion of the injected spin
current into charge imbalance through the spin Hall effect. Such a voltage is
proportional to the component of the injected spins that is perpendicular to
the plane defined by the spin current direction and the voltage probes. These
experiments reveal opportunities for efficient spin detection without the need
for magnetic materials, which could lead to useful spintronics devices that
integrate information processing and data storage.Comment: 5 pages, 4 figures. Accepted for publication in Nature (pending
format approval
Model-Independent Analysis of Tri-bimaximal Mixing -- a Softly-Broken Hidden or an Accidental Symmetry?
To address the issue of whether tri-bimaximal mixing (TBM) is a softly-broken
hidden or an accidental symmetry, we adopt a model-independent analysis in
which we perturb a neutrino mass matrix leading to TBM in the most general way
but leave the three texture zeros of the diagonal charged lepton mass matrix
unperturbed. We compare predictions for the perturbed neutrino TBM parameters
with those obtained from typical SO(10) grand unified theories with a variety
of flavor symmetries. Whereas SO(10) GUTs almost always predict a normal mass
hierarchy for the light neutrinos, TBM has a priori no preference for neutrino
masses. We find, in particular for the latter, that the value of |U_{e3}| is
very sensitive to the neutrino mass scale and ordering. Observation of
|U_{e3}|^2 > 0.001 to 0.01 within the next few years would be incompatible with
softly-broken TBM and a normal mass hierarchy and would suggest that the
apparent TBM symmetry is an accidental symmetry instead. No such conclusions
can be drawn for the inverted and quasi-degenerate hierarchy spectra.Comment: 14 pages, 8 figures. Typos corrected, references added. To appear in
PL
Phosfinder: a web server for the identification of phosphate-binding sites on protein structures
Phosfinder is a web server for the identification of phosphate binding sites in protein structures. Phosfinder uses a structural comparison algorithm to scan a query structure against a set of known 3D phosphate binding motifs. Whenever a structural similarity between the query protein and a phosphate binding motif is detected, the phosphate bound by the known motif is added to the protein structure thus representing a putative phosphate binding site. Predicted binding sites are then evaluated according to (i) their position with respect to the query protein solvent-excluded surface and (ii) the conservation of the binding residues in the protein family. The server accepts as input either the PDB code of the protein to be analyzed or a user-submitted structure in PDB format. All the search parameters are user modifiable. Phosfinder outputs a list of predicted binding sites with detailed information about their structural similarity with known phosphate binding motifs, and the conservation of the residues involved. A graphical applet allows the user to visualize the predicted binding sites on the query protein structure. The results on a set of 52 apo/holo structure pairs show that the performance of our method is largely unaffected by ligand-induced conformational changes. Phosfinder is available at http://phosfinder.bio.uniroma2.it
A global sampler of single particle tracking solutions for single molecule microscopy.
The dependence on model-fitting to evaluate particle trajectories makes it difficult for single particle tracking (SPT) to resolve the heterogeneous molecular motions typical of cells. We present here a global spatiotemporal sampler for SPT solutions using a Metropolis-Hastings algorithm. The sampler does not find just the most likely solution but also assesses its likelihood and presents alternative solutions. This enables the estimation of the tracking error. Furthermore the algorithm samples the parameters that govern the tracking process and therefore does not require any tweaking by the user. We demonstrate the algorithm on synthetic and single molecule data sets. Metrics for the comparison of SPT are generalised to be applied to a SPT sampler. We illustrate using the example of the diffusion coefficient how the distribution of the tracking solutions can be propagated into a distribution of derived quantities. We also discuss the major challenges that are posed by the realisation of a SPT sampler
B -> Xs l_i^+ l_j^+ Decays with R-parity Violation
We derive the upper bounds on certain products of R-parity- and
lepton-flavor-violating couplings from B \ra X_s {l_i}^+ {l_j}^- decays.
These modes of B-meson decays can constrain the product combinations of the
couplings with one or more heavy generation indices which are comparable with
or stronger than the present bounds. From the studies of the invariant dilepton
mass spectrum and the forward backward asymmetry of the emitted leptons we note
the possibility of detecting R-parity-violating signals even when the total
decay rate due to R-parity violating couplings is comparable with that in the
standard model and discriminating two types of R-parity-violating signals. The
general expectation of the enhancement of the forward backward asymmetry of the
emitted leptons in the minimal supersymmetric standard model with R-parity may
be corrupted by R-parity violation.Comment: 10 pages, Revtex, 1 table and 2 figure
Role of Continuous Glucose Monitoring in Clinical Trials: Recommendations on Reporting.
Thanks to significant improvements in the precision, accuracy, and usability of continuous glucose monitoring (CGM), its relevance in both ambulatory diabetes care and clinical research is increasing. In this study, we address the latter perspective and derive provisional reporting recommendations. CGM systems have been available since around the year 2000 and used primarily in people with type 1 diabetes. In contrast to self-measured glucose, CGM can provide continuous real-time measurement of glucose levels, alerts for hypoglycemia and hyperglycemia, and a detailed assessment of glycemic variability. Through a broad spectrum of derived glucose data, CGM should be a useful tool for clinical evaluation of new glucose-lowering medications and strategies. It is the only technology that can measure hyperglycemic and hypoglycemic exposure in ambulatory care, or provide data for comprehensive assessment of glucose variability. Other advantages of current CGM systems include the opportunity for improved self-management of glycemic control, with particular relevance to those at higher risk of or from hypoglycemia. We therefore summarize the current status and limitations of CGM from the perspective of clinical trials and derive suggested recommendations for how these should facilitate optimal CGM use and reporting of data in clinical research
Dynamical R-parity Breaking at the LHC
In a class of extensions of the minimal supersymmetric standard model with
(B-L)/left-right symmetry that explains the neutrino masses, breaking R-parity
symmetry is an essential and dynamical requirement for successful gauge
symmetry breaking. Two consequences of these models are: (i) a new kind of
R-parity breaking interaction that protects proton stability but adds new
contributions to neutrinoless double beta decay and (ii) an upper bound on the
extra gauge and parity symmetry breaking scale which is within the large hadron
collider (LHC) energy range. We point out that an important prediction of such
theories is a potentially large mixing between the right-handed charged lepton
() and the superpartner of the right-handed gauge boson (), which leads to a brand new class of R-parity violating interactions of
type and \widetilde{d^c}^\dagger\u^c
e^c. We analyze the relevant constraints on the sparticle mass spectrum and
the LHC signatures for the case with smuon/stau NLSP and gravitino LSP. We note
the "smoking gun" signals for such models to be lepton flavor/number violating
processes: (or ) and
(or ) without
significant missing energy. The predicted multi-lepton final states and the
flavor structure make the model be distinguishable even in the early running of
the LHC.Comment: 30 pages, 13 figures, 6 tables, reference adde
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