Structural and electrochemical investigation of BaZr0.7Ce0.2Y0.1O3-δ proton conducting ceramics synthesized by spark plasma sintering

In this thesis, BaZr0.7Ce0.2Y0.1O3-δ was synthesized by spark plasma sintering (SPS). In an extensive study, SPS process parameters and their influence on the material properties were systematically investigated to provides a better understanding of the sintering mechanisms occurring during SPS. Additionally, the proton diffusion and their confinement within the crystal structure were investigated by neutron spectroscopy. As an outlook, a proof of concept with an SPS process for co-sintering of membrane-electrode-assemblies with an application in protonic ceramic electrolysers is given.In dieser Arbeit wurde der Protonenleiter BaZr0.7Ce0.2Y0.1O3-δ mittels des Spark Plasma Sinterns (SPS) hergestellt. In einer umfangreichen Studie wurden die SPS Prozessparameter und deren Auswirkungen auf die Materialeigenschaften systematisch untersucht, um einen Beitrag zum besseren Verständnis der dem Sinterprozess zugrundeliegenden Mechanismen zu leisten. Zusätzlich wurden die Diffusion und Einbindungen der Protonen im Kristallgitter durch Neutronen Spektroskopie untersucht. Als Ausblick liegt ein erstes Proof-of-Concept für einen Co-Sinterprozess von Membran-Elektroden-Einheiten vor

Determining a Role for Ventromedial Prefrontal Cortex in Encoding Action-Based Value Signals During Reward-Related Decision Making

Considerable evidence has emerged to implicate ventromedial prefrontal cortex in encoding expectations of future reward during value-based decision making. However, the nature of the learned associations upon which such representations depend is much less clear. Here, we aimed to determine whether expected reward representations in this region could be driven by action–outcome associations, rather than being dependent on the associative value assigned to particular discriminative stimuli. Subjects were scanned with functional magnetic resonance imaging while performing 2 variants of a simple reward-related decision task. In one version, subjects made choices between 2 different physical motor responses in the absence of discriminative stimuli, whereas in the other version, subjects chose between 2 different stimuli that were randomly assigned to different responses on a trial-by-trial basis. Using an extension of a reinforcement learning algorithm, we found activity in ventromedial prefrontal cortex tracked expected future reward during the action-based task as well as during the stimulus-based task, indicating that value representations in this region can be driven by action–outcome associations. These findings suggest that ventromedial prefrontal cortex may play a role in encoding the value of chosen actions irrespective of whether those actions denote physical motor responses or more abstract decision options

So Far So Good: Building the Evidence Base to Promote a Successful Future for the Curriculum for Wales

This Executive Summary presents high level messages which emerge from the analysis and synthesis of the findings of surveys and interviews with members of every Area of Learning Experience Group (Section 1) and interviews with senior policy makers (Section 2). Section 3 of this report (using evidence to promote a Successful Future for the Curriculum for Wales) provides more detail on ideas that are important for The Curriculum for Wales to be successful in future. In the spirit of co-construction, all readers are invited to consider this Section 3 and to discuss within their own communities possible implications for sustainable long term change: • what contributions they might make to ensure that currently successful aspects within an existing programme are sustained and • how participants might work collaboratively to address areas likely to raise the level of risk to programme success. Findings The worldwide COVID pandemic has resulted in unprecedented levels of change in education systems internationally. However, the purposes-led approach that Curriculum for Wales seeks to build has never seemed more relevant. These purposes are relevant not only for learners but for everyone involved in the Curriculum for Wales. Building a successful future for a Curriculum for Wales: so far so good • There is much that is positive in the findings that emerge from this report. • There remains strong commitment to critical engagement with Curriculum for Wales amongst all communities What is it crucial to sustain in the next phase of development? • A clear focus on the purposes • The use of evidence from policy, practice and research to inform thinking • A focus on learning with curriculum, pedagogy and assessment promoting and supporting progression in learning • All programme participants as learners • Co-construction and subsidiarity as the modus operandi of Curriculum for Wales. What might need further thinking or greater emphasis? The authors of this report acknowledge that the research focus may have led to a concentration on particular aspects of the programme. However, six themes emerged for either further thinking or greater emphasis • Shared understanding of key ideas • Progression • Assessment • Co-construction and subsidiarity • Coherence, policy and systemic integrity • Professional learning. Given its potential impact on education in Wales, it can be argued that the Curriculum for Wales represents exceptional value for money

Q methodology and a Delphi poll: a useful approach to researching a narrative approach to therapy

Q methodology and a Delphi poll combined qualitative and quantitative methods to explore definitions of White and Epston's (1990) narrative approach to therapy among a group of UK practitioners. A Delphi poll was used to generate statements about narrative therapy. The piloting of statements by the Delphi panel identified agreement about theoretical ideas underpinning narrative therapy and certain key practices. A wider group of practitioners ranked the statements in a Q sort and made qualitative comments about their sorting. Quantitative methods (principal components analysis) were used to extract eight accounts of narrative therapy, five of which are qualitatively analysed in this paper. Agreement and differences were identified across a range of issues, including the social construction of narratives, privileging a political stance or narrative techniques and the relationship with other therapies, specifically systemic psychotherapy. Q methodology, combined with the Delphi poll, was a unique and innovative feature of this study

Leading Learning Networks in Education

This study is one of the main outcomes of Leading Learning by Networking, an Erasmus+ project. It concerns the management of learning networks in schools with regard to the mission of these networks in the context of growing diversity. The text consists of three main parts. The opening chapter is of theoretical study, dealing with the term Professional learning networks and various factors that facilitate this form of collaboration in schools. Attention is also paid to the role of headteachers in the creation of and support for learning networks. The second part is a summary of the results of a qualitative research, which was carried out by means of interviews, aimed at recognition of some aspects of networking in selected schools in the partner countries. Part three describes a range of data obtained from a questionnaire survey on headteachers’ needs and experience in the management of learning networks

Distribution of Matrix Metalloproteinases in Human Atherosclerotic Carotid Plaques and Their Production by Smooth Muscle Cells and Macrophage Subsets

In this study, the potential of matrix metalloproteinase (MMP) sense for detection of atherosclerotic plaque instability was explored. Secondly, expression of MMPs by macrophage subtypes and smooth muscle cells (SMCs) was investigated. Twenty-three consecutive plaques removed during carotid endarterectomy were incubated in MMPSense (TM) 680 and imaged with IVISA (R) Spectrum. mRNA levels of MMPs, macrophage markers, and SMCs were determined in plaque specimens, and in in vitro differentiated M1 and M2 macrophages. There was a significant difference between autofluorescence signals and MMPSense signals, both on the intraluminal and extraluminal sides of plaques. MMP-9 and CD68 messenger RNA (mRNA) expression was higher in hot spots, whereas MMP-2 and alpha SMA expression was higher in cold spots. In vitro M2 macrophages had higher mRNA expression of MMP-1, MMP-9, MMP-12, and TIMP-1 compared to M1 macrophages. MMP-9 is most dominantly MMP present in atherosclerotic plaques and is produced by M2 rather than M1 macrophages

Cost-effectiveness of problem-solving treatment in comparison with usual care for primary care patients with menthal health problems: a randomized trial

BACKGROUND: Mental health problems are common and are associated with increased disability and health care costs. Problem-Solving Treatment (PST) delivered to these patients by nurses in primary care might be efficient. The aim of this study was to evaluate the cost-effectiveness of PST by mental health nurses compared with usual care (UC) by the general practitioner for primary care patients with mental health problems. METHODS: An economic evaluation from a societal perspective was performed alongside a randomized clinical trial. Patients with a positive General Health Questionnaire score (score ≥ 4) and who visited their general practitioner at least three times during the past 6 months were eligible. Outcome measures were improvement on the Hospital Anxiety and Depression Scale and QALYs based on the EQ-5D. Resource use was measured using a validated questionnaire. Missing cost and effect data were imputed using multiple imputation techniques. Bootstrapping was used to analyze costs and cost-effectiveness of PST compared with UC. RESULTS: There were no statistically significant differences in clinical outcomes at 9 months. Mean total costs were €4795 in the PST group and €6857 in the UC group. Costs were not statistically significantly different between the two groups (95% CI -4698;359). The cost-effectiveness analysis showed that PST was cost-effective in comparison with UC. Sensitivity analyses confirmed these findings. CONCLUSIONS: PST delivered by nurses seems cost-effective in comparison with UC. However, these results should be interpreted with caution, since the difference in total costs was mainly caused by 3 outliers with extremely high indirect costs in the UC group. TRIAL REGISTRATION: Nederlands Trial Register ISRCTN5102101

A concept for major incident triage: full-scaled simulation feasibility study

<p>Abstract</p> <p>Background</p> <p>Efficient management of major incidents involves triage, treatment and transport. In the absence of a standardised interdisciplinary major incident management approach, the Norwegian Air Ambulance Foundation developed Interdisciplinary Emergency Service Cooperation Course (TAS). The TAS-program was established in 1998 and by 2009, approximately 15 500 emergency service professionals have participated in one of more than 500 no-cost courses. The TAS-triage concept is based on the established triage Sieve and Paediatric Triage Tape models but modified with slap-wrap reflective triage tags and paediatric triage stretchers. We evaluated the feasibility and accuracy of the TAS-triage concept in full-scale simulated major incidents.</p> <p>Methods</p> <p>The learners participated in two standardised bus crash simulations: without and with competence of TAS-triage and access to TAS-triage equipment. The instructors calculated triage accuracy and measured time consumption while the learners participated in a self-reported before-after study. Each question was scored on a 7-point Likert scale with points labelled "Did not work" (1) through "Worked excellent" (7).</p> <p>Results</p> <p>Among the 93 (85%) participating emergency service professionals, 48% confirmed the existence of a major incident triage system in their service, whereas 27% had access to triage tags. The simulations without TAS-triage resulted in a mean over- and undertriage of 12%. When TAS-Triage was used, no mistriage was found. The average time from "scene secured to all patients triaged" was 22 minutes (range 15-32) without TAS-triage vs. 10 minutes (range 5-21) with TAS-triage. The participants replied to "How did interdisciplinary cooperation of triage work?" with mean 4,9 (95% CI 4,7-5,2) before the course vs. mean 5,8 (95% CI 5,6-6,0) after the course, p < 0,001.</p> <p>Conclusions</p> <p>Our modified triage Sieve tool is feasible, time-efficient and accurate in allocating priority during simulated bus accidents and may serve as a candidate for a future national standard for major incident triage.</p

Ocean warming drives rapid dynamic activation of a marine-terminating glacier on the west Antarctic Peninsula

Ice dynamic change is the primary cause of mass loss from the Antarctic Ice Sheet, thus it is important to understand the processes driving ice-ocean interactions and the timescale on which major change can occur. Here we use satellite observations to measure a rapid increase in speed and collapse of the ice shelf fronting Cadman Glacier in the absence of surface meltwater ponding. Between November 2018 and December 2019 ice speed increased by 94 ± 4% (1.47 ± 0.6 km/yr), ice discharge increased by 0.52 ± 0.21 Gt/yr, and the calving front retreated by 8 km with dynamic thinning on grounded ice of 20.1 ± 2.6 m/yr. This change was concurrent with a positive temperature anomaly in the upper ocean, where a 400 m deep channel allowed warm water to reach Cadman Glacier driving the dynamic activation, while neighbouring Funk and Lever Glaciers were protected by bathymetric sills across their fjords. Our results show that forcing by warm ocean water can cause the rapid onset of dynamic imbalance and increased ice discharge from glaciers on the Antarctic Peninsula, highlighting the region’s sensitivity to future climate variability

So Far So Good: Building the Evidence Base to Promote a Successful Future for the Curriculum for Wales

This Executive Summary presents high level messages which emerge from the analysis and synthesis of the findings of surveys and interviews with members of every Area of Learning Experience Group (Section 1) and interviews with senior policy makers (Section 2). Section 3 of this report (using evidence to promote a Successful Future for the Curriculum for Wales) provides more detail on ideas that are important for The Curriculum for Wales to be successful in future. In the spirit of co-construction, all readers are invited to consider this Section 3 and to discuss within their own communities possible implications for sustainable long term change: • What contributions they might make to ensure that currently successful aspects within an existing programme are sustained and • How participants might work collaboratively to address areas likely to raise the level of risk to programme success