Research on Alternative Dispute Resolution Procedures

[Excerpt] Alternative dispute resolution (ADR) encompasses a range of procedures, such as mediation, arbitration, ombudspersons, and peer review, that provide alternative mechanisms for resolving disputes and conflicts, both in the workplace and in other settings. In the field of employment relations, recent years have seen a growing number and diversity of ADR procedures used, particularly in nonunion workplaces and in resolving employment law disputes (Ewing 1989; Feuille and Delaney 1992; Feuille and Chachere 1995; Colvin 2003a). Much of the past research on ADR has focused on the general question of what the most effective technique is for resolving conflicts. The assumption behind much of this research is that the primary goal of dispute resolution is simply the efficiency of resolution and that this is a goal shared by all parties. But dispute resolution does not occur in a vacuum, separated from other aspects of work and employment relations. Indeed, one of the initial questions to be addressed in evaluating ADR procedures is what they are an “alternative” to. Evaluating the impact of ADR procedures depends in large measure on how one evaluates the process that ADR is replacing. Furthermore, recent research is increasingly recognizing that ADR procedures can have a number of different outcomes for and impacts on different parties to a dispute. The impact of ADR procedures may be evaluated very differently for employers versus employees, but also for employees directly involved in disputes versus other employees in the same workplace

Incorporating Distributed Debris Thickness in a Glacio-Hydrological Model: Khumbu Himalaya, Nepal

Understanding the future evolution of Himalayan glaciers is important in terms of runoff that provides an essential water source to local populations and has far-reaching downstream impacts. However, the climatic response of glaciers in High-Mountain Asia is complicated by ice stagnation and considerable supraglacial debris coverage, which insulates the ice from warming. Typical runoff modelling only crudely incorporates debris cover and there is currently no consensus on how significantly this may impact future glacier and runoff evolution. Here, a glacio-hydrological model is modified to incorporate fully distributed debris cover, using melt reduction factors that vary depending on debris thickness, and to redistribute mass losses according to observed surface elevation changes. A range of debris thickness data are implemented, including a remote-sensing survey and a modelled debris surface, to analyse the sensitivity of glacier evolution and runoff to possible future debris-cover changes in a series of experiments in the upper Khumbu catchment, Nepal. Simulations are undertaken using climate input data from Regional Climate Model simulations from CORDEX (Coordinated Regional Downscaling Experiment) which are further statistically downscaled using data from the Pyramid meteorological station. Results suggest that the accurate calibration of the model to volume change compensates for the inclusion of distributed debris cover but only if the climatic sensitivity of the calibration period (1999–2010) and the nature of the debris-covered surface remain constant during future simulations. Altering the nature of the debris surface has a significant impact on simulated ice volume, with melt rates under debris suppressed by up to 85 %. The sensitivity of runoff ranges from 60 to 140 million m3 yr-1, although there are considerable uncertainties relating to non-glacial snow melt. Moreover, incorporating locally enhanced melt at ice cliffs into the model also impacts upon volume loss and discharge, with a greater proportion of ice cliffs leading to enhanced volume losses compared to a homogeneous debris surface. Finally, using the most representative model configuration, the future evolution of Khumbu Glacier under various climate scenarios shows continued mass losses with a reduction in volume ranging from 60 % to 97 % by 2100. Runoff trends show an initial increase followed by an eventual decrease, with runoff in 2100 predicted to be 8 % lower than current levels

L-functions with large analytic rank and abelian varieties with large algebraic rank over function fields

The goal of this paper is to explain how a simple but apparently new fact of linear algebra together with the cohomological interpretation of L-functions allows one to produce many examples of L-functions over function fields vanishing to high order at the center point of their functional equation. The main application is that for every prime p and every integer g>0 there are absolutely simple abelian varieties of dimension g over Fp(t) for which the BSD conjecture holds and which have arbitrarily large rank.Comment: To appear in Inventiones Mathematica

Surface Instability in Windblown Sand

We investigate the formation of ripples on the surface of windblown sand based on the one-dimensional model of Nishimori and Ouchi [Phys. Rev. Lett. 71, 197 (1993)], which contains the processes of saltation and grain relaxation. We carry out a nonlinear analysis to determine the propagation speed of the restabilized ripple patterns, and the amplitudes and phases of their first, second, and third harmonics. The agreement between the theory and our numerical simulations is excellent near the onset of instability. We also determine the Eckhaus boundary, outside which the steady ripple patterns are unstable.Comment: 23 pages, 8 figure

Fusion of secretory vesicles isolated from rat liver

Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy. The number of fused vesicles increases with increasing Ca2+-concentrations and is half maximal around 10–6 m. Other divalent cations (Ba2+, Sr2+, and Mg2+) were ineffective. Mg2+ inhibits Ca2+-induced fusion. Therefore, the fusion of secretory vesiclesin vitro is Ca2+ specific and exhibits properties similar to the exocytotic process of various secretory cells. Various substances affecting secretionin vivo (microtubular inhibitors, local anethetics, ionophores) were tested for their effect on membrane fusion in our system. The fusion of isolated secretory vesicles from liver was found to differ from that of pure phospholipid membranes in its temperature dependence, in its much lower requirement for Ca2+, and in its Ca2+-specificity. Chemical and enzymatic modifications of the vesicle membrane indicate that glycoproteins may account for these differences

Nonextensivity in Geological Faults?

Geological fault systems, as the San Andreas fault (SAF) in USA, constitute typical examples of self-organizing systems in nature. In this paper, we have considered some geophysical properties of the SAF system to test the viability of the nonextensive models for earthquakes developed in [Phys. Rev. E {\bf 73}, 026102, 2006]. To this end, we have used 6188 earthquakes events ranging in the magnitude interval $2 < m < 8$ that were taken from the Network Earthquake International Center catalogs (NEIC, 2004-2006) and the Bulletin of the International Seismological Centre (ISC, 1964-2003). For values of the Tsallis nonextensive parameter $q \simeq 1.68$, it is shown that the energy distribution function deduced in above reference provides an excellent fit to the NEIC and ISC SAF data.Comment: 9 pages, 1 figure, standard LaTeX fil

p-forms on d-spherical tessellations

The spectral properties of p-forms on the fundamental domains of regular tesselations of the d-dimensional sphere are discussed. The degeneracies for all ranks, p, are organised into a double Poincare series which is explicitly determined. In the particular case of coexact forms of rank (d-1)/2, for odd d, it is shown that the heat--kernel expansion terminates with the constant term, which equals (-1)^{p+1}/2 and that the boundary terms also vanish, all as expected. As an example of the double domain construction, it is shown that the degeneracies on the sphere are given by adding the absolute and relative degeneracies on the hemisphere, again as anticipated. The eta invariant on a fundamental domain is computed to be irrational. The spectral counting function is calculated and the accumulated degeneracy give exactly. A generalised Weyl-Polya conjecture for p-forms is suggested and verified.Comment: 23 pages. Section on the counting function adde

Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine

Background: The measurement of gene expression in post-digital rectal examination (DRE) urine specimens provides a non-invasive method to determine a patient’s risk of prostate cancer. Many currently available assays use whole urine or cell pellets for the analysis of prostate cancer-associated genes, although the use of extracellular vesicles (EVs) has also recently been of interest. We investigated the expression of prostate-, kidney-, and bladder- specific transcripts and known prostate cancer biomarkers in urine EVs. Methods: Cell pellets and EVs were recovered from post-DRE urine specimens, with the total RNA yield and quality determined by Bioanalyzer. The levels of prostate, kidney, and bladder- associated transcripts in EVs were assessed by TaqMan qPCR and targeted sequencing. Results: RNA was more consistently recovered from the urine EV specimens, with over 80% of the patients demonstrating higher RNA yields in the EV fraction as compared to urine cell pellets. The median EV RNA yield of 36.4 ng was significantly higher than the median urine cell pellet RNA yield of 4.8 ng. Analysis of the post-DRE urine EVs indicated that prostate-specific transcripts were more abundant than kidney- or bladder-specific transcripts. Additionally, patients with prostate cancer had significantly higher levels of the prostate cancer-associated genes PCA3 and ERG. Conclusions: Post-DRE urine EVs are a viable source of prostate-derived RNAs for biomarker discovery and prostate cancer status can be distinguished from analysis of these specimens. Continued analysis of urine EVs offers the potential discovery of novel biomarkers for pre- biopsy prostate cancer detection

Self-dual noncommutative \phi^4-theory in four dimensions is a non-perturbatively solvable and non-trivial quantum field theory

We study quartic matrix models with partition function Z[E,J]=\int dM \exp(trace(JM-EM^2-(\lambda/4)M^4)). The integral is over the space of Hermitean NxN-matrices, the external matrix E encodes the dynamics, \lambda>0 is a scalar coupling constant and the matrix J is used to generate correlation functions. For E not a multiple of the identity matrix, we prove a universal algebraic recursion formula which gives all higher correlation functions in terms of the 2-point function and the distinct eigenvalues of E. The 2-point function itself satisfies a closed non-linear equation which must be solved case by case for given E. These results imply that if the 2-point function of a quartic matrix model is renormalisable by mass and wavefunction renormalisation, then the entire model is renormalisable and has vanishing \beta-function. As main application we prove that Euclidean \phi^4-quantum field theory on four-dimensional Moyal space with harmonic propagation, taken at its self-duality point and in the infinite volume limit, is exactly solvable and non-trivial. This model is a quartic matrix model, where E has for N->\infty the same spectrum as the Laplace operator in 4 dimensions. Using the theory of singular integral equations of Carleman type we compute (for N->\infty and after renormalisation of E,\lambda) the free energy density (1/volume)\log(Z[E,J]/Z[E,0]) exactly in terms of the solution of a non-linear integral equation. Existence of a solution is proved via the Schauder fixed point theorem. The derivation of the non-linear integral equation relies on an assumption which we verified numerically for coupling constants 0<\lambda\leq (1/\pi).Comment: LaTeX, 64 pages, xypic figures. v4: We prove that recursion formulae and vanishing of \beta-function hold for general quartic matrix models. v3: We add the existence proof for a solution of the non-linear integral equation. A rescaling of matrix indices was necessary. v2: We provide Schwinger-Dyson equations for all correlation functions and prove an algebraic recursion formula for their solutio

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer. Those with sufficient follow-up were found to have recovered substantial immunity in the absence of any serious adverse events up to 5 years after treatment. To determine the influence of vector integration on lymphoid reconstitution, we compared retroviral integration sites (RISs) from peripheral blood CD3(+) T lymphocytes of 5 patients taken between 9 and 30 months after transplantation with transduced CD34(+) progenitor cells derived from 1 further patient and I healthy donor. Integration occurred preferentially in gene regions on either side of transcription start sites, was clustered, and correlated with the expression level in CD34(+) progenitors during transduction. In contrast to those in CD34(+) cells, RISs recovered from engrafted CD3(+)T cells were significantly overrepresented within or near genes encoding proteins with kinase or transferase activity or involved in phosphorus metabolism. Although gross patterns of gene expression were unchanged in transduced cells, the divergence of RIS target frequency between transduced progenitor cells and post-thymic T lymphocytes indicates that vector integration influences cell survival, engraftment, or proliferation