Respuestas del δ13C foliar y características foliares a la precipitación y temperatura en un ecosistema árido del noroeste de China

El δ13C foliar es ampliamente usado para explicar estrategias relacionadas con la disponibilidad de recursos en diferentes ambientes. Sin embargo, la respuesta conjunta del δ13C foliar a la precipitación y temperatura así como la relación entre el δ13C foliar y las características foliares no están claras. El δ13C foliar y su relación con las características foliares [tamaño de hoja (LS), longitud foliar (LL), ancho foliar (LW), relación entre la longitud y el ancho foliar (L:W), área foliar específica (SLA) y concentración de N foliar (en una base de peso seco) (Nmass)] fueron investigadas en la especie de arbusto dominante Nitraria tangutorum Bobr en la región árida (Dengkou y Minqin) del noroeste de China. El estudio se efectuó bajo condiciones de varias cantidades de precipitación simuladas (PGS) y temperaturas ambientales (TGS) en las estaciones de crecimiento de 2008, 2009 y 2010. Los resultados mostraron que LS, LW, LL, SLA y Nmass se incrementaron significativamente cuando las cantidades de PGS se incrementaron, pero hubo tendencias de reducción en dichas características cuando las TGS aumentaron. Sin embargo, la mayoría de las relaciones negativas entre las características foliares y las TGS no fueron obvias en Minqin. En ambos sitios, L:W se incrementó cuando las PGS y TGS aumentaron. Hubo un cambio en la relación negativa entre el δ13C foliar-PGS a través de Minqin y Dengkou, lo cual condujo a la falta de efectos de la precipitación en el δ13C foliar a través de ambos sitios, y mayor δ13C foliar a menor precipitación en Minqin. A través de Minqin y Dengkou, PGS solo pudo explicar un 14% de la variación en el δ13C foliar. La combinación de PGS y TGS pudo explicar un 64% de la variación en el δ13C foliar. Las características foliares (LW y L:W) mejoraron aún más la estimación del δ13C foliar. Las combinaciones de PGS, TGS, LW y L:W pudieron explicar un 84% de la variación en el δ13C foliar. Nuestro estudio demostró la importancia de las características foliares en explorar las respuestas del δ13C foliar a cambios globales en ecosistemas áridos.Leaf δ13C is widely used to explain plant strategies related to resource availability in different environments. To understand the coupled response of leaf δ13C to precipitation, temperature and the relationship between leaf δ13C and leaf traits in arid ecosystems, the leaf δ13C and leaf traits (leaf size (LS), leaf length (LL), leaf width (LW), leaf length to width ratio (L:W), specific leaf area (SLA) and mass-based leaf nitrogen concentration (Nmass)) of Nitraria tangutorum Bobr. under simulated increasing precipitation (PGS) and ambient temperature (TGS) in plant growing season from 2008 to 2010 and the relationships between leaf δ13C and leaf traits were investigated in the arid region (Dengkou and Minqin) of northwestern China. Our results showed that LS, LW, LL, SLA and Nmass significantly increased with increasing PGS, but had downward tendencies with increasing TGS although the majority of the negative relationships between leaf traits and TGS were not obvious in Minqin. At the two study sites, L:W increased simultaneously with increasing PGS and TGS. There was a shift in the negative leaf δ13C-PGS relationship across Minqin and Dengkou, which conduce to the lacking effect of precipitation on leaf δ13C across the two sites and higher leaf δ13C in lower precipitation fields in Minqin. Across Minqin and Dengkou, PGS could only explain 14% of the variation in leaf δ13C. The combinations of PGS and TGS could explain 64% of the variation in leaf δ13C. Leaf traits (LW and L:W) could be used to further improve the estimation of leaf δ13C. The combinations of PGS, TGS, LW and L:W could explain 84 % of the variation in leaf δ13C. Our study demonstrated the importance of leaf traits in exploring the responses of leaf δ13C to global changes in arid ecosystems.Fil: Xin, Z.M.. Chinese Academy of Forestry. Institute of Desertification Studies; China. Chinese Academy of Forestry. Experimental Center of Desert Forestry; ChinaFil: Liu, M.H.. Chinese Academy of Forestry. Experimental Center of Desert Forestry; ChinaFil: Lu, Q.. Chinese Academy of Forestry. Institute of Desertification Studies; China. State Forestry Administration. Kumtag Desert Ecosystem Research Station; ChinaFil: Busso, Carlos Alberto. Universidad Nacional del Sur. Departamento de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina. State Forestry Administration. Kumtag Desert Ecosystem Research Station; ChinaFil: Zhu, Y.J.. State Forestry Administration. Kumtag Desert Ecosystem Research Station; China. Chinese Academy of Forestry. Institute of Desertification Studies; ChinaFil: Li, Z.. Chinese Academy of Forestry. Experimental Center of Desert Forestry; ChinaFil: Huang, Y.R.. Chinese Academy of Forestry. Experimental Center of Desert Forestry; ChinaFil: Li, X.L.. Chinese Academy of Forestry. Experimental Center of Desert Forestry; ChinaFil: Luo, F.M.. Chinese Academy of Forestry. Experimental Center of Desert Forestry; ChinaFil: Bao, F.. Chinese Academy of Forestry. Institute of Desertification Studies; ChinaFil: Qian, J.Q.. Henan Agricultural University. College of Forestry; ChinaFil: Li, Y.H.. Chinese Academy of Forestry. Institute of Desertification Studies; China. State Forestry Administration. Kumtag Desert Ecosystem Research Station; Chin

Identification of neprilysin as a potential target of arteannuin using computational drug repositioning

ABSTRACT The discovery of arteannuin (qinghaosu) in the 20th Century was a major advance for medicine. Besides functioning as a malaria therapy, arteannuin is a pharmacological agent in a range of other diseases, but its mechanism of action remains obscure. In this study, the reverse docking server PharmMapper was used to identify potential targets of arteannuin. The results were checked using the chemical-protein interactome servers DRAR-CPI and DDI-CPI, and verified by AutoDock Vina. The results showed that neprilysin (also known as CD10), a common acute lymphoblastic leukaemia antigen, was the top disease-related target of arteannuin. The chemical-protein interactome and docking results agreed with those of PharmMapper, further implicating neprilysin as a potential target. Although experimental verification is required, this study provides guidance for future pharmacological investigations into novel clinical applications for arteannuin

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Periodicities in the Daily Proton Fluxes from 2011 to 2019 Measured by the Alpha Magnetic Spectrometer on the International Space Station from 1 to 100 GV

We present the precision measurement of the daily proton fluxes in cosmic rays from May 20, 2011 to October 29, 2019 (a total of 2824 days or 114 Bartels rotations) in the rigidity interval from 1 to 100 GV based on 5.5×109 protons collected with the Alpha Magnetic Spectrometer aboard the International Space Station. The proton fluxes exhibit variations on multiple timescales. From 2014 to 2018, we observed recurrent flux variations with a period of 27 days. Shorter periods of 9 days and 13.5 days are observed in 2016. The strength of all three periodicities changes with time and rigidity. The rigidity dependence of the 27-day periodicity is different from the rigidity dependences of 9-day and 13.5-day periods. Unexpectedly, the strength of 9-day and 13.5-day periodicities increases with increasing rigidities up to ∼10 GV and ∼20 GV, respectively. Then the strength of the periodicities decreases with increasing rigidity up to 100 GV.</p

Precision Measurement of the Proton Flux in Primary Cosmic Rays from Rigidity 1 GV to 1.8 TV with the Alpha Magnetic Spectrometer on the International Space Station

A precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1 GV to 1.8 TV is presented based on 300 million events. Knowledge of the rigidity dependence of the proton flux is important in understanding the origin, acceleration, and propagation of cosmic rays. We present the detailed variation with rigidity of the flux spectral index for the first time. The spectral index progressively hardens at high rigidities.</p