STEPAR: an automatic code to infer stellar atmospheric parameters

Context. StePar is an automatic code written in Python 3.X designed to compute the stellar atmospheric parameters T_(eff), log g, [Fe/H], and ξ of FGK-type stars by means of the equivalent width (EW) method. This code has already been extensively tested in different spectroscopic studies of FGK-type stars with several spectrographs and against thousands of Gaia-ESO Survey UVES U580 spectra of late-type, low-mass stars as one of its 13 pipelines. Aims. We describe the code that we tested against a library of well characterised Gaia benchmark stars. We also release the code to the community and provide the link for download. Methods. We carried out the required EW determination of Fe i and Fe ii spectral lines using the automatic tool TAME. StePar implements a grid of MARCS model atmospheres and the MOOG radiative transfer code to compute stellar atmospheric parameters by means of a Downhill Simplex minimisation algorithm. Results. We show the results of the benchmark star test and also discuss the limitations of the EW method, and hence the code. In addition, we find a small internal scatter for the benchmark stars of 9 ± 32 K in T_(eff), 0.00 ± 0.07 dex in log g, and 0.00 ± 0.03 dex in [Fe/H]. Finally, we advise against using StePar on double-lined spectroscopic binaries or spectra with R 15 km s^(−1) , and on stars later than K4 or earlier than F6

Mesozooplankton distribution, production and respiration in the global ocean.

Mesozooplankton biomass, abundance and mass-specific physiological rates as well as community production and respiration in the upper 2000 m were assessed from samples collected during the Malaspina circumnavigation expedition (~35ºN-40ºS) using an image-based analysis system (IBS). Equations relating metabolic rates, temperature, and body weight, were developed according to temperature ranges found at the different ocean regions and depth layers. High abundance and biomass were observed in the epipelagic zone and decreasing with depth as expected. However, high biomass was also found beyond 1000 m related to the colder and productive waters of the eastern regions of the Indian and Pacific Oceans. Specific growth and respiration rates followed a similar pattern and were highly correlated with temperature (r2=0.835 and 0.806 , respectively). Therefore, higher values were observed in the tropical and subtropical zones as the effect of higher temperature. Community production and respiration were considerably higher in the epipelagic layer, matching the distribution of biomass, with high values below 1000 m in the eastern Pacific/Indian Oceans. Global metabolism assessed through the IBS was similar to previous results based on data review.MALASPINA (CSD2008-00077

Vertical biogeographical overview of the Zooplankton community across the Atlantic, Pacific and Indian ocean (35ºN-40ºS)

From December 2010 to June 2011 the mesozooplankton has been sampled at the deep Atlantic, Indian and Pacific Ocean (*). From surface to 3000 m depth a HYDROBIOSS multinet was used distinguishing the epipelagic (77%), mesopelagic (11%) and bathypelagic zones (11%), where five layers were usually sampled (0-200, 200-500, 500-1000, 1000-2000 and 2000-3000 m depth). Among the three oceans, no large differences on abundance were found when taxonomic groups were considered, being always depth the most important factor affecting the vertical zooplankton distribution. The zooplankton abundance strongly decreased with depth and very low abundance was found at deeper waters. Very irregular spatial distribution was observed all across the three oceans, finding the lowest abundance in the south and western Pacific region. Copepods were always the most abundant contributors of the zooplankton community (84%) and more than 260 species identified. They were followed by chaetognaths (5%), siphonophores (3%), ostracods (2%) and euphausiids (1%). In a biogeographical overview, the vertical distribution of the most abundant copepods is analyzed, finding the largest copepods at deeper stratum, where small cosmopolitan copepods were also found

Preventive treatments for breast cancer: recent developments

Breast cancer is a burden for western societies, and an increasing one in emerging economies, because of its high incidence and enormous psychological, social, sanitary and economic costs. However, breast cancer is a preventable disease in a significant proportion. Recent developments in the armamentarium of effective drugs for breast cancer prevention (namely exemestane and anastrozole), the new recommendation from the National Institute for Health and Care Excellence to use preventative drugs in women at high risk as well as updated Guidelines from the US Preventive Services Task Force and the American Society of Clinical Oncology should give renewed momentum to the pharmacological prevention of breast cancer. In this article we review recent major developments in the field and examine their ongoing repercussion for breast cancer prevention. As a practical example, the potential impact of preventive measures in Spain is evaluated and a course of practical actions is delineated

Comparison of the WRF and HARMONIE models ability for mountain wave warnings

Mountain lee waves usually involve aircraft icing and turbulence events. These weather phenomena, in turn, are a threat to aviation safety. For this reason, mountain lee waves are an interesting subject of study for the scientific community. This paper analyses several mountain lee waves events in the south-east of the Guadarrama mountain range, near the Adolfo Suarez Madrid-Barajas airport (Spain), using the Weather Research and Forecasting (WRF) and the HARMONIE-AROME high-resolution numerical models. For this work, simulated brightness temperature from the optimum WRF parametrization schemes and from the HARMONIE are validated using satellite observations to evaluate the performance of the models in reproducing the lenticular clouds associated to mountain lee waves. The brightness temperature probability density shows interesting differences between both models. Following, a mountain wave characterization is performed simulating some atmospheric variables (wind direction, wind speed, atmospheric stability, liquid water content and temperature) in several grid points located in the leeward, windward and over the summit of the mountains. The characterization results are compared for both numerical models and a decision tree is developed for each to forecast and warn the mountain lee waves, lenticular clouds and icing events with a 24 to 48 h lead time. These warnings are validated using several skill scores, revealing similar results for both models

Characterization of the K2-38 planetary system: Unraveling one of the densest planets known to date

.-- Toledo-Padrón, B. et al.Context. An accurate characterization of the known exoplanet population is key to understanding the origin and evolution of planetary systems. Determining true planetary masses through the radial velocity (RV) method is expected to experience a great improvement thanks to the availability of ultra-stable echelle spectrographs. Aims. We took advantage of the extreme precision of the new-generation echelle spectrograph ESPRESSO to characterize the transiting planetary system orbiting the G2V star K2-38 located at 194 pc from the Sun with V 11.4. This system is particularly interesting because it could contain the densest planet detected to date. Methods. We carried out a photometric analysis of the available K2 photometric light curve of this star to measure the radius of its two known planets, K2-38b and K2-38c, with Pb = 4.01593 ± 0.00050 d and Pc = 10.56103 ± 0.00090 d, respectively. Using 43 ESPRESSO high-precision RV measurements taken over the course of 8 months along with the 14 previously published HIRES RV measurements, we modeled the orbits of the two planets through a Markov chain Monte Carlo analysis, significantly improving their mass measurements. Results. Using ESPRESSO spectra, we derived the stellar parameters, Teff = 5731 ± 66, log g = 4.38 ± 0.11 dex, and [Fe/H] = 0.26 ± 0.05 dex, and thus the mass and radius of K2-38, Ma = 1.03-0.02+0.04 MaS and Ra = 1.06-0.06+0.09 RaS. We determine new values for the planetary properties of both planets. We characterize K2-38b as a super-Earth with RP = 1.54 ± 0.14 RaS and Mp = 7.3-1.0+1.1 MaS, and K2-38c as a sub-Neptune with RP = 2.29 ± 0.26 RaS and Mp = 8.3-1.3+1.3 MaS. Combining the radius and mass measurements, we derived a mean density of ρp = 11.0-2.8+4.1 g cm-3 for K2-38b and ρp = 3.8-1.1+1.8 g cm-3 for K2-38c, confirming K2-38b as one of the densest planets known to date. Conclusions. The best description for the composition of K2-38b comes from an iron-rich Mercury-like model, while K2-38c is better described by a rocky-model with H2 envelope. The maximum collision stripping boundary shows how giant impacts could be the cause for the high density of K2-38b. The irradiation received by each planet places them on opposite sides of the radius valley. We find evidence of a long-period signal in the RV time-series whose origin could be linked to a 0.25-3 MJ planet or stellar activity.With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737

Vertical variability of trophic positions of zooplankton in the deep Ocean

Zooplankton plays a key role in oceanic ecosystems. However, the trophic ecology of organisms in deep layers of the ocean is poorly known. In this study we analyze the variability of trophic positions of zooplankton collected across three ocean basins in the epi-, meso and bathypelagic domains. Stable carbon and nitrogen isotopes were used as indicators of the sources of nutrients and positions within the food web. The enrichment in heavy nitrogen isotopes with depth and the correlation between surface and deep samples revealed that deep zooplankton was supported by local epipelagic production, subsequently processed through the water column. In addition the nitrogen isotope enrichment of carnivores vs. omnivores was consistent across ocean biomes and water layers, suggesting a similar trophic structure of the pelagic food web in the deep ocean despite variations in the nitrogen sources. Siphonofora, Chaetognata and Myctophida were the top predators while Calanoid Copepoda and Mysidacea displayed the lowest trophic positions. In contrast, carbon isotopes did not show significant variations with depth or trophic groups implying low influence of coastal production in deep ocean food webs

An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer

16 pags., 8 figs.Breast cancer is the most commonly diagnosed and leading cause of cancer death among women worldwide. Mitogen-activated protein kinase-interacting kinases (MNKs) promote the expression of several oncogenic proteins and are overexpressed in several types of cancer. In human cells, there are four isoforms of MNKs. The truncated isoform MNK1b, first described in our laboratory, has a higher basal activity and is constitutively active. Aptamers are emerging in recent years as potential therapeutic agents that show significant advantages over drugs of other nature. We have previously obtained and characterized a highly specific aptamer against MNK1b, named apMNK2F, with a dissociation constant in the nanomolar range, which produces significant inhibition of proliferation, migration, and colony formation in breast cancer cells. Furthermore, its sequence analysis predicted two G-quadruplex structures. In this work, we show the optimization process of the aptamer to reduce its size, improving its stability. The obtained aptamer, named apMNKQ2, is able to inhibit proliferation, colony formation, migration, and invasion in breast cancer cells. In murine models of breast cancer, apMNKQ2 has demonstrated its efficacy in reducing tumor volume and the number of metastases. In conclusion, apMNKQ2 could be used as an anti-tumor drug in the future.C.P.-D. was supported by grant RTC-2014-1986-1 from the Ministry of Economy and Competitiveness (Spain). R.F.-M... by predoctoral contract (PEJD-2018-BMD-4416) from the Community of Madrid (Spain) and FPU19/02929 from the Ministry of Science, Innovation and Universities (Spain). R.C.-B. for predoctoral contracts (PEJD 2016-BMD-2145 and 2018-BMD-9201) from the Community of Madrid and grant RTC2019-07227-1. M. EM., and V.M.G. are researchers at FIBio-HRC. Supported by grants RTC2019-07227-1, PID2020-116620GB-T.I.00, and PID2019-105417RB-I00, funded by MCIN/ AEI /10.13039/501100011033 (Ministry of Economy and Competitiveness, Spain).Peer reviewe

Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2

Objectives: There is little information about carbapenemase-producing (CP) Citrobacter spp.We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15). Methods: In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE. Results: Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM- 2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI-blaVIM-1 - aacA4-dfrB1-aadA1-catB2-qacE¿1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon. Conclusions: We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including coproduction of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications

Measurement of the 240Pu(n,f) cross-section at the CERN n-TOF facility : First results from experimental area II (EAR-2)

The accurate knowledge of the neutron-induced fission cross-sections of actinides and other isotopes involved in the nuclear fuel cycle is essential for the design of advanced nuclear systems, such as Generation-IV nuclear reactors. Such experimental data can also provide the necessary feedback for the adjustment of nuclear model parameters used in the evaluation process, resulting in the further development of nuclear fission models. In the present work, the 240Pu(n,f) cross-section was measured at CERN's n-TOF facility relative to the well-known 235U(n,f) cross section, over a wide range of neutron energies, from meV to almost MeV, using the time-of-flight technique and a set-up based on Micromegas detectors. This measurement was the first experiment to be performed at n-TOF's new experimental area (EAR-2), which offers a significantly higher neutron flux compared to the already existing experimental area (EAR-1). Preliminary results as well as the experimental procedure, including a description of the facility and the data handling and analysis, are presented