506 research outputs found
Quantum incompressibility of a falling Rydberg atom, and a gravitationally-induced charge separation effect in superconducting systems
Freely falling point-like objects converge towards the center of the Earth.
Hence the gravitational field of the Earth is inhomogeneous, and possesses a
tidal component. The free fall of an extended quantum object such as a hydrogen
atom prepared in a high principal-quantum-number stretch state, i.e., a
circular Rydberg atom, is predicted to fall more slowly that a classical
point-like object, when both objects are dropped from the same height from
above the Earth. This indicates that, apart from "quantum jumps," the atom
exhibits a kind of "quantum incompressibility" during free fall in
inhomogeneous, tidal gravitational fields like those of the Earth. A
superconducting ring-like system with a persistent current circulating around
it behaves like the circular Rydberg atom during free fall. Like the electronic
wavefunction of the freely falling atom, the Cooper-pair wavefunction is
"quantum incompressible." The ions of the ionic lattice of the superconductor,
however, are not "quantum incompressible," since they do not possess a globally
coherent quantum phase. The resulting difference during free fall in the
response of the nonlocalizable Cooper pairs of electrons and the localizable
ions to inhomogeneous gravitational fields is predicted to lead to a charge
separation effect, which in turn leads to a large repulsive Coulomb force that
opposes the convergence caused by the tidal, attractive gravitational force on
the superconducting system. A "Cavendish-like" experiment is proposed for
observing the charge separation effect induced by inhomogeneous gravitational
fields in a superconducting circuit. This experiment would demonstrate the
existence of a novel coupling between gravity and electricity via
macroscopically coherent quantum matter.Comment: `2nd Vienna Symposium for the Foundations of Modern Physics'
Festschrift MS for Foundations of Physic
Using Abrupt Changes in Magnetic Susceptibility within Type-II Superconductors to Explore Global Decoherence Phenomena
A phenomenon of a periodic staircase of macroscopic jumps in the admitted
magnetic field has been observed, as the magnitude of an externally applied
magnetic field is smoothly increased or decreased upon a superconducting (SC)
loop of type II niobium-titanium wire which is coated with a
non-superconducting layer of copper. Large temperature spikes were observed to
occur simultaneously with the jumps, suggesting brief transitions to the normal
state, caused by en masse motions of Abrikosov vortices. An experiment that
exploits this phenomenon to explore the global decoherence of a large
superconducting system will be discussed, and preliminary data will be
presented. Though further experimentation is required to determine the actual
decoherence rate across the superconducting system, multiple classical
processes are ruled out, suggesting that jumps in magnetic flux are fully
quantum mechanical processes which may correspond to large group velocities
within the global Cooper pair wavefunction.Comment: 13 pages, 4 figures, part of proceedings for FQMT 2011 conference in
Prague, Czech Republi
Can a charged ring levitate a neutral, polarizable object? Can Earnshaw's Theorem be extended to such objects?
Stable electrostatic levitation and trapping of a neutral, polarizable object
by a charged ring is shown to be theoretically impossible. Earnshaw's Theorem
precludes the existence of such a stable, neutral particle trap.Comment: 11 pages, 1 figur
A strongly magnetized pulsar within grasp of the Milky Way's supermassive black hole
The center of our Galaxy hosts a supermassive black hole, Sagittarius (Sgr)
A*. Young, massive stars within 0.5 pc of SgrA* are evidence of an episode of
intense star formation near the black hole a few Myr ago, which might have left
behind a young neutron star traveling deep into SgrA*'s gravitational
potential. On 2013 April 25, a short X-ray burst was observed from the
direction of the Galactic center. Thanks to a series of observations with the
Chandra and the Swift satellites, we pinpoint the associated magnetar at an
angular distance of 2.4+/-0.3 arcsec from SgrA*, and refine the source spin
period and its derivative (P=3.7635537(2) s and \dot{P} = 6.61(4)x10^{-12}
s/s), confirmed by quasi simultaneous radio observations performed with the
Green Bank (GBT) and Parkes antennas, which also constrain a Dispersion Measure
of DM=1750+/-50 pc cm^{-3}, the highest ever observed for a radio pulsar. We
have found that this X-ray source is a young magnetar at ~0.07-2 pc from SgrA*.
Simulations of its possible motion around SgrA* show that it is likely (~90%
probability) in a bound orbit around the black hole. The radiation front
produced by the past activity from the magnetar passing through the molecular
clouds surrounding the Galactic center region, might be responsible for a large
fraction of the light echoes observed in the Fe fluorescence features.Comment: ApJ Letters in pres
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions that interact with signalling effector proteins. Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix α3/loop 7/helix α4 interface. We show that these DARPins specifically inhibit KRAS/effector interactions and the dependent downstream signalling pathways in cancer cells. Binding by the DARPins at that region influences KRAS/effector interactions in different ways, including KRAS nucleotide exchange and inhibiting KRAS dimerization at the plasma membrane. These results highlight the importance of targeting the α3/loop 7/α4 interface, a previously untargeted site in RAS, for specifically inhibiting KRAS function
On Pulsar Distance Measurements and their Uncertainties
Accurate distances to pulsars can be used for a variety of studies of the
Galaxy and its electron content. However, most distance measures to pulsars
have been derived from the absorption (or lack thereof) of pulsar emission by
Galactic HI gas, which typically implies that only upper or lower limits on the
pulsar distance are available. We present a critical analysis of all measured
HI distance limits to pulsars and other neutron stars, and translate these
limits into actual distance estimates through a likelihood analysis that
simultaneously corrects for statistical biases. We also apply this analysis to
parallax measurements of pulsars in order to obtain accurate distance estimates
and find that the parallax and HI distance measurements are biased in different
ways, because of differences in the sampled populations. Parallax measurements
typically underestimate a pulsar's distance because of the limited distance to
which this technique works and the consequential strong effect of the Galactic
pulsar distribution (i.e. the original Lutz-Kelker bias), in HI distance
limits, however, the luminosity bias dominates the Lutz-Kelker effect, leading
to overestimated distances because the bright pulsars on which this technique
is applicable are more likely to be nearby given their brightness.Comment: 32 pages, 1 figure, 2 tables; Accepted for publication in the
Astrophysical Journa
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Reduced free asparagine in wheat grain resulting from a natural deletion of TaASNB2: investigating and exploiting diversity in the asparagine synthetase gene family to improve wheat quality
Background: Understanding the determinants of free asparagine concentration in wheat grain is necessary to reduce levels of the processing contaminant acrylamide in baked and toasted wheat products. Although crop management strategies can help reduce asparagine levels, breeders have limited options to select for genetic variation underlying this trait. Asparagine synthetase enzymes catalyse a critical step in asparagine biosynthesis in plants and, in wheat, are encoded by five homeologous gene triads that exhibit distinct expression profiles. Within this family, TaASN2 genes are highly expressed during grain development but TaASN-B2 is absent in some varieties.
Results:
Natural genetic diversity in the asparagine synthetase gene family was assessed in different wheat varieties revealing instances of presence/absence variation and other polymorphisms, including some predicted to affect the function of the encoded protein. The presence and absence of TaASN-B2 was determined across a range of UK and global common wheat varieties and related species, showing that the deletion encompassing this gene was already present in some wild emmer wheat genotypes. Expression profiling confirmed that TaASN2 transcripts were only detectable in the grain, while TaASN3.1 genes were highly expressed during the early stages of grain development. TaASN-A2 was the most highly expressed TaASN2 homeologue in most assayed wheat varieties. TaASN-B2 and TaASN-D2 were expressed at similar, lower levels in varieties possessing TaASN-B2. Expression of TaASN-A2 and TaASN-D2 did not increase to compensate for the absence of TaASN-B2, so total TaASN2 expression was lower in varieties lacking TaASN-B2. Consequently, free asparagine levels in field-produced grain were, on average, lower in varieties lacking TaASN-B2, although the effect was lost when free asparagine accumulated to very high levels as a result of sulphur deficiency.
Conclusions: Selecting wheat genotypes lacking the TaASN-B2 gene may be a simple and rapid way for breeders to reduce free asparagine levels in commercial wheat grain
The magnetized medium around the radio galaxy B2 0755+37: an interaction with the intra-group gas
We explore the magneto-ionic environment of the isolated radio galaxy B2
0755+37 using detailed imaging of the distributions of Faraday rotation and
depolarization over the radio source from Very Large Array observations at
1385,1465 and 4860 MHz and new X-ray data from XMM-Newton. The Rotation Measure
(RM) distribution is complex, with evidence for anisotropic fluctuations in two
regions. The approaching lobe shows low and uniform RM in an unusual `stripe'
along an extension of the jet axis and a linear gradient transverse to this
axis over its Northern half. The leading edge of the receding lobe shows
arc-like RM structures with sign reversals. Elsewhere, the RM structures are
reasonably isotropic. The RM power spectra are well described by cut-off power
laws with slopes ranging from 2.1 to 3.2 in different sub-regions. The
corresponding magnetic-field autocorrelation lengths, where well-determined,
range from 0.25 to 1.4 kpc. It is likely that the fluctuations are mostly
produced by compressed gas and field around the leading edges of the lobes. We
identify areas of high depolarization around the jets and inner lobes. These
could be produced by dense gas immediately surrounding the radio emission
containing a magnetic field which is tangled on small scales. We also identify
four ways in which the well known depolarization (Faraday depth) asymmetry
between jetted and counter-jetted lobes of extended radio sources can be
modified by interactions with the surrounding medium.Comment: 16 pages, 13 figures, accepted for publication in MNRAS. Full
resolution paper available at: ftp://ftp.ira.inaf.it/pub/outgoing/guidetti/
Subjects: Cosmology and Extragalactic Astrophysics (astro-ph.CO
Cultural Orientations of sport managers
Various interpretations of sport management are cultural constructs underpinned by core assumptions and values held by members of professional communities. Sport managers world wide share common problems, but differ in how they resolve them. These universal differences emerge from the relationships they form with other people, and their attitude to time, activities and the natural environment. This paper examines the role of sport managers’ cultural orientations in the interpretation and practice of sport management. Using a multiple dimension model (Hampden-Turner and Trompenaars, 2000) it sketches the cultural profiles of fifteen sport managers from seven countries. A combination of methods was employed including questionnaires, interviews and participant observation. It is contended that the culture of sport management concerns a social process by which managers get involved in reconciling seven fundamental cultural dilemmas in order to perform tasks and achieve certain ends. Thus, a knowledge of the cultural meaning of sport management in a particular country would equip sport managers with a valuable tool in managing both the cultural diversity of their own work forces and in developing appropriate cross-cultural skills needed for running international events, marketing campaigns, sponsorship deals and joint ventures
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