Deaths certified as asthma and use of medical services: A national case-control study

This is an open access publication. The official published version can be accessed from the link below.Background: Studies have linked asthma death to either increased or decreased use of medical services. Methods: A population based case-control study of asthma deaths in 1994–8 was performed in 22 English, six Scottish, and five Welsh health authorities/boards. All 681 subjects who died were under the age of 65 years with asthma in Part I on the death certificates. After exclusions, 532 hospital controls were matched to 532 cases for age, district, and date of asthma admission/death. Data were extracted blind from primary care records. Results: The median age of the subjects who died was 53 years; 60% of cases and 64% of controls were female. There was little difference in outpatient attendance (55% and 55%), hospital admission for asthma (51% and 54%), and median inpatient days (20 days and 15 days) in the previous 5 years. After mutual adjustment and adjustment for sex, using conditional logistic regression, three variables were independently associated with asthma death: fewer general practice contacts (odds ratio 0.82 (95% confidence interval (CI) 0.74 to 0.91) per 5 contacts) in the previous year, more home visits (1.14 (95% CI 1.08 to 1.21) per visit) in the previous year, and fewer peak expiratory flow recordings (0.83 (95% CI 0.74 to 0.92) per occasion) in the previous 3 months. These associations were similar after adjustment for markers of severity, psychosocial factors, systemic steroids, short acting bronchodilators and antibiotics, although the association with peak flow was weakened and just lost significance. Conclusion: Asthma death is associated with less use of primary care services. Both practice and patient factors may be involved and a better understanding of these may offer possibilities for reducing asthma death.This study was funded jointly between the National Research and Development Asthma Management Programme (contract number AM1/ 05/002) and the National Asthma Campaign through a grant from Glaxo Wellcome (now GlaxoSmithKline)

Carbon monoxide in the solar atmosphere I. Numerical method and two-dimensional models

The radiation hydrodynamic code CO5BOLD has been supplemented with the time-dependent treatment of chemical reaction networks. Advection of particle densities due to the hydrodynamic flow field is also included. The radiative transfer is treated frequency-independently, i.e. grey, so far. The upgraded code has been applied to two-dimensional simulations of carbon monoxide (CO) in the non-magnetic solar photosphere and low chromosphere. For this purpose a reaction network has been constructed, taking into account the reactions which are most important for the formation and dissociation of CO under the physical conditions of the solar atmosphere. The network has been strongly reduced to 27 reactions, involving the chemical species H, H2, C, O, CO, CH, OH, and a representative metal. The resulting CO number density is highest in the cool regions of the reversed granulation pattern at mid-photospheric heights and decreases strongly above. There, the CO abundance stays close to a value of 8.3 on the usual logarithmic abundance scale with [H]=12 but is reduced in hot shock waves which are a ubiquitous phenomenon of the model atmosphere. For comparison, the corresponding equilibrium densities have been calculated, based on the reaction network but also under assumption of instantaneous chemical equilibrium by applying the Rybicki & Hummer (RH) code by Uitenbroek (2001). Owing to the short chemical timescales, the assumption holds for a large fraction of the atmosphere, in particular the photosphere. In contrast, the CO number density deviates strongly from the corresponding equilibrium value in the vicinity of chromospheric shock waves. Simulations with altered reaction network clearly show that the formation channel via hydroxide (OH) is the most important one under the conditions of the solar atmosphere.Comment: 15 pages, 6 figures, final version will contain online materia

A far-UV survey of three hot, metal-polluted white dwarf stars: WD0455-282, WD0621-376, and WD2211-495

Using newly obtained high-resolution data ($R\sim{1\times{10}^{5}}$) from the \textit{Hubble Space Telescope}, and archival UV data from the \textit{Far Ultraviolet Spectroscopic Explorer} we have conducted a detailed UV survey of the three hot, metal-polluted white dwarfs WD0455-282, WD0621-376, and WD2211-495. Using bespoke model atmospheres we measured $T_{\mathrm{eff}}$, log $g$, and photospheric abundances for these stars. In conjunction with data from Gaia we measured masses, radii, and gravitational redshift velocities for our sample of objects. We compared the measured photospheric abundances with those predicted by radiative levitation theory, and found that the observed Si abundances in all three white dwarfs, and the observed Fe abundances in WD0621-376 and WD2211-495, were larger than those predicted by an order of magnitude. These findings imply not only an external origin for the metals, but also ongoing accretion, as the metals not supported by radiative levitation would sink on extremely short timescales. We measured the radial velocities of several absorption features along the line of sight to the three objects in our sample, allowing us to determine the velocities of the photospheric and interstellar components along the line of sight for each star. Interestingly, we made detections of circumstellar absorption along the line of sight to WD0455-282 with three velocity components. To our knowledge, this is the first such detection of multi-component circumstellar absorption along the line of sight to a white dwarf.Comment: 19 pages, 23 figures, 8 tables. Accepted for publication in the Monthly Notices of the Royal Astronomical Societ

Coexistence of orbital and quantum critical magnetoresistance in FeSe1−x_{1-x}Sx_{x}

The recent discovery of a non-magnetic nematic quantum critical point (QCP) in the iron chalcogenide family FeSe$_{1-x}$S$_{x}$ has raised the prospect of investigating, in isolation, the role of nematicity on the electronic properties of correlated metals. Here we report a detailed study of the normal state transverse magnetoresistance (MR) in FeSe$_{1-x}$S$_{x}$ for a series of S concentrations spanning the nematic QCP. For all temperatures and \textit{x}-values studied, the MR can be decomposed into two distinct components: one that varies quadratically in magnetic field strength $\mu_{0}\textit{H}$ and one that follows precisely the quadrature scaling form recently reported in metals at or close to a QCP and characterized by a \textit{H}-linear MR over an extended field range. The two components evolve systematically with both temperature and S-substitution in a manner that is determined by their proximity to the nematic QCP. This study thus reveals unambiguously the coexistence of two independent charge sectors in a quantum critical system. Moreover, the quantum critical component of the MR is found to be less sensitive to disorder than the quadratic (orbital) MR, suggesting that detection of the latter in previous MR studies of metals near a QCP may have been obscured.Comment: 19 pages (including Supplemental Material), 12 figure

Synthesis and reactivity of N-allenyl cyanamides

N-Allenyl cyanamides have been accessed via a one-pot deoxycyanamidation–isomerization approach using propargyl alcohol and N-cyano-N-phenyl-p-methylbenzenesulfonamide. The utility of this novel class of allenamide was explored through derivatization, with hydroarylation, hydroamination, and cycloaddition protocols employed to access an array of cyanamide products that would be challenging to access using existing methods

Deposition of inhaled charged ultrafine particles in a simple tracheal model

The deposition of ultrafine (d {le} 200 nm) particles on airway surfaces is an important determinant of the radiation dose that results from inhalation of radon progeny. The activity median diameter of particles to which radon daughters attach is small (10--140 nm). In the absence of charge, deposition in the upper airways of the respiratory system occurs by impaction for large particles and diffusion for small particles. Sedimentation is negligible due to the high flow rates in these airways. Experiments conducted in hollow casts and in vivo in humans have all shown an increase in deposition due to the particle charge. In vivo experimental results showed that there exists a threshold value of charge on the particle (q{sub c}) above which the electrostatic charge enhances deposition. These experiments were performed for particles for which deposition by diffusion is small (d {le} 300 nm). Deposition of ultrafine particles in the airways may occur by a combined mechanism of diffusion and electrostatic charge

Structure of the outer layers of cool standard stars

Context: Among late-type red giants, an interesting change occurs in the structure of the outer atmospheric layers as one moves to later spectral types in the Hertzsprung-Russell diagram: a chromosphere is always present, but the coronal emission diminishes and a cool massive wind steps in. Aims: Where most studies have focussed on short-wavelength observations, this article explores the influence of the chromosphere and the wind on long-wavelength photometric measurements. Methods: The observational spectral energy distributions are compared with the theoretical predictions of the MARCS atmosphere models for a sample of 9 K- and M-giants. The discrepancies found are explained using basic models for flux emission originating from a chromosphere or an ionized wind. Results: For 7 out of 9 sample stars, a clear flux excess is detected at (sub)millimeter and/or centimeter wavelengths. The precise start of the excess depends upon the star under consideration. The flux at wavelengths shorter than about 1 mm is most likely dominated by an optically thick chromosphere, where an optically thick ionized wind is the main flux contributor at longer wavelengths. Conclusions: Although the optical to mid-infrared spectrum of the studied K- and M-giants is well represented by a radiative equilibrium atmospheric model, the presence of a chromosphere and/or ionized stellar wind at higher altitudes dominates the spectrum in the (sub)millimeter and centimeter wavelength ranges. The presence of a flux excess also has implications on the role of these stars as fiducial spectrophotometric calibrators in the (sub)millimeter and centimeter wavelength range.Comment: 13 pages, 6 figures, 7 pages of online material, submitted to A&