COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Background: Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods: The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results: The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions: This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.EPICOVIDEHA has received funds from Optics COMMITTM (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223)

Sea-level rise in Venice: historic and future trends (review article)

The city of Venice and the surrounding lagoonal ecosystem are highly vulnerable to variations in relative sea level. In the past ∼150 years, this was characterized by an average rate of relative sea-level rise of about 2.5 mm/year resulting from the combined contributions of vertical land movement and sea-level rise. This literature review reassesses and synthesizes the progress achieved in quantification, understanding and prediction of the individual contributions to local relative sea level, with a focus on the most recent studies. Subsidence contributed to about half of the historical relative sea-level rise in Venice. The current best estimate of the average rate of sea-level rise during the observational period from 1872 to 2019 based on tide-gauge data after removal of subsidence effects is 1.23 ± 0.13 mm/year. A higher – but more uncertain – rate of sea-level rise is observed for more recent years. Between 1993 and 2019, an average change of about +2.76 ± 1.75 mm/year is estimated from tide-gauge data after removal of subsidence. Unfortunately, satellite altimetry does not provide reliable sea-level data within the Venice Lagoon. Local sea-level changes in Venice closely depend on sea-level variations in the Adriatic Sea, which in turn are linked to sea-level variations in the Mediterranean Sea. Water mass exchange through the Strait of Gibraltar and its drivers currently constitute a source of substantial uncertainty for estimating future deviations of the Mediterranean mean sea-level trend from the global-mean value. Regional atmospheric and oceanic processes will likely contribute significant interannual and interdecadal future variability in Venetian sea level with a magnitude comparable to that observed in the past. On the basis of regional projections of sea-level rise and an understanding of the local and regional processes affecting relative sea-level trends in Venice, the likely range of atmospherically corrected relative sea-level rise in Venice by 2100 ranges between 32 and 62 cm for the RCP2.6 scenario and between 58 and 110 cm for the RCP8.5 scenario, respectively. A plausible but unlikely high-end scenario linked to strong ice-sheet melting yields about 180 cm of relative sea-level rise in Venice by 2100. Projections of human-induced vertical land motions are currently not available, but historical evidence demonstrates that they have the potential to produce a significant contribution to the relative sea-level rise in Venice, exacerbating the hazard posed by climatically induced sea-level changes

Validar a guerra: a construção do regime de Expertise estratégica

This article is intended to contribute to the interpretative analysis of war. For that purpose, it investigates how some apparatuses located in strategic thinking help to make modern war a social practice considered both technically feasible and, at the same time, legitimate for soldiers. In so doing, it makes use of two different but closely related theoretical fields, pragmatic sociology (finding inspiration in the work of scholars such as Luc Boltanski, Nicolas Dodier and Francis Chateauraynaud), and the sociology of scientific knowledge (based mostly on the work of Bruno Latour). On the one hand, the sociology of scientific knowledge has developed a productive questioning of the construction of scientific facts that is particularly relevant to the present research. On the other hand, pragmatic sociology generates a compatible framework able to describe collective actions. The combination of both approaches allows the description of the formation of a strategic expertise regime that supports the technical legitimacy of the use of military force. Together, the sociology of scientific knowledge and pragmatic sociology bring a particularly relevant perspective to research pertaining to war.info:eu-repo/semantics/publishe

Carte géologique de Vihiers

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L-asparaginase-based treatment of 15 western patients with extranodal NK/T-cell lymphoma and leukemia and a review of the literature.

International audienceBACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type, and aggressive NK-cell leukemia are highly aggressive diseases with a poor outcome. PATIENTS AND METHODS: We report a multicentric French retrospective study of 15 patients with relapsed, refractory, or disseminated disease, treated with L-asparaginase-containing regimens in seven French centers. Thirteen patients were in relapse and/or refractory and 10 patients were at stage IV. RESULTS: All but two of the patients had an objective response to L-asparaginase-based treatment. Seven patients reached complete remission and only two relapsed. CONCLUSION: These data, although retrospective, confirm the excellent activity of L-asparaginase-containing regimens in refractory extranodal NK/T-cell lymphoma and aggressive NK-cell leukemia. Therefore, L-asparaginase-based regimen should be considered as a salvage treatment, especially for patients with disseminated disease. First-line L-asparaginase combination therapy for extranodal NK/T-cell lymphoma and aggressive NK-cell leukemia should be tested in prospective trials

An overview of the StraPolEté project : dynamics, aerosols and bromine content of the polar region in summertime

International audienceThe polar stratosphere in the summertime remains largely unexplored. Dynamical conditions are characterized by large scale transport and mixing between air masses of higher and lower latitude origins. Understanding these exchanges is crucial since they have a large impact on the distribution of trace gases and aerosols at polar latitudes, and thus on the stratospheric ozone budget. Ozone change affects the radiative balance, the coupling between troposphere and stratosphere, and therefore the climate. In the framework of the International Polar Year, the STRAPOLETE project starts on January 2009. It is associated with a successful balloon borne campaign which took place close to Kiruna (Sweeden) from 2 August 2009 to 12 September 2009 with eight balloon flights. During this campaign the main characteristics of the summertime arctic stratosphere have been captured. The data set obtained using UV-visible and infrared instruments, remote and in situ sensing embarked spectrometers will provide detailed information on vertical distributions of more than fifteen chemical tracers and reactive species from the upper troposphere to the middle stratosphere. A number of in situ optical aerosol counters, a UV-visible remote spectrometer for the aerosol extinction and a photopolarimeter will provide information on the nature and size distribution of the stratospheric aerosols. These balloon measurements with high precision and high vertical resolution are relevant to qualify the dynamical processes occuring in this region during summertime, the aerosols variability, the bromine abundance and establish a reference state of the polar summer stratosphere. The data set is "complete" by satellite data offering large spatial coverage of the region of interest. Data analysis is made using relevant dynamical (trajectory calculations, contour advection model) and chemistry-transport models (CTM) to highlight major mechanisms that controlled the distribution of tracers, aerosols and bromine. An overview of the project, its scientific issues, the measurements obtained will be presented, as well as preliminary results and comparisons between measurements and models outputs