1,755 research outputs found
Surface Architecture of Histoplasma Capsulatum
The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease
DNA strand break repair and neurodegeneration.
A number of DNA repair disorders are known to cause neurological problems. These disorders can be broadly characterised into early developmental, mid-to-late developmental or progressive. The exact developmental processes that are affected can influence disease pathology, with symptoms ranging from early embryonic lethality to late-onset ataxia. The category these diseases belong to depends on the frequency of lesions arising in the brain, the role of the defective repair pathway, and the nature of the mutation within the patient. Using observations from patients and transgenic mice, we discuss the importance of double strand break repair during neuroprogenitor proliferation and brain development and the repair of single stranded lesions in neuronal function and maintenance
An Investigation Into the Electrical Activity of Tender, Resting Paraspinal Muscles Using Surface Electromyography: A Pilot Study
Abnormal resting paraspinal muscle activity has been claimed to be responsible for changes in spinal tissue texture which are detectible by manual palpation. This pilot study investigated whether there was significant electrical activity in paraspinal musculature that was tender and that appeared to have altered tissue texture on palpation. Sixteen healthy volunteers between 18 and 35 years of age had their thoracic erector spinae mass palpated bilaterally from spinal levels T3 to T10 to identify paraspinal regions exhibiting altered tissue texture relative to the contralateral muscle mass. Surface electromyography (sEMG) was used to measure electrical activity in the muscle mass at the selected levels. No significant differences in electrical activity were observed between the tender and non-tender muscle masses, although a large difference existed in the one symptomatic subject. All muscle sites displayed EMG activity at rest, although the source of activity is not clear. A number of methodological problems with the EMG recording were encountered and are discussed. Future research is recommended using symptomatic participants
Observation of Hadronic W Decays in t-tbar Events with the Collider Detector at Fermilab
We observe hadronic W decays in t-tbar -> W (-> l nu) + >= 4 jet events using
a 109 pb-1 data sample of p-pbar collisions at sqrt{s} = 1.8 TeV collected with
the Collider Detector at Fermilab (CDF). A peak in the dijet invariant mass
distribution is obtained that is consistent with W decay and inconsistent with
the background prediction by 3.3 standard deviations. From this peak we measure
the W mass to be 77.2 +- 4.6 (stat+syst) GeV/c^2. This result demonstrates the
presence of two W bosons in t-tbar candidates in the W (-> l nu) + >= 4 jet
channel.Comment: 20 pages, 4 figures, submitted to PR
Search for a Technicolor omega_T Particle in Events with a Photon and a b-quark Jet at CDF
If the Technicolor omega_T particle exists, a likely decay mode is omega_T ->
gamma pi_T, followed by pi_T -> bb-bar, yielding the signature gamma bb-bar. We
have searched 85 pb^-1 of data collected by the CDF experiment at the Fermilab
Tevatron for events with a photon and two jets, where one of the jets must
contain a secondary vertex implying the presence of a b quark. We find no
excess of events above standard model expectations. We express the result of an
exclusion region in the M_omega_T - M_pi_T mass plane.Comment: 14 pages, 2 figures. Available from the CDF server (PS with figs):
http://www-cdf.fnal.gov/physics/pub98/cdf4674_omega_t_prl_4.ps
FERMILAB-PUB-98/321-
Search for Chargino-Neutralino Associated Production at the Fermilab Tevatron Collider
We have searched in collisions at = 1.8 TeV for events
with three charged leptons and missing transverse energy. In the Minimal
Supersymmetric Standard Model, we expect trilepton events from
chargino-neutralino (\chione \chitwo) pair production, with subsequent decay
into leptons. We observe no candidate , ,
or events in 106 pb integrated
luminosity. We present limits on the sum of the branching ratios times cross
section for the four channels: \sigma_{\chione\chitwo}\cdot
BR(\chione\chitwo\to 3\ell+X) 81.5 \mgev\sp and
M_\chitwo > 82.2 \mgev\sp for , ~\mgev\sp and
M_\squark= M_\gluino.Comment: 9 pages and 3 figure
Measurement of J/Psi and Psi(2S) Polarization in ppbar Collisions at sqrt(s) = 1.8 TeV
We have measured the polarization of J/Psi and Psi(2S) mesons produced in
p\bar{p} collisions at \sqrt{s} = 1.8 TeV, using data collected at CDF during
1992-95.
The polarization of promptly produced J/Psi [Psi(2S)] mesons is isolated from
those produced in B-hadron decay, and measured over the kinematic range 4[5.5]
< P_T < 20 GeV/c and |y| < 0.6. For P_T \gessim 12 GeV/c we do not observe
significant polarization in the prompt component.Comment: Revised version, accepted for publication in Physical Review Letter
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