2,380 research outputs found
Bias and consistency in time delay estimation methods: case of the double quasar HE 1104-1805
We present a short re-evaluation of a recently published time delay estimate
for the gravitational lens system HE 1104-1805 with emphasis on important
methodological aspects: bias of the statistics, inconsistency of the methods
and use of the purposeful selection of data points(or so-called "cleaning") at
the preprocessing stage. We show how the inadequate use of simple analysis
methods can lead to too strong conclusions. Our analysis shows that there are
indications for the time delay in HE 1104-1805 to be between -0.9 and -0.7
years, but still with a large uncertainty.Comment: 5 pages, 5 figures, accepted as a Letter to the Editor in A&
Three photometric methods tested on ground-based data of Q 2237+0305
The Einstein Cross, Q~2237+0305, has been photometrically observed in four
bands on two successive nights at NOT (La Palma, Spain) in October 1995. Three
independent algorithms have been used to analyse the data: an automatic image
decomposition technique, a CLEAN algorithm and the new MCS deconvolution code.
The photometric and astrometric results obtained with the three methods are
presented. No photometric variations were found in the four quasar images.
Comparison of the photometry from the three techniques shows that both
systematic and random errors affect each method. When the seeing is worse than
1.0", the errors from the automatic image decomposition technique and the Clean
algorithm tend to be large (0.04-0.1 magnitudes) while the deconvolution code
still gives accurate results (1{sigma} error below 0.04) even for frames with
seeing as bad as 1.7". Reddening is observed in the quasar images and is found
to be compatible with either extinction from the lensing galaxy or colour
dependent microlensing. The photometric accuracy depends on the light
distribution used to model the lensing galaxy. In particular, using a numerical
galaxy model, as done with the MCS algorithm, makes the method less seeing
dependent. Another advantage of using a numerical model is that eventual
non-homogeneous structures in the galaxy can be modeled. Finally, we propose an
observational strategy for a future photometric monitoring of the Einstein
Cross.Comment: 9 pages, accepted for publication in A&
Absolute diffuse calibration of IRAC through mid-infrared and radio study of HII regions
We investigate the diffuse absolute calibration of the InfraRed Array Camera
on the Spitzer Space Telescope at 8.0microns using a sample of 43 HII regions
with a wide range of morphologies near GLON=312deg. For each region we
carefully measure sky-subtracted,point-source- subtracted, areally-integrated
IRAC 8.0-micron fluxes and compare these with Midcourse Space eXperiment (MSX)
8.3-micron images at two different spatial resolutions, and with radio
continuum maps. We determine an accurate median ratio of IRAC
8.0-micron/MSX\8.3-micron fluxes, of 1.55+/-0.15. From robust spectral energy
distributions of these regions we conclude that the present 8.0-micron diffuse
calibration of the SST is 36% too high compared with the MSX validated
calibration, perhaps due to scattered light inside the camera. This is an
independent confirmation of the result derived for the diffuse calibration of
IRAC by the Spitzer Science Center (SSC).
From regression analyses we find that 843-MHz radio fluxes of HII regions and
mid-infrared (MIR) fluxes are linearly related for MSX at 8.3-microns and
Spitzer at 8.0 microns, confirming the earlier MSX result by Cohen & Green. The
median ratio of MIR/843-MHz diffuse continuum fluxes is 600 times smaller in
nonthermal than thermal regions, making it a sharp discriminant. The ratios are
largely independent of morphology up to a size of ~24 arcsec. We provide
homogeneous radio and MIR morphologies for all sources. MIR morphology is not
uniquely related to radio structure. Compact regions may have MIR filaments
and/or diffuse haloes, perhaps infrared counter- parts to weakly ionized radio
haloes found around compact HII regions. We offer two IRAC colour-colour plots
as quantitative diagnostics of diffuse HII regions.Comment: 29 pages, LaTeX (aastex), incl. 31 PostScript (ps,eps) figures and 5
tables. Accepted by MNRAS (main journal). Replaced an unused file and added
this URL for people wishing to download a version with high-resolution
images: http://www.astro.wisc.edu/sirtf/martin.hii.accepted.pd
Systemic linear polyethylenimine (LâPEI)âmediated gene delivery in the mouse
Background
Several nonviral vectors including linear polyethylenimine(LâPEI) confer a pronounced lung tropism to plasmid DNA when injected into the mouse tail vein in a nonionic solution.
Methods and results
We have optimized this route by injecting 50â”g DNA with excess LâPEI (PEI nitrogen/DNA phosphate=10) in a large volume of 5% glucose (0.4âml). In these conditions, 1â5% of lung cells were transfected (corresponding to 2âng luciferase/mg protein), the other organs remaining essentially refractory to transfection (1â10âpg luciferase/mg protein).ÎČâGalactosidase histochemistry confirmed alveolar cells, including pneumocytes, to be the main target, thus leading to the puzzling observation that the lung microvasculature must be permeable to cationic LâPEI/DNA particles of ca 60ânm. A smaller injected volume, premixing of the complexes with autologous mouse serum, as well as removal of excess free LâPEI, all severely decreased transgene expression in the lung. Arterial or portal vein delivery did not increase transgene expression in other organs.
Conclusions
These observations suggest that effective lung transfection primarily depends on the injection conditions: the large nonionic glucose bolus prevents aggregation as well as mixing of the cationic complexes and excess free LâPEI with blood. This may favour vascular leakage in the region where the vasculature is dense and fragile, i.e. around the lung alveoli. Cationic particles can thus reach the epithelium from the basolateral side where their receptors (heparan sulphate proteoglycans) are abundant
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Estimated Association of Construction Work with Risks of COVID-19 Infection and Hospitalization in Texas
IMPORTANCE: Policy makers have relaxed restrictions for certain non-essential industries, including construction, jeopardizing the effectiveness of social distancing measures and putting already at-risk populations at greater risk of coronavirus disease 2019 (COVID-19) infection. In Texas, Latinx populations are overly represented among construction workers, and thus have elevated rates of exposure that are compounded by prevalent high-risk comorbidities and lack of access to healthcare. OBJECTIVE: To assess the association between construction work during the COVID-19 pandemic and hospitalization rates for construction workers and the surrounding community. DESIGN, SETTING, AND PARTICIPANTS: This decision analytical model used a mathematical model of COVID-19 transmission, stratified by age and risk group, with construction workers modeled explicitly. The model was based on residents of the Austin-Round Rock metropolitan statistical area, with a population of 2.17 million. Based on 500 stochastic simulations for each of 15 scenarios that varied the size of the construction workforce and level of worksite transmission risk, the association between continued construction work and hospitalizations was estimated and then compared with anonymized line-list hospitalization data from central Texas through August20, 2020. EXPOSURES: Social distancing interventions, size of construction workforce, and level of disease transmission at construction worksites. MAIN OUTCOMES AND MEASURES: For each scenario, the total number of COVID-19 hospitalizations and the relative risk of hospitalization among construction workers was projected and then compared with relative risks estimated from reported hospitalization data. RESULTS: Allowing unrestricted construction work was associated with an increase of COVID-19 hospitalization rates through mid-August 2020 from 0.38 per 1000 residents to 1.5 per 1000 residents and from 0.22 per 1000 construction workers to 9.3 per 1000 construction workers. This increased risk was estimated to be offset by safety measures (such as thorough cleaning of equipment between uses, wearing of protective equipment, limits on the number of workers at a worksite, and increased health surveillance) that were associated with a 50% decrease in transmission. The observed relative risk of hospitalization among construction workers compared with other occupational categories among adults aged 18 to 64 years was 4.9 (95%CI,3.8-6.2). CONCLUSIONS AND RELEVANCE: The findings of this study suggest that unrestricted work in high-contact industries, such as construction, is associated with a higher level of community transmission, increased risks to at-risk workers, and larger health disparities among members of racial and ethnic minority groups.This study was supported, in part, by contract 75D-301-19-C-05930 from the US Centers for Disease Control and Prevention and grant R01AI151176 from the National Institutes of Health.Dell Medical SchoolIntegrative Biolog
Speeding up Simplification of Polygonal Curves using Nested Approximations
We develop a multiresolution approach to the problem of polygonal curve
approximation. We show theoretically and experimentally that, if the
simplification algorithm A used between any two successive levels of resolution
satisfies some conditions, the multiresolution algorithm MR will have a
complexity lower than the complexity of A. In particular, we show that if A has
a O(N2/K) complexity (the complexity of a reduced search dynamic solution
approach), where N and K are respectively the initial and the final number of
segments, the complexity of MR is in O(N).We experimentally compare the
outcomes of MR with those of the optimal "full search" dynamic programming
solution and of classical merge and split approaches. The experimental
evaluations confirm the theoretical derivations and show that the proposed
approach evaluated on 2D coastal maps either shows a lower complexity or
provides polygonal approximations closer to the initial curves.Comment: 12 pages + figure
Temporal evolution of sand corridors in a <i>Posidonia oceanica</i> seascape: a 15-year study
The spatial dynamic of Posidonia oceanica meadows is a process extending over centuries. This paper shows evidence of the natural dynamics of P. oceanica âshifting intermattesâ or âsand corridorsâ (hereafter SCs): unvegetated patches within a dense meadow. We studied features and temporal evolution (2001-2015) of 5 SCs in the Calvi Bay (Corsica) at 15 m depth and followed the characteristics the P. oceanica meadow lining the edge of patches. All SCs show a similar topography. The eroded side is a vertical edge where roots, rhizomes and sediments are visible, when on the opposite colonized side, the sand is at the same level as the continuous meadow. The vertical edge reaches a maximum height of 160 cm and is eroded by orbital bottom currents with a maximum speed of 12 cm.s-1, the erosion speed ranging from 0.6 to 15 cm.y-1. SCs progress toward the coastline with a mean speed of 10 cm.y-1, the rate of colonization by P. oceanica shoots ranging from 1.5 to 21 cm.y-1. We calculated that the studied SCs would reach the coastline within 500 to 600 years. We finally discuss the implication of such dynamic in the framework of meadowsâ colonization assessment and the seascape dynamic
A resolved analysis of cold dust and gas in the nearby edge-on spiral NGC 891
We investigate the connection between dust and gas in the nearby edge-on
spiral galaxy NGC 891. High resolution Herschel PACS and SPIRE 70, 100, 160,
250, 350, and 500 m images are combined with JCMT SCUBA 850 m
observations to trace the far-infrared/submillimetre spectral energy
distribution (SED). Maps of the HI 21 cm line and CO(J=3-2) emission trace the
atomic and molecular hydrogen gas, respectively. We fit one-component modified
blackbody models to the integrated SED, finding a global dust mass of
8.510 M and an average temperature of 232 K. We
also fit the pixel-by-pixel SEDs to produce maps of the dust mass and
temperature. The dust mass distribution correlates with the total stellar
population as traced by the 3.6 m emission. The derived dust temperature,
which ranges from approximately 17 to 24 K, is found to correlate with the 24
m emission. Allowing the dust emissivity index to vary, we find an average
value of = 1.90.3. We confirm an inverse relation between the dust
emissivity spectral index and dust temperature, but do not observe any
variation of this relationship with vertical height from the mid-plane of the
disk. A comparison of the dust properties with the gaseous components of the
ISM reveals strong spatial correlations between the surface mass densities of
dust and the molecular hydrogen and total gas surface densities. Observed
asymmetries in the dust temperature, and the H-to-dust and total
gas-to-dust ratios hint that an enhancement in the star formation rate may be
the result of larger quantities of molecular gas available to fuel star
formation in the NE compared to the SW. Whilst the asymmetry likely arises from
dust obscuration due to the geometry of the line-of-sight projection of the
spiral arms, we cannot exclude an enhancement in the star formation rate in the
NE side of the disk.Comment: Accepted for publication in A&A. 21 pages, including 13 figures and 4
table
Biomass Burning Aerosols in the Amazon Basin, Characterised by Lidar, Optical Particle Counters, and Modelling
This is the final version. Available from EDP Sciences via the DOI in this record.âŻThis article has no abstract.Natural Environment Research Council (NERC)Met Offic
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