Use of accelerometry to investigate physical activity in dogs receiving chemotherapy

Objectives: To perform a preliminary study to assess whether single-agent palliative or adjuvant chemotherapy has an impact on objectively measured physical activity in dogs. Methods: Fifteen dogs with neoplasia (treatment group) wore ActiGraph™ accelerometers for 5-day periods before, during and after receiving single-agent adjuvant or palliative chemotherapy. Mean 5-day total physical activity and time spent in three different intensities of activity (sedentary, light-moderate and vigorous) before, during and after receiving chemotherapy were compared to a group of 15 healthy dogs (control group). Results were also compared within the treatment group across time. Results: Prior to chemotherapy, treated dogs tended to be less active than control dogs. Treatment group dogs were slightly more active at restaging than they were prior to treatment but had similar activity levels to control dogs. Marked effects of chemotherapy on physical activity were not detected. Physical activity was slightly lower in treated dogs during chemotherapy when compared to control dogs but there was a slight increase in physical activity of treated dogs during chemotherapy when compared with pretreatment recordings. There was little change in the mean 5-day total physical activity between treated dogs during chemotherapy and at restaging but a mild decrease in time spent sedentary and increase in time spent in light-moderate activity at this comparison of time points. Clinical Significance: Single-agent adjuvant or palliative chemotherapy had minimal impact on physical activity levels in dogs with neoplasia

Spectral Analysis and the Dynamic Response of Complex Networks

The eigenvalues and eigenvectors of the connectivity matrix of complex networks contain information about its topology and its collective behavior. In particular, the spectral density $\rho(\lambda)$ of this matrix reveals important network characteristics: random networks follow Wigner's semicircular law whereas scale-free networks exhibit a triangular distribution. In this paper we show that the spectral density of hierarchical networks follow a very different pattern, which can be used as a fingerprint of modularity. Of particular importance is the value $\rho(0)$, related to the homeostatic response of the network: it is maximum for random and scale free networks but very small for hierarchical modular networks. It is also large for an actual biological protein-protein interaction network, demonstrating that the current leading model for such networks is not adequate.Comment: 4 pages 14 figure

Global Patterns of Synchronization in Human Communications

Social media are transforming global communication and coordination. The data derived from social media can reveal patterns of human behavior at all levels and scales of society. Using geolocated Twitter data, we have quantified collective behaviors across multiple scales, ranging from the commutes of individuals, to the daily pulse of 50 major urban areas and global patterns of human coordination. Human activity and mobility patterns manifest the synchrony required for contingency of actions between individuals. Urban areas show regular cycles of contraction and expansion that resembles heartbeats linked primarily to social rather than natural cycles. Business hours and circadian rhythms influence daily cycles of work, recreation, and sleep. Different urban areas have characteristic signatures of daily collective activities. The differences are consistent with a new emergent global synchrony that couples behavior in distant regions across the world. A globally synchronized peak that includes exchange of ideas and information across Europe, Africa, Asia and Australasia. We propose a dynamical model to explain the emergence of global synchrony in the context of increasing global communication and reproduce the observed behavior. The collective patterns we observe show how social interactions lead to interdependence of behavior manifest in the synchronization of communication. The creation and maintenance of temporally sensitive social relationships results in the emergence of complexity of the larger scale behavior of the social system.Comment: 20 pages, 12 figures. arXiv admin note: substantial text overlap with arXiv:1602.0621

A photometric search for transients in galaxy clusters

We have begun a program to search for supernovae and other transients in the fields of galaxy clusters with the 2.3m Bok Telescope on Kitt Peak. We present our automated photometric methods for data reduction, efficiency characterization, and initial spectroscopy. With this program, we aim to ultimately identify $\sim$25-35 cluster SN Ia ($\sim$10 of which will be intracluster, hostless events) and constrain the SN Ia rate associated with old, passive stellar populations. With these measurements we will constrain the relative contribution of hostless and hosted SN Ia to the metal enrichment of the intracluster medium. In the current work, we have identified a central excess of transient events within $1.25 r_{200}$ in our cluster fields after statistically subtracting out the 'background' transient rate taken from an off-cluster CCD chip. Based on the published rate of SN Ia for cluster populations we estimate that $\sim$20 percent of the excess cluster transients are due to cluster SN Ia, a comparable fraction to core collapse (CC) supernovae and the remaining are likely to be active galactic nuclei. Interestingly, we have identified three intracluster SN candidates, all of which lay beyond $R>r_{200}$. These events, if truly associated with the cluster, indicate a large deficit of intracluster (IC) SN at smaller radii, and may be associated with the IC stars of infalling groups or indicate that the intracluster light (ICL) in the cluster outskirts is actively forming stars which contribute CC SN or prompt SN Ia.Comment: Updated to match accepted version; 26 pages, 14 figures, AJ accepte

The Radio Jet Associated with the Multiple V380 Ori System

The giant Herbig-Haro object 222 extends over $\sim$6$'$ in the plane of the sky, with a bow shock morphology. The identification of its exciting source has remained uncertain over the years. A non-thermal radio source located at the core of the shock structure was proposed to be the exciting source. However, Very Large Array studies showed that the radio source has a clear morphology of radio galaxy and a lack of flux variations or proper motions, favoring an extragalactic origin. Recently, an optical-IR study proposed that this giant HH object is driven by the multiple stellar system V380 Ori, located about 23$'$ to the SE of HH 222. The exciting sources of HH systems are usually detected as weak free-free emitters at centimeter wavelengths. Here we report the detection of an elongated radio source associated with the Herbig Be star or with its close infrared companion in the multiple V380 Ori system. This radio source has the characteristics of a thermal radio jet and is aligned with the direction of the giant outflow defined by HH~222 and its suggested counterpart to the SE, HH~1041. We propose that this radio jet traces the origin of the large scale HH outflow. Assuming that the jet arises from the Herbig Be star, the radio luminosity is a few times smaller than the value expected from the radio-bolometric correlation for radio jets, confirming that this is a more evolved object than those used to establish the correlation.Comment: 13 pages, 3 figure

Caltech Core-Collapse Project (CCCP) observations of type IIn supernovae: typical properties and implications for their progenitor stars

Type IIn Supernovae (SNe IIn) are rare events, constituting only a few percent of all core-collapse SNe, and the current sample of well observed SNe IIn is small. Here, we study the four SNe IIn observed by the Caltech Core-Collapse Project (CCCP). The CCCP SN sample is unbiased to the extent that object selection was not influenced by target SN properties. Therefore, these events are representative of the observed population of SNe IIn. We find that a narrow P-Cygni profile in the hydrogen Balmer lines appears to be a ubiquitous feature of SNe IIn. Our light curves show a relatively long rise time (>20 days) followed by a slow decline stage (0.01 to 0.15 mag/day), and a typical V-band peak magnitude of M_V=-18.4 +/- 1.0 mag. We measure the progenitor star wind velocities (600 - 1400 km/s) for the SNe in our sample and derive pre-explosion mass loss rates (0.026 - 0.12 solar masses per year). We compile similar data for SNe IIn from the literature, and discuss our results in the context of this larger sample. Our results indicate that typical SNe IIn arise from progenitor stars that undergo LBV-like mass-loss shortly before they explode.Comment: ApJ, submitte