Evaluating elbow osteoarthritis within the prehistoric Tiwanaku state using generalized estimating equations (GEE).

OBJECTIVES:Studies of osteoarthritis (OA) in human skeletal remains can come with scalar problems. If OA measurement is noted as present or absent in one joint, like the elbow, results may not identify specific articular pathology data and the sample size may be insufficient to address research questions. If calculated on a per data point basis (i.e., each articular surface within a joint), results may prove too data heavy to comprehensively understand arthritic changes, or one individual with multiple positive scores may skew results and violate the data independence required for statistical tests. The objective of this article is to show that the statistical methodology Generalized Estimating Equations (GEE) can solve scalar issues in bioarchaeological studies. MATERIALS AND METHODS:Using GEE, a population-averaged statistical model, 1,195 adults from the core and one colony of the prehistoric Tiwanaku state (AD 500-1,100) were evaluated bilaterally for OA on the seven articular surfaces of the elbow joint. RESULTS:GEE linked the articular surfaces within each individual specimen, permitting the largest possible unbiased dataset, and showed significant differences between core and colony Tiwanaku peoples in the overall elbow joint, while also pinpointing specific articular surfaces with OA. Data groupings by sex and age at death also demonstrated significant variation. A pattern of elbow rotation noted for core Tiwanaku people may indicate a specific pattern of movement. DISCUSSION:GEE is effective and should be encouraged in bioarchaeological studies as a way to address scalar issues and to retain all pathology information

Description of post-mortem findings in an antarctic fur seal (Arctochepalus gazella)

Cada año, entre noviembre y diciembre, centenares de ejemplares de lobo marino antártico (Arctocephalus gazella) suelen arribar a las costas del continente antártico para reproducirse. En ocasiones, algunos de estos ejemplares mueren en la playa y sus cuerpos son cubiertos por la nieve, manteniéndolos congelados por meses. En este trabajo se comunican los hallazgos post-mortem de un lobo marino antártico encontrado congelado en la Zona Antártica Especialmente Protegida N°132 (ZAEP 132), Isla 25 de Mayo/King George, Islas Shetland del Sur, Antártida. Los resultados aportan datos sobre la anatomía de la especie, describiendo además la presencia de una colecta pericárdica.Every year, between November and December, hundreds of Antarctic fur seals (Arctocephalus gazella) arrive to the coasts of Antarctic continent to breed. Occasionally, some individuals die on the beach and their bodies are covered by snow, keeping them frozen for months. The aim of this work is to communicate the post-mortem findings in an Antarctic fur seal in the Antarctic Specially Protected Area N°132 (ZAEP 132), Island May 25/King George, South Shetland Islands, Antarctica. The results provide data on the anatomy of the species and also report the presence of a pericardial effusion.Facultad de Ciencias Veterinarias (FCV)Facultad de Ciencias Naturales y Museo (FCNM

Description of post-mortem findings in an antarctic fur seal (Arctochepalus gazella)

Cada año, entre noviembre y diciembre, centenares de ejemplares de lobo marino antártico (Arctocephalus gazella) suelen arribar a las costas del continente antártico para reproducirse. En ocasiones, algunos de estos ejemplares mueren en la playa y sus cuerpos son cubiertos por la nieve, manteniéndolos congelados por meses. En este trabajo se comunican los hallazgos post-mortem de un lobo marino antártico encontrado congelado en la Zona Antártica Especialmente Protegida N°132 (ZAEP 132), Isla 25 de Mayo/King George, Islas Shetland del Sur, Antártida. Los resultados aportan datos sobre la anatomía de la especie, describiendo además la presencia de una colecta pericárdica.Every year, between November and December, hundreds of Antarctic fur seals (Arctocephalus gazella) arrive to the coasts of Antarctic continent to breed. Occasionally, some individuals die on the beach and their bodies are covered by snow, keeping them frozen for months. The aim of this work is to communicate the post-mortem findings in an Antarctic fur seal in the Antarctic Specially Protected Area N°132 (ZAEP 132), Island May 25/King George, South Shetland Islands, Antarctica. The results provide data on the anatomy of the species and also report the presence of a pericardial effusion.Facultad de Ciencias Veterinarias (FCV)Facultad de Ciencias Naturales y Museo (FCNM

Description of post-mortem findings in an antarctic fur seal (Arctochepalus gazella)

Cada año, entre noviembre y diciembre, centenares de ejemplares de lobo marino antártico (Arctocephalus gazella) suelen arribar a las costas del continente antártico para reproducirse. En ocasiones, algunos de estos ejemplares mueren en la playa y sus cuerpos son cubiertos por la nieve, manteniéndolos congelados por meses. En este trabajo se comunican los hallazgos post-mortem de un lobo marino antártico encontrado congelado en la Zona Antártica Especialmente Protegida N°132 (ZAEP 132), Isla 25 de Mayo/King George, Islas Shetland del Sur, Antártida. Los resultados aportan datos sobre la anatomía de la especie, describiendo además la presencia de una colecta pericárdica.Every year, between November and December, hundreds of Antarctic fur seals (Arctocephalus gazella) arrive to the coasts of Antarctic continent to breed. Occasionally, some individuals die on the beach and their bodies are covered by snow, keeping them frozen for months. The aim of this work is to communicate the post-mortem findings in an Antarctic fur seal in the Antarctic Specially Protected Area N°132 (ZAEP 132), Island May 25/King George, South Shetland Islands, Antarctica. The results provide data on the anatomy of the species and also report the presence of a pericardial effusion.Facultad de Ciencias Veterinarias (FCV)Facultad de Ciencias Naturales y Museo (FCNM

A methodology to downscale water demand data with application to the Andean region (Ecuador, Peru, Bolivia, Chile)

Mountainous regions are a hotspot for water scarcity and anthropogenic pressure on water resources. Substantial uncertainty surrounds projections of future climate and water availability. Furthermore, quantitative and distributed data on water demand are generally scarce, dispersed, and highly heterogeneous. This forms a major bottleneck to studying water resources issues and developing strategies to improve water resource management. Here we present a methodology to produce and evaluate high-resolution gridded maps of anthropogenic surface water demand with application to the Andean region. These data are disaggregated according to the major types of water demand: domestic users, irrigated area, and hydropower. This dataset was built by homogenizing, integrating, and interpolating data obtained from various national institutions in charge of water resource management as well as relevant global datasets. The maps can be used to research anthropogenic impacts on water resources, and to guide regional decision-making in regions such as the Andes

The Oldest Case of Decapitation in the New World (Lapa do Santo, East-Central Brazil)

We present here evidence for an early Holocene case of decapitation in the New World (Burial 26), found in the rock shelter of Lapa do Santo in 2007. Lapa do Santo is an archaeological site located in the Lagoa Santa karst in east-central Brazil with evidence of human occupation dating as far back as 11.7-12.7 cal kyBP (95.4% interval). An ultra-filtered AMS age determination on a fragment of the sphenoid provided an age range of 9.1-9.4 cal kyBP (95.4% interval) for Burial 26. The interment was composed of an articulated cranium, mandible and first six cervical vertebrae. Cut marks with a v-shaped profile were observed in the mandible and sixth cervical vertebra. The right hand was amputated and laid over the left side of the face with distal phalanges pointing to the chin and the left hand was amputated and laid over the right side of the face with distal phalanges pointing to the forehead. Strontium analysis comparing Burial 26's isotopic signature to other specimens from Lapa do Santo suggests this was a local member of the group. Therefore, we suggest a ritualized decapitation instead of trophy-taking, testifying for the sophistication of mortuary rituals among hunter-gatherers in the Americas during the early Archaic period. In the apparent absence of wealth goods or elaborated architecture, Lapa do Santo's inhabitants seemed to use the human body to express their cosmological principles regarding death

Canvass: a crowd-sourced, natural-product screening library for exploring biological space

NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A. acknowledges support from NSF (CHE-1665145) and NIH (GM126221). M.K.B. acknowledges support from NIH (5R01GM110131). N.Z.B. thanks support from NIGMS, NIH (R01GM114061). J.K.C. acknowledges support from NSF (CHE-1665331). J.C. acknowledges support from the Fogarty International Center, NIH (TW009872). P.A.C. acknowledges support from the National Cancer Institute (NCI), NIH (R01 CA158275), and the NIH/National Institute of Aging (P01 AG012411). N.K.G. acknowledges support from NSF (CHE-1464898). B.C.G. thanks the support of NSF (RUI: 213569), the Camille and Henry Dreyfus Foundation, and the Arnold and Mabel Beckman Foundation. C.C.H. thanks the start-up funds from the Scripps Institution of Oceanography for support. J.N.J. acknowledges support from NIH (GM 063557, GM 084333). A.D.K. thanks the support from NCI, NIH (P01CA125066). D.G.I.K. acknowledges support from the National Center for Complementary and Integrative Health (1 R01 AT008088) and the Fogarty International Center, NIH (U01 TW00313), and gratefully acknowledges courtesies extended by the Government of Madagascar (Ministere des Eaux et Forets). O.K. thanks NIH (R01GM071779) for financial support. T.J.M. acknowledges support from NIH (GM116952). S.M. acknowledges support from NIH (DA045884-01, DA046487-01, AA026949-01), the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program (W81XWH-17-1-0256), and NCI, NIH, through a Cancer Center Support Grant (P30 CA008748). K.N.M. thanks the California Department of Food and Agriculture Pierce's Disease and Glassy Winged Sharpshooter Board for support. B.T.M. thanks Michael Mullowney for his contribution in the isolation, elucidation, and submission of the compounds in this work. P.N. acknowledges support from NIH (R01 GM111476). L.E.O. acknowledges support from NIH (R01-HL25854, R01-GM30859, R0-1-NS-12389). L.E.B., J.K.S., and J.A.P. thank the NIH (R35 GM-118173, R24 GM-111625) for research support. F.R. thanks the American Lebanese Syrian Associated Charities (ALSAC) for financial support. I.S. thanks the University of Oklahoma Startup funds for support. J.T.S. acknowledges support from ACS PRF (53767-ND1) and NSF (CHE-1414298), and thanks Drs. Kellan N. Lamb and Michael J. Di Maso for their synthetic contribution. B.S. acknowledges support from NIH (CA78747, CA106150, GM114353, GM115575). W.S. acknowledges support from NIGMS, NIH (R15GM116032, P30 GM103450), and thanks the University of Arkansas for startup funds and the Arkansas Biosciences Institute (ABI) for seed money. C.R.J.S. acknowledges support from NIH (R01GM121656). D.S.T. thanks the support of NIH (T32 CA062948-Gudas) and PhRMA Foundation to A.L.V., NIH (P41 GM076267) to D.S.T., and CCSG NIH (P30 CA008748) to C.B. Thompson. R.E.T. acknowledges support from NIGMS, NIH (GM129465). R.J.T. thanks the American Cancer Society (RSG-12-253-01-CDD) and NSF (CHE1361173) for support. D.A.V. thanks the Camille and Henry Dreyfus Foundation, the National Science Foundation (CHE-0353662, CHE-1005253, and CHE-1725142), the Beckman Foundation, the Sherman Fairchild Foundation, the John Stauffer Charitable Trust, and the Christian Scholars Foundation for support. J.W. acknowledges support from the American Cancer Society through the Research Scholar Grant (RSG-13-011-01-CDD). W.M.W.acknowledges support from NIGMS, NIH (GM119426), and NSF (CHE1755698). A.Z. acknowledges support from NSF (CHE-1463819). (Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH); CHE-1665145 - NSF; CHE-1665331 - NSF; CHE-1464898 - NSF; RUI: 213569 - NSF; CHE-1414298 - NSF; CHE1361173 - NSF; CHE1755698 - NSF; CHE-1463819 - NSF; GM126221 - NIH; 5R01GM110131 - NIH; GM 063557 - NIH; GM 084333 - NIH; R01GM071779 - NIH; GM116952 - NIH; DA045884-01 - NIH; DA046487-01 - NIH; AA026949-01 - NIH; R01 GM111476 - NIH; R01-HL25854 - NIH; R01-GM30859 - NIH; R0-1-NS-12389 - NIH; R35 GM-118173 - NIH; R24 GM-111625 - NIH; CA78747 - NIH; CA106150 - NIH; GM114353 - NIH; GM115575 - NIH; R01GM121656 - NIH; T32 CA062948-Gudas - NIH; P41 GM076267 - NIH; R01GM114061 - NIGMS, NIH; R15GM116032 - NIGMS, NIH; P30 GM103450 - NIGMS, NIH; GM129465 - NIGMS, NIH; GM119426 - NIGMS, NIH; TW009872 - Fogarty International Center, NIH; U01 TW00313 - Fogarty International Center, NIH; R01 CA158275 - National Cancer Institute (NCI), NIH; P01 AG012411 - NIH/National Institute of Aging; Camille and Henry Dreyfus Foundation; Arnold and Mabel Beckman Foundation; Scripps Institution of Oceanography; P01CA125066 - NCI, NIH; 1 R01 AT008088 - National Center for Complementary and Integrative Health; W81XWH-17-1-0256 - Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program; P30 CA008748 - NCI, NIH, through a Cancer Center Support Grant; California Department of Food and Agriculture Pierce's Disease and Glassy Winged Sharpshooter Board; American Lebanese Syrian Associated Charities (ALSAC); University of Oklahoma Startup funds; 53767-ND1 - ACS PRF; PhRMA Foundation; P30 CA008748 - CCSG NIH; RSG-12-253-01-CDD - American Cancer Society; RSG-13-011-01-CDD - American Cancer Society; CHE-0353662 - National Science Foundation; CHE-1005253 - National Science Foundation; CHE-1725142 - National Science Foundation; Beckman Foundation; Sherman Fairchild Foundation; John Stauffer Charitable Trust; Christian Scholars Foundation)Published versionSupporting documentatio