Gender (In)equality and Football. What about the RFEF CSR Committee in the Case of the 2020 Super Cup in Saudi Arabia?

[EN] This article discusses the trajectory that the so-called Corporate Social Responsibility Committee of the Royal Spanish Football Federation took place. This advisory body was established in 2019 and dissolved in mid-2020. We are interested in knowing the actions it may carry out during that period. To this end, we analyse the testimonies of interviews with some of the external members who were part of the committee. We focus on those actions on gender equality and for this particular aim we study the paradigmatic case of the celebration of the Spanish Super Cup in Saudi Arabia. This is a controversial event, on which the Committee made concrete recommendations.[ES] Este artículo analiza el recorrido que tuvo el denominado Comité de Responsabilidad Social Corporativa de la Real Federación Española de Fútbol (RFEF). Se trata de un órgano consultivo constituido en 2019 y disuelto a mediados de 2020. Nos interesa conocer las acciones que llevó a cabo en ese periodo. Para ello, se interpretan los testimonios de entrevistas realizadas a algunos de los miembros externos que formaron parte del comité. Nos centramos en aquellas actuaciones en materia de igualdad de género y con esta intención se propone como caso paradigmático la celebración de la Super Copa de España en Arabia Saudí. Se trata de un acontecimiento controvertido, sobre el que el Comité planteó recomendaciones concretas.López Martínez, G.; Terradellas Piferrer, MR.; Meseguer Sánchez, JV. (2021). (Des)igualdad de género y fútbol. ¿Qué fue del Comité de RSC de la RFEF en el caso de la Supercopa en Arabia Saudí de 2020?. https://doi.org/10.4995/citecma.2021.14417OJSBackman, Jules. 1975. Social responsibility and accountability. New York: New York University Press.Barrio, Estrella; y Enrique, Ana Mª. 2015. "La Responsabilidad Social Corporativa en las empresas y su relación con los grupos de interés. Los casos de Unilever y Nestlé", aDResearch ESIC (11), pp. 26-39. https://doi.org/10.7263/adresic-011-02Buil, Isabel, y otros. 2012. "La estrategia de marketing con causa: Factores determinantes de su éxito", Universia Business Review 36, pp. 90-107.Carroll, Archie B. 1999. Corporate social responsibility evolution of a definitional construct. Business & Society, 38(3), 268-295. https://doi.org/10.1177/000765039903800303Costas, Antón (2018): Conferencia pronunciada en el marco de las II Jornadas de la Càtedra de RSU de la UdG. Consultar en: https://youtu.be/o4kLIIS8M_gDavis, Keith. 1960. "Can business afford to ignore social responsibilities?", California Management Review, 2(3), 70-76. https://doi.org/10.2307/41166246De la Cuesta, Marta, y otros. 2002. La responsabilidad social corporativa: una aplicación a España. Madrid: UNEDEells, Richard; Walton, Clarence. 1961. Conceptual foundations of Business. Homewood, III: Richard D. Irwin.Friedman, Milton. 1962. Capitalism and freedom. Chicago: University of Chicago Press.González, Diana. 2006. "¿Es la responsabilidad social corporativa realmente una responsabilidad o es una estrategia económica?, Nuevas Tendencias,63, pp. 21-39.Lafuente, David, (Ed.) (2019): 9 debates necesarios sobre Responsabilidad Social. 87 reflexiones de expertos. Granada: Comares.López Martínez, Gabriel. (2019). "RSC y fútbol: la memoria de sostenibilidad como documento de transparencia", Revista Española de Transparencia, 8, pp. 45-57. https://doi.org/10.51915/ret.46McGuire, Joseph Williams. 1963. Business and society. New York: McGraw-Hill.Meseguer-Sánchez, Víctor; Abad-Segura, Emilio.; Belmonte-Ureña, Luis Jesús; Molina-Moreno, Valentín. 2020. "Examining the Research Evolution on the Socio-Economic and Environmental Dimensions on University Social Responsibility", Environmental Research and Public Health, 17, 4729, pp. 1-30. https://doi.org/10.3390/ijerph17134729Sarmiento del Valle, Santiago. 2011. "La Responsabilidad Social Empresarial: gestión estratégica para la supervivencia de las empresas", Dimens. Empres. 9, nº 2, pp. 6-15.Vázquez Oteo, Orencio; Cordero Sanz, Carlos. (2007). "Análisis empírico de la información emitida por las empresas del IBEX 35 en materia de responsabilidad social corporativa", Ekonomiaz, 65, pp. 150-183

Electrocardiographic Changes in a Patient With Pulmonary Embolism and Septic Shock

Various electrocardiography (ECG) abnormalities have been reported in patients who present with pulmonary embolism (PE). Severe sepsis is also associated with ECG changes that may mimic ST elevation myocardial infarction. We report a case of an elderly patient with PE and septic shock associated with striking ECG changes

The MACC-II 2007-2008 reanalysis: atmospheric dust validation and characterization over northern Africa and Middle East

Presentación realizada en: MACC-II Open Science Conference celebrada en Bruselas del 27 al 30 de enero de 2014

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization

The origin recognition complex (ORC) of Saccharomyces cerevisiae binds origin DNA and cooperates with Cdc6 and Cdt1 to load the replicative helicase MCM2–7 onto DNA. Helicase loading involves two MCM2–7 hexamers that assemble into a double hexamer around double-stranded DNA. This reaction requires ORC and Cdc6 ATPase activity, but it is unknown how these proteins control MCM2–7 double hexamer formation. We demonstrate that mutations in Cdc6 sensor-2 and Walker A motifs, which are predicted to affect ATP binding, influence the ORC–Cdc6 interaction and MCM2–7 recruitment. In contrast, a Cdc6 sensor-1 mutant affects MCM2–7 loading and Cdt1 release, similar as a Cdc6 Walker B ATPase mutant. Moreover, we show that Orc1 ATP hydrolysis is not involved in helicase loading or in releasing ORC from loaded MCM2–7. To determine whether Cdc6 regulates MCM2–7 double hexamer formation, we analysed complex assembly. We discovered that inhibition of Cdc6 ATPase restricts MCM2–7 association with origin DNA to a single hexamer, while active Cdc6 ATPase promotes recruitment of two MCM2–7 hexamer to origin DNA. Our findings illustrate how conserved Cdc6 AAA+ motifs modulate MCM2–7 recruitment, show that ATPase activity is required for MCM2–7 hexamer dimerization and demonstrate that MCM2–7 hexamers are recruited to origins in a consecutive process

The MACC-II 2007–2008 reanalysis: atmospheric dust evaluation and characterization over northern Africa and the Middle East

In the present work, atmospheric mineral dust from a MACC-II short reanalysis run for 2 years (2007–2008) has been evaluated over northern Africa and the Middle East using satellite aerosol products (from MISR, MODIS and OMI satellite sensors), ground-based AERONET data, in situ PM10 concentrations from AMMA, and extinction vertical profiles from two ground-based lidars and CALIOP satellite-based lidar. The MACC-II aerosol optical depth (AOD) spatial and temporal (seasonal and interannual) variability shows good agreement with those provided by satellite sensors. The capability of the model to reproduce the AOD, Ångström exponent (AE) and dust optical depth (DOD) from daily to seasonal time-scale is quantified over 26 AERONET stations located in eight geographically distinct regions by using statistical parameters. Overall DOD seasonal variation is fairly well simulated by MACC-II in all regions, although the correlation is significantly higher in dust transport regions than in dust source regions. The ability of MACC-II in reproducing dust vertical profiles has been assessed by comparing seasonal averaged extinction vertical profiles simulated by MACC-II under dust conditions with corresponding extinction profiles obtained with lidar instruments at M'Bour and Santa Cruz de Tenerife, and with CALIOP.This work has been supported by EU-project Monitoring Atmospheric Composition and Climate (MACC-II) under the European Union Seventh Framework Programme, grant agreement number 283576. J. M. Baldasano and S. Basart acknowledge the Severo Ochoa (SEV-2011-00067) program of the Spanish Government and the mobility program from the Catalan Government (BE-DGR 2012)

Tenecteplase for ST-elevation myocardial infarction in a patient treated with drotrecogin alfa (activated) for severe sepsis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Drotrecogin alfa (activated) (DrotAA), an activated protein C, promotes fibrinolysis in patients with severe sepsis. There are no reported cases or studies that address the diagnosis and treatment of myocardial infarction in septic patients treated with DrotAA.</p> <p>Case presentation</p> <p>A 59-year-old Caucasian man with septic shock secondary to community-acquired pneumonia treated with DrotAA, subsequently developed an ST-elevation myocardial infarction 12 hours after starting DrotAA. DrotAA was stopped and the patient was given tenecteplase thrombolysis resulting in complete resolution of ST-elevation and no adverse bleeding events. DrotAA was restarted to complete the 96-hour course. The sepsis resolved and the patient was discharged from hospital.</p> <p>Conclusion</p> <p>In patients with severe sepsis or septic shock complicated by myocardial infarction, it is difficult to determine if the myocardial infarction is an isolated event or caused by the sepsis process. The efficacy and safety of tenecteplase thrombolysis in septic patients treated with DrotAA need further study.</p

Numerical Prediction of Dust

Covers the whole breadth of mineral dust research, from a scientific perspective Presents interdisciplinary work including results from field campaigns, satellite observations, laboratory studies, computer modelling and theoretical studies Explores the role of dust as a player and recorder of environmental change This volume presents state-of-the-art research about mineral dust, including results from field campaigns, satellite observations, laboratory studies, computer modelling and theoretical studies. Dust research is a new, dynamic and fast-growing area of science and due to its multiple roles in the Earth system, dust has become a fascinating topic for many scientific disciplines. Aspects of dust research covered in this book reach from timescales of minutes (as with dust devils, cloud processes, and radiation) to millennia (as with loess formation and oceanic sediments), making dust both a player and recorder of environmental change. The book is structured in four main parts that explore characteristics of dust, the global dust cycle, impacts of dust on the Earth system, and dust as a climate indicator. The chapters in these parts provide a comprehensive, detailed overview of this highly interdisciplinary subject. The contributions presented here cover dust from source to sink and describe all the processes dust particles undergo while travelling through the atmosphere. Chapters explore how dust is lifted and transported, how it affects radiation, clouds, regional circulations, precipitation and chemical processes in the atmosphere, and how it deteriorates air quality. The book explores how dust is removed from the atmosphere by gravitational settling, turbulence or precipitation, how iron contained in dust fertilizes terrestrial and marine ecosystems, and about the role that dust plays in human health. We learn how dust is observed, simulated using computer models and forecast. The book also details the role of dust deposits for climate reconstructions. Scientific observations and results are presented, along with numerous illustrations. This work has an interdisciplinary appeal and will engage scholars in geology, geography, chemistry, meteorology and physics, amongst others with an interest in the Earth system and environmental change

Desert dust outbreak in the Canary Islands (February 2020): assessment and impacts

World Weather Research Programme (WWRP 2021–1

Progressive Purkinje Cell Degeneration in tambaleante Mutant Mice Is a Consequence of a Missense Mutation in HERC1 E3 Ubiquitin Ligase

The HERC gene family encodes proteins with two characteristic domains: HECT and RCC1-like. Proteins with HECT domains have been described to function as ubiquitin ligases, and those that contain RCC1-like domains have been reported to function as GTPases regulators. These two activities are essential in a number of important cellular processes such as cell cycle, cell signaling, and membrane trafficking. Mutations affecting these domains have been found associated with retinitis pigmentosa, amyotrophic lateral sclerosis, and cancer. In humans, six HERC genes have been reported which encode two subgroups of HERC proteins: large (HERC1-2) and small (HERC3-6). The giant HERC1 protein was the first to be identified. It has been involved in membrane trafficking and cell proliferation/growth through its interactions with clathrin, M2-pyruvate kinase, and TSC2 proteins. Mutations affecting other members of the HERC family have been found to be associated with sterility and growth retardation. Here, we report the characterization of a recessive mutation named tambaleante, which causes progressive Purkinje cell degeneration leading to severe ataxia with reduced growth and lifespan in homozygous mice aged over two months. We mapped this mutation in mouse chromosome 9 and then performed positional cloning. We found a G⇔A transition at position 1448, causing a Gly to Glu substitution (Gly483Glu) in the highly conserved N-terminal RCC1-like domain of the HERC1 protein. Successful transgenic rescue, with either a mouse BAC containing the normal copy of Herc1 or with the human HERC1 cDNA, validated our findings. Histological and biochemical studies revealed extensive autophagy associated with an increase of the mutant protein level and a decrease of mTOR activity. Our observations concerning this first mutation in the Herc1 gene contribute to the functional annotation of the encoded E3 ubiquitin ligase and underline the crucial and unexpected role of this protein in Purkinje cell physiology

CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs

CD98 heavy chain (CD98hc) is a multifunctional transmembrane spanning scaffolding protein whose extracellular domain binds with light chain amino acid transporters (Lats) to form the heterodimeric amino acid transporters (HATs). It also interacts with β1 and β3 integrins by its transmembrane and cytoplasmic domains. This interaction is proposed to be the mechanism whereby CD98 mediates cell survival and growth via currently undefined signaling pathways. In this study, we determined whether the critical function of CD98-dependent amino acid transport also plays a role in cell proliferation and defined the signaling pathways that mediate CD98-dependent proliferation of murine renal inner medullary collecting duct (IMCD) cells. We demonstrate that downregulating CD98hc expression resulted in IMCD cell death. Utilizing overexpression studies of CD98hc mutants that either lacked a cytoplasmic tail or were unable to bind to Lats we showed that CD98 increases serum-dependent cell proliferation by a mechanism that requires the CD98hc cytoplasmic tail. We further demonstrated that CD98-dependent amino acid transport increased renal tubular epithelial cell proliferation by a mechanism that does not require the CD98hc cytoplasmic tail. Both these mechanisms of increased renal tubular epithelial cell proliferation are mediated by Erk and p38 MAPK signaling. Although increased amino transport markedly activated mTor signaling, this pathway did not alter cell proliferation. Thus, these studies demonstrate that in IMCD cells, the cytoplasmic and extracellular domains of CD98hc regulate cell proliferation by distinct mechanisms that are mediated by common MAPK signaling pathways