Reports of injury risks and reasons for choice of sleep environments for infants and toddlers

OBJECTIVE: Compare mothers\u27 reports of injuries for infants and toddlers sleeping with crib-bumpers/mesh-liners/no-barriers and reasons for these sleep environment choices. METHODS: A cross-sectional survey of mothers subscribing to a parenting magazine and using crib bumpers (n = 224), mesh liners (n = 262), and no barriers (n = 842). Analyses of four possible injuries (face-covered, climb-out/fall, slat-entrapment, hit-head) including multivariate logistic regression adjusted for missing data/demographics and Chi squared analyses of reasons for mothers\u27 choices. RESULTS: Maternal reports of finding infants/toddlers with face covered had 3.5 times higher adjusted odds (aOR) for crib bumper versus mesh liner use. Breathing difficulties and wedgings were reported for infants/toddlers using crib bumpers but not mesh liners. Climb-outs/falls showed no significant difference in aORs for crib bumpers versus no-barriers and mesh liners versus no barriers. Reports of slat-entrapment were less likely for mothers using crib bumpers and mesh liners than using no barrier (aOR = .28 and .32). Reports of hit-heads were less likely for crib bumpers vs no barrier (aOR = .38) with no significant difference between mesh liners versus no barrier use. Mothers using crib bumpers and mesh liners felt their choice prevented slat-entrapment (89%, 91%); 93.5% of crib bumper users felt their choice prevented hit-heads. Significantly more mesh liner than crib bumper users chose them because There is no suffocation risk (64.1% vs. 40.6%), while 83.6% of no-barrier users chose them because I was concerned about suffocation risk. CONCLUSIONS FOR PRACTICE: Mothers appeared to be more concerned about preventing minor risks than suffocation. Understanding reasons for mothers\u27 use of barriers/no-barriers is important in tailoring counseling for mothers with infants/toddlers

Respiratie bij vogels: een functioneel-anatomische benadering

The mechanism of avian respiration is still controversial. It is fundamentally different from respiration in mammals. Although during in-and expiration a continuous caudocranial airflow is present within the tertiary bronchi and the air capillaries of the avian lung, the air flow within the entire respiratory system is still equivocal. Several patterns explaining the air flow during in-and expiration have been proposed during the past century. Moreover, various anatomical structures and aerodynamic mechanisms have recently been described in an attempt to explain the proposed mechanisms of respiration. This manuscript gives an overview of the anatomy of the avian respiratory system and the hypotheses concerning the physiology of avian respiration

Short-wavelength out-of-band EUV emission from Sn laser-produced plasma

We present the results of spectroscopic measurements in the extreme ultraviolet (EUV) regime (7-17 nm) of molten tin microdroplets illuminated by a high-intensity 3-J, 60-ns Nd:YAG laser pulse. The strong 13.5 nm emission from this laser-produced plasma is of relevance for next-generation nanolithography machines. Here, we focus on the shorter wavelength features between 7 and 12 nm which have so far remained poorly investigated despite their diagnostic relevance. Using flexible atomic code calculations and local thermodynamic equilibrium arguments, we show that the line features in this region of the spectrum can be explained by transitions from high-lying configurations within the Sn$^{8+}$-Sn$^{15+}$ ions. The dominant transitions for all ions but Sn$^{8+}$ are found to be electric-dipole transitions towards the $n$=4 ground state from the core-excited configuration in which a 4$p$ electron is promoted to the 5$s$ sub-shell. Our results resolve some long-standing spectroscopic issues and provide reliable charge state identification for Sn laser-produced plasma, which could be employed as a useful tool for diagnostic purposes.Comment: 11 pages, 4 figure

A new perspective on GCRT J1745-3009

Two WSRT observations were performed and five archival VLA data were reduced in order to redetect the enigmatic radio transient GCRT J1745-3009. The source was not redetected. We were, however, able to extract important new information from the discovery dataset. Our reanalysis excludes models that predict symmetric bursts, but the transient white dwarf pulsar is favoured. Although we now have more contraints on the properties of this source, we are still unsure about its basic model.Comment: 11 pages, 5 figure

Detailed study of the GRB 030329 radio afterglow deep into the non-relativistic phase

We explore the physics behind one of the brightest radio afterglows ever, GRB 030329, at late times when the jet is non-relativistic. We determine the physical parameters of the blast wave and its surroundings, in particular the index of the electron energy distribution, the energy of the blast wave, and the density (structure) of the circumburst medium. We then compare our results with those from image size measurements. We observed the GRB 030329 radio afterglow with the Westerbork Synthesis Radio Telescope and the Giant Metrewave Radio Telescope at frequencies from 325 MHz to 8.4 GHz, spanning a time range of 268-1128 days after the burst. We modeled all the available radio data and derived the physical parameters. The index of the electron energy distribution is p=2.1, the circumburst medium is homogeneous, and the transition to the non-relativistic phase happens at t_NR ~ 80 days. The energy of the blast wave and density of the surrounding medium are comparable to previous findings. Our findings indicate that the blast wave is roughly spherical at t_NR, and they agree with the implications from the VLBI studies of image size evolution. It is not clear from the presented dataset whether we have seen emission from the counter jet or not. We predict that the Low Frequency Array will be able to observe the afterglow of GRB 030329 and many other radio afterglows, constraining the physics of the blast wave during its non-relativistic phase even further.Comment: 9 pages, 2 figures; accepted for publication in Astronomy & Astrophysics after minor revisions; small changes in GMRT fluxes at 1280 MH

An automated archival VLA transients survey

In this paper we present the results of a survey for radio transients using data obtained from the Very Large Array archive. We have reduced, using a pipeline procedure, 5037 observations of the most common pointings - i.e. the calibrator fields. These fields typically contain a relatively bright point source and are used to calibrate `target' observations: they are therefore rarely imaged themselves. The observations used span a time range ~ 1984 - 2008 and consist of eight different pointings, three different frequencies (8.4, 4.8 and 1.4 GHz) and have a total observing time of 435 hours. We have searched for transient and variable radio sources within these observations using components from the prototype LOFAR transient detection system. In this paper we present the methodology for reducing large volumes of Very Large Array data; and we also present a brief overview of the prototype LOFAR transient detection algorithms. No radio transients were detected in this survey, therefore we place an upper limit on the snapshot rate of GHz frequency transients > 8.0 mJy to rho less than or equal to 0.032 deg^-2 that have typical timescales 4.3 to 45.3 days. We compare and contrast our upper limit with the snapshot rates - derived from either detections or non-detections of transient and variable radio sources - reported in the literature. When compared with the current Log N - Log S distribution formed from previous surveys, we show that our upper limit is consistent with the observed population. Current and future radio transient surveys will hopefully further constrain these statistics, and potentially discover dominant transient source populations. In this paper we also briefly explore the current transient commissioning observations with LOFAR, and the impact they will make on the field.Comment: Accepted for publication in MNRA

Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells.

Ferric chelates may be used as oral iron supplements or phosphate binders but both ferric citrate and ferric EDTA have been shown to promote tumor burden in murine models of colon cancer. Here we studied their effects on cancer cell growth, at typical supplemental iron levels encountered in the gastrointestinal tract (0.01-0.2 mM). Caco-2 and/or Hutu-80 cells were exposed to these forms of chelated iron or to ferrous sulfate and outcomes were assessed using cell proliferation assays, proteome profiler arrays, western blot, and ELISA. Ferric EDTA and ferric citrate increased cellular levels of the onco-protein amphiregulin and its receptor (EGFr) which in turn stimulated the activation of the MAP kinase ERK. Simultaneously, the expression of the negative Wnt regulator, DKK-1, increased suggesting that cell proliferation through the Wnt pathway may be less pronounced in the presence of ferric EDTA and ferric citrate, unlike for ferrous sulfate. Moreover, ferrous sulfate did not increase levels of cellular amphiregulin or EGFr. We conclude that specific iron compounds affect cell signaling differently and some may increase the risk of colon cancer advancement in an amphiregulin-dependent fashion. Further scrutiny of safe oral iron use is merited

Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines

We previously showed that two iron compounds that are orally ingested by humans, namely ferric EDTA and ferric citrate, can induce an oncogenic growth factor (amphiregulin) in human intestinal epithelial adenocarcinoma cell lines. Here, we further screened these iron compounds, plus four other iron chelates and six iron salts (i.e., 12 oral iron compounds in total), for their effects on biomarkers of cancer and inflammation. Ferric pyrophosphate and ferric EDTA were the main inducers of amphiregulin and its receptor monomer, IGFr1. Moreover, at the maximum iron concentrations investigated (500 \ub5M), the highest levels of amphiregulin were induced by the six iron chelates, while four of these also increased IGfr1. In addition, we observed that ferric pyrophosphate promoted signaling via the JAK/STAT pathway by up-regulating the cytokine receptor subunit IFN-γr1 and IL-6. For pro-inflammatory cyclooxygenase-2 (COX-2), ferric pyrophosphate but not ferric EDTA elevated intracellular levels. This, however, did not drive the other biomarkers based on COX-2 inhibition studies and was probably downstream of IL-6. We conclude that of all oral iron compounds, iron chelates may particularly elevate intracellular amphiregulin. Ferric pyrophosphate additionally induced COX-2, probably because of the high IL-6 induction that was observed with this compound