425 research outputs found
Evaluación de la hemostasis
We try to explain the coagulation mechanism evaluation through our own clinical experience
Star formation triggered by the Galactic HII region RCW 120: First results from the Herschel Space Observatory
By means of different physical mechanisms, the expansion of HII regions can
promote the formation of new stars of all masses. RCW 120 is a nearby Galactic
HII region where triggered star formation occurs. This region is well-studied -
there being a wealth of existing data - and is nearby. However, it is
surrounded by dense regions for which far infrared data is essential to obtain
an unbiased view of the star formation process and in particular to establish
whether very young protostars are present. We attempt to identify all Young
Stellar Objects (YSOs), especially those previously undetected at shorter
wavelengths, to derive their physical properties and obtain insight into the
star formation history in this region. We use Herschel-PACS and -SPIRE images
to determine the distribution of YSOs observed in the field. We use a spectral
energy distribution fitting tool to derive the YSOs physical properties.
Herschel-PACS and -SPIRE images confirm the existence of a young source and
allow us to determine its nature as a high-mass (8-10 MSun) Class 0 object
(whose emission is dominated by a massive envelope) towards the massive
condensation 1 observed at (sub)-millimeter wavelengths. This source was not
detected at 24 micron and only barely seen in the MISPGAL 70 micron data.
Several other red sources are detected at Herschel wavelengths and coincide
with the peaks of the millimeter condensations. SED fitting results for the
brightest Herschel sources indicate that, apart from the massive Class 0 that
forms in condensation 1, young low mass stars are forming around RCW 120. The
YSOs observed on the borders of RCW 120 are younger than its ionizing star,
which has an age of about 2.5 Myr.Comment: 5 pqges, 3 figures, accepted by A&A (Special issue on the Herschel
first results
GastropatÃa hipertrófica de pÃloro : resolución quirúrgica de tres casos clÃnicos mediante la técnica de pÃloroplastia Y-U
Descripción de la técnica de piloroplastia en colgajo antral y-U en la resolución de 3 casos clÃnicos de gastropatÃa por hipertrofia crónica del pÃloro.Description of the y-U antral flap advancement pyloroplasty to the resolution of 3 clinic cases of chronic hypertrophic pyloric gastropathy
Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor
CLR457; Inhibidor Pan-PI3K; Fase ICLR457; Inhibidor Pan-PI3K; Fase ICLR457; Pan-PI3K inhibitor; Phase IBackground CLR457 is an orally bioavailable pan-phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor. Methods CLR457 anti-tumor activity and pharmacokinetics (PK) were characterized by in vitro biochemical assays and in vivo tumor xenografts. A first-in-human study was conducted to determine the maximum tolerated dose (MTD), safety, PK, and efficacy of CLR457. Successive cohorts of patients with advanced solid tumors with PI3K pathway activation received increasing CLR457 doses according to a Bayesian escalation model based on the rate of dose limiting toxicity (DLT) in the first 28-day cycle. Results CLR457 inhibited p110α, p110β, p110δ and p110γ isoforms with an IC50 of 89 ± 29 nM, 56 ± 35 nM, 39 ± 10 nM and 230 ± 31 nM, respectively. CLR457 exhibited dose-dependent antitumor activity and interfered with glucose homeostasis in PI3K-mutant tumor xenografts. 31 patients received doses ranging from 5 to 100 mg. DLTs included grade 3 hyperglycemia and rash (3). In the 100 mg cohort (n = 11), 3 (27.3%) patients had DLTs and all patients (100%) experienced ≥ grade 3 toxicity with rash (45.5%) as the most common event. The MTD was not determined. For the entire study population, stomatitis (45.2%), diarrhea (38.7%), rash (35.5%) were the most common any grade toxicities—51.6% patients experienced ≥ Grade 3 toxicity. CLR457 was rapidly absorbed with limited accumulation and linear PK. PK modeling indicated that pharmacologically active concentrations were achieved at the highest dose tested (100 mg), though no objective responses were observed. Conclusion CLR457 clinical development was terminated due to poor tolerability and limited antitumor activity. These results emphasize the difficulty of achieving a wide therapeutic index when targeting all class I PI3K-isoforms.Novartis Pharmaceuticals Corporation
Pharmacokinetic (Pk) Activity of Cabazitaxel (Cbz) in Patients (Pts) with Renal Impairment (Ri)
n/
Herschel Observations of the W43 "mini-starburst"
Aims: To explore the infrared and radio properties of one of the closest
Galactic starburst regions. Methods: Images obtained with the Herschel Space
Observatory at wavelengths of 70, 160, 250, 350, and 500 microns using the PACS
and SPIRE arrays are analyzed and compared with radio continuum VLA data and 8
micron images from the Spitzer Space Telescope. The morphology of the
far-infrared emission is combined with radial velocity measurements of
millimeter and centimeter wavelength transitions to identify features likely to
be associated with the W43 complex. Results: The W43 star-forming complex is
resolved into a dense cluster of protostars, infrared dark clouds, and ridges
of warm dust heated by massive stars. The 4 brightest compact sources with L >
1.5 x 10^4 Lsun embedded within the Z-shaped ridge of bright dust emission in
W43 remain single at 4" (0.1 pc) resolution. These objects, likely to be
massive protostars or compact clusters in early stages of evolution are
embedded in clumps with masses of 10^3 to 10^4 Msun, but contribute only 2% to
the 3.6 x 10^6 Lsun far-IR luminosity of W43 measured in a 16 by 16 pc box. The
total mass of gas derived from the far-IR dust emission inside this region is
~10^6 Msun. Cometary dust clouds, compact 6 cm radio sources, and warm dust
mark the locations of older populations of massive stars. Energy release has
created a cavity blowing-out below the Galactic plane. Compression of molecular
gas in the plane by the older HII region near G30.684-0.260 and the bipolar
structure of the resulting younger W43 HII region may have triggered the
current mini-star burst.Comment: 5 pages, 3 figures, accepted for A&A Special Issu
Probing the Early Evolution of Young High-Mass Stars
Near-infrared imaging surveys of high-mass star-forming regions reveal an
amazingly complex interplay between star formation and the environment
(Churchwell et al. 2006; Alvarez et al. 2004). By means of near-IR spectroscopy
the embedded massive young stars can be characterized and placed in the context
of their birth site. However, so far spectroscopic surveys have been hopelessly
incomplete, hampering any systematic study of these very young massive stars.
New integral field instrumentation available at ESO has opened the possibility
to take a huge step forward by obtaining a full spectral inventory of the
youngest massive stellar populations in star-forming regions currently
accessible. Simultaneously, the analysis of the extended emission allows the
characterization of the environmental conditions. The Formation and Early
Evolution of Massive Stars (FEMS) collaboration aims at setting up a large
observing campaign to obtain a full census of the stellar content, ionized
material, outflows and PDR's over a sample of regions that covers a large
parameter space. Complementary radio, mm and infrared observations will be used
for the characterization of the deeply embedded population. For the first eight
regions we have obtained 40 hours of SINFONI observations. In this
contribution, we present the first results on three regions that illustrate the
potential of this strategy.Comment: To appear in ASP Conf. Proceedings of "Massive Star Formation:
Observations confront Theory", H. Beuther et al. (eds.), held in Heidelberg,
September 200
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic intervention. Here, we show that Hedgehog pathway mutations predict chemotherapy resistance in human T-ALL, and drive oncogenic transformation in a zebrafish model of the disease. We found Hedgehog pathway mutations in 16% of 109 childhood T-ALL cases, most commonly affecting its negative regulator PTCH1. Hedgehog mutations were associated with resistance to induction chemotherapy (P = 0.009). Transduction of wild-type PTCH1 into PTCH1-mutant T-ALL cells induced apoptosis (P = 0.005), a phenotype that was reversed by downstream Hedgehog pathway activation (P = 0.007). Transduction of most mutant PTCH1, SUFU, and GLI alleles into mammalian cells induced aberrant regulation of Hedgehog signaling, indicating that these mutations are pathogenic. Using a CRISPR/Cas9 system for lineage-restricted gene disruption in transgenic zebrafish, we found that ptch1 mutations accelerated the onset of notch1-induced T-ALL (P = 0.0001), and pharmacologic Hedgehog pathway inhibition had therapeutic activity. Thus, Hedgehog-activating mutations are driver oncogenic alterations in high-risk T-ALL, providing a molecular rationale for targeted therapy in this disease
ALMA Observations of Asteroid 3 Juno at 60 Kilometer Resolution
We present Atacama Large Millimeter/submillimeter Array (ALMA) 1.3 mm
continuum images of the asteroid 3 Juno obtained with an angular resolution of
0.042 arcseconds (60 km at 1.97 AU). The data were obtained over a single 4.4
hr interval, which covers 60% of the 7.2 hr rotation period, approximately
centered on local transit. A sequence of ten consecutive images reveals
continuous changes in the asteroid's profile and apparent shape, in good
agreement with the sky projection of the three-dimensional model of the
Database of Asteroid Models from Inversion Techniques. We measure a geometric
mean diameter of 259pm4 km, in good agreement with past estimates from a
variety of techniques and wavelengths. Due to the viewing angle and inclination
of the rotational pole, the southern hemisphere dominates all of the images.
The median peak brightness temperature is 215pm13 K, while the median over the
whole surface is 197pm15 K. With the unprecedented resolution of ALMA, we find
that the brightness temperature varies across the surface with higher values
correlated to the subsolar point and afternoon areas, and lower values beyond
the evening terminator. The dominance of the subsolar point is accentuated in
the final four images, suggesting a reduction in the thermal inertia of the
regolith at the corresponding longitudes, which are possibly correlated to the
location of the putative large impact crater. These results demonstrate ALMA's
potential to resolve thermal emission from the surface of main belt asteroids,
and to measure accurately their position, geometric shape, rotational period,
and soil characteristics.Comment: 8 pages, 3 figures, 2 tables, accepted for publication in the
Astrophysical Journal Letter
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