Gonadal function in males after chemotherapy for early-stage Hodgkin's lymphoma treated in four subsequent trials by the European Organisation for Research and Treatment of Cancer: EORTC Lymphoma Group and the Groupe d'Etude des Lymphomes de l'Adulte.

Contains fulltext : 51705.pdf (publisher's version ) (Open Access)PURPOSE: To analyze fertility in male patients treated with various combinations of radiotherapy and chemotherapy, with or without alkylating agents, or with radiotherapy alone for Hodgkin's lymphoma. PATIENTS AND METHODS: Follicle-stimulating hormone (FSH) levels were measured in patients with early-stage upper-diaphragmatic disease enrolled in four European Organisation for Research and Treatment of Cancer (EORTC) trials (H6-H9). Median follow-up after therapy was 32 months. Patients with FSH measurement at least 12 months after end of treatment (n = 355) were selected to assess post-treatment fertility. Patients with FSH measurement 0 to 9 months after therapy (n = 349) were selected to analyze fertility recovery; of these, patients with elevated FSH (> 10 U/L; n = 101) were followed until recovery. Factors predictive for therapy-related infertility were assessed by logistic regression. RESULTS: The proportion of elevated FSH was 3% and 8% in patients treated with radiotherapy only or with nonalkylating chemotherapy (doxorubicin, bleomycin, vinblastine, dacarbazine [ABVD], epirubicin, bleomycin, vinblastine, prednisone [EBVP]); it was 60% (P < .001) after chemotherapy containing alkylating agents (mechlorethamine, vincristine, procarbazine, prednisone [MOPP], MOPP/doxorubicin, bleomycin, vinblastine [ABV], bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone [BEACOPP]). After a median time of 19 months, recovery of fertility occurred in 82% of patients treated without alkylating chemotherapy. This proportion was 30%, statistically (P < .001) lower in those treated with alkylating chemotherapy, and median time to recovery was 27 months. The post-treatment proportion of elevated FSH increased significantly (P < .001) with the dose of alkylating chemotherapy administered, and recovery was less frequent and slower after higher doses. Age more than 50 years and stage II disease also contributed to poor outcome. CONCLUSION: Fertility can be secured after nonalkylating chemotherapy for Hodgkin's lymphoma. In contrast, alkylating chemotherapy has a dismal effect, even after a limited number of cycles

The impact of treatment, socio-demographic and clinical characteristics on health-related quality of life among Hodgkin’s and non-Hodgkin’s lymphoma survivors: a systematic review

Cancer survivors are at risk of experiencing adverse physical and psychosocial effects of their cancer and its treatment. Both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) survivors face problems that can affect their health-related quality of life (HRQoL). The authors systematically reviewed the literature on HRQoL among HL and NHL survivors. A PubMed and PsychINFO literature search for original articles published until May 2011 was performed. Twenty-four articles, which met the predefined inclusion criteria, were subjected to a quality checklist. HL survivors showed the most problems in (role) physical, social and cognitive functioning, general health, fatigue and financial problems. In addition, HL survivors treated with a combination of therapies, with older age and female sex reported worse HRQoL. NHL survivors showed the most problems in physical functioning, appetite loss, vitality and financial problems. Having had chemotherapy was negatively associated with HRQoL, but no differences in chemotherapy regimens were found. Furthermore, in NHL survivors not meeting public exercise guidelines, HRQoL is low but can be improved with more exercise. More research on the longitudinal comparison between HL and NHL survivors and healthy controls should be performed in order to better understand the long-term (side) effects of treatment on HRQoL and possibilities to alleviate these

Parenthood in survivors of Hodgkin lymphoma: an EORTC-GELA general population case-control study.

Contains fulltext : 108966.pdf (publisher's version ) (Open Access)PURPOSE: We investigated the impact of Hodgkin lymphoma (HL) on parenthood, including factors influencing parenthood probability, by comparing long-term HL survivors with matched general population controls. PATIENTS AND METHODS: A Life Situation Questionnaire was sent to 3,604 survivors treated from 1964 to 2004 in successive clinical trials. Responders were matched with controls (1:3 or 4) for sex, country, education, and year of birth (10-year groups). Controls were given an artificial date of start of treatment equal to that of their matched case. The main end point was presence of biologic children after treatment, which was evaluated by using conditional logistic regression analysis. Logistic regression analysis was used to analyze factors influencing spontaneous post-treatment parenthood. RESULTS: In all, 1,654 French and Dutch survivors were matched with 6,414 controls. Median follow-up was 14 years (range, 5 to 44 years). After treatment, the odds ratio (OR) for having children was 0.77 (95% CI, 0.68 to 0.87; P < .001) for survivors compared with controls. Of 898 survivors who were childless before treatment, 46.7% achieved post-treatment parenthood compared with 49.3% of 3,196 childless controls (OR, 0.87; P = .08). Among 756 survivors with children before treatment, 12.4% became parents after HL treatment compared with 22.2% of 3,218 controls with children before treatment (OR, 0.49; P < .001). Treatment with alkylating agents, second-line therapy, and age older than 35 years at treatment appeared to reduce the chances of spontaneous post-treatment parenthood. CONCLUSION: Survivors of HL had slightly but significantly fewer children after treatment than matched general population controls. The difference concerned only survivors who had children before treatment and appears to have more personal than biologic reasons. The chance of successful post-treatment parenthood was 76%

A full year of aerosol size distribution data from the central Arctic under an extreme positive Arctic Oscillation : insights from the Multidisciplinarydrifting Observatory for the Study of Arctic Climate (MOSAiC) expedition

The Arctic environment is rapidly changing due to accelerated warming in the region. The warming trend is driving a decline in sea ice extent, which thereby enhances feedback loops in the surface energy budget in the Arctic. Arctic aerosols play an important role in the radiative balance and hence the climate response in the region, yet direct observations of aerosols over the Arctic Ocean are limited. In this study, we investigate the annual cycle in the aerosol particle number size distribution (PNSD), particle number concentration (PNC), and black carbon (BC) mass concentration in the central Arctic during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition. This is the first continuous, year-long data set of aerosol PNSD ever collected over the sea ice in the central Arctic Ocean. We use a k-means cluster analysis, FLEXPART simulations, and inverse modeling to evaluate seasonal patterns and the influence of different source regions on the Arctic aerosol population. Furthermore, we compare the aerosol observations to land-based sites across the Arctic, using both long-term measurements and observations during the year of the MOSAiC expedition (2019-2020), to investigate interannual variability and to give context to the aerosol characteristics from within the central Arctic. Our analysis identifies that, overall, the central Arctic exhibits typical seasonal patterns of aerosols, including anthropogenic influence from Arctic haze in winter and secondary aerosol processes in summer. The seasonal pattern corresponds to the global radiation, surface air temperature, and timing of sea ice melting/freezing, which drive changes in transport patterns and secondary aerosol processes. In winter, the Norilsk region in Russia/Siberia was the dominant source of Arctic haze signals in the PNSD and BC observations, which contributed to higher accumulation-mode PNC and BC mass concentrations in the central Arctic than at land-based observatories. We also show that the wintertime Arctic Oscillation (AO) phenomenon, which was reported to achieve a record-breaking positive phase during January-March 2020, explains the unusual timing and magnitude of Arctic haze across the Arctic region compared to longer-term observations. In summer, the aerosol PNCs of the nucleation and Aitken modes are enhanced; however, concentrations were notably lower in the central Arctic over the ice pack than at land-based sites further south. The analysis presented herein provides a current snapshot of Arctic aerosol processes in an environment that is characterized by rapid changes, which will be crucial for improving climate model predictions, understanding linkages between different environmental processes, and investigating the impacts of climate change in future Arctic aerosol studies.Peer reviewe

On the conceptualization and measurement of flow

This chapter introduces in chronological order the three main measurement methods – the Flow Questionnaire, the Experience Sampling Method, and the standardized scales of the componential approach – that researchers developed and used in conducting research on the flow state. Each measurement method and underlying conceptualization is explained, and its strengths and limitations are then discussed in relation to the other measurement methods and associated conceptualizations. The analysis reveals that, although the concept of flow remained stable since its inception, the models of flow that researchers developed in conjunction with the measurement methods changed substantially over time. Moreover, the findings obtained by applying the various measurement methods led to corroborations and disconfirmations of the underlying models, and hence provided indications on how to interpret and possibly modify flow theory. The chapter then analyzes the emerging process approach, which conceptualizes and measures flow as a dynamic path rather than an object, and highlights its potential for integrating flow and creativity within the same conceptual framework. The final section outlines new directions for developing more valid and useful measurement methods that can help to advance the understanding of flow, its antecedents, and its consequences

Dispositifs de formation et d'accompagnement à l'usage pédagogique du numérique pour les enseignants du supérieur : point de situation et perspectives françaises

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Proposition d’une méthode et d’outils pour étudier le côté obscur du flow en contexte éducatif

International audienceCette communication s’inscrit principalement dans l’axe dédié à la recherche en psychologie positive (Seligman et Csikszentmihalyi, 2000) dans le champ de l'éducation et de la formation plus spécifiquement dans l’étude des environnements numériques qui soutiennent le flow des apprenants (Heutte, Fenouillet et al., 2014 ; Heutte et al., sous presse). Selon Csikszentmihalyi (1990), le flow correspond à l’émotion liée à l’état psychologique caractérisé par un sentiment de fluidité mentale et d'intense concentration sur des tâches qui mobilisent toutes nos compétences. Il s’agit d’une expérience autotélique dans la mesure où c’est le bien-être procuré par l’activité en tant que telle qui alimente la persistance dans cette activité. Si la très grande majorité des recherches ont mis en évidence de nombreux bénéfices positifs du flow (pour revue : Csikszentmihalyi, 2014), depuis peu, quelques chercheurs tentent d’identifier le « Dark Side of Flow » (Partington et al., 2009 ; Schüler, 2012) : un côté plus "obscur" du flow qui pourraient notamment expliquer certains comportements à risque (sports extrêmes) ou excessifs (jeux vidéos).Dans le même ordre d’idée, nous (Vallerand, 2015 ; Vallerand et al. ,2003) distinguons deux formes de passion : la passion harmonieuse (PH) et la passion obsessive (PO). La PH se caractérise par la liberté avec laquelle l'individu s'engage dans l'activité et surtout l’insère harmonieusement avec les autres aspects de sa vie. La PO est caractérisée par un puissant désir de faire l’activité́ qui en vient à contrôler l'individu et qui occupe une place disproportionnée et envahissante par rapport aux autres aspects de sa vie.Enfin, nous complétons notre cadre théorique par la prise en compte des travaux concernant la distinction entre les émotions positives et négatives (Diener et al., 2009).Objectif de la rechercheNos travaux souhaitent mettre en évidence le « Dark Side of Flow » en formation, à savoir les déterminants psychologiques de comportements excessifs liés à la persistance à vouloir toujours plus comprendre. Une première étude en contexte de formation à distance mettait en évidence que des étudiants africains perçoivent un niveau de flow et d’émotions négatives plus importants que des étudiants européens (Heutte, Kaplan et al., 2014).Nous souhaitons désormais présenter l’analyse de 345 réponses à un questionnaire, d’étudiants inscrits en 2015 dans un autre dispositif. Cette fois-ci, nous avons notamment utilisé :• l’échelle de mesure du Flow en éducation (EduFlow-2, Heutte et al. 2016) ; • l’échelle de passion générale (Vallerand et al., 2003)• l’échelle de perception des émotions positives et négatives (Martin-Krumm et al., 2015)Nos analyses ont pour finalités : 1. d’identifier plus particulièrement les individus ayant un niveau de flow, de passion obsessive et d’émotions négatives élevés ;2. de vérifier la pertinence d’une modélisation permettant d’éclairer les contributions entre les différentes dimensions du flow (notamment l’immersion dans la tâche et l’altération du temps), les différentes formes de passion (PH vs PO), ainsi que les différents types d’émotions. Cette communication sera l’occasion de présenter et de partager nos premiers résultats et de contribuer ainsi à une meilleure compréhension du côté obscur du flow.RéférencesCsikszentmihalyi, M. (1990). Flow: The Psychology of Optimal Experience. New York, Harper and Row.Csikszentmihalyi, M. (2014). Applications of Flow in Human Development and Education : The Collected Works of Mihaly Csikszentmihalyi. Springer Netherlands.Diener, E., Wirtz, D., Tov, W., Kim-Prieto, C., Choi. D., Oishi, S., & Biswas-Diener, R. (2009). New measures of well-being: Flourishing and positive and negative feelings. Social Indicators Research, 39, 247-266.Heutte, J., Fenouillet, F., Boniwell, I., Martin-Krumm, C., & Csikszentmihalyi, M. (2014). Optimal learning experience in digital environments: theoretical concepts, measure and modelisation, Symposium "Digital Learning in 21st Century Universities", Georgia Institute of Technology (Georgia Tech), Atlanta, GA.Heutte, J., Fenouillet, F., Kaplan, J., Martin-Krumm, C., & Bachelet, R., (sous presse). The EduFlow model - A Contribution Toward the Study of Optimal Learning Environments. In, L. Harmat, F. Ørsted Andersen, F. Ullén, & J. Wright (Dir.) Flow Experience: Empirical Research and Applications. Springer, Dordrecht, The Netherlands.Heutte, J., Fenouillet, F., Martin-Krumm, C., Boniwell, I., & Csikszentmihalyi, M. (2016). Proposal for a conceptual evolution of the flow in education (EduFlow) model. In M. Bassi et J. Heutte, Invited symposium “Flow research: conceptual advancements and applications”, 8th European Conference on Positive Psychology (ECPP 2016), Angers, France.Heutte, J., Kaplan, J., Fenouillet, F., Caron, P.-A., & Rosselle, M. (2014). MOOC User Persistence - Lessons from French Educational Policy Adoption and Deployment of a Pilot Course. In L. Uden, J. Sinclair, Y.-H. Tao, & D. Liberona (Dir.), Learning Technology for Education in Cloud. MOOC and Big Data (LTEC'14), Communications in Computer and Information Science Vol. 446, pp. 13–24. Springer International Publishing.Martin-Krumm, C., Fenouillet, F., Kern, L., Csillik, A., Besançon, M., Heutte, J., Paquet, Y., Lecorre, B., & Diener, E. (2015). French validation of the Scale of Positive and Negative Experience (SPANE), Fourth World Congress on Positive Psychology (IPPA), Orlando, FL.Partington, S., Partington, E., & Olivier, S. (2009). The dark side of flow: a qualitative study of dependence in big wave surfing. The Sport Psychologist, 23, 170 - 186.Riva, G., Baños, R.-M., Botella C., Wiederhold B.-K., & Gaggioli A. (2012) Positive technology: using interactive technologies to promote positive functioning. Cyberpsychology, behavior and social networking, 15(2), 69-77. Schüler, J. (2012). The dark side of the moon. In S. Engeser, Advances in Flow Research. New York, 123-137.Vallerand, R. J., (2015). The Psychology of Passion: A Dualistic Model, Oxford University Press.Vallerand, R.J., Blanchard, C.M., Mageau, G.A., Koestner, R., Ratelle, C., Léonard, M., Gagné, M., & Marsolais, J. (2003). Les passions de l'âme: On obsessive and harmonious passion. Journal of Personality and Social Psychology, 85, 756-767

Mediating effects of Flow on harmonious passion: contribution to the exploration of bright side and dark side of Flow in educational context

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Étude des liens entre les caractéristiques instrumentales et les différents types de motivations des participants dans un MOOC

Dans les MOOC, le paradoxe entre l’engouement massif et la chute tout aussi massive de la participation renouvelle la problématique de la persistance du fait de l’importance de l’abandon. En vue d’éclairer les déterminants de cette persistance, cette contribution rend compte d’outils mobilisés dans le cadre d’une étude exploratoire réalisée auprès des participants (N = 10 700) inscrits dans un MOOC francophone. Cette étude est l’occasion d’utiliser deux nouveaux outils de mesure : l’échelle de perception instrumentale des communautés (PIC) et l’échelle de motivation en formation d’adultes (EMFA). Conformément aux attentes, les résultats de cette étude mettent en évidence les liens entre les perceptions instrumentales et les différents types de motivations : les liens les plus élevés s’observent au niveau de la régulation intégrée de la motivation extrinsèque. Il ressort aussi de cette étude que les deux nouveaux outils (PIC et EMFA) complètent utilement l’outillage conceptuel et méthodologique du monitorage en temps réel des MOOC

A novel qPCR based-method for detection and quantification of three recurrent species of Penicillium isolated from bioaerosols in mold-damaged homes

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