21 research outputs found
Exponential Distribution of Locomotion Activity in Cell Cultures
In vitro velocities of several cell types have been measured using computer
controlled video microscopy, which allowed to record the cells' trajectories
over several days. On the basis of our large data sets we show that the
locomotion activity displays a universal exponential distribution. Thus, motion
resulting from complex cellular processes can be well described by an
unexpected, but very simple distribution function. A simple phenomenological
model based on the interaction of various cellular processes and finite ATP
production rate is proposed to explain these experimental results.Comment: 4 pages, 3 figure
Socio-spatial variations in urban food price and availability and their implications for healthy eating
Available from British Library Document Supply Centre- DSC:DXN057211 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
A phenotypic culture system for the molecular analysis of CNS myelination in the spinal cord
Studies of central nervous system myelination lack defined in vitro models which would effectively dissect molecular mechanisms of myelination that contain cells of the correct phenotype. Here we describe a co-culture of purified motoneurons and oligodendrocyte progenitor cells, isolated from rat embryonic spinal cord using a combination of immunopanning techniques. This model illustrates differentiation of oligodendrocyte progenitors into fully functional mature oligodendrocytes that myelinate axons. It also illustrates a contribution of axons to the rate of oligodendrocyte maturation and myelin gene expression. The defined conditions used allow molecular analysis of distinct stages of myelination and precise manipulation of inductive cues affecting axonal–oligodendrocyte interactions. This phenotypic in vitro myelination model can provide valuable insight into our understanding of demyelinating disorders, such as multiple sclerosis and traumatic diseases such as spinal cord injury where demyelination represents a contributing factor to the pathology of the disorder
Infant feeding effects on early neurocognitive development in asian children
10.3945/ajcn.114.095414American Journal of Clinical Nutrition1012326-336GUSTO (Growing up towards Healthy Outcomes