L’E-portafoli de l’estudiant en la fase inicial

En aquest treball es presenta l'ús del dossier o portafoli de l'estudiant en la docència de dues assignatures de fase inicial dels graus de l’àmbit de l’Enginyeria Industrial que s'imparteixen a l'Escola Universitària d'Enginyeria Tècnica Industrial de Barcelona (EUETIB). L'ús del dossier de l'estudiant com a eina d'aprenentatge actiu ha estat utilitzada amb èxit en nombrosos contextos. Les pràctiques no són una part aïllada de la matèria, sinó que són l'activitat clau que canalitza els esforços dels alumnes i del professorat per aconseguir els objectius docents. El dossier electrònic (e-portafoli) de laboratori permet que l'alumne aprengui, anant més enllà d’elaborar una mera recopilació d'exercicis realitzats. Les activitats a l'aula donen suport a la compartició del coneixement i afavoreixen la retroacció contínua. Per comprovar els resultats de l'aplicació d'aquesta tècnica s’ha realitzat un estudi a partir de la recopilació de dades referents a la docència amb l’e-portafoli. L'estudi s'emmarca en els objectius del GtPOE del projecte RIMA de la UPC. En conclusió, la inclusió de l’e-portafoli en la docència contribueix a la millora de la motivació i és un factor rellevant en la millora de la qualitat docent.Peer Reviewe

Heterometallic complexes with cube-type [MTi3N4] cores containing Group 10 metals in a variety of oxidation states

Treatment of [{Ti(η5-C5Me5)(μ-NH)}3(μ3-N)] (1) with one equivalent of [Ni(cod)2] (cod = 1,5-cyclooctadiene) in toluene at 60-80°C and subsequent addition of diphenylacetylene, trans-stilbene or triphenylphosphane afforded the nickel(0) complexes [LNi{(μ3-NH)3Ti3(η5-C5Me5)3(μ3-N)}] (L = PhCCPh (2), PhCHCHPh (3), PPh3 (4)). The nickel(ii) complex [I2Ni{(μ3-NH)3Ti3(η5-C5Me5)3(μ3-N)}] (5) was prepared by analogous addition of iodine to the solution obtained from the heating of 1 and [Ni(cod)2]. Treatment of 1 with one equivalent of [Pd(dba)2] (dba = dibenzylideneacetone) in toluene at room temperature led to the palladium(0) complex [(dba)Pd{(μ3-NH)3Ti3(η5-C5Me5)3(μ3-N)}] (6). Compound 6 reacted immediately with chloroform-d1 to give the palladium dichloride derivative [Cl2Pd{(μ3-NH)2Ti3(η5-C5Me5)3(μ-NH)(μ3-N)}] (7), which was prepared by treatment of 1 with [PdCl2(cod)] at room temperature. Addition of iodine to a toluene solution of 6 afforded the analogous palladium(ii) derivative [I2Pd{(μ3-NH)2Ti3(η5-C5Me5)3(μ-NH)(μ3-N)}] (8). Complex 6 reacted with two equivalents of dimethylacetylenedicarboxylate (dmad) to give the metallacyclopentadiene palladium(ii) complex [{(MeOOC)4C4}Pd{(μ3-NH)2Ti3(η5-C5Me5)3(μ-NH)(μ3-N)}] (9) via oxidative coupling. The treatment of 1 with [Pt(nbe)3] (nbe = norbornene) in toluene at room temperature gave the platinum(0) complex [(nbe)Pt{(μ3-NH)3Ti3(η5-C5Me5)3(μ3-N)}] (10). Compound 10 reacted with excess iodine to afford the platinum(iv) ionic derivative [I3Pt{(μ3-NH)3Ti3(η5-C5Me5)3(μ3-N)}]2(I3)(I5) (11) via an intermediate platinum(ii) complex [I2Pt{(μ3-NH)2Ti3(η5-C5Me5)3(μ-NH)(μ3-N)}] (12). The X-ray crystal structures of 5, 8, 9 and 11 have been determined.Ministerio de Ciencia e Innovación de España, Universidad de Alcalá, Ministerio de Educación y Ciencia de Españ

Characterization of non-intentional emissions from distributed energy resources up to 500 kHz: A case study in Spain

[EN] Narrow Band Power Line Communications (NB-PLC) systems are currently used for smart metering and power quality monitoring as a part of the Smart Grid (SG) concept. However, non-intentional emissions generated by the devices connected to the grid may sometimes disturb the communications and isolate metering equipment. Though some research works have been recently developed to characterize these emissions, most of them have been limited to frequencies below 150 kHz and they are mainly focused on in-house electronic appliances and lightning devices. As NB-PLC can also be allocated in higher frequencies up to 500 kHz, there is still a lack of analysis in this frequency range, especially for emissions from Distributed Energy Resources (DERs). The identification and characterization of the emissions is essential to develop solutions that avoid a negative impact on the proper performance of NB-PLC. In this work, the non-intentional emissions of different types of DERs composing a representative microgrid have been measured in the 35–500 kHz frequency range and analyzed both in time and frequency domains. Different working conditions and coupling and commutation procedures to mains are considered in the analysis. Results are then compared to the limits recommended by regulatory bodies for spurious emissions from communication systems in this frequency band, as no specific limits for DERs have been established. Field measurements show clear differences in the characteristics of non-intentional emissions for different devices, working conditions and coupling procedures and for frequencies below and above 150 kHz. Results of this study demonstrate that a further characterization of the potential emissions from the different types of DERs connected to the grid is required in order to guarantee current and future applications based on NB-PLC.This work has been financially supported in part by the Basque Government (Elkartek program)

L'e-portafoli de l'estudiant en la fase inicial

En aquest treball es presenta l'ús del dossier o portafoli de l'estudiant en la docència de dues assignatures de fase inicial dels graus de l’àmbit de l’Enginyeria Industrial que s'imparteixen a l'Escola Universitària d'Enginyeria Tècnica Industrial de Barcelona #EUETIB#. L'ús del dossier de l'estudiant com a eina d'aprenentatge actiu ha estat utilitzada amb èxit en nombrosos contextos. Les pràctiques no són una part aïllada de la matèria, sinó que són l'activitat clau que canalitza els esforços dels alumnes i del professorat per aconseguir els objectius docents. El dossier electrònic #e-portafoli# de laboratori permet que l'alumne aprengui, anant més enllà d’elaborar una mera recopilació d'exercicis realitzats. Les activitats a l'aula donen suport a la compartició del coneixement i afavoreixen la retroacció contínua. Per comprovar els resultats de l'aplicació d'aquesta tècnica s’ha realitzat un estudi a partir de la recopilació de dades referents a la docència amb l’e-portafoli. L'estudi s'emmarca en els objectius del GtPOE del projecte RIMA de la UPC. En conclusió, la inclusió de l’e-portafoli en la docència contribueix a la millora de la motivació i és un factor rellevant en la millora de la qualitat docent.Postprint (published version

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID‑19

Background. COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or viral RNA load in plasma is associated with severe COVID-19 and also to this dysregulated response. Methods. A total of 250 patients with COVID-19 were recruited (50 outpatients, 100 hospitalized ward patients and 100 critically ill). Viral RNA detection and quantification in plasma was performed using droplet digital PCR, targeting the N1 and N2 regions of the SARS-CoV-2 nucleoprotein gene. The association between SARS-CoV-2 RNAemia and viral RNA load in plasma with severity was evaluated by multivariate logistic regression. Correlations between viral RNA load and biomarkers evidencing dysregulation of host response were evaluated by calculating the Spearman correlation coefficients. Results. The frequency of viral RNAemia was higher in the critically ill patients (78%) compared to ward patients (27%) and outpatients (2%) (p < 0.001). Critical patients had higher viral RNA loads in plasma than non-critically ill patients, with non-survivors showing the highest values. When outpatients and ward patients were compared, viral RNAemia did not show significant associations in the multivariate analysis. In contrast, when ward patients were compared with ICU patients, both viral RNAemia and viral RNA load in plasma were associated with critical illness (OR [CI 95%], p): RNAemia (3.92 [1.183–12.968], 0.025), viral RNA load (N1) (1.962 [1.244–3.096], 0.004); viral RNA load (N2) (2.229 [1.382–3.595], 0.001). Viral RNA load in plasma correlated with higher levels of chemokines (CXCL10, CCL2), biomarkers indicative of a systemic inflammatory response (IL-6, CRP, ferritin), activation of NK cells (IL-15), endothelial dysfunction (VCAM-1, angiopoietin-2, ICAM-1), coagulation activation (D-Dimer and INR), tissue damage (LDH, GPT), neutrophil response (neutrophils counts, myeloperoxidase, GM-CSF) and immunodepression (PD-L1, IL-10, lymphopenia and monocytopenia). Conclusions. SARS-CoV-2 RNAemia and viral RNA load in plasma are associated with critical illness in COVID-19. Viral RNA load in plasma correlates with key signatures of dysregulated host responses, suggesting a major role of uncontrolled viral replication in the pathogenesis of this disease.This work was supported by awards from the Canadian Institutes of Health Research, the Canadian 2019 Novel Coronavirus (COVID-19) Rapid Research Funding initiative (CIHR OV2 – 170357), Research Nova Scotia (DJK), Atlantic Genome/Genome Canada (DJK), Li-Ka Shing Foundation (DJK), Dalhousie Medical Research Foundation (DJK), the “Subvenciones de concesión directa para proyectos y programas de investigación del virus SARS‐CoV2, causante del COVID‐19”, FONDO–COVID19, Instituto de Salud Carlos III (COV20/00110, CIBERES, 06/06/0028), (AT) and fnally by the “Convocatoria extraordinaria y urgente de la Gerencia Regional de Salud de Castilla y León, para la fnanciación de proyectos de investigación en enfermedad COVID-19” (GRS COVID 53/A/20) (CA). DJK is a recipient of the Canada Research Chair in Translational Vaccinology and Infammation. APT was funded by the Sara Borrell Research Grant CD018/0123 funded by Instituto de Salud Carlos III and co-fnanced by the European Development Regional Fund (A Way to Achieve Europe programme). The funding sources did not play any role neither in the design of the study and collection, not in the analysis, in the interpretation of data or in writing the manuscript

Famílies botàniques de plantes medicinals

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Innovaciones y mejoras en el proyecto tutoría entre compañeros. Curso 2015-2016

Memoria ID-0137. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016