Taxonomic status and behavioural documentation of the troglobiont Lithobius matulici (Myriapoda, Chilopoda) from the Dinaric Alps: Are there semiaquatic centipedes in caves?

Lithobius matulici Verhoeff, 1899 is redescribed based on type material and newly collected specimens. Strandiolus jugoslavicus Hoffer, 1937, described from another cave in the same region in Bosnia and Hercegovina, is presented as a junior subjective synonym of L. matulici (syn. nov.). L. matulici is shown to be most closely related to Lithobius remyi Jawlowski, 1933, type species of the subgenus-Thracolithobius Matic, 1962. The completeness of the chitin-lines on the forcipular coxosternite is discussed as a promising character for interspecific differentiation within Lithobiomorpha. Documentation of hitherto unknown semiaquatic behaviour in L. matulici and other cave-dwelling centipede species from Heizeguvinian-, Montenegrin- and Pyrenean caves is presented

DeVoS: Deniable Yet Verifiable Vote Updating

peer reviewedInternet voting systems are supposed to meet the same high standards as traditional paper-based systems when used in real political elections: freedom of choice, universal and equal suffrage, secrecy of the ballot, and independent verifiability of the election result. Although numerous Internet voting systems have been proposed to achieve these challenging goals simultaneously, few come close in reality. We propose a novel publicly verifiable and practically efficient Internet voting system, DeVoS, that advances the state of the art. The main feature of DeVoS is its ability to protect voters' freedom of choice in several dimensions. First, voters in DeVoS can intuitively update their votes in a way that is deniable to observers but verifiable by the voters; in this way voters can secretly overwrite potentially coerced votes. Second, in addition to (basic) vote privacy, DeVoS also guarantees strong participation privacy by end-to-end hiding which voters have submitted ballots and which have not. Finally, DeVoS is fully compatible with Perfectly Private Audit Trail, a state-of-the-art Internet voting protocol with practical everlasting privacy. In combination, DeVoS offers a new way to secure free Internet elections with strong and long-term privacy properties

DeVoS: Deniable Yet Verifiable Vote Updating

Internet voting systems are supposed to meet the same high standards as traditional paper-based systems when used in real political elections: freedom of choice, universal and equal suffrage, secrecy of the ballot, and independent verifiability of the election result. Although numerous Internet voting systems have been proposed to achieve these challenging goals simultaneously, few come close in reality. We propose a novel publicly verifiable and practically efficient Internet voting system, DeVoS, that advances the state of the art. The main feature of DeVoS is its ability to protect voters\u27 freedom of choice in several dimensions. First, voters in DeVoS can intuitively update their votes in a way that is deniable to observers but verifiable by the voters; in this way voters can secretly overwrite potentially coerced votes. Second, in addition to (basic) vote privacy, DeVoS also guarantees strong participation privacy by end-to-end hiding which voters have submitted ballots and which have not. Finally, DeVoS is fully compatible with Perfectly Private Audit Trail, a state-of-the-art Internet voting protocol with practical everlasting privacy. In combination, DeVoS offers a new way to secure free Internet elections with strong and long-term privacy properties

Quasiliving cationic ring-opening polymerization of 2-ethyl-2-oxazoline in benzotrifluoride, as an alternative reaction medium

Cationic ring-opening polymerization (CROP) of 2-ethyl-2-oxazoline (EtOx) was systematically investigated in benzotrifluoride (BTF), which is considered as an environmentally less harmful solvent than many conventional reaction media. Simultaneously, polymerizations in conventional solvents, such as acetonitrile, N,N-dimethylacetamide and toluene, were also carried out for comparison in the 80-100 degrees C temperature range. Kinetic experiments revealed that the monomer consumption occurs by first order kinetics and the number average molecular weights linearly increase in line with the theoretical molecular weight as a function of monomer conversion. These findings indicate that the polymerization takes place by quasiliving CROP in all the investigated solvents, including BTF as well, resulting in PEtOx with prederminded molecular weights and polydispersities of 1.3-15. The highest polymerization rates were obtained in BTF, resulting in high conversions in short reaction times at 100 degrees C reaction temperature. The Arrhenius parameters of the polymerization of EtOx in BTF indicates relatively high activation energy in comparison with other applied solvents, however, a compensation effect between the activation energies and frequency factor is observed for such polymerization in a variety of solvents. Our findings are expected to enable the convenient synthesis of polyoxazolines and polyoxazoline-based well-defined polymer architectures in BTF, an environmentally advantageous alternative solvent to harmful polymerization media, with high polymerization rates in short reaction times without the need for any special conditions or equipment.Peer reviewe

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from melanoma and non-melanoma skin cancer (or keratinocyte carcinoma) from occupational exposure to solar ultraviolet radiation, to inform the development of the WHO/ILO joint methodology. Objectives: We aim to systematically review studies on occupational exposure to solar ultraviolet radiation (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework and conducting both systematic reviews in tandem and in a harmonized way. Data sources: Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Ovid Medline, PubMed, EMBASE, and Web of Science. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand-search reference list of previous systematic reviews and included study records and consult additional experts. Study eligibility and criteria: We will include working-age ( 6515 years) workers in the formal and informal economy in any WHO and/or ILO Member State, but exclude children (<15 years) and unpaid domestic workers. For Systematic Review 1, we will include quantitative studies on the prevalence of relevant levels of occupational exposure to solar ultraviolet radiation (i.e. <0.33 SED/d and 650.33 SED/d) and of the total working time spent outdoors, stratified by country, sex, age and industrial sector or occupation, in the years 1960 to 2018. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the effect of any occupational exposure to solar ultraviolet radiation (i.e., 650.33 SED/d) on the prevalence of, incidence of or mortality due to melanoma and non-melanoma skin cancer, compared with the theoretical minimum risk exposure level (i.e. <0.33 SED/d). Study appraisal and synthesis methods: At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess the risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2. PROSPERO registration number: CRD42018094817

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study

<p>Abstract</p> <p>Background</p> <p>In addition to smoking, genetic predisposition is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Genetic association studies of new candidate genes in COPD may lead to improved understanding of the pathogenesis of the disease.</p> <p>Methods</p> <p>Two proposed casual single nucleotide polymorphisms (SNP) <it>(rs1051740, rs2234922) </it>in microsomal epoxide hydrolase (<it>EPHX1</it>) and three SNPs <it>(rs1801282, rs1800571, rs3856806) </it>in peroxisome proliferator-activated receptor gamma (<it>PPARG</it>), a new candidate gene, were genotyped in a case-control study (272 COPD patients and 301 controls subjects) in Hungary. Allele frequencies and genotype distributions were compared between the two cohorts and trend test was also used to evaluate association between SNPs and COPD. To estimate the strength of association, odds ratios (OR) (with 95% CI) were calculated and potential confounding variables were tested in logistic regression analysis. Association between haplotypes and COPD outcome was also assessed.</p> <p>Results</p> <p>The distribution of imputed <it>EPHX1 </it>phenotypes was significantly different between the COPD and the control group (P = 0.041), OR for the slow activity phenotype was 1.639 (95% CI = 1.08- 2.49; P = 0.021) in our study. In logistic regression analysis adjusted for both variants, also age and pack-year, the rare allele of His447His of <it>PPARG </it>showed significant association with COPD outcome (OR = 1.853, 95% CI = 1.09-3.14, P = 0.0218). In haplotype analysis the GC haplotype of <it>PPARG </it>(OR = 0.512, 95% CI = 0.27-0.96, P = 0.035) conferred reduced risk for COPD.</p> <p>Conclusions</p> <p>The "slow" activity-associated genotypes of <it>EPHX1 </it>were associated with increased risk of COPD. The minor His447His allele of <it>PPARG </it>significantly increased; and the haplotype containing the minor Pro12Ala and the major His447His polymorphisms of <it>PPARG </it>decreased the risk of COPD.</p

The Psychological Science Accelerator: Advancing Psychology Through a Distributed Collaborative Network

Source at https://doi.org/10.1177/2515245918797607.Concerns about the veracity of psychological research have been growing. Many findings in psychological science are based on studies with insufficient statistical power and nonrepresentative samples, or may otherwise be limited to specific, ungeneralizable settings or populations. Crowdsourced research, a type of large-scale collaboration in which one or more research projects are conducted across multiple lab sites, offers a pragmatic solution to these and other current methodological challenges. The Psychological Science Accelerator (PSA) is a distributed network of laboratories designed to enable and support crowdsourced research projects. These projects can focus on novel research questions or replicate prior research in large, diverse samples. The PSA’s mission is to accelerate the accumulation of reliable and generalizable evidence in psychological science. Here, we describe the background, structure, principles, procedures, benefits, and challenges of the PSA. In contrast to other crowdsourced research networks, the PSA is ongoing (as opposed to time limited), efficient (in that structures and principles are reused for different projects), decentralized, diverse (in both subjects and researchers), and inclusive (of proposals, contributions, and other relevant input from anyone inside or outside the network). The PSA and other approaches to crowdsourced psychological science will advance understanding of mental processes and behaviors by enabling rigorous research and systematic examination of its generalizability