Impact of the COVID-19 Pandemic on Delay in Treatment Initiation for Oral Cavity and Oropharyngeal Cancer in Brazil

Objective: To analyze the impact of the COVID-19 pandemic on the interval between diagnosis and initiation of treatment for oral cavity and oropharyngeal cancer in Brazil. Material and Methods: A time series study was conducted using secondary data extracted from the DATASUS system. The three-year period from 2019 to 2021 was selected to represent the baseline, onset, and peak of reported COVID-19 cases. The dependent variable of the study was the delay in starting anticancer treatment (>60 days after histopathologic diagnosis). Time series were analyzed using joint-point regression and monthly percentage changes (MPC) were estimated. Results: For oral cavity cancer, there were two periods of decrease in the delay in treatment initiation, from January 2019 to June 2020 (MPC= -0.75, 95% CI = -0.3 to -3.2, p=0.004) and from November 2020 to December 2021 (MPC= -1.41, 95% CI = -2.2 to -0.6, p=0.001). For oropharyngeal cancer, there was an increase in the percentage of delays in treatment initiation from January 2019 to February 2020 (MPC= 0.86, 95% CI = 0.2 to 1.5, p=0.014) and from May 2020 to December 2020 (MPC= 3.66, 95% CI = 1.2 to 6.2, p=0.005), with a decrease from December 2020 to December 2021 (MPC= -1.40, 95% CI = -2.3 to -0.5, p=0.003). Conclusion: The COVID-19 pandemic in Brazil had a greater impact on treatment initiation delay for oropharyngeal cancer than for oral cavity cancer. However, the percentage of delay in treatment initiation for oropharyngeal cancer showed fluctuation, with an increase in the pre-pandemic period and a decrease after December 2020

Contribuição do T-Gov à gestão do conhecimento

O governo eletrônico (T-Gov) tem buscado consolidar sua atuação oferecendo ao cidadão melhoria da gestão interna, mediante a integração com parceiros e fornecedores. Para atender a essas expectativas, uma infraestrutura de rede cuja finalidade é compartilhar o conhecimento e a experiência dos diferentes órgãos públicos está sendo criada na prestação dos serviços. Diante desse contexto, almeja-se um melhor atendimento ao cidadão por intermédio do acesso às novas tecnologias. O intuito é oferecer-lhe informação e serviços governamentais de melhor qualidade. Com isso, espera-se ampliar suas ações. Sem a preocupação de esgotar o tema, o presente artigo enseja discutir qual seria a contribuição do T-Gov na gestão do conhecimento. Desse modo, para a pesquisa propriamente dita, realizou-se um levantamento na literatura especializada, a fim de obter maiores informações acerca do assunto. Metodologicamente, trata-se de uma pesquisa bibliográfica. A princípio, serão comentados, de forma breve, a definição do conhecimento e os tipos de conhecimento - tácito e explícito -, conforme a visão de Nonaka e Takeuchi (1997). Assuntos como a gestão do conhecimento, seus conceitos e evolução da GC também serão tratados. Por fim, apresenta-se uma abordagem sobre a mídia, os tipos de mídia mais utilizados na atualidade, a contribuição do T-Gov para a gestão do conhecimento, gestão pública no contexto da gestão do conhecimento, governo eletrônico e a TV digital. Palavras-chave: Governo eletrônico. Gestão pública. Gestão do conhecimento

Immunohistochemical expression of OCT4 and CD44 in major and minor salivary gland neoplasms

The aim of this study was to identify tumor parenchyma cells exhibiting immunohistochemical profile of stem cells by evaluating the immunoreactivity of OCT4 and CD44 in a number of cases of salivary gland neoplasms. The sample consisted of 20 pleomorphic adenomas, 20 mucoepidermoid carcinomas, and 20 adenoid cystic carcinomas located in major and minor salivary glands. The expression of OCT4 and CD44 was evaluated by the percentage of positive cells and the intensity of expression. All studied cases showed positive expression of OCT4 and CD44 and higher values than the control groups. For OCT4, luminal and non-luminal cells were immunostained in the case of pleomorphic adenomas and adenoid cystic carcinomas. Moreover, the immunoreactivity of CD44 was particularly evident in the nonluminal cells of these lesions. In mucoepidermoid carcinomas, there was immunoreactivity for both markers in squamous and intermediate cells and absence of staining in mucous cells. For both markers, a significantly higher immunostaining was verified in neoplasms located in the major salivary glands compared with lesions in minor salivary glands (p<0.001). In the total sample and in minor salivary glands, malignant neoplasms exhibited higher immunoreactivity for OCT4 than pleomorphic adenoma. A significant moderate positive correlation (r = 0.444 and p ≤ 0.001) was found between OCT4 and CD44 immunoexpression in the total sample. The high expression of OCT4 and CD44 may indicate that these proteins play an important role in identifying tumor stem cells

BRSMG Uai: common bean cultivar with carioca grain type and upright plant architecture

The common bean cultivar with carioca grain type, BRSMG Uai, is recommended for cultivation in Minas Gerais and stands out for its upright plant architecture, which facilitates cultivation and mechanical harvesting. This cultivar has high yield potential and is resistant to the major races of anthracnose that occur in region

BRSMG Realce: Common bean cultivar with striped grains for the state of Minas Gerais

The common bean cultivar “BRSMG Realce”, recommended for the state of Minas Gerais, has high yield potential and resistance to powdery mildew, bacterial wilt and to anthracnose pathotypes 65, 73, 77, 81, 91, 475 and 479. The plants and pods are high, resulting in lower loss during mechanical harves

DIFERENTES GENÓTIPOS DE MILHO PARA PRODUÇÃO DE MINIMILHO

Minimilho ou “baby corn” é o nome dado à inflorescência feminina do milho, antes da polinização, ou seja, é a espiga de milho em desenvolvimento. A colheita é realizada manualmente e ocorre de dois a três dias após a emissão dos estilo-estigmas. Ele é consumido in natura ou em conservas acidificadas na forma de petisco, picles, saladas e na confecção de pratos como risotos, sopas e guarnições acompanhadas com carnes e peixe grelhados O minimilho é considerado uma hortícola, devido o tempo gasto da semeadura à colheita. A produção de minimilho pode ser considerado com uma das alternativas para diversificar a produção e aumentar a rentabilidade na agricultura familiar.  Objetivou-se com a realização deste trabalho elaborar uma revisão de literatura sobre avaliação de diferentes genótipos de milho para produção de minimilho. Com base na literatura ainda não é possível recomendar cultivares de milho para produção de minimilho

The nature of the compact HII region Sh 2-89 and its stellar content

We present an analysis of the structure and properties of the compact HII region Sh 2-89, and certain of the young stellar objects (YSOs) within this regime, using mid-infrared (MIR) mapping derived from the Spitzer Space Telescope (SST) and visual slit spectroscopy of the inner regions of the source. We show that the region has a bipolar structure, and contains a variety of Class I and II YSOs. Much of the MIR emission appears to be dominated by PAH emission bands, which cause strong increases in flux in the 5.8 and 8.0 microns photometric channels, whilst the variation of H_alpha, [NII] at 6583 A, [SII] at 6716+6731 A, and MIR emission profiles confirms the presence of complex ionisation fronts, and ionisation stratification.Comment: 12 pages, 6 figures, Accepted for publication in MNRAS. 33 pages in arXi