610 research outputs found
Evidence of continued injecting drug use after attaining sustained treatment-induced clearance of the hepatitis C virus: implications for reinfection
Background:
People who inject drugs (PWID) are at the greatest risk of hepatitis C virus (HCV) infection, yet are often denied immediate treatment due to fears of on-going risk behaviour. Our principal objective was to examine evidence of continued injecting drug use among PWID following successful treatment for HCV and attainment of a sustained viral response (SVR).
Methods:
PWID who attained SVR between 1992 and June 2012 were selected from the National Scottish Hepatitis C Clinical Database. Hospitalisation and mortality records were sourced for these patients using record linkage techniques. Our primary outcome variable was any hospitalisation or death, which was indicative of injecting drugs post-SVR.
Results:
The cohort comprised 1170 PWID (mean age at SVR 39.6y; 76% male). The Kaplan Meier estimate of incurring the primary outcome after three years of SVR was 10.59% (95% CI, 8.75â12.79) After adjusting for confounding, the risk of an injection related hospital episode or death post-SVR was significantly increased with advancing year of SVR: AHR:1.07 per year (95% CI, 1.01â1.14), having a pre-SVR acute alcohol intoxication-related hospital episode: AHR:1.83 (95% CI, 1.29â2.60), and having a pre-SVR opiate or injection-related hospital episode: AHR:2.59 (95% CI, 1.84â3.64).
Conclusion:
Despite attaining the optimal treatment outcome, these data indicate that an increasing significant minority of PWID continue to inject post-SVR at an intensity which leads to either hospitalisation or death and increased risk of reinfection
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Effect of thinning and prescribed fire restoration treatments on woody debris and snag dynamics in a Sierran old-growth, mixed-conifer forest
Forest managers have little information of the effects of common restoration treatments, thinning and burning, on dead woody material (DWM) dynamics in fire-suppressed forests. Fine woody debris (FWD; 0.6â29.9 cm), coarse woody debris (CWD; â„30.0 cm), and snags (â„5 cm) were inventoried and mapped in eighteen 4 ha plots before and after applying thinning (overstory, understory, and no thinning) and burning (burn and no burn) treatments. The combination of burning and thinning reduced FWD and CWD quantity and mean piece size, removed highly decayed logs, and increased small (5.0â24.9 cm) snag recruitment. In contrast, thin-only treatments produced similar results but increased FWD and did not remove many small snags. There were no differences in DWM response between the two thinning treatments. Log and snag spatial patterns prior to and following treatment were similar. These results indicate that burning in combination with thinning is more effective at reducing surface FWD and CWD, and removing small trees than are burn-only and thin-only treatments. Although large snags and logs were consumed in the burn, long-term recruitment of these habitat structures relies on managers retaining large-diameter trees. Repeated burns need to be conducted after initial restoration treatments to understand natural patterns of DWM
Distance-dependent defensive coloration in the poison frog <i>Dendrobates tinctorius</i>, Dendrobatidae
Significance
Poison dart frogs are well known for their deadly toxins and bright colors; they are a classic example of warning coloration. However, conspicuousness is not the only consideration; defensive coloration must be effective against a diverse predator community with a variety of different visual systems, and variable knowledge of prey defenses and motivation to attack. We found that the bright colors of
Dendrobates tinctorius
are highly salient at close-range but blend together to match the background when viewed from a distance.
D. tinctorius
combines aposematism and camouflage without necessarily compromising the efficacy of either strategy, producing bright colors while reducing encounters with predators. These data highlight the importance of incorporating viewing distance and pattern distribution into studies of signal design.
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Dimpled elastic sheets: a new class of non-porous negative Poissonâs ratio materials
In this study, we report a novel periodic material with negative Poissonâs ratio (also called auxetic materials) fabricated by denting spherical dimples in an elastic flat sheet. While previously reported auxetic materials are either porous or comprise at least two phases, the material proposed here is non-porous and made of a homogeneous elastic sheet. Importantly, the auxetic behavior is induced by a novel mechanism which exploits the out-of-plane deformation of the spherical dimples. Through a combination of experiments and numerical analyses, we demonstrate the robustness of the proposed concept, paving the way for developing a new class of auxetic materials that significantly expand their design space and possible applications
Panama Canal Tolls: Instruction of the Secretary of State of January 17, 1913, to the American Charge D\u27Affaires at London, and the British Notes of July 8, 1912, and November 14, 1912, to Which it Replies
This book is a collection of typed letters and documents between the Taft administration and the foreign service of Great Britain on the opening of the Panama Canal and the placing of tolls on vessels using the canal. The reports draw on the Clayton-Bulwer Treaty of 1850 giving equal importance of the US and Great Britain in New World trading as well as the Hay-Pauncefote Treaty of 1901 allowing the US to build the Panama canal.https://digitalcommons.ursinus.edu/fmhw_speeches/1012/thumbnail.jp
Forward to the past: reinventing intelligence-led policing in Britain
Drawing on archival, secondary material and primary research, this paper examines 'Total Policing', the strategy recently adopted by London's Metropolitan Police. It situates that analysis within a critical examination of other innovative policing strategies previously employed in Britain. It argues that the prospects for Total Policing depend upon the resolution of long-standing problems such as: the inadequacy and inefficiency of local intelligence work; the paucity of evidence for the success of commanders' previous efforts to harness together the component parts of their forces in pursuit of a single mission; and, above all, a seeming inability to learn the lessons of the past. © 2013 © 2013 Taylor & Francis
Pathway to the Square Kilometre Array - The German White Paper -
The Square Kilometre Array (SKA) is the most ambitious radio telescope ever
planned. With a collecting area of about a square kilometre, the SKA will be
far superior in sensitivity and observing speed to all current radio
facilities. The scientific capability promised by the SKA and its technological
challenges provide an ideal base for interdisciplinary research, technology
transfer, and collaboration between universities, research centres and
industry. The SKA in the radio regime and the European Extreme Large Telescope
(E-ELT) in the optical band are on the roadmap of the European Strategy Forum
for Research Infrastructures (ESFRI) and have been recognised as the essential
facilities for European research in astronomy.
This "White Paper" outlines the German science and R&D interests in the SKA
project and will provide the basis for future funding applications to secure
German involvement in the Square Kilometre Array.Comment: Editors: H. R. Kl\"ockner, M. Kramer, H. Falcke, D.J. Schwarz, A.
Eckart, G. Kauffmann, A. Zensus; 150 pages (low resolution- and colour-scale
images), published in July 2012, language English (including a foreword and
an executive summary in German), the original file is available via the MPIfR
homepag
Emerging Infectious Disease leads to Rapid Population Decline of Common British Birds
Emerging infectious diseases are increasingly cited as threats to wildlife, livestock and humans alike. They can threaten geographically isolated or critically endangered wildlife populations; however, relatively few studies have clearly demonstrated the extent to which emerging diseases can impact populations of common wildlife species. Here, we report the impact of an emerging protozoal disease on British populations of greenfinch Carduelis chloris and chaffinch Fringilla coelebs, two of the most common birds in Britain. Morphological and molecular analyses showed this to be due to Trichomonas gallinae. Trichomonosis emerged as a novel fatal disease of finches in Britain in 2005 and rapidly became epidemic within greenfinch, and to a lesser extent chaffinch, populations in 2006. By 2007, breeding populations of greenfinches and chaffinches in the geographic region of highest disease incidence had decreased by 35% and 21% respectively, representing mortality in excess of half a million birds. In contrast, declines were less pronounced or absent in these species in regions where the disease was found in intermediate or low incidence. Also, populations of dunnock Prunella modularis, which similarly feeds in gardens, but in which T. gallinae was rarely recorded, did not decline. This is the first trichomonosis epidemic reported in the scientific literature to negatively impact populations of free-ranging non-columbiform species, and such levels of mortality and decline due to an emerging infectious disease are unprecedented in British wild bird populations. This disease emergence event demonstrates the potential for a protozoan parasite to jump avian host taxonomic groups with dramatic effect over a short time period
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
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