24 research outputs found

    Experiences of the Flipped Classroom method Does it make students more motivated?

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    The aim of this paper is to highlight use of the flipped classroom method, and how teachers perceive this teaching practice. More specific the research focus on whether the teachers’ experience that the model leads to increased motivation in the students learning process. The background for the research is generated from qualitative interviews with teachers, and the empirical data obtained is from semi-structured interviews with these informants. The results show that the flipped classroom method in fact did increase participation and cooperation, which in turn generated motivation and willing students. The teachers got more time for guidance of each student, which provided more solid knowledge on each student’s academic level

    Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer

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    Purpose: Since combination of Toll-like receptor (TLR) ligands could boost antitumor immunity, we evaluated the efficacy of dendritic cell (DC) vaccines upon dual activation of TLR9 and TLR7 in breast cancer models. Methods: DCs were generated from mouse bone marrow or peripheral blood from healthy human donors and stimulated with CpG1826 (mouse TLR9 agonist), CpG2006 or IMT504 (human TLR9 agonists) and R848 (TLR7 agonist). Efficacy of antitumor vaccines was evaluated in BALB/c mice bearing metastatic mammary adenocarcinomas. Results: CpG-DCs improved the survival of tumor-bearing mice, reduced the development of lung metastases and generated immunological memory. However, dual activation of TLRs impaired the efficacy of DC vaccines. In vitro, we found that R848 inhibited CpG-mediated maturation of murine DCs. A positive feedback loop in TLR9 mRNA expression was observed upon CpG stimulation that was inhibited in the presence of R848. Impaired activation of NF-ÎșB was detected when TLR9 and TLR7 were simultaneously activated. Blockade of nitric oxide synthase (NOS) and indoleamine-pyrrole-2,3-dioxygenase (IDO) improved the activation of CpG-DCs. When we evaluated the effect of combined activation of TLR9 and TLR7 in human DCs, we found that R848 induced robust DC activation that was inhibited by TLR9 agonists. Conclusions: These observations provide insight in the biology of TLR9 and TLR7 crosstalk and suggest caution in the selection of agonists for multiple TLR stimulation. Blockade of NOS and IDO could improve the maturation of antitumor DC vaccines. R848 could prove a useful adjuvant for DC vaccines in human patients.Fil: Moreno Ayala, Mariela Alejandra. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; ArgentinaFil: Gottardo, MarĂ­a Florencia. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de BiologĂ­a Celular e HistologĂ­a; ArgentinaFil: Gori, MarĂ­a Soledad. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Nicola Candia, Alejandro Javier. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; ArgentinaFil: Caruso, Carla Mariana. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de BiologĂ­a Celular e HistologĂ­a; ArgentinaFil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y BotĂĄnicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y BotĂĄnicos; Argentina. Universidad de Buenos Aires. Facultad de OdontologĂ­a. CĂĄtedra de FisiologĂ­a; ArgentinaFil: Imsen, Mercedes. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; ArgentinaFil: Klein, Slobodanka Mariana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂ­a ; ArgentinaFil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂ­a ; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de BiologĂ­a Celular e HistologĂ­a; Argentina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Salamone, Gabriela Veronica. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Castro, Maria G.. University of Michigan; Estados UnidosFil: Seilicovich, Adriana. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de BiologĂ­a Celular e HistologĂ­a; ArgentinaFil: Candolfi, Marianela. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; Argentin

    Teacher autonomy and teacher agency: a comparative study in Brazilian and Norwegian lower secondary education

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    Teacher autonomy and teacher agency are positively related to teachers’ motivation and engagement in teaching. This paper combines the concepts of teacher autonomy and teacher agency to study how Brazilian and Norwegian lower secondary teachers respond to an accountability system marked by a centralised outcomes-based curriculum and testing. Teacher autonomy concerns the relations between teachers’ scope of action and the state’s role in providing resources and regulations that extend or constrain this scope of action. Teacher agency refers to teachers’ professional action based on their perceptions and experiences of their scope of action as they navigate accountability to respond to educational dilemmas at hand. The findings show that teachers navigate policies in a variety of forms to fit their needs and beliefs and those of their students. Brazilian teachers have a constrained scope of action and possibilities for achieving agency in comparison with their Norwegian counterparts. Norwegian teachers also have their individual autonomy constrained by extended state control over the curriculum and testing. However, the practice of collective work opens up for the exercise of agency because of the possibility of reflection and collective construction of teaching plans and strategies that frame and legitimise teaching wor

    The Norwegian bureaucratic aristocracy and their manor houses in the thirteenth and fourteenth centuries

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    Except royal castles in major Norwegian towns, only two stone castles were built by Norwegian aristocrats in the High Middle Ages. All other aristocrats lived in wooden buildings. Of these only Lagmannsstova at Aga in Hardanger remains. It has been attributed to the appeal court judge Sigurd Brynjulffson, though to have been constructed at the end of the thirteenth century as one unique building. However, investigations show that the remaining hall made up less than onethird of a building complex containing two halls, a chapel, kitchen and living quarters, all built at the first half of the thirteenth century. Investigations also show that the powers of the appeal court judge were drastically expanded at the same time, not at least by the Norwegian Code of the realm of 1274. By relating judicial powers and manor house, we get a quite different image of the Norwegian aristocracy and bureaucracy in the High Middle Ages than the popular one of an egalitarian peasant society
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