Unification of couplings and soft supersymmetry breaking terms in 4D superstring models

We consider the predictions for the hierarchy of mass scales, the fine structure constant, the radii of compactification and the soft SUSY breaking terms which follow if SUSY breaking is triggered by a gaugino condensate.Comment: 16 pages (LaTeX) Oxford preprint OUTP-93-32

Unification Scale in String Theory

We study the unification scale and gauge coupling constant in 4D string theory. We show that the fine structure constant is determined by the dimension of the hidden gauge group and only $SU(6)$ and $SO(9)$ are consistent with minimal string unification while the unification scale can be of order of $10^{16}\,GeV$.Comment: 12 pages (LaTeX

A new scenario for string unification

We present a new scenario for gauge coupling unification in flipped SU(5) string models, which identifies the $M_{32}$ scale of SU(3) and SU(2) unification with the empirical $M_{\rm LEP}\sim10^{15-16}$~GeV scale, and the $M_{51}$ scale of SU(5) and U(1) unification with the theoretical $M_{\rm string}\sim5\times10^{17}$~GeV string unification scale. The vacuum shift necessary for the cancellation of the anomalous $\rm U_A(1)$ and an SU(4) hidden sector with fractionally-charged particles, play a crucial role in the dynamical determination of all intermediate mass scales in this scenario.Comment: 8 pages, LaTeX, 2 figures (uuencoded

Dos embarazadas de la maqbara de la Calle Herrerías (Tudela, Navarra) (s. IX-XI)

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Laser floating zone growth: Overview, singular materials, broad applications, and future perspectives

The Laser Floating Zone (LFZ) technique, also known as Laser-Heated Pedestal Growth (LHPG), has been developed throughout the last several decades as a simple, fast, and crucible-free method for growing high-crystalline-quality materials, particularly when compared to the more conventional Verneuil, Bridgman-Stockbarger, and Czochralski methods. Multiple worldwide efforts have, over the years, enabled the growth of highly oriented polycrystalline and single-crystal high-melting materials. This work attempted to critically review the most representative advancements in LFZ apparatus and experimental parameters that enable the growth of high-quality polycrystalline materials and single crystals, along with the most commonly produced materials and their relevant physical properties. Emphasis will be given to materials for photonics and optics, as well as for electrical applications, particularly superconducting and thermoelectric materials, and to the growth of metastable phases. Concomitantly, an analysis was carried out on how LFZ may contribute to further understanding equilibrium vs. non-equilibrium phase selectivity, as well as its potential to achieve or contribute to future developments in the growth of crystals for emerging applications

E-cadherin expression is associated with somatostatin analogue response in acromegaly

Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs) represent the primary medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy after unsuccessful pituitary surgery. However, a considerable proportion of patients do not adequately respond to SSAs treatment, and therefore, there is an urgent need to identify biomarkers predictors of response to SSAs. The aim of this study was to examine E‐cadherin expression by immunohistochemistry in fifty‐five GH‐producing pituitary tumours and determine the potential association with response to SSAs as well as other clinical and histopathological features. Acromegaly patients with tumours expressing low E‐cadherin levels exhibit a worse response to SSAs. E‐cadherin levels are associated with GH‐producing tumour histological subtypes. Our results indicate that the immunohistochemical detection of E‐cadherin might be useful in categorizing acromegaly patients based on the response to SSAs.ISCIII‐Subdirección General de Evaluación y Fomento de la Investigación PI13/02043 PI16/00175FEDER PI13/02043 PI16/00175Junta de Andalucía A‐0023‐2015 A‐0003‐2016 CTS‐1406 BIO‐0139Andalusian Ministry of Health C‐0015‐2014CIBERobn PI13/ 02043 PI16/0017

Classe invertida (flipped classroom). Experiència en el grau d'Infermeria.

Projecte finalitzat desembre 2015En l’aula invertida (flipped classroom) (FC), els estudiants treballen fora de classe, tasques prèviament preparades amb aquest fi pel professorat. L’objectiu del estudi es motivar als estudiants suplint per FC les classes teòriques magistrals. Superar favorablement FC evita l’examen final (30% de l’avaluació). Context d’aplicació: grup C, 89 estudiants (finalitzen n=81). Programa de Ciències Psicosocials Aplicades a la Salut, assignatura anual, formació bàsica, 9 ECTS, primer curs, Grau d’Infermeria, tarda, segon semestre, curs 2014-15. Metodologia: resposta escrita a preguntes amb suport bibliogràfic i avaluació amb instruments específics estandaritzats. A classe: avaluació per parells i contrastos verbals sobre continguts, tutelats per la professora, que presenta una segona avaluació setmanal (campus virtual). Resultats: Contrast estadístic de notes FC amb examen test, igual al realitzat en grup A (intraclasse). Puntuació (sobre 10) superior a FC (mitja: 7,96 + DE: 0,67) que en l’examen (mitja 5,89 + DE: 1,26), <0.001. També es contrasten resultats d’examen de FC i de grup A (mitja: 6,02 + DE 1,18) (interclasse) i no es troben diferencies estadísticament significatives 0.508 . Degut a que el grup C (FC) no s’havia preparat ni estudiat l’examen, la diferencia de dècimes mostra una adquisició de coneixements favorable per la experiència flipped classroom.2014PID-UB/5

Epigenetic and post-transcriptional regulation of somatostatin receptor subtype 5 (SST5) in pituitary and pancreatic neuroendocrine tumors

Somatostatin receptor subtype 5 (SST5) is an emerging biomarker and actionable target in pituitary (PitNETs) and pancreatic (PanNETs) neuroendocrine tumors. Transcriptional and epigenetic regulation of SSTR5 gene expression and mRNA biogenesis is poorly understood. Recently, an overlapping natural antisense transcript, SSTR5-AS1, potentially regulating SSTR5 expression, was identified. We aimed to elucidate whether epigenetic processes contribute to the regulation of SSTR5 expression in PitNETs (somatotropinomas) and PanNETs. We analyzed the SSTR5/SSTR5-AS1 human locus in silico to identify CpG islands. SSTR5 and SSTR5-AS1 expression was assessed by quantitative real-time PCR (qPCR) in 27 somatotropinomas, 11 normal pituitaries (NPs), and 15 PanNETs/paired adjacent (control) samples. We evaluated methylation grade in four CpG islands in the SSTR5/SSTR5-AS1 genes. Results revealed that SSTR5 and SSTR5-AS1 were directly correlated in NP, somatotropinoma, and PanNET samples. Interestingly, selected CpG islands were differentially methylated in somatotropinomas compared with NPs. In PanNETs cell lines, SSTR5-AS1 silencing downregulated SSTR5 expression, altered aggressiveness features, and influenced pasireotide response. These results provide evidence that SSTR5 expression in PitNETs and PanNETs can be epigenetically regulated by the SSTR5-AS1 antisense transcript and, indirectly, by DNA methylation, which may thereby impact tumor behavior and treatment response.Junta de AndalucíaMinisterio de EconomíaMinisterio de Ciencia e Innovació

Estudio paleopatológico de la necrópolis mudéjar de la calle Colón, 3 (Novelda, Alicante)

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Aula invertida: experiencia en el Grado de Enfermería

En el aula invertida, los estudiantes trabajan autónomamente tareas previamente preparadas con este fin por el profesorado. Objetivo: evaluar el aula invertida como innovación docente y contrastar los resultados con grupo con docencia tradicional. Contexto: primer curso del Grado de Enfermería en la asignatura troncal Ciencias Psicosociales Aplicadas a la Salud (grupo C, n=81). Metodología: cualitativa y cuantitativa con la inclusión de instrumentos estandarizados ad hoc. Destaca la evaluación por pares y contrastes verbales sobre contenidos tutelados por el profesorado. Se realizó evaluación del grupo control y el grupo experimental y se contrastaron los resultados de las cualificaciones obtenidas. Resultados. Puntuación sobre 10 con medias y desviación estándar: Intraclase, superior en el aula invertida (7,96 + 0,67) frente a (5,89 + 1,26) en examen (p-valor < 0,001). Interclase, grupo experimental (5,89 + 1,26) y grupo control (6,02 + 1,16), (p-valor 0,508). Sin hallazgo de diferencias estadísticamente significativas. Conclusión: Sin preparación para el examen y gran esfuerzo adicional, destacó la satisfacción por parte del profesorado y de los estudiantes, el aula invertida se mostró claramente favorable para la adquisición de conocimientos en la asignatura de Enfermería probada