Searching for a tactile target: the impact of set-size on the N140cc

The time needed to find a visual target amongst distractors (search task) can increase as a function of the distractors’ number (set-size) in the search-array (inefficient search). While the allocation of attention in search tasks has been extensively investigated and debated in the visual domain, little is known about these mechanisms in touch. Initial behavioral evidence shows inefficient search behavior when participants have to distinguish between target and distractors defined by their vibro-tactile frequencies. In the present study, to investigate the allocation of attention to items of the search-array we measured the N140cc during a tactile task in which the set-size was manipulated. The N140cc is a lateralized component of event-related brain potentials recently described as a psychophysiological marker of attentional allocation in tactile search tasks. Participants localized the target, a singleton frequency, while ignoring one, three or five homogeneous distractors. Results showed that error rates linearly increased as a function of set-size, while response times were not affected. Reliable N140cc components were observed for all set-sizes. Crucially, the N140cc amplitude decreased as the number of distractors increased. We argue that the presence of additional distractors hindered the preattentive analysis of the search array resulting in increased uncertainty about the target location (inefficient preattentive stage). This, in turn, increased the variability of the deployment of attention to the target, resulting in reduced N140cc amplitudes. Consistent with existing behavioral evidence, these findings highlight systematic differences between the visual and the tactile attentional systems

Peripheral neurological disturbances, autonomic dysfunction, and antineuronal antibodies in adult celiac disease before and after a gluten-free diet

Thirty-two consecutive adult celiac disease (CD) patients (pts), complaining of peripheral neuropathy (12 pts), autonomic dysfunction (17 pts), or both (3 pts), were evaluated to assess the presence of neurological damage (by clinical neurological evaluation and electrophysiological study) and antineuronal antibodies and to assess the effect of a gluten-free diet (GFD) on the course of the neurological symptoms and on antineuronal antibodies. At entry, 12 of 32 (38%) pts showed signs and symptoms of neurological damage: 7 of 12 (58%), peripheral neurological damage; 3 of 12 (25%), autonomic dysfunction; and 2 (17%), both peripheral neurological damage and autonomic dysfunction. The overall TNS score was 105 at entry. Anti-GM1 antibodies were present in 5 of 12 (42%) pts: 3 showed peripheral neurological damage and 2 showed both peripheral neurological damage and autonomic dysfunction. One year after the GFD was started, histological lesions were still present in only 10 of 12 (83%) pts. TNS score was 99, 98, 98, and 101 at the 3rd, 6th, 9th, and 12th month after the GFD was started, so it did not improve throughout the follow-up. None of the pts showed disappearance of antineuronal antibodies throughout the follow-up. We conclude that adult CD patients may show neurological damage and presence of antineuronal antibodies. Unfortunately, these findings do not disappear with a GFD

Fostering Awareness and Personalization of Learning Artificial Intelligence

This paper illustrates the activities of the projects SMAILE and AILEAP, which are devoted to foster the growth of awareness and readyness to learn artificial intelligence in the general population. The first project was mainly oriented to children and young adults, while the second is more oriented to the personalization of the learning experience also in professionals

Unveiling [CII] clumps in a lensed star-forming galaxy at z ~ 3.4

Observations at UV and optical wavelengths have revealed that galaxies at z~1-4 host star-forming regions, dubbed "clumps", which are believed to form due to the fragmentation of gravitationally unstable, gas-rich disks. However, the detection of the parent molecular clouds that give birth to such clumps is still possible only in a minority of galaxies, mostly at z~1. We investigated the [CII] and dust morphology of a z~3.4 lensed galaxy hosting four clumps detected in the UV continuum. We aimed to observe the [CII] emission of individual clumps that, unlike the UV, is not affected by dust extinction, to probe their nature and cold gas content. We conducted ALMA observations probing scales down to ~300 pc and detected three [CII] clumps. One (dubbed "NE") coincides with the brightest UV clump, while the other two ("SW" and "C") are not detected in the UV continuum. We do not detect the dust continuum. We converted the [CII] luminosity of individual clumps into molecular gas mass and found Mmol~10^8 Msun. By complementing it with the star formation rate (SFR) estimate from the UV continuum, we estimated the gas depletion time (tdep) of clumps and investigated their location in the Schmidt-Kennicutt plane. While the NE clump has a short tdep=0.16 Gyr, comparable with high-redshift starbursts, the SW and C clumps instead have longer tdep>0.65 Gyr and are likely probing the initial phases of star formation. The lack of dust continuum detection is consistent with the blue UV continuum slope estimated for this galaxy (beta~-2.5) and it indicates that dust inhomogeneities do not significantly affect the detection of UV clumps in this target. We pushed the observation of the cold gas content of individual clumps up to z~3.4 and showed that the [C II] line emission is a promising tracer of molecular clouds at high redshift, allowing the detection of clumps with a large range of depletion times.Comment: Accepted for publication in A&

Understanding public speakers’ performance: first contributions to support a computational approach

Communication is part of our everyday life and our ability to communicate can have a significant role in a variety of contexts in our personal, academic, and professional lives. For long, the characterization of what is a good communicator has been subject to research and debate by several areas, particularly in Education, with a focus on improving the performance of teachers. In this context, the literature suggests that the ability to communicate is not only defined by the verbal component, but also by a plethora of non-verbal contributions providing redundant or complementary information, and, sometimes, being the message itself. However, even though we can recognize a good or bad communicator, objectively, little is known about what aspects – and to what extent—define the quality of a presentation. The goal of this work is to create the grounds to support the study of the defining characteristics of a good communicator in a more systematic and objective form. To this end, we conceptualize and provide a first prototype for a computational approach to characterize the different elements that are involved in communication, from audiovisual data, illustrating the outcomes and applicability of the proposed methods on a video database of public speakers.publishe

Stellar feedback in a clumpy galaxy at z ∼ 3.4

Giant star-forming regions (clumps) are widespread features of galaxies at z ≈ 1−4. Theory predicts that they can play a crucial role in galaxy evolution, if they survive to stellar feedback for >50 Myr. Numerical simulations show that clumps’ survival depends on the stellar feedback recipes that are adopted. Up to date, observational constraints on both clumps’ outflows strength and gas removal time-scale are still uncertain. In this context, we study a line-emitting galaxy at redshift z ≃ 3.4 lensed by the foreground galaxy cluster Abell 2895. Four compact clumps with sizes ≲280 pc and representative of the low-mass end of clumps’ mass distribution (stellar masses ≲2 × 108 M⊙) dominate the galaxy morphology. The clumps are likely forming stars in a starbursting mode and have a young stellar population (∼10 Myr). The properties of the Lyman-α (Lyα) emission and nebular far-ultraviolet absorption lines indicate the presence of ejected material with global outflowing velocities of ∼200–300 km s−1. Assuming that the detected outflows are the consequence of star formation feedback, we infer an average mass loading factor (η) for the clumps of ∼1.8–2.4 consistent with results obtained from hydrodynamical simulations of clumpy galaxies that assume relatively strong stellar feedback. Assuming no gas inflows (semiclosed box model), the estimates of η suggest that the time-scale over which the outflows expel the molecular gas reservoir (≃7 × 108 M⊙) of the four detected low-mass clumps is ≲50 Myr

Sodium valproate in migraine without aura and medication overuse headache: A randomized controlled trial

Objective: To assess the efficacy, safety and tolerability of sodium valproate (800. mg/die) compared with placebo in medication-overuse headache patients with a history of migraine without aura. Methods: This is a multicenter, randomized, double-blind, placebo-controlled study enrolled medication-overuse headache patients for a 3-month treatment period with sodium valproate (800. mg/day) or placebo after a 6 day outpatient detoxification regimen, followed by a 3-month follow-up. Primary outcome was defined by the proportion of patients achieving ≥50% reduction in the number of days with headache per month (responders) from the baseline to the last 4 weeks of the 3-month treatment. Multivariate logistic regression models were used on the primary endpoint, adjusting for age, sex, disease duration, comorbidity and surgery. The last-observation-carried-forward method was used to adjust for missing values. Results: Nine sites enrolled 130 patients and, after a 6-day detoxification phase, randomized 88 eligible patients. The 3-month responder rate was higher in the sodium valproate (45.0%) than in the placebo arm (23.8%) with an absolute difference of about 20% (p=0.0431). Sodium valproate had safety and tolerability profiles comparable to placebo. Conclusions: The present study supports the efficacy and safety of sodium valproate in the treatment of medication overuse headache with history of migraine after detoxification

Epidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018

Since 2014, Brazil has experienced an unprecedented epidemic caused by chikungunya virus (CHIKV), with several waves of East-Central-South-African (ECSA) lineage transmission reported across the country. In 2018, Rio de Janeiro state, the third most populous state in Brazil, reported 41% of all chikungunya cases in the country. Here we use evolutionary and epidemiological analysis to estimate the timescale of CHIKV-ECSA-American lineage and its epidemiological patterns in Rio de Janeiro. We show that the CHIKV-ECSA outbreak in Rio de Janeiro derived from two distinct clades introduced from the Northeast region in mid-2015 (clade RJ1, n = 63/67 genomes from Rio de Janeiro) and mid-2017 (clade RJ2, n = 4/67). We detected evidence for positive selection in non-structural proteins linked with viral replication in the RJ1 clade (clade-defining: nsP4-A481D) and the RJ2 clade (nsP1-D531G). Finally, we estimate the CHIKV-ECSA's basic reproduction number (R0) to be between 1.2 to 1.6 and show that its instantaneous reproduction number (Rt) displays a strong seasonal pattern with peaks in transmission coinciding with periods of high Aedes aegypti transmission potential. Our results highlight the need for continued genomic and epidemiological surveillance of CHIKV in Brazil, particularly during periods of high ecological suitability, and show that selective pressures underline the emergence and evolution of the large urban CHIKV-ECSA outbreak in Rio de Janeiro