Исследование характеристик ядерных трековых мембран для создания дренажной системы в лечении глаукомы

In this article has been researched possibility of using nuclear track membrane for fluid transport in the implementation and maintenance of the cornea weaklydehydrated state

On group strategy-proof mechanisms for a many-to-one matching model

For the many-to-one matching model in which firms have substitutable and quota q-separable preferences over subsets of workers we show that the workers-optimal stable mechanism is group strategy-proof for the workers. In order to prove this result, we also show that under this domain of preferences (which contains the domain of responsive preferences of the college admissions problem) the workers-optimal stable matching is weakly Pareto optimal for the workers and the Blocking Lemma holds as well. We exhibit an example showing that none of these three results remain true if the preferences of firms are substitutable but not quota q-separable.The work of R. Martínez, A. Neme, and J. Oviedo is partially supported by Research Grant 319502 from the Universidad Nacional de San Luis (Argentina). The work of J. Massó is partially supported by Research Grants BEC2002-2130 from the Dirección General de Investigación Científica y Técnica (Spanish Ministry of Science and Technology) and 2001SGR-00162 from the Departament d’Universitats, Recerca i Societat de la Informació (Generalitat de Catalunya)

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders

Разработка системы импульсного питания сварной дуги с разделением токоподвода к изделию

Объектом исследования является: процесс сварки неплавящимся электродом в аргоне. Предмет исследования ? сварочная дуга горящая в импульсном режиме на постоянном токе. Цель работы ? является исследование и разработка системы импульсного питания сварной дуги с разделением токоподвода к изделию. В процессе исследования проводились анализ методов повышения эффективности и способы сварки неплавящимся электродом с применением импульсного питания сварочной дуги, проведен анализ сварки модулированным током и предложен наиболее перспективный способ. В результате исследования разработана принципиальная электрическая схема модулятора обеспечивающее двойной токоподвод к изделию.Object of research: the process of Non-consumable Electrode Arc welding in argon. Subject of research: welding arc burning in the pulsed mode at direct current. Purpose of research: is the research and development of a pulsed power supply system for a welded arc with the separation of the current lead to the product. In the process of the investigation, methods of increasing efficiency and methods for welding with a non-consumable electrode were analyzed using pulse welding arc welding, an analysis of modulated current welding was performed and the most promising method was proposed. Results of research: a basic electrical circuit of the modulator was developed to provide a double current lead to the product

Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome

Dysfunctional basal ganglia loops are thought to underlie the clinical picture of Tourette syndrome (TS). By altering dopaminergic activity in the affected neural structures, bilateral deep brain stimulation is assumed to have a modulatory effect on dopamine transmission resulting in an amelioration of tics. While the majority of published case reports deals with the application of bilateral stimulation, the present study aims at informing about the high effectiveness of unilateral stimulation of pallidal and nigral thalamic territories in TS. Potential implications and gains of the unilateral approach are discussed

Cognitive and emotional empathy in individuals at clinical high risk of psychosis

Background Impairments of social cognition are considered core features of schizophrenia and are established predictors of social functioning. However, affective aspects of social cognition including empathy have far less been studied than its cognitive dimensions. The role of empathy in the development of schizophrenia remains largely elusive. Methods Emotional and cognitive empathy were investigated in large sample of 120 individuals at Clinical High Risk of Psychosis (CHR-P) and compared with 50 patients with schizophrenia and 50 healthy controls. A behavioral empathy assessment, the Multifaceted Empathy Test, was implemented, and associations of empathy with cognition, social functioning, and symptoms were determined. Results Our findings demonstrated significant reductions of emotional empathy in individuals at CHR-P, while cognitive empathy appeared intact. Only individuals with schizophrenia showed significantly reduced scores of cognitive empathy compared to healthy controls and individuals at CHR-P. Individuals at CHR-P were characterized by significantly lower scores of emotional empathy and unspecific arousal for both positive and negative affective valences compared to matched healthy controls and patients with schizophrenia. Results also indicated a correlation of lower scores of emotional empathy and arousal with higher scores of prodromal symptoms. Conclusion Findings suggest that the tendency to 'feel with' an interaction partner is reduced in individuals at CHR-P. Altered emotional reactivity may represent an additional, early vulnerability marker, even if cognitive mentalizing is grossly unimpaired in the prodromal stage. Different mechanisms might contribute to reductions of cognitive and emotional empathy in different stages of non-affective psychotic disorders and should be further explored