Distribución y selección de ambientes de los isópodos talasoides del río de la Plata, República Argentina

Hasta el presente los trabajos sobre los isópodos talasoides argentinos estaban limitados al estudio sistemático (Giambiagi, 1922; Calabrese, 1931). El presente trabajo es el inicio de una línea de investigación sobre la biología y ecología de estos isópodos en el Río de la Plata. Los objetivos de la presente contribución son: determinar las especies presentes en el litoral argentino del Río de la Plata, analizar la selección de ambientes de las especies de isópodos hallados, analizar el patrón de distribución de estas especies.Facultad de Ciencias Naturales y Muse

Special issue on applications of speech and language technologies in healthcare

In recent years, the exploration and uptake of digital health technologies have advanced rapidly with a real potential impact to revolutionise healthcare delivery and associated industries [...

Absolute kinematics of radio source components in the complete S5 polar cap sample. IV. Proper motions of the radio cores over a decade and spectral properties

We have carried out a high-precision astrometric analysis of two very-long-baseline-interferometry (VLBI) epochs of observation of the 13 extragalactic radio sources in the complete S5 polar cap sample. The VLBI epochs span a time baseline of 10 years and enable us to achieve precisions in the proper motions of the source cores up to a few micro-arcseconds per year. The observations were performed at 14.4 GHz and 43.1 GHz, and enable us to estimate the frequency core-shifts in a subset of sources, for which the spectral-index distributions can be computed. We study the source-position stability by analysing the changes in the relative positions of fiducial source points (the jet cores) over a decade. We find motions of 0.1-0.9 mas among close-by sources between the two epochs, which imply drifts in the jet cores of approximately a few tens of micro-as per year. These results have implications for the standard Active Galactic Nucleus (AGN) jet model (where the core locations are supposed to be stable in time). For one of our sources, 0615+820, the morphological and spectral properties in year 2010, as well as the relative astrometry between years 2000 and 2010, suggest the possibility of either a strong parsec-scale interaction of the AGN jet with the ISM, a gravitational lens with ~1 mas diameter, or a resolved massive binary black hole

VLBI for Gravity Probe B. III. A Limit on the Proper Motion of the "Core" of the Quasar 3C 454.3

We made VLBI observations at 8.4 GHz between 1997 and 2005 to estimate the coordinates of the "core" component of the superluminal quasar, 3C 454.3, the ultimate reference point in the distant universe for the NASA/Stanford Gyroscope Relativity Mission, Gravity Probe B. These coordinates are determined relative to those of the brightness peaks of two other compact extragalactic sources, B2250+194 and B2252+172, nearby on the sky, and within a celestial reference frame (CRF), defined by a large suite of compact extragalactic radio sources, and nearly identical to the International Celestial Reference Frame 2 (ICRF2). We find that B2250+194 and B2252+172 are stationary relative to each other, and also in the CRF, to within 1-sigma upper limits of 15 and 30 micro-arcsec/yr in RA and decl., respectively. The core of 3C 454.3 appears to jitter in its position along the jet direction over ~0.2 mas, likely due to activity close to the putative supermassive black hole nearby, but on average is stationary in the CRF within 1-sigma upper limits on its proper motion of 39 micro-arcsec/yr (1.0c) and 30 micro-arcsec/yr (0.8c) in RA and decl., respectively, for the period 2002 - 2005. Our corresponding limit over the longer interval, 1998 - 2005, of more importance to GP-B, is 46 and 56 micro-arcsec/yr in RA and decl., respectively. Some of 3C 454.3's jet components show significantly superluminal motion with speeds of up to ~200 micro-arcsec/yr or 5c in the CRF. The core of 3C 454.3 thus provides for Gravity Probe B a sufficiently stable reference in the distant universe.Comment: Accepted for publication in the Astrophysical Journal Supplement Serie

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms.

Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage leukemia (MLL) fusion protein-driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor, leads to growth inhibition in a human erythroleukemic (HEL) cell line as well as in erythroid precursors isolated from polycythemia vera patients. One of the genes most highly downregulated by I-BET151 was LMO2, an important oncogenic regulator of hematopoietic stem cell development and erythropoiesis. We previously reported that LMO2 transcription is dependent upon Janus kinase 2 (JAK2) kinase activity in HEL cells. Here, we show that the transcriptional changes induced by a JAK2 inhibitor (TG101209) and I-BET151 in HEL cells are significantly over-lapping, suggesting a common pathway of action. We generated JAK2 inhibitor resistant HEL cells and showed that these retain sensitivity to I-BET151. These data highlight I-BET151 as a potential alternative treatment against myeloproliferative neoplasms driven by constitutively active JAK2 kinase.The Kouzarides laboratory was supported by Cancer Research UK, Leukaemia and Lymphoma Research, GlaxoSmithKline and BBSRC. The Green laboratory was supported by Cancer Research UK and Leukaemia and Lymphoma Research, UK. The Gottgens laboratory was supported by Cancer Research UK and Leukaemia and Lymphoma Research, UK. The Huntly laboratory was supported by Cancer Research UK and Leukaemia and Lymphoma Research, UK. M. A Dawson, E Cannizzaro and M. Wiese are funded by the Wellcome Trust Beit Fellowship.This is the accepted manuscript version of the article. The final version is available from http://www.nature.com/leu/journal/v28/n1/full/leu2013234a.html

Los niveles en ayunas de Apolipoproteína b48 no son útiles como marcador de la Hiperliproteinemia tipo I

Los quilomicrones se encuentran elevados en las hiperlipoproteinemias tipo I y tipo V; diferenciar ambas requiere una tediosa ultracentrifugación. Esta comunicación trata de evaluar si la cuantificación en ayunas de la apolipoproteina B48 podría ser útil para diferenciarlasUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Spanish Preanalytical Quality Monitoring Program (SEQC), an overview of 12 years' experience

Preanalytical variables, such as sample collection, handling and transport, may affect patient results. Preanalytical phase quality monitoring should be established in order to minimize laboratory errors and improve patient safety. A retrospective study (2001-2013) of the results obtained through the Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC) External quality assessment (preanalytical phase) was performed to summarize data regarding the main factors affecting preanalytical phase quality. Our aim was to compare data from 2006 to 2013 with a previously published manuscript assessing the 2001-2005 period. A significant decrease in rejection rates was observed both for blood and urine samples. For serum samples, the most frequent rejection causes in the first period were non-received samples (37.5%), hemolysis (29.3%) and clotted samples (14.4%). Conversely, in the second period, hemolysis was the main rejection cause (36.2%), followed by non-received samples (34.5%) and clotted samples (11.1%). For urine samples, the main rejection cause overall was a non-received sample (up to 86.1% of cases in the second period, and 81.6% in the first). For blood samples with anticoagulant, the number of rejections also decreased. While plasma-citrate-ESR still showed the highest percentages of rejections (0.980% vs. 1.473%, p<0.001), the lowest corresponded to whole-blood EDTA (0.296% vs. 0.381%, p<0.001). For the majority of sample types, a decrease in preanalytical errors was confirmed. Improvements in organization, implementation of standardized procedures in the preanalytical phase, and participation in a Spanish external quality assessment scheme may have notably contributed to error reduction in this phase

Country-report pattern corrections of new cases allow accurate 2-week predictions of COVID-19 evolution with the Gompertz model

Accurate short-term predictions of COVID-19 cases with empirical models allow Health Officials to prepare for hospital contingencies in a two–three week window given the delay between case reporting and the admission of patients in a hospital. We investigate the ability of Gompertz-type empiric models to provide accurate prediction up to two and three weeks to give a large window of preparation in case of a surge in virus transmission. We investigate the stability of the prediction and its accuracy using bi-weekly predictions during the last trimester of 2020 and 2021. Using data from 2020, we show that understanding and correcting for the daily reporting structure of cases in the different countries is key to accomplish accurate predictions. Furthermore, we found that filtering out predictions that are highly unstable to changes in the parameters of the model, which are roughly 20%, reduces strongly the number of predictions that are way-off. The method is then tested for robustness with data from 2021. We found that, for this data, only 1–2% of the one-week predictions were off by more than 50%. This increased to 3% for two-week predictions, and only for three-week predictions it reached 10%