The Intercultural Skills Graduates and Businesses in Europe Need Today

It was the aim of the two surveys with European graduates and employers respectively to investigate the importance of intercultural competencies and skills for student employability and business success for European enterprise, now and in the future. The two surveys gave important insights into key factors that support the development of intercultural skills and competencies for graduates and employers across four countries and five different European regions, as well as five distinct universities. Our analysis shows clearly that one of the most important factors is the key role of experience with, and exposure to, people from different cultural backgrounds. Both students and employers scored much higher on important intercultural competencies such as cultural empathy, cognitive flexibility, open-mindedness, and tolerance for ambiguity, if they had frequent interactions with people from other cultures. This was also true for speaking at least one or more foreign languages at an intermediate or advanced level. Foreign language competence is an important intercultural skill not only for communication but also an important way in which cultural empathy and cognitive flexibility are learned and trained. In line with these results, both students and employers who had more exposure to different cultures also felt there was more need to pay attention to intercultural issues and support the development of intercultural skills than those with less experience of different cultures. Furthermore, our results from both the student and the employer surveys seem to reflect differences between more urban/metropolitan centres and more rural areas with smaller towns. London and Bursa are the two largest cities and the most metropolitan areas in our sample with a more multicultural population, whereas Worcester and Leuven are both smaller cities and the regions with the least ethnic diversity. Halmstad falls somewhere in between with a similar size and ethnic composition of the city and region as Worcester and Leuven, but the university itself has a very multicultural and mature student body that is very similar to LSBU in central London. While we cannot directly influence these regional differences in urbanisation and multiculturalism it is certainly important to be aware of them

The Intercultural Skills Graduates and Businesses in Europe Need Today

This ERASMUS+ funded project, “Developing the cross-cultural skills of graduates in response to the needs of European enterprise”, is developed in response to recent research highlighting the importance of intercultural competencies for graduates wanting to work in Europe, the employers’ needs, and the intercultural competencies and skills higher education institutions provide. This project aims to develop the intercultural competencies of graduates in the EU by enhancing the quality and relevance of their knowledge and skills to enable them to be active professionals in the European working environment. Five Higher Education Institutions have participated in this study: University of Worcester (Project lead, UK), London South Bank University (UK), UC Leuven-Limburg (Belgium), Halmstad University (Sweden), and Bursa Uludağ University (Turkey). The diversity of these partners, their respective regional and national contexts, and their experience in working together with regional businesses are central to achieve the project aims. As the first output of the project, this report presents results based on two types of analysis methods and data collected from four European countries (UK, Sweden, Belgium, and Turkey). Firstly, two surveys and the quantitative analysis of data collected from 585 student surveys responses and 403 employer survey responses and secondly, on an analysis of qualitative data collected through 50 interviews with employees in European organizations and 50 interviews with students studying in European universities

Passive and active ventricular elastances of the left ventricle

BACKGROUND: Description of the heart as a pump has been dominated by models based on elastance and compliance. Here, we are presenting a somewhat new concept of time-varying passive and active elastance. The mathematical basis of time-varying elastance of the ventricle is presented. We have defined elastance in terms of the relationship between ventricular pressure and volume, as: dP = EdV + VdE, where E includes passive (E(p)) and active (E(a)) elastance. By incorporating this concept in left ventricular (LV) models to simulate filling and systolic phases, we have obtained the time-varying expression for E(a )and the LV-volume dependent expression for E(p). METHODS AND RESULTS: Using the patient's catheterization-ventriculogram data, the values of passive and active elastance are computed. E(a )is expressed as: [Image: see text]; E(p)is represented as: [Image: see text]. E(a )is deemed to represent a measure of LV contractility. Hence, Peak dP/dt and ejection fraction (EF) are computed from the monitored data and used as the traditional measures of LV contractility. When our computed peak active elastance (E(a,max)) is compared against these traditional indices by linear regression, a high degree of correlation is obtained. As regards E(p), it constitutes a volume-dependent stiffness property of the LV, and is deemed to represent resistance-to-filling. CONCLUSIONS: Passive and active ventricular elastance formulae can be evaluated from a single-beat P-V data by means of a simple-to-apply LV model. The active elastance (E(a)) can be used to characterize the ventricle's contractile state, while passive elastance (E(p)) can represent a measure of resistance-to-filling

Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione

BACKGROUND: Increased airway epithelial proliferation is frequently observed in smokers. To elucidate the molecular mechanisms leading to these epithelial changes, we studied the effect of cigarette smoke condensate (CSC) on cell proliferation, wound closure and mitogen activated protein kinase (MAPK) activation. We also studied whether modulation of intracellular glutathione/thiol levels could attenuate CSC-induced cell proliferation. METHODS: Cells of the bronchial epithelial cell line NCI-H292 and subcultures of primary bronchial epithelial cells were used for the present study. The effect of CSC on epithelial proliferation was assessed using 5-bromo-2-deoxyuridine (BrdU) incorporation. Modulation of epithelial wound repair was studied by analysis of closure of 3 mm circular scrape wounds during 72 hours of culture. Wound closure was calculated from digital images obtained at 24 h intervals. Activation of mitogen-activated protein kinases was assessed by Western blotting using phospho-specific antibodies. RESULTS: At low concentrations CSC increased proliferation of NCI-H292 cells, whereas high concentrations were inhibitory as a result of cytotoxicity. Low concentrations of CSC also increased epithelial wound closure of both NCI-H292 and PBEC, whereas at high concentrations closure was inhibited. At low, mitogenic concentrations, CSC caused persistent activation of ERK1/2, a MAPK involved in cell proliferation. Inhibition of cell proliferation by high concentrations of CSC was associated with activation of the pro-apoptotic MAP kinases p38 and JNK. Modulation of intracellular glutathione (GSH)/thiol levels using N-acetyl-L-cysteine, GSH or buthionine sulphoximine (BSO), demonstrated that both the stimulatory and the inhibitory effects of CSC were regulated in part by intracellular GSH levels. CONCLUSION: These results indicate that CSC may increase cell proliferation and wound closure dependent on the local concentration of cigarette smoke and the anti-oxidant status. These findings are consistent with increased epithelial proliferation in smokers, and may provide further insight in the development of lung cancer

Erratum to Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

International audienc

Management of intra-abdominal infections : recommendations by the WSES 2016 consensus conference

This paper reports on the consensus conference on the management of intra-abdominal infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual World Society of Emergency Surgery (WSES) meeting. This document covers all aspects of the management of IAIs. The Grading of Recommendations Assessment, Development and Evaluation recommendation is used, and this document represents the executive summary of the consensus conference findings.Peer reviewe

Viable Tumor Tissue Adherent to Needle Applicators after Local Ablation: A Risk Factor for Local Tumor Progression

Background. Local tumor progression (LTP) is a serious complication after local ablation of malignant liver tumors, negatively influencing patient survival. LTP may be the result of incomplete ablation of the treated tumor. In this study, we determined whether viable tumor cells attached to the needle applicator after ablation was associated with LTP and disease-free survival. Methods. In this prospective study, tissue was collected of 96 consecutive patients who underwent local liver ablations for 130 liver malignancies. Cells and tissue attached to the needle applicators were analyzed for viability using glucose-6-phosphate-dehydrogenase staining and autofluorescence intensity levels of H&E stained sections. Patients were followed-up until disease progression. Results. Viable tumor cells were found on the needle applicators after local ablation in 26.7% of patients. The type of needle applicator used, an open approach, and the omission of track ablation were significantly correlated with viable tumor tissue adherent to the needle applicator. The presence of viable cells was an independent predictor of LTP. The attachment of viable cells to the needle applicators was associated with a shorter time to LTP. Conclusions. Viable tumor cells adherent to the needle applicators were found after ablation of 26.7% of patients. An independent risk factor for viable cells adherent to the needle applicators is the omission of track ablation. We recommend using only RFA devices that have track ablation functionality. Adherence of viable tumor cells to the needle applicator after local ablation was an independent risk factor for LT