До питання проблематики розвитку логістичного аутсорсингу ринку України

Genomic imprinting, the epigenetic process by which transcription occurs from a single parental allele, is believed influence social behaviours in mammals. An important social behaviour is group living, which is enriched in Eutherian mammals relative to monotremes and marsupials. Group living facilitates resource acquisition, defence of territory and co-care of young, but requires a stable social group with complex inter-individual relationships. Co-occurring with increased group living in Eutherians is an increase in the number of imprinted loci, including that spanning the maternally expressed Cdkn1c. Using a ‘loss-of-imprinting’ model of Cdkn1c (Cdkn1cBACx1), we demonstrated that two-fold over expression of Cdkn1c results in abnormal social behaviours. Although our previous work indicated that male Cdkn1cBACx1 mice were more dominant as measured by tube-test encounters with unfamiliar wild-type males. Building upon this work, using more ecologically relevant assessments of social dominance, indicated that within their normal social group, Cdkn1cBACx1 mice did not occupy higher ranking positions. Nevertheless, we find that presence of Cdkn1cBACx1 animals within a group leads to instability of the normal social hierarchy, as indicated by greater variability in social rank within the group over time and an increase in territorial behaviour in WT cage-mates. Consequently, these abnormal behaviours led to an increased incidence of fighting and wounding within the group. Taken together these data indicate that normal expression of Cdkn1c is required for maintaining stability of the social group and suggests that the acquisition of monoallelic expression of Cdkn1c may have enhanced social behaviour in Eutherian mammals to facilitate group living

Epilepsy and intellectual disability linked protein Shrm4 interaction with GABA B Rs shapes inhibitory neurotransmission

Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we report that Shrm4 is localized to synapses where it regulates dendritic spine morphology and interacts with the C terminus of GABA B receptors (GABA B Rs) to control their cell surface expression and intracellular trafficking via a dynein-dependent mechanism. Knockdown of Shrm4 in rat severely impairs GABA B R activity causing increased anxiety-like behaviour and susceptibility to seizures. Moreover, Shrm4 influences hippocampal excitability by modulating tonic inhibition in dentate gyrus granule cells, in a process involving crosstalk between GABA B Rs and extrasynaptic \uce-subunit-containing GABA A Rs. Our data highlights a role for Shrm4 in synaptogenesis and in maintaining GABA B R-mediated inhibition, perturbation of which may be responsible for the involvement of Shrm4 in cognitive disorders and epilepsy

Tracking Cats: Problems with Placing Feline Carnivores on δ18O, δD Isoscapes

Several felids are endangered and threatened by the illegal wildlife trade. Establishing geographic origin of tissues of endangered species is thus crucial for wildlife crime investigations and effective conservation strategies. As shown in other species, stable isotope analysis of hydrogen and oxygen in hair (δD(h), δ(18)O(h)) can be used as a tool for provenance determination. However, reliably predicting the spatial distribution of δD(h) and δ(18)O(h) requires confirmation from animal tissues of known origin and a detailed understanding of the isotopic routing of dietary nutrients into felid hair.We used coupled δD(h) and δ(18)O(h) measurements from the North American bobcat (Lynx rufus) and puma (Puma concolor) with precipitation-based assignment isoscapes to test the feasibility of isotopic geo-location of felidae. Hairs of felid and rabbit museum specimens from 75 sites across the United States and Canada were analyzed. Bobcat and puma lacked a significant correlation between H/O isotopes in hair and local waters, and also exhibited an isotopic decoupling of δ(18)O(h) and δD(h). Conversely, strong δD and δ(18)O coupling was found for key prey, eastern cottontail rabbit (Sylvilagus floridanus; hair) and white-tailed deer (Odocoileus virginianus; collagen, bone phosphate).Puma and bobcat hairs do not adhere to expected pattern of H and O isotopic variation predicted by precipitation isoscapes for North America. Thus, using bulk hair, felids cannot be placed on δ(18)O and δD isoscapes for use in forensic investigations. The effective application of isotopes to trace the provenance of feline carnivores is likely compromised by major controls of their diet, physiology and metabolism on hair δ(18)O and δD related to body water budgets. Controlled feeding experiments, combined with single amino acid isotope analysis of diets and hair, are needed to reveal mechanisms and physiological traits explaining why felid hair does not follow isotopic patterns demonstrated in many other taxa

Current opinion on the role of testosterone in the development of prostate cancer: a dynamic model

Background: Since the landmark study conducted by Huggins and Hodges in 1941, a failure to distinguish between the role of testosterone in prostate cancer development and progression has led to the prevailing opinion that high levels of testosterone increase the risk of prostate cancer. To date, this claim remains unproven. Presentation of the Hypothesis: We present a novel dynamic mode of the relationship between testosterone and prostate cancer by hypothesizing that the magnitude of age-related declines in testosterone, rather than a static level of testosterone measured at a single point, may trigger and promote the development of prostate cancer. Testing of the Hypothesis: Although not easily testable currently, prospective cohort studies with population-representative samples and repeated measurements of testosterone or retrospective cohorts with stored blood samples from different ages are warranted in future to test the hypothesis. Implications of the Hypothesis: Our dynamic model can satisfactorily explain the observed age patterns of prostate cancer incidence, the apparent conflicts in epidemiological findings on testosterone and risk of prostate cancer, racial disparities in prostate cancer incidence, risk factors associated with prostate cancer, and the role of testosterone in prostate cancer progression. Our dynamic model may also have implications for testosterone replacement therapy

Can Explanatory Style be Scored from TAT Protocols?

Explanatory style is a cognitive personality variable reflecting how people habitually explain the causes of bad events that involve themselves. Usually measured with a questionnaire, it can also be scored from verbal material such as interviews and essays. Unexplored to date is whether explanatory style can be assessed from stories written in response to pictures. College students (N = 108) completed the Expanded Attributional Style Questionnaire (EASQ) and the Beck Depression Inventory (BDJ) and responded to four Thematic Apperception Test (TAT) pictures chosen to elicit negative themes. Causal explanations were identified in the TAT protocols and reliably rated along the attributional dimensions of stability and globality. These ratings were consistent within subjects, and they correlated with the BDI. They correlated with globality as measured by the EASQ but not with stability.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68565/2/10.1177_0146167294201010.pd

George Herbert Mead: contribuições para a história da psicologia social George Herbert Mead: contributions to history of the social psychology

Com este artigo pretende-se contribuir para a compreensão histórica de um autor/personagem da Psicologia. Analisamos e acrescemos conhecimento sobre George Herbert Mead e os desdobramentos de sua teoria psicossocial. Para esse propósito, explicitaremos, no texto, uma das vertentes analíticas utilizadas em nossa dissertação, qual seja: por meio da abordagem social em história da psicologia, confrontamos a vida de Mead com momentos de constituição da psicologia, colocando em relevo aspectos centrais dessa interlocução nem sempre identificados. Correlacionamos a história de Mead com questões sociais, políticas, econômicas e científicas, assim como suas conexões com práticas e valores culturais específicos de sua época. Buscamos compreender sua limitada difusão na ciência psicológica, dando, assim, continuidade ao processo de (re)volta do autor.<br>This article intends to contribute to historical understanding of author/character of Psychology. We analyzed and enlarged knowledge about George Herbert Mead and the developing of his psychosocial theory. For this reason, we will explain in the text as analytical side used in our dissertation, in other words: through of the social approach in history of psychology we confront the life of Mead with facts of constitution of the psychology, emphasizing central aspects of this discussion not always identified. We correlate the history of Mead with social, politic, economic and scientific questions as well as his connections with practices and specific cultural values of his time. We look to understand his limited diffusion in the psychological science, giving, so, continuity to the process of returns of the author