Cause related marketing and its impact on sales: mediating by brand loyalty and customer purchase intention

The objective of this study is to test both CRM and sales are related direct one and examines the impact of CRM campaigns on brand loyalty, consumer purchase intention and ultimately on sales. The questionnaire was distributed among students and employees of different universities and organizations. A total of 629 properly filled questionnaires were processed for analysis. A five point Likert scale was used to assess the respondents’ level of agreement or disagreement. This study concludes that the cause related marketing campaigns have positive influence on the sale activities of companies. This link is also mediated by brand loyalty and consumer purchase intention that eventually have positive effect on sales

Diversified Traditional Wooden Implements Used in Agriculture and Animal Husbandry Practices in Ladakh

The traditional wooden tools are the necessities of the daily life of the people of Ladakh region and are linked directly with geographical conditions of the region. A lot of diversity in the wooden tools used by the tribal farmers of Ladakh since ancient times is observed. The tools are made up of different, locally available materials in a unique fashion by the localites. These wooden implements are preferred over modern one’s because of their multipurpose uses. Secondly these traditional implements find wide applicability in the region because of steep terrain, where the scope of mechanized farm implements is very limited. In the present study few important traditional tools of Ladakh have been presented. The important tools viz; chepo, shak, zungba, rzgeem, saddle, khem, khaczhay, thougk, gourgur, butter churner, plough, smeing, rbhat, grookook etc. have been described in detail in this paper

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose its aggregation-prone hydrophobic core, prompting self-assembly of mutant p53 into inactive cytosolic amyloid-like aggregates. Screening an oligopyridylamide library, previously shown to inhibit amyloid formation associated with Alzheimer\u2019s disease and type II diabetes, identified a tripyridylamide, ADH-6, that abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. Moreover, ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53\u2019s transcriptional activity, leading to cell cycle arrest and apoptosis. Notably, ADH-6 treatment effectively shrinks xenografts harboring mutant p53, while exhibiting no toxicity to healthy tissue, thereby substantially prolonging survival. This study demonstrates the successful application of a bona fide small-molecule amyloid inhibitor as a potent\ua0anticancer agent

Helicity-dependent cross sections and double-polarization observable E in η photoproduction from quasifree protons and neutrons

Precise helicity-dependent cross sections and the double-polarization observable E were measured for η photoproduction from quasifree protons and neutrons bound in the deuteron. The η → 2γ and η → 3π0 → 6γ decay modes were used to optimize the statistical quality of the data and to estimate systematic uncertainties. The measurement used the A2 detector setup at the tagged photon beam of the electron accelerator MAMI in Mainz. A longitudinally polarized deuterated butanol target was used in combination with a circularly polarized photon beam from bremsstrahlung of a longitudinally polarized electron beam. The reaction products were detected with the electromagnetic calorimeters Crystal Ball and TAPS, which covered 98% of the full solid angle. The results show that the narrow structure observed earlier in the unpolarized excitation function of η photoproduction off the neutron appears only in reactions with antiparallel photon and nucleon spin (σ1/2). It is absent for reactions with parallel spin orientation (σ3/2) and thus very probably related to partial waves with total spin 1/2. The behavior of the angular distributions of the helicity-dependent cross sections was analyzed by fitting them with Legendre polynomials. The results are in good agreement with a model from the Bonn-Gatchina group, which uses an interference of P11 and S11 partial waves to explain the narrow structure

Hydrogen injection in a dual fuel engine fueled with low-pressure injection of methyl ester of peruvenia thevetia [MEPT] for diesel engine maintenance application

The present work is mapped to scrutinize the consequence of biodiesel and gaseous fuel properties, and their impact on compression-ignition (CI) engine combustion and emission characteristics in single and dual fuel operation. Biodiesel prepared from non-edible oil source derived from Thevetia peruviana belonging to the plant family of Apocynaceaeis. The fuel has been referred as methyl ester of Thevetia peruviana (METP) and adopted as pilot fuel for the effective combustion of compressed gaseous fuel of hydrogen. This investigation is an effort to augment the engine performance of a biodiesel-gaseous fueled diesel engine operated under varied engine parameters. Subsequently, consequences of gas flow rate, injection timing, gas entry type, and manifold gas injection on the modified dual-fuel engine using conventional mechanical fuel injections (CMFIS) for optimum engine performance were investigated. Fuel consumption, CO, UHC, and smoke formations are spotted to be less besides higher NOx emissions compared to CMFIS operation. The fuel burning features such as ignition delay, burning interval, and variation of pressure and heat release rates with crank angle are scrutinized and compared with base fuel. Sustained research in this direction can convey practical engine technology, concerning fuel combinations in the dual fuel mode, paving the way to alternatives which counter the continued fossil fuel utilization that has detrimental impacts on the climate

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods: We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2·5th and 97·5th percentiles across 1000 posterior draws for each quantity of interest. Findings: From an estimated 13·7 million (95% UI 10·9–17·1) infection-related deaths in 2019, there were 7·7 million deaths (5·7–10·2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13·6% (10·2–18·1) of all global deaths and 56·2% (52·1–60·1) of all sepsis-related deaths in 2019. Five leading pathogens—Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa—were responsible for 54·9% (52·9–56·9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185–285) per 100 000 population, and lowest in the high-income super-region, with 52·2 deaths (37·4–71·5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation: The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Funding: Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care, using UK aid funding managed by the Fleming Fund

First measurement of polarisation transfer Cx′nC^n_{x'} in deuteron photodisintegration

A first measurement of the polarisation transfer from a circularly-polarised photon to the final state neutron ($C^n_{x'}$) in deuterium photodisintegration has been carried out. This quantity is determined over the photon energy range 370~--~700~MeV and for neutron centre-of-mass breakup angles $\sim45-120^{\circ}$. The polarisation of the final state neutrons was determined by an ancillary large-acceptance nucleon polarimeter, surrounding a cryogenic liquid deuterium target within the Crystal Ball detector at MAMI. The polarimeter characterised $(n,p)$ charge exchange of the ejected neutrons to determine their polarisation. The new $C^n_{x'}$ data are also compared to a theoretical model based on nucleonic and nucleon resonance degrees of freedom constrained by the current world-database of deuterium photodisintegration measurements. Structures in $C^n_{x'}$ observed in the region of the $d^*(2380)$ could not be explained by conventional models of deuteron photodisintegration

Genetic architecture of common bunt resistance in winter wheat using genome-wide association study

Background: Common bunt (caused by Tilletia caries and T. foetida) has been considered as a major disease in wheat (Triticum aestivum) following rust (Puccinia spp.) in the Near East and is economically important in the Great Plains, USA. Despite the fact that it can be easily controlled using seed treatment with fungicides, fungicides often cannot or may not be used in organic and low-input fields. Planting common bunt resistant genotypes is an alternative. Results: To identify resistance genes for Nebraska common bunt race, the global set of differential lines were inoculated. Nine differential lines carrying nine different genes had 0% infected heads and seemed to be resistant to Nebraska race. To understand the genetic basis of the resistance in Nebraska winter wheat, a set of 330 genotypes were inoculated and evaluated under field conditions in two locations. Out of the 330 genotypes, 62 genotypes had different degrees of resistance. Moreover, plant height, chlorophyll content and days to heading were scored in both locations. Using genome-wide association study, 123 SNPs located on fourteen chromosomes were identified to be associated with the resistance. Different degrees of linkage disequilibrium was found among the significant SNPs and they explained 1.00 to 9.00% of the phenotypic variance, indicating the presence of many minor QTLs controlling the resistance. Conclusion: Based on the chromosomal location of some of the known genes, some SNPs may be associated with Bt1, Bt6, Bt11 and Bt12 resistance loci. The remaining significant SNPs may be novel alleles that were not reported previously. Common bunt resistance seems to be an independent trait as no correlation was found between a number of infected heads and chlorophyll content, days to heading or plant height

Signatures of the d∗(2380)d^*(2380) hexaquark in d(γγ,pn⃗p\vec{n})

We report a measurement of the spin polarisation of the recoiling neutron in deuterium photodisintegration, utilising a new large acceptance polarimeter within the Crystal Ball at MAMI. The measured photon energy range of 300~--~700~MeV provides the first measurement of recoil neutron polarisation at photon energies where the quark substructure of the deuteron plays a role, thereby providing important new constraints on photodisintegration mechanisms. A very high neutron polarisation in a narrow structure centred around $E_{\gamma}\sim$~570~MeV is observed, which is inconsistent with current theoretical predictions employing nucleon resonance degrees of freedom. A Legendre polynomial decomposition suggests this behaviour could be related to the excitation of the $d^*(2380)$ hexaquark

Single π0\pi^0 Production Off Neutrons Bound in Deuteron with Linearly Polarized Photons

The quasifree $\overrightarrow{\gamma} d\to\pi^0n(p)$ photon beam asymmetry, $\Sigma$, has been measured at photon energies, $E_\gamma$, from 390 to 610 MeV, corresponding to center of mass energy from 1.271 to 1.424 GeV, for the first time. The data were collected in the A2 hall of the MAMI electron beam facility with the Crystal Ball and TAPS calorimeters covering pion center-of-mass angles from 49 to 148$^\circ$. In this kinematic region, polarization observables are sensitive to contributions from the $\Delta (1232)$ and $N(1440)$ resonances. The extracted values of $\Sigma$ have been compared to predictions based on partial-wave analyses (PWAs) of the existing pion photoproduction database. Our comparison includes the SAID, MAID, and Bonn-Gatchina analyses; while a revised SAID fit, including the new $\Sigma$ measurements, has also been performed. In addition, isospin symmetry is examined as a way to predict $\pi^0n$ photoproduction observables, based on fits to published data in the channels $\pi^0p$, $\pi^+n$, and $\pi^-p$.Comment: 11 pages, 9 figures, 5 tables; fixed 2 glitche