The Social Networks of Korean Female Adult Learners in a Middle School

This study investigates the social networks of Korean female adult learners in middle school through social network analysis and examines the development of these networks by interviewing the main actors involved

The variation of relative magnetic helicity around major flares

We have investigated the variation of magnetic helicity over a span of several days around the times of 11 X-class flares which occurred in seven active regions (NOAA 9672, 10030, 10314, 10486, 10564, 10696, and 10720) using the magnetograms taken by the Michelson Doppler Imager (MDI) on board the Solar and Heliospheric Observatory (SOHO). As a major result we found that each of these major flares was preceded by a significant helicity accumulation over a long period (0.5 to a few days). Another finding is that the helicity accumulates at a nearly constant rate and then becomes nearly constant before the flares. This led us to distinguish the helicity variation into two phases: a phase of monotonically increasing helicity and the following phase of relatively constant helicity. As expected, the amount of helicity accumulated shows a modest correlation with time-integrated soft X-ray flux during flares. However, the average helicity change rate in the first phase shows even stronger correlation with the time-integrated soft X-ray flux. We discuss the physical implications of this result and the possibility that this characteristic helicity variation pattern can be used as an early warning sign for solar eruptions

FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells

BACKGROUND: Hematopoiesis is a complex developmental process controlled by a large number of factors that regulate stem cell renewal, lineage commitment and differentiation. Secreted proteins, including the hematopoietic growth factors, play critical roles in these processes and have important biological and clinical significance. We have employed representational difference analysis to identify genes that are differentially expressed during experimentally induced myeloid differentiation in the murine EML hematopoietic stem cell line. RESULTS: One identified clone encoded a previously unidentified protein of 541 amino acids that contains an amino terminal signal sequence but no other characterized domains. This protein is a member of family of related proteins that has been named family with sequence similarity 20 (FAM20) with three members (FAM20A, FAM20B and FAM20C) in mammals. Evolutionary comparisons revealed the existence of a single FAM20 gene in the simple vertebrate Ciona intestinalis and the invertebrate worm Caenorhabditis elegans and two genes in two insect species, Drosophila melanogaster and Anopheles gambiae. Six FAM20 family members were identified in the genome of the pufferfish, Fugu rubripes and five members in the zebrafish, Danio rerio. The mouse Fam20a protein was ectopically expressed in a mammalian cell line and found to be a bona fide secreted protein and efficient secretion was dependent on the integrity of the signal sequence. Expression analysis revealed that the Fam20a gene was indeed differentially expressed during hematopoietic differentiation and that the other two family members (Fam20b and Fam20c) were also expressed during hematcpoiesis but that their mRNA levels did not vary significantly. Likewise FAM20A was expressed in more limited set of human tissues than the other two family members. CONCLUSIONS: The FAM20 family represents a new family of secreted proteins with potential functions in regulating differentiation and function of hematopoietic and other tissues. The Fam20a mRNA was only expressed during early stages of hematopoietic development and may play a role in lineage commitment or proliferation. The expansion in gene number in different species suggests that the family has evolved as a result of several gene duplication events that have occurred in both vertebrates and invertebrates

Demography of SDSS early-type galaxies from the perspective of radial color gradients

We have investigated the radial g-r color gradients of early-type galaxies in the Sloan Digital Sky Survey (SDSS) DR6 in the redshift range 0.00<z<0.06. The majority of massive early-type galaxies show a negative color gradient (red-cored) as generally expected for early-type galaxies. On the other hand, roughly 30 per cent of the galaxies in this sample show a positive color gradient (blue-cored). These "blue-cored" galaxies often show strong H beta absorption line strengths and/or emission line ratios that are indicative of the presence of young stellar populations. Combining the optical data with Galaxy Evolution Explorer (GALEX) UV photometry, we find that all blue-cored galaxies show UV-optical colors that can only be explained by young stellar populations. This implies that most of the residual star formation in early-type galaxies is centrally concentrated. Blue-cored galaxies are predominantly low velocity dispersion systems. A simple model shows that the observed positive color gradients (blue-cored) are visible only for a billion years after a star formation episode for the typical strength of recent star formation. The observed effective radius decreases and the mean surface brightness increases due to this centrally-concentrated star formation episode. As a result, the majority of blue-cored galaxies may lie on different regions in the Fundamental Plane from red-cored ellipticals. However, the position of the blue-cored galaxies on the Fundamental Plane cannot be solely attributed to recent star formation but require substantially lower velocity dispersion. We conclude that a low-level of residual star formation persists at the centers of most of low-mass early-type galaxies, whereas massive ones are mostly quiescent systems with metallicity-driven red cores.Comment: 15 pages, 19 figures, accepted for publication in ApJ

Genetics of kidney development: pathogenesis of renal anomalies

Congenital anomalies of the kidney and urinary tract (CAKUT) account for more than 50% of abdominal masses found in neonates and involve about 0.5% of all pregnancies. CAKUT has a major role in renal failure, and increasing evidence suggests that certain abnormalities predispose to the development of hypertension and cardiovascular disease in adulthood. To understand the pathogenesis of human renal anomalies, understanding the development of kidney is important. Diverse anomalies of the kidney corresponding to defects at a particular stage of development have been documented recently; however, more research is required to understand the molecular networks underlying kidney development, and such an investigation will provide a clue to the therapeutic intervention for CAKUT

Genetics of kidney development: pathogenesis of renal anomalies

Congenital anomalies of the kidney and urinary tract (CAKUT) account for more than 50% of abdominal masses found in neonates and involve about 0.5% of all pregnancies. CAKUT has a major role in renal failure, and increasing evidence suggests that certain abnormalities predispose to the development of hypertension and cardiovascular disease in adulthood. To understand the pathogenesis of human renal anomalies, understanding the development of kidney is important. Diverse anomalies of the kidney corresponding to defects at a particular stage of development have been documented recently; however, more research is required to understand the molecular networks underlying kidney development, and such an investigation will provide a clue to the therapeutic intervention for CAKUT

Probing black hole accretion tracks, scaling relations, and radiative efficiencies from stacked X-ray active galactic nuclei

The masses of supermassive black holes at the centres of local galaxies appear to be tightly correlated with the mass and velocity dispersions of their galactic hosts. However, the local Mbh–Mstar relation inferred from dynamically measured inactive black holes is up to an order-of-magnitude higher than some estimates from active black holes, and recent work suggests that this discrepancy arises from selection bias on the sample of dynamical black hole mass measurements. In this work, we combine X-ray measurements of the mean black hole accretion luminosity as a function of stellar mass and redshift with empirical models of galaxy stellar mass growth, integrating over time to predict the evolving Mbh–Mstar relation. The implied relation is nearly independent of redshift, indicating that stellar and black hole masses grow, on average, at similar rates. Matching the de-biased local Mbh–Mstar relation requires a mean radiative efficiency ε ≳ 0.15, in line with theoretical expectations for accretion on to spinning black holes. However, matching the ‘raw’ observed relation for inactive black holes requires ε ∼ 0.02, far below theoretical expectations. This result provides independent evidence for selection bias in dynamically estimated black hole masses, a conclusion that is robust to uncertainties in bolometric corrections, obscured active black hole fractions, and kinetic accretion efficiency. For our fiducial assumptions, they favour moderate-to-rapid spins of typical supermassive black holes, to achieve ε ∼ 0.12–0.20. Our approach has similarities to the classic Soltan analysis, but by using galaxy-based data instead of integrated quantities we are able to focus on regimes where observational uncertainties are minimized

CB2 and GPR55 receptors as therapeutic targets for systemic immune dysregulation

The endocannabinoid system (ECS) is involved in many physiological processes and has been suggested to play critical roles in the immune response and the central nervous system (CNS). Therefore, ECS modulation has potential therapeutic effects on immune dysfunctional disorders, such as sepsis and CNS injury-induced immunodeficiency syndrome (CIDS). In sepsis, excessive release of pro- and anti-inflammatory mediators results in multi-organ dysfunction/failure and death. In CIDS, an acute CNS injury dysregulates a normally well-balanced interplay between the CNS and immune system, leading to increased patients’ susceptibility to infections. In this review, we will discuss potential therapeutic modulation of the immune response in sepsis and CNS injury by manipulation of the ECS representing a novel target for immunotherapy