74 research outputs found
Propofol has delayed myocardial protective effects after a regional ischemia/reperfusion injury in an in vivo rat heart model
Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis
We retrospectively compared the outcomes of 225 patients with adult acquired aplastic anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those treated by alloHSCT from alternative donors (ADs). Univariate and multivariate analyses of factors associated with survival were performed. Multivariate analysis showed that age at alloHSCT of โค31 years, MRD, successful engraftment, absence of acute graft-versus-host disease (aGVHD), and platelet engraftment at โค21 days, were independent predictors of longer survival. In addition, time to aGVHD and cumulative nonrelapse mortality (NRM) were better in MRD than in AD recipients. Using propensity score matching (PSM), we performed a case-control study comparing 25 patients in each group who underwent alloHSCT from MRDs and ADs. Pretransplantation clinical factors were well balanced in either group. Median survival time was similar, and no statistically significant difference in transplantation outcomes was apparent when MRD and AD recipients were compared. In conclusion, our results suggest that alloHSCT from an AD should be considered earlier in adult patients with AA who do not have an MRD
Inter-arm arterial pressure difference caused by prone position in the thoracic outlet syndrome patient -A case report-
Thoracic outlet syndrome has neurologic symptoms caused by compression of brachial plexus, blood vessel symptoms are caused by compression of the artery or vein. The authors report a case of sudden decrease in blood pressure of the left arm after turning the patient from supine position to prone position. They confirmed that the patient had thoracic outlet syndrome after performing computed tomography
Interleukin-13 and Its Receptors in Idiopathic Interstitial Pneumonia: Clinical Implications for Lung Function
Idiopathic interstitial pneumonia (IIP) is characterized by varying degrees of interstitial fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-ฮณ has antifibrotic potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-ฮณ were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10 nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of IL-13 and IL-13Rฮฑ1/ฮฑ2 in lung tissues was analyzed using ELISA and immunohistochemistry. IL-13 levels were significantly higher in IPF patients than the others (P<0.05). IL-4 levels were higher in both IPF and NSIP patients than in normal controls (P<0.05), and IFN-ฮณ levels were lower in NSIP patients than in normal controls (P=0.047). IL-13 levels correlated inversely with FVC% (r=-0.47, P=0.043) and DLCO% (r=-0.58, P=0.014) in IPF and NSIP patients. IL-13 was strongly expressed in the smooth muscle, bronchial epithelium, alveolar macrophages and endothelium of IPF patients. IL-13Rฮฑ1, rather than IL-13Rฮฑ2, was strongly expressed in the smooth muscle, bronchial epithelium, and endothelium of IPF patients. IL-13 and its receptors may contribute to the pathogenesis of fibrosis in IIP and appear to be related to the severity of the disease
Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (1996-2005): A Retrospective Multicenter Study
The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children. We retrospectively surveyed invasive bacterial infections in immunocompetent children caused by eight major pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 to 2005. A total of 768 cases were identified. S. agalactiae (48.1%) and S. aureus (37.2%) were the most common pathogens in infants younger than 3 months. S. agalactiae was a common cause of meningitis (73.0%), bacteremia without localization (34.0%), and arthritis (50%) in this age group. S. pneumoniae (45.3%) and H. influenzae (20.4%) were common in children aged 3 months to 5 yr. S. pneumoniae was a common cause of meningitis (41.6%), bacteremia without localization (40.0%), and bacteremic pneumonia (74.1%) in this age group. S. aureus (50.6%), Salmonella species (16.9%), and S. pneumoniae (16.3%) were common in older children. A significant decline in H. influenzae infections over the last 10 yr was noted. S. agalactiae, S. pneumoniae, and S. aureus are important pathogens responsible for invasive bacterial infections in Korean children
Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database
On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID-19), increasing remdesivir prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remdesivir remain unknown. We aimed to characterize the CV adverse drug reactions (ADRs) associated with remdesivir using VigiBase, an individual case safety report database of the World Health Organization (WHO). Disproportionality analyses of CV-ADRs associated with remdesivir were performed using reported odds ratios and information components. We conducted in vitro experiments using cardiomyocytes derived from human pluripotent stem cell cardiomyocytes (hPSC-CMs) to confirm cardiotoxicity of remdesivir. To distinguish drug-induced CV-ADRs from COVID-19 effects, we restricted analyses to patients with COVID-19 and found that, after adjusting for multiple confounders, cardiac arrest (adjusted odds ratio [aOR]: 1.88, 95% confidence interval [CI]: 1.08โ3.29), bradycardia (aOR: 2.09, 95% CI: 1.24โ3.53), and hypotension (aOR: 1.67, 95% CI: 1.03โ2.73) were associated with remdesivir. In vitro data demonstrated that remdesivir reduced the cell viability of hPSC-CMs in time- and dose-dependent manners. Physicians should be aware of potential CV consequences following remdesivir use and implement adequate CV monitoring to maintain a tolerable safety margin
Depolarization Ratio Retrievals Using AERONET Sun Photometer Data
We present linear particle depolarization ratios (LPDRs) retrieved from measurements with an AERONET Sun photometer at the Gwangju Institute of Science and Technology (GIST), Korea (35.10 degrees N, 126.53 E) between 19 October and 3 November 2009. The Sun photometer data were classified into three categories according to Angstrom exponent and size distribution: 1) pure Asian dust (19 October 2009), 2) Asian dust mixed with urban pollution observed in the period from 20-26 October 2009, and 3) clean conditions (3 November). We show that the LPDRs can be used to distinguish among Asian dust, mixed aerosol, and non-Asian dust in the atmosphere. The mean LPDR of the pure Asian dust case is 23%. Mean LPDRs are 13% for the mixed case. The lowest mean LPDR is 6% in the clean case. We compare our results to vertically resolved LPDRs (at 532 nm) measured by a Raman LIDAR system at the same site. In most cases, we find good agreement between LPDRs derived with Sun photometer and measured by LIDAR.Peer reviewe
Totally endovascular aortic arch repair by branched stent graft placement
Several methods for endovascular aortic arch repair have been proposed to reduce the morbidity and mortality associated with conventional open surgery for aortic arch aneurysms. We report our experience with aortic arch aneurysm repair by a totally endovascular technique, that is, a โreversedโ stent graft technique using branched stent grafts
Genetic polymorphisms of the IL-1ฮฒ genes in periodontally healthy Korean population
Interleukine-1(IL-1)์ ์ฌ๋ฌ ๊ฐ์ง ๊ธฐ๋ฅ์ ๊ฐ์ง ์ธ์ดํ ์นด์ธ์ผ๋ก์จ ๋ฏธ์๋ฌผ์ ๋ํ ๋ฉด์ญ๋ฐ์์ ์ผ์ผํจ๋ค. IL-1์ ์ ์ ์ ๋คํ์ฑ๊ณผ ์น์ฃผ์งํ๊ณผ์ ๊ด๋ จ์ฑ์ ๋ํ ๋ง์ ์ฐ๊ตฌ๊ฐ ์์ด์์ง๋ง, ๋๋ถ๋ถ์ด ๋ฐฑ์ธ์ ๋์์ผ๋ก ํ ์ฐ๊ตฌ์๋ค. ์ดํ ์ค๊ตญ์ธ๊ณผ ์ผ๋ณธ์ธ์ ๋์์ผ๋ก ํ ์ฐ๊ตฌ์์ IL-1์ ์ ์ ์ ๋คํ์ฑ์ ๋ถํฌ๊ฐ ์ธ์ข
๊ฐ์ ์ฐจ์ด๋ฅผ ๋ณด์ธ๋ค๋ ์ ์ด ๋ฐ๊ฒฌ๋์๋ค. ์ด๋ฒ ์ฐ๊ตฌ์์๋ ์น์ฃผ์ ์ผ๋ก ๊ฑด๊ฐํ ํ๊ตญ์ธ์์ IL-1ฮฒ-511, IL-1ฮฒ+3954, IL-1RN์ ๋ํ ์ ์ ์ํ์ ๋ถํฌ๋ฅผ ์กฐ์ฌํ๊ณ ์ ํ์๋ค. ์์ธ๋ํ๊ต ์น๊ณผ๋ณ์์ ๊ทผ๋ฌดํ๋ ์น๊ณผ์์ฌ, ์น๊ณผ์์์ฌ, ๊ฐํธ์กฐ๋ฌด์ฌ ๋ฐ ์์ธ๋ํ๊ต ์น๊ณผ๋ํ 4ํ๋
ํ์ ์ค ์น์ฃผ๋ญ ๊น์ด์ ๋ถ์ฐฉ์์ค์ด 4mm ์ดํ์ธ ์น์ฃผ์ ์ผ๋ก ๊ฑด๊ฐํ ํ๊ตญ์ธ 65๋ช
์ ๋์์ผ๋ก ํ์๋ค. IL-1ฮฒ-511, IL-1ฮฒ+3954, IL-1RN์ ์ ์ ์ ๋คํ์ฑ์ ๋ถ๋ฆฌํ DNA์ ๊ฐ ๋๋ฆฝ์ ์ ์์ ํน์ด์ฑ์ ์ง๋ primer๋ฅผ ๋ฃ๊ณ PCR(Polymerase Chain Reaction)๋ฒ์ ์ด์ฉํ์ฌ ์ฆํญ์ํจํ ์ ๊ธฐ์๋๋ฒ์ ์ด์ฉํ์ฌ ๊ฐ ๋๋ฆฝ์ ์ ์์ ์กด์ฌ๋ฅผ ํ์ธํจ์ผ๋ก์จ ๊ฒฐ์ ํ์๋ค. IL-1ฮฒ-511 ๋๋ฆฝ์ ์ ์ 11, ๋๋ฆฝ์ ์ ์ 12, ๋๋ฆฝ์ ์ ์ 22์ ์ ์ ์ํ์ ๋ํ์ฌ ๊ฐ๊ฐ 23.1%, 49.2%, 26.2%์ ๋ถํฌ๋ฅผ ๋ณด์๋ค. IL-1ฮฒ+3954์ ์ ์ ์ ๋คํ์ฑ์ ๋๋ฆฝ์ ์ ์ 11, ๋๋ฆฝ์ ์ ์ 12์ ์ ์ ์ํ์ ๋ํ์ฌ ๊ฐ๊ฐ 89.2%, 10.8%์ ๋ถํฌ๋ฅผ ๋ณด์์ผ๋ฉฐ, ๋๋ฆฝ์ ์ ์ 22์ ์ ์ ์ํ์ ๊ฐ๋ ์ฌ๋์ ํ๋ช
๋ ๋ฐ๊ฒฌ๋์ง ์์๋ค. IL-1RN์ ์ ์ ์ํ์ 5๊ฐ์ง์ ๋๋ฆฝ์ ์ ์ ์ค์์ 1, ๋๋ฆฝ์ ์ ์ 2, ๋๋ฆฝ์ ์ ์ 4๋ง์ผ ๋ฐ๊ฒฌ๋์์ผ๋ฉฐ, ๋๋ฆฝ์ ์ ์ 11, ๋๋ฆฝ์ ์ ์ 12, ๋๋ฆฝ์ ์ ์ 14์ ์ ์ ์ํ์ด 86.2%, 12.3%, 1.5%๋ก ๋ถํฌํ์๋ค. ์ด๋ฅผ ๋ฐํ์ผ๋ก ๊ฐ ๋๋ฆฝ์ ์ ์์ ๋ฐ์๋น๋ ๊ณ์ฐํ ๊ฒฐ๊ณผ IL-1ฮฒ-511์์๋ ๋๋ฆฝ์ ์ ์ 1๊ณผ 2์ ๋น์จ์ด ๊ฑฐ์ ์ ์ฌํ์์ผ๋ (47.7%, 52.3%), IL-1ฮฒ+3954, IL-1RN์์๋ ๋๋ฆฝ์ ์ ์ 1์ด 90%์ด์ ๋ฐ๊ฒฌ๋์์ผ๋ฉฐ, ๋ํ ๋๋ฆฝ์ ์ ์ 1์ธ์ ๋ค๋ฅธ ๋๋ฆฝ์ ์ ์๊ฐ ๋ฐ๊ฒฌ๋ ๊ฒฝ์ฐ, ๋ชจ๋ ์ดํ์ ํฉ์ฒด์๋ค. ์ด ์ฐ๊ตฌ๋ IL-1ฮฒ-511, IL-1ฮฒ+3954, IL-1RN์ ๋ํ ์ ์ ์ํ์ ๋ถํฌ๋ฅผ ์กฐ์ฌํ ๊ฒ์ผ๋ก ํ๊ตญ์ธ์์ ์ด๋ค ์ ์ ์์ ์ ์ ์ํ์ ๋ถํฌ๋ ๋ฐฑ์ธ์์์ ๋ถํฌ์ ์ฐจ์ด๋ฅผ ๋ณด์ด๊ณ ์์๋ค. ์ดํ ์น์ฃผ์งํ์์ ์ ์ ์ํ ๋ถํฌ์์ ๋น๊ต๋ก ์น์ฃผ์งํ๊ณผ IL-1ฮฒ-511, IL-1ฮฒ+3954, IL-1RN์ ์ ์ ์๋คํ์ฑ๊ณผ์ ๊ด๋ จ์ฑ์ ๊ดํ ์ถ๊ฐ์ ์ธ ์ฐ๊ตฌ๊ฐ ํ์ํ ๊ฒ์ผ๋ก ์ฌ๊ฒจ์ง๋ค.This study was supported by a grant of the Korea Health 21 R & D Project. Ministry of Health & Welfare. Republic of Kore
์น์ฃผ์ ์ผ๋ก ๊ฑด๊ฐํ ํ๊ตญ์ธ์์ IL-1 ฮฒ ์ ์ ์์ ์ ์ ์ ๋คํ์ฑ ๋ฐ์๋น๋์ ๊ดํ ์ฐ๊ตฌ
Interleukine-1(IL-1)์ ์ฌ๋ฌ๊ฐ์ง ๊ธฐ๋ฅ์ ๊ฐ์ง ์ธ์ดํ ์นด์ธ์ผ๋ก์จ ๋ฏธ์๋ฌผ์ ๋ํ ๋ฉด์ญ๋ฐ์์ ์ผ์ผํจ๋ค. IL-1์ ์ ์ ์ ๋คํ์ฑ๊ณผ ์น์ฃผ์งํ๊ณผ์ ๊ด๋ จ์ฑ์ ๋ํ ๋ง์ ์ฐ๊ตฌ๊ฐ ์์ด์์ง๋ง, ๋๋ถ๋ถ์ด ๋ฐฑ์ธ์ ๋์์ผ๋ก ํ ์ฐ๊ตฌ์๋ค. ์ดํ ์ค๊ตญ์ธ๊ณผ ์ผ๋ณธ์ธ์ ๋์์ผ๋ก ํ ์ฐ๊ตฌ์์ IL-1์ ์ ์ ์ ๋คํ์ฑ์ ๋ถํฌ๊ฐ ์ธ์ข
๊ฐ์ ์ฐจ์ด๋ฅผ ๋ณด์ธ๋ค๋ ์ ์ด ๋ฐ๊ฒฌ๋์๋ค. ์ด๋ฒ ์ฐ๊ตฌ์์๋ ์น์ฃผ์ ์ผ๋ก ๊ฑด๊ฐํ ํ๊ตญ์ธ์์ IL-1 ฮฒ-511, IL-1 ฮฒ+3954, IL-1RN์ ๋ํ ์ ์ ์ํ์ ๋ถํฌ๋ฅผ ์กฐ์ฌํ๊ณ ์ ํ์๋ค.
์์ธ๋ํ๊ต ์น๊ณผ๋ณ์์์ ๊ทผ๋ฌดํ๋ ์น๊ณผ์์ฌ, ์น๊ณผ์์์ฌ, ๊ฐํธ์กฐ๋ฌด์ฌ ๋ฐ ์์ธ๋ํ๊ต ์น๊ณผ๋ํ 4ํ๋
ํ์ ์ค ์น์ฃผ๋ญ ๊น์ด์ ๋ถ์ฐฉ์์ค์ด 4mm ์ดํ์ธ ์น์ฃผ์ ์ผ๋ก ๊ฑด๊ฐํ ํ๊ตญ์ธ 65๋ช
์ ๋์์ผ๋ก ํ์๋ค. IL-1 ฮฒ-511, IL-1 ฮฒ+3954, IL-1RN์ ์ ์ ์ ๋คํ์ฑ์ ๋ถ๋ฆฌํ DNA์ ๊ฐ ๋๋ฆฝ์ ์ ์์ ํน์ด์ฑ์ ์ง๋ primer๋ฅผ ๋ฃ๊ณ PCR(Polymerase Chain Reaction)๋ฒ์ ์ด์ฉํ์ฌ ์ฆํญ์ํจํ ์ ๊ธฐ์๋๋ฒ์ ์ด์ฉํ์ฌ ๊ฐ ๋๋ฆฝ์ ์ ์์ ์กด์ฌ๋ฅผ ํ์ธํฉ์ผ๋ก์จ ๊ฒฐ์ ํ์๋ค.
IL-1 ฮฒ-511 ๋๋ฆฝ์ ์ ์ 11, ๋๋ฆฝ์ ์ ์ 12, ๋๋ฆฝ์ ์ ์ 22์ ์ ์ ์ํ์ ๋ํ์ฌ ๊ฐ๊ฐ 23.1%, 49.2%, 26.2%์ ๋ถํฌ๋ฅผ ๋ณด์๋ค. IL-1 ฮฒ+3954์ ์ ์ ์ ๋คํ์ฑ์ ๋๋ฆฝ์ ์ ์ 11, ๋๋ฆฝ์ ์ ์ 12์ ์ ์ ์ํ์ ๋ํ์ฌ ๊ฐ๊ฐ 89.2%, 10.8%์ ๋ถํฌ๋ฅผ ๋ณด์์ผ๋ฉฐ, ๋๋ฆฝ์ ์ ์ 22์ ์ ์ ์ํ์ ๊ฐ๋ ์ฌ๋์ ํ๋ช
๋ ๋ฐ๊ฒฌ๋์ง ์์๋ค. IL-1RN์ ์ ์ ์ํ์ 5๊ฐ์ง์ ๋๋ฆฝ์ ์ ์ ์ค์์ ๋๋ฆฝ์ ์ ์ 1, ๋๋ฆฝ์ ์ ์ 2, ๋๋ฆฝ์ ์ ์ 4๋ง์ด ๋ฐ๊ฒฌ๋์์ผ๋ฉฐ, ๋๋ฆฝ์ ์ ์ 11, ๋๋ฆฝ์ ์ ์ 12, ๋๋ฆฝ์ ์ ์ 14์ ์ ์ ์ํ์ด 86.2%, 12.3%, 1.5%๋ก ๋ถํฌํ์๋ค.This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.(02-PJ1-PG10-20507-0008
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