Composite likelihood estimation for the Brown-Resnick process

Genton et al. (2011) investigated the gain in efficiency when triplewise, rather than pairwise, likelihood is used to fit the popular Smith max-stable model for spatial extremes. We generalize their results to the Brown-Resnick model and show that the efficiency gain is substantial only for very smooth processes, which are generally unrealistic in application

An Extension Educator Perspective on Adverse Childhood Experiences

Research on adverse childhood experiences (ACEs) has garnered a great deal of attention and is increasingly used to demonstrate the negative impact of stressful and traumatic childhood experiences on psychological and physical health. ACEs have become a focus of local and state organizations and coalitions concerned about the well-being of children and their families, resulting in a growing number of Extension professionals becoming involved in these initiatives. In this article we provide an overview and analysis of seminal and more recent ACEs research and offer suggestions about where an understanding of and response to ACEs might fit into the work of Extension educators

Geostatistics of Dependent and Asymptotically Independent Extremes

Spatial modeling of rare events has obvious applications in the environmental sciences and is crucial when assessing the effects of catastrophic events (such as heatwaves or widespread flooding) on food security and on the sustainability of societal infrastructure. Although classical geostatistics is largely based on Gaussian processes and distributions, these are not appropriate for extremes, for which max-stable and related processes provide more suitable models. This paper provides a brief overview of current work on the statistics of spatial extremes, with an emphasis on the consequences of the assumption of max-stability. Applications to winter minimum temperatures and daily rainfall are describe

The Use of Participatory Methods in Researching the Experiences of Children and Young People

Participatory research methods offer a very promising approach for gaining in-depth understanding of young people’s lives. However, when adopting such approaches, researchers need to be aware of methodological and theoretical issues. The aim of this article is to present a discussion of ways in which participatory methods may be used as a research strategy when investigating young people’s experiences and emotions. We explore the potential of these methods as well as some of their limitations

Управління трудовим потенціалом при створенні інноваційної продукції

Super-resolution microscopy (SRM) bypasses the diffraction limit, a physical barrier that restricts the optical resolution to roughly 250 nm and was previously thought to be impenetrable. SRM techniques allow the visualization of subcellular organization with unprecedented detail, but also confront biologists with the challenge of selecting the best-suited approach for their particular research question. Here, we provide guidance on how to use SRM techniques advantageously for investigating cellular structures and dynamics to promote new discoveries

Video-rate multi-color structured illumination microscopy with simultaneous real-time reconstruction

Super-resolved structured illumination microscopy (SR-SIM) is among the fastest fluorescence microscopy techniques capable of surpassing the optical diffraction limit. Current custom-build instruments are able to deliver two-fold resolution enhancement with high acquisition speed. SR-SIM is usually a two-step process, with raw-data acquisition and subsequent, time-consuming post-processing for image reconstruction. In contrast, wide-field and (multi-spot) confocal techniques produce high-resolution images instantly. Such immediacy is also possible with SR-SIM, by tight integration of a video-rate capable SIM with fast reconstruction software. Here we present instant SR-SIM by VIGOR (Video-rate Immediate GPU-accelerated Open-Source Reconstruction). We demonstrate multi-color SR-SIM at video frame-rates, with less than 250 ms delay between measurement and reconstructed image display. This is achieved by modifying and extending high-speed SR-SIM image acquisition with a new, GPU-enhanced, network-enabled image-reconstruction software. We demonstrate high-speed surveying of biological samples in multiple colors and live imaging of moving mitochondria as an example of intracellular dynamics