140 research outputs found
Wireless network cocast: location-aware cooperative communications with linear network coding
Comparison of space-time evolutions of hot/dense matter in =17 and 130 GeV relativistic heavy ion collisions based on a hydrodynamical model
Based on a hydrodynamical model, we compare 130 GeV/ Au+Au collisions at
RHIC and 17 GeV/ Pb+Pb collisions at SPS. The model well reproduces the
single-particle distributions of both RHIC and SPS.
The numerical solution indicates that huge amount of collision energy in RHIC
is mainly used to produce a large extent of hot fluid rather than to make a
high temperature matter; longitudinal extent of the hot fluid in RHIC is much
larger than that of SPS and initial energy density of the fluid is only 5%
higher than the one in SPS. The solution well describes the HBT radii at SPS
energy but shows some deviations from the ones at RHIC.Comment: 28 pages, 21 figures, REVTeX4, one figure is added and some figures
are replace
Phases of QCD, Thermal Quasiparticles and Dilepton Radiation from a Fireball
We calculate dilepton production rates from a fireball adapted to the
kinematical conditions realized in ultrarelativistic heavy ion collisions over
a broad range of beam energies. The freeze-out state of the fireball is fixed
by hadronic observables. We use this information combined with the initial
geometry of the collision region to follow the space-time evolution of the
fireball. Assuming entropy conservation, its bulk thermodynamic properties can
then be uniquely obtained once the equation of state (EoS) is specified. The
high-temperature (QGP) phase is modelled by a non-perturbative quasiparticle
model that incorporates a phenomenological confinement description, adapted to
lattice QCD results. For the hadronic phase, we interpolate the EoS into the
region where a resonance gas approach seems applicable, keeping track of a
possible overpopulation of the pion phase space. In this way, the fireball
evolution is specified without reference to dilepton data, thus eliminating it
as an adjustable parameter in the rate calculations. Dilepton emission in the
QGP phase is then calculated within the quasiparticle model. In the hadronic
phase, both temperature and finite baryon density effects on the photon
spectral function are incorporated. Existing dilepton data from CERES at 158
and 40 AGeV Pb-Au collisions are well described, and a prediction for the
PHENIX setup at RHIC for sqrt(s) = 200 AGeV is given.Comment: 31 pages, 15 figures, final versio
Last Call for RHIC Predictions
This paper contains the individual contributions of all speakers of the
session on 'Last Call for RHIC Predictions' at Quark Matter 99, and a summary
by the convenor.Comment: 56 pages, psfig, epsf, epsfig, graphicx style files required,
Proceedings of the XIV Int. Conf. on Nucleus-Nucleus Collisions, Quark Matter
99, Torino, Italy, May 10 - 15, 1999. Typographical mistakes corrected and
figure numbers change
Statistical optimization of culture conditions by response surface methodology for synthesis of lipase with Enterobacter aerogenes
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Early collective expansion: Relativistic hydrodynamics and the transport properties of QCD matter
Relativistic hydrodynamics for ideal and viscous fluids is discussed as a
tool to describe relativistic heavy-ion collisions and to extract transport
properties of the quark-gluon plasma from experimentally measured hadron
momentum spectra.Comment: Review article, 54 pages, 25 figure
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
Pathogenic Germline Variants in 10,389 Adult Cancers
We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including novel associations of SDHA in melanoma and PALB2 in stomach adenocarcinoma. The 659 predisposition variants and 18 additional large deletions in tumor suppressors, including ATM, BRCA1, and NF1, showed low gene expression and frequent (43%) loss of heterozygosity or biallelic two-hit events. We also discovered 33 such variants in oncogenes, including missenses in MET, RET, and PTPN11 associated with high gene expression. We nominated 47 additional predisposition variants from prioritized VUSs supported by multiple evidences involving case-control frequency, loss of heterozygosity, expression effect, and co-localization with mutations and modified residues. Our integrative approach links rare predisposition variants to functional consequences, informing future guidelines of variant classification and germline genetic testing in cancer. A pan-cancer analysis identifies hundreds of predisposing germline variants
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types
Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome Atlas (TCGA), and we identified 119 splicing factor genes with significant non-silent mutation patterns, including mutation over-representation, recurrent loss of function (tumor suppressor-like), or hotspot mutation profile (oncogene-like). Furthermore, RNA sequencing analysis revealed altered splicing events associated with selected splicing factor mutations. In addition, we were able to identify common gene pathway profiles associated with the presence of these mutations. Our analysis suggests that somatic alteration of genes involved in the RNA-splicing process is common in cancer and may represent an underappreciated hallmark of tumorigenesis
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