Concert recording 2016-11-28

[Track 1]. Reading #1 Lieder nach Gedicht von Eduard Mörike. Das verlassene Mägdelein [Track 2]. Zitronenfalter im April Nixe Binsefuss [Track 3]. Verborgenheit / Hugo Wolf -- [Track 4]. Reading #2 Lieder nach Gedichten von Joseph von Eichendorff. Die Nacht [Track 5]. Verschwiegene Liebe [Track 6]. Die Zigeunerin / Hugo Wolf -- [Track 7]. Reading #3 Lieder nach Gedichten von Johann Wolfgang von Goethe. [Track 8]. Mignon I [Track 9]. Mignon II [Track 10]. Mignon (Kennst du das Land...) / Hugo Wolf -- [Track 11]. Reading #4 Spanisches Liederbuch. [Track 12]. Klinge, linge, mein Pandero [Track 13]. In dem Schatten meiner Locken [Track 14]. Mögen alle bösen Zungen / Hugo Wolf -- [Track 15]. Reading #5 Italienisches Liederbuch. [Track 16]. Auch kleine Dinge [Track 17]. Du denkst mit einem Fädchen mich zu fangen [Track 18]. Mein Liebster singt [Track 19]. Schweig einmal still [Track 20]. Ich hab in Pennan einen Liebsten wohnen [Track 21]. Encore / Hugo Wolf

Interference Archive: A Free Space for Social Movement Culture

This paper discusses activist archives within the context of community archives and the practices of archiving activism. Interference Archive (IA), a volunteer-run independent archive in Brooklyn, New York, is presented as one example of an activist archive. We explain the manner in which IA functions as a transmovement and prefigurative “free space” under Francis Poletta’s typology of movement spaces. Through this explanation, we illustrate how the structures of free spaces can help us understand the way activist archives forge connections between communities and the ways that they create new networks of solidarity through the archival process

The Rio Grande Rise and Jean Charcot Seamount Chain - microcontinents or the trail of the Tristan-Gough hotspot? Cruise No. MSM 82, 18 March 2019 - 24 April 2019, Montevideo (Uruguay) - Montevideo (Uruguay), RIOGRANDE

Rio Grande Rise: microcontinent, mantle plume, or both? The origin of the Rio Grande Rise (RGR) is debated. It could represent a continental sliver, or a large igneous province that was emplaced in the late Cretaceous after the opening of the South Atlantic Ocean. The interplay between the RGR and the nearby Jean Charcot Seamount Chain (JCSC) is also not understood. Cruise MSM82 dredge sampled rocks from the JCSC and the RGR and measured two seismic refraction profiles across the RGR where it is bisected by a long rift graben. A range of geophysical data were also collected during much of the expedition, including magnetics, gravity, bathymetry (Kongsberg EM 122), sub-bottom profiling (ATLAS PARASOUND DS P70) and ADCP data. The combination of geochronological, geochemical and geophysical information will provide a unique window on the relation between mantle plumes, continental fragments and the evolution of large igneous provinces

Modifying Ligand-Induced and Constitutive Signaling of the Human 5-HT4 Receptor

G protein–coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered by the molecular and functional diversity of GPCRs and the paucity of ligands with specific signaling effects. To better compare the effects of activating different G-protein signaling pathways through ligand-induced or constitutive signaling, we developed a new series of RASSLs (receptors activated solely by synthetic ligands) that activate different G-protein signaling pathways. These RASSLs are based on the human 5-HT4b receptor, a GPCR with high constitutive Gs signaling and strong ligand-induced G-protein activation of the Gs and Gs/q pathways. The first receptor in this series, 5-HT4-D100A or Rs1 (RASSL serotonin 1), is not activated by its endogenous agonist, serotonin, but is selectively activated by the small synthetic molecules GR113808, GR125487, and RO110-0235. All agonists potently induced Gs signaling, but only a few (e.g., zacopride) also induced signaling via the Gq pathway. Zacopride-induced Gq signaling was enhanced by replacing the C-terminus of Rs1 with the C-terminus of the human 5-HT2C receptor. Additional point mutations (D66A and D66N) blocked constitutive Gs signaling and lowered ligand-induced Gq signaling. Replacing the third intracellular loop of Rs1 with that of human 5-HT1A conferred ligand-mediated Gi signaling. This Gi-coupled RASSL, Rs1.3, exhibited no measurable signaling to the Gs or Gq pathway. These findings show that the signaling repertoire of Rs1 can be expanded and controlled by receptor engineering and drug selection

Hierarchical chemosensory regulation of male-male social interactions in Drosophila

Pheromones regulate male social behaviors in Drosophila, but the identities and behavioral role(s) of these chemosensory signals, and how they interact, are incompletely understood. We found that (z)-7-tricosene, a male-enriched cuticular hydrocarbon that was previously shown to inhibit male-male courtship, was essential for normal levels of aggression. The mechanisms by which (z)-7-tricosene induced aggression and suppressed courtship were independent, but both required the gustatory receptor Gr32a. Sensitivity to (z)-7-tricosene was required for the aggression-promoting effect of 11-cis-vaccenyl acetate (cVA), an olfactory pheromone, but (z)-7-tricosene sensitivity was independent of cVA. (z)-7-tricosene and cVA therefore regulate aggression in a hierarchical manner. Furthermore, the increased courtship caused by depletion of male cuticular hydrocarbons was suppressed by a mutation in the olfactory receptor Or47b. Thus, male social behaviors are controlled by gustatory pheromones that promote aggression and suppress courtship, and whose influences are dominant to olfactory pheromones that enhance these behaviors

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.publishe

Explaining the rise of moralizing religions : a test of competing hypotheses using the Seshat Databank

The causes, consequences, and timing of the rise of moralizing religions in world history have been the focus of intense debate. Progress has been limited by the availability of quantitative data to test competing theories, by divergent ideas regarding both predictor and outcomes variables, and by differences of opinion over methodology. To address all these problems, we utilize Seshat: Global History Databank, a large storehouse of information designed to test theories concerning the evolutionary drivers of social complexity. In addition to the Big Gods hypothesis, which proposes that moralizing religion contributed to the success of increasingly large-scale complex societies, we consider the role of warfare, animal husbandry, and agricultural productivity in the rise of moralizing religions. Using a broad range of new measures of belief in moralizing supernatural punishment, we find strong support for previous research showing that such beliefs did not drive the rise of social complexity. By contrast, our analyses indicate that intergroup warfare, supported by resource availability, played a major role in the evolution of both social complexity and moralizing religions. Thus, the correlation between social complexity and moralizing religion seems to result from shared evolutionary drivers, rather than from direct causal relationships between these two variables

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD.

Objective: To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. Methods: To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. Results: As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. Conclusions: Collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD