118 research outputs found
An Advocacy Approach for More Effective Program Delivery And Coordination: A Case Study of Maine\u27s Housing Rehab Techs
A detailed case analysis of the Maine Housing Rehabilitation Project provides an exploratory observation of the innovative use of human resources at the federal, state and regional levels through an evolutionary development process of housing rehabilitation technicians. Functioning largely as advocate planners and human service delivery administrators through self-expanded roles, these individuals were able to promote change in the context of this intergovernmental environment. The analysis presented here reveals findings of intrastate regional differences between the urban and rural areas. Low income citizens appear to be the main beneficiaries of a proactive style of leadership that was performed by the most productive rehab techs. The autonomy of their roles afforded all technicians a degree of freedom to produce different results through experimentation
The effect of Holstein-Friesian genotype and feeding system on selected performance parameters of dairy cows on grass-based systems of milk production in Ireland
End of project reportThe overall objective of this project was to assess, the effect of strain of Holstein-Friesian dairy cow, pasture-based feed system (FS) and their interaction on animal performance in terms of milk productivity and lactation profile, body weight (BW), body condition score (BCS), feed intake and energy balance (EB), reproductive performance and overall economic profitability
Highly Sideophile Element Abundance Constraints on the Nature of the Late Accretionary Histories of Earth, Moon and Mars
The highly siderophile elements (HSE) include Re, Os, Ir, Ru, Pt and Pd. These elements are initially nearly-quantitatively stripped from planetary silicate mantles during core segregation. They then may be re-enriched in mantles via continued accretion sans continued core segregation. This suite of elements and its included long-lived radiogenic isotopes systems (Re-187 (right arrow) Os-187; Pt-190 (right arrow) Os-186) can potentially be used to fingerprint the characteristics of late accreted materials. The fingerprints may ultimately be useful to constrain the prior nebular history of the dominant late accreted materials, and to compare the proportion and genesis of late accretionary materials added to the inner planets. The past ten years have seen considerable accumulation of isotopic and compositional data for HSE present in the Earth's mantle, lunar mantle and impact melt breccias, and Martian meteorites. Here we review some of these data and consider the broader implications of the compiled data
Understanding the association between negative symptoms and performance on effort-based decision-making tasks: The importance of defeatist performance beliefs
Effort-based decision-making paradigms are increasingly utilized to gain insight into the nature of motivation deficits. Research has shown associations between effort-based decision making and experiential negative symptoms; however, the associations are not consistent. The current study had two primary goals. First, we aimed to replicate previous findings of a deficit in effort-based decision making among individuals with schizophrenia on a test of cognitive effort. Second, in a large sample combined from the current and a previous study, we sought to examine the association between negative symptoms and effort by including the related construct of defeatist beliefs. The results replicated previous findings of impaired cognitive effort-based decision making in schizophrenia. Defeatist beliefs significantly moderated the association between negative symptoms and effort-based decision making such that there was a strong association between high negative symptoms and deficits in effort-based decision making, but only among participants with high levels of defeatist beliefs. Thus, our findings suggest the relationship between negative symptoms and effort performance may be understood by taking into account the role of defeatist beliefs, and finding that might explain discrepancies in previous studies
Long-term monitoring of the TeV emission from Mrk 421 with the ARGO-YBJ experiment
ARGO-YBJ is an air shower detector array with a fully covered layer of
resistive plate chambers. It is operated with a high duty cycle and a large
field of view. It continuously monitors the northern sky at energies above 0.3
TeV. In this paper, we report a long-term monitoring of Mrk 421 over the period
from 2007 November to 2010 February. This source was observed by the
satellite-borne experiments Rossi X-ray Timing Explorer and Swift in the X-ray
band. Mrk 421 was especially active in the first half of 2008. Many flares are
observed in both X-ray and gamma-ray bands simultaneously. The gamma-ray flux
observed by ARGO-YBJ has a clear correlation with the X-ray flux. No lag
between the X-ray and gamma-ray photons longer than 1 day is found. The
evolution of the spectral energy distribution is investigated by measuring
spectral indices at four different flux levels. Hardening of the spectra is
observed in both X-ray and gamma-ray bands. The gamma-ray flux increases
quadratically with the simultaneously measured X-ray flux. All these
observational results strongly favor the synchrotron self-Compton process as
the underlying radiative mechanism.Comment: 30 pages, 8 figure
Observations of Milky Way Dwarf Spheroidal galaxies with the Fermi-LAT detector and constraints on Dark Matter models
We report on the observations of 14 dwarf spheroidal galaxies with the Fermi
Gamma-Ray Space Telescope taken during the first 11 months of survey mode
operations. The Fermi telescope provides a new opportunity to test particle
dark matter models through the expected gamma-ray emission produced by pair
annihilation of weakly interacting massive particles (WIMPs). Local Group dwarf
spheroidal galaxies, the largest galactic substructures predicted by the cold
dark matter scenario, are attractive targets for such indirect searches for
dark matter because they are nearby and among the most extreme dark matter
dominated environments. No significant gamma-ray emission was detected above
100 MeV from the candidate dwarf galaxies. We determine upper limits to the
gamma-ray flux assuming both power-law spectra and representative spectra from
WIMP annihilation. The resulting integral flux above 100 MeV is constrained to
be at a level below around 10^-9 photons cm^-2 s^-1. Using recent stellar
kinematic data, the gamma-ray flux limits are combined with improved
determinations of the dark matter density profile in 8 of the 14 candidate
dwarfs to place limits on the pair annihilation cross-section of WIMPs in
several widely studied extensions of the standard model. With the present data,
we are able to rule out large parts of the parameter space where the thermal
relic density is below the observed cosmological dark matter density and WIMPs
(neutralinos here) are dominantly produced non-thermally, e.g. in models where
supersymmetry breaking occurs via anomaly mediation. The gamma-ray limits
presented here also constrain some WIMP models proposed to explain the Fermi
and PAMELA e^+e^- data, including low-mass wino-like neutralinos and models
with TeV masses pair-annihilating into muon-antimuon pairs. (Abridged)Comment: 25 pages, 4 figures, accepted to ApJ, Corresponding authors: J.
Cohen-Tanugi, C. Farnier, T.E. Jeltema, E. Nuss, and S. Profum
Fermi Large Area Telescope Constraints on the Gamma-ray Opacity of the Universe
The Extragalactic Background Light (EBL) includes photons with wavelengths
from ultraviolet to infrared, which are effective at attenuating gamma rays
with energy above ~10 GeV during propagation from sources at cosmological
distances. This results in a redshift- and energy-dependent attenuation of the
gamma-ray flux of extragalactic sources such as blazars and Gamma-Ray Bursts
(GRBs). The Large Area Telescope onboard Fermi detects a sample of gamma-ray
blazars with redshift up to z~3, and GRBs with redshift up to z~4.3. Using
photons above 10 GeV collected by Fermi over more than one year of observations
for these sources, we investigate the effect of gamma-ray flux attenuation by
the EBL. We place upper limits on the gamma-ray opacity of the Universe at
various energies and redshifts, and compare this with predictions from
well-known EBL models. We find that an EBL intensity in the optical-ultraviolet
wavelengths as great as predicted by the "baseline" model of Stecker et al.
(2006) can be ruled out with high confidence.Comment: 42 pages, 12 figures, accepted version (24 Aug.2010) for publication
in ApJ; Contact authors: A. Bouvier, A. Chen, S. Raino, S. Razzaque, A.
Reimer, L.C. Reye
Multicenter Evaluation of a Novel Surveillance Paradigm for Complications of Mechanical Ventilation
Ventilator-associated pneumonia (VAP) surveillance is time consuming, subjective, inaccurate, and inconsistently predicts outcomes. Shifting surveillance from pneumonia in particular to complications in general might circumvent the VAP definition's subjectivity and inaccuracy, facilitate electronic assessment, make interfacility comparisons more meaningful, and encourage broader prevention strategies. We therefore evaluated a novel surveillance paradigm for ventilator-associated complications (VAC) defined by sustained increases in patients' ventilator settings after a period of stable or decreasing support.We assessed 600 mechanically ventilated medical and surgical patients from three hospitals. Each hospital contributed 100 randomly selected patients ventilated 2-7 days and 100 patients ventilated >7 days. All patients were independently assessed for VAP and for VAC. We compared incidence-density, duration of mechanical ventilation, intensive care and hospital lengths of stay, hospital mortality, and time required for surveillance for VAP and for VAC. A subset of patients with VAP and VAC were independently reviewed by a physician to determine possible etiology.Of 597 evaluable patients, 9.3% had VAP (8.8 per 1,000 ventilator days) and 23% had VAC (21.2 per 1,000 ventilator days). Compared to matched controls, both VAP and VAC prolonged days to extubation (5.8, 95% CI 4.2-8.0 and 6.0, 95% CI 5.1-7.1 respectively), days to intensive care discharge (5.7, 95% CI 4.2-7.7 and 5.0, 95% CI 4.1-5.9), and days to hospital discharge (4.7, 95% CI 2.6-7.5 and 3.0, 95% CI 2.1-4.0). VAC was associated with increased mortality (OR 2.0, 95% CI 1.3-3.2) but VAP was not (OR 1.1, 95% CI 0.5-2.4). VAC assessment was faster (mean 1.8 versus 39 minutes per patient). Both VAP and VAC events were predominantly attributable to pneumonia, pulmonary edema, ARDS, and atelectasis.Screening ventilator settings for VAC captures a similar set of complications to traditional VAP surveillance but is faster, more objective, and a superior predictor of outcomes
Reduction of Pavlovian bias in schizophrenia: Enhanced effects in clozapine-administered patients
The negative symptoms of schizophrenia (SZ) are associated with a pattern of reinforcement learning (RL) deficits likely related to degraded representations of reward values. However, the RL tasks used to date have required active responses to both reward and punishing stimuli. Pavlovian biases have been shown to affect performance on these tasks through invigoration of action to reward and inhibition of action to punishment, and may be partially responsible for the effects found in patients. Forty-five patients with schizophrenia and 30 demographically-matched controls completed a four-stimulus reinforcement learning task that crossed action ("Go" or "NoGo") and the valence of the optimal outcome (reward or punishment-avoidance), such that all combinations of action and outcome valence were tested. Behaviour was modelled using a six-parameter RL model and EEG was simultaneously recorded. Patients demonstrated a reduction in Pavlovian performance bias that was evident in a reduced Go bias across the full group. In a subset of patients administered clozapine, the reduction in Pavlovian bias was enhanced. The reduction in Pavlovian bias in SZ patients was accompanied by feedback processing differences at the time of the P3a component. The reduced Pavlovian bias in patients is suggested to be due to reduced fidelity in the communication between striatal regions and frontal cortex. It may also partially account for previous findings of poorer "Go-learning" in schizophrenia where "Go" responses or Pavlovian consistent responses are required for optimal performance. An attenuated P3a component dynamic in patients is consistent with a view that deficits in operant learning are due to impairments in adaptively using feedback to update representations of stimulus value
Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock
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