Tungsten cladding of reactor fuels

Tungsten cladding of reactor fuel

High-growth firms: introduction to the special section

High-growth firms (HGFs) have attracted considerable attention recently, as academics and policymakers have increasingly recognized the highly skewed nature of many metrics of firm performance. A small number of HGFs drives a disproportionately large amount of job creation, while the average firm has a limited impact on the economy. This article explores the reasons for this increased interest, summarizes the existing literature, and highlights the methodological considerations that constrain and bias research. This special section draws attention to the importance of HGFs for future industrial performance, explores their unusual growth trajectories and strategies, and highlights the lack of persistence of high growth. Consequently, while HGFs are important for understanding the economy and developing public policy, they are unlikely to be useful vehicles for public policy given the difficulties involved in predicting which firms will grow, the lack of persistence in high growth levels, and the complex and often indirect relationship between firm capability, high growth, and macro-economic performance

La culpabilité des survivants de la Shoah proposition théologique en vue d'un chemin de libération intérieure et de pardon

Un lourd silence, entourant la Shoah, a trop longtemps nourri chez les survivants et leurs descendants la honte et la culpabilité d'être juifs. Des intervenants, psychologues et autres, ont réussi à libérer leur parole ; en effet, le partage des expériences et des émotions a permis aux survivants de jeter un regard nouveau sur leur judaïté et de retrouver leur fierté intérieure. Leur plus grande souffrance a été le silence du Dieu de l'Alliance, ressenti comme un abandon. À cet égard, Hans Jonas et Élie Wiesel témoignent de cette foi ébranlée. À leur suite, nous avançons le chemin du pardon comme expérience libératrice de la culpabilité et du talion. En notre qualité de théologienne et de fille de survivant, cette voie du dépassement de soi et de sens de responsabilité nous est apparue pleine d'ouverture et de promesse. Elle permet de quitter le ressentiment, de cheminer vers la vie avec Dieu et les autres et de retrouver la paix et la liberté intérieure

Randomness and semimeasures

A semimeasure is a generalization of a probability measure obtained by relaxing the additivity requirement to superadditivity. We introduce and study several randomness notions for left-c.e. semimeasures, a natural class of effectively approximable semimeasures induced by Turing functionals. Among the randomness notions we consider, the generalization of weak 2-randomness to left-c.e. semimeasures is the most compelling, as it best reflects Martin-Löf randomness with respect to a computable measure. Additionally, we analyze a question of Shen, a positive answer to which would also have yielded a reasonable randomness notion for left-c.e. semimeasures. Unfortunately, though, we find a negative answer, except for some special cases

ASCENS: Engineering Autonomic Service-Component Ensembles

Today’s developers often face the demanding task of developing software for ensembles: systems with massive numbers of nodes, operating in open and non-deterministic environments with complex interactions, and the need to dynamically adapt to new requirements, technologies or environmental conditions without redeployment and without interruption of the system’s functionality. Conventional development approaches and languages do not provide adequate support for the problems posed by this challenge. The goal of the ASCENS project is to develop a coherent, integrated set of methods and tools to build software for ensembles. To this end we research foundational issues that arise during the development of these kinds of systems, and we build mathematical models that address them. Based on these theories we design a family of languages for engineering ensembles, formal methods that can handle the size, complexity and adaptivity required by ensembles, and software-development methods that provide guidance for developers. In this paper we provide an overview of several research areas of ASCENS: the SOTA approach to ensemble engineering and the underlying formal model called GEM, formal notions of adaptation and awareness, the SCEL language, quantitative analysis of ensembles, and finally software-engineering methods for ensembles

Phylogeny of Galactolipid Synthase Homologs Together with their Enzymatic Analyses Revealed a Possible Origin and Divergence Time for Photosynthetic Membrane Biogenesis

The photosynthetic membranes of cyanobacteria and chloroplasts of higher plants have remarkably similar lipid compositions. In particular, thylakoid membranes of both cyanobacteria and chloroplasts are composed of galactolipids, of which monogalactosyldiacylglycerol (MGDG) is the most abundant, although MGDG biosynthetic pathways are different in these organisms. Comprehensive phylogenetic analysis revealed that MGDG synthase (MGD) homologs of filamentous anoxygenic phototrophs Chloroflexi have a close relationship with MGDs of Viridiplantae (green algae and land plants). Furthermore, analyses for the sugar specificity and anomeric configuration of the sugar head groups revealed that one of the MGD homologs exhibited a true MGDG synthetic activity. We therefore presumed that higher plant MGDs are derived from this ancestral type of MGD genes, and genes involved in membrane biogenesis and photosystems have been already functionally associated at least at the time of Chloroflexi divergence. As MGD gene duplication is an important event during plastid evolution, we also estimated the divergence time of type A and B MGDs. Our analysis indicated that these genes diverged ∼323 million years ago, when Spermatophyta (seed plants) were appearing. Galactolipid synthesis is required to produce photosynthetic membranes; based on MGD gene sequences and activities, we have proposed a novel evolutionary model that has increased our understanding of photosynthesis evolution

Stable reference genes for the measurement of transcript abundance during larval caste development in the honeybee

Many genes are differentially regulated by caste development in the honeybee. Identifying and understanding these differences is key to discovering the mechanisms underlying this process. To identify these gene expression differences requires robust methods to measure transcript abundance. RT-qPCR is currently the gold standard to measure gene expression, but requires stable reference genes to compare gene expression changes. Such reference genes have not been established for honeybee caste development. Here, we identify and test potential reference genes that have stable expression throughout larval development between the two female castes. In this study, 15 candidate reference genes were examined to identify the most stable reference genes. Three algorithms (GeNorm, Bestkeeper and NormFinder) were used to rank the candidate reference genes based on their stability between the castes throughout larval development. Of these genes Ndufa8 (the orthologue of a component of complex one of the mitochondrial electron transport chain) and Pros54 (orthologous to a component of the 26S proteasome) were identified as being the most stable. When these two genes were used to normalise expression of two target genes (previously found to be differentially expressed between queen and worker larvae by microarray analysis) they were able to more accurately detect differential expression than two previously used reference genes (awd and RpL12). The identification of these novel reference genes will be of benefit to future studies of caste development in the honeybee