3 research outputs found
Distinct Alterations in Mitochondrial Mass and Function Characterize Different Models of Apoptosis
- Author
- Asher
- Baffy
- Bursch
- Chance
- Cossarizza
- Cuende
- David Hockenbery
- Dunn
- Elizabeth Caldwell
- Gottschalk
- Hockenbery
- Hockenbery
- Holly Vanderwerff
- Horst
- Jacobson
- Kerr
- Kerr
- Klion
- Krajewski
- Kung
- Köhler
- Levi-Montalcini
- Maftah
- Mancini
- Minn
- Muchmore
- Murphy
- Neupert
- Newmeyer
- Nordeen
- Papadimitriou
- Petit
- Reers
- Reipert
- Richter
- Riparbelli
- Sophie Camilleri-Broët
- Turrens
- Urbani
- Vayssiere
- Vercesi
- Waring
- Wyllie
- Yin
- Young
- Zacharchuk
- Zakeri
- Zamzami
- Zamzami
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
- Author
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Bakker Stephan J. L.
- Banas Bernhard
- Bansal Nisha
- Bergler Tobias
- Bergmann Sven
- Bianca Martina La
- Biggs Mary L.
- Biino Ginevra
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bottinger Erwin P.
- Boutin Thibaud S.
- Brenner Hermann
- Brumpton Ben
- Burkhardt Ralph
- Böger Carsten A.
- Campbell Archie
- Campbell Harry
- Carroll Robert J.
- Catamo Eulalia
- Chai Jin-Fang
- Chambers John C.
- Chasman Daniel I.
- Chee Miao-Li
- Chee Miao-Ling
- Cheng Ching-Yu
- Christensen Kaare
- Chu Audrey Y.
- Citterio Lorena
- Ciullo Marina
- Cocca Massimiliano
- Concas Maria Pina
- Cook James P.
- Coresh Josef
- Corre Tanguy
- Correa Adolfo
- Cusi Daniele
- Czamara Darina
- Daw E. Warwick
- de Borst Martin H.
- de Borst Martin H.
- De Grandi Alessandro
- de Mutsert Renée
- de Vries Aiko P. J.
- Dehghan Abbas
- Delgado Graciela E.
- Devuyst Olivier
- Dittrich Katalin
- Divers Jasmin
- Dorajoo Rajkumar
- Eckardt Kai-Uwe
- Ehret Georg
- Elliott Paul
- Endlich Karlhans
- Esko Tõnu
- Evans Michele K.
- Feitosa Mary F.
- Felicita Sala Cinzia
- Felix Janine F.
- Feresin Agnese
- Foo Valencia Hui Xian
- Francescatto Margherita
- Franke Andre
- Freedman Barry I.
- Freitag-Wolf Sandra
- Friedlander Yechiel
- Fuchsberger Christian
- Gansevoort Ron T.
- Gao He
- Gao Xin
- Gasparini Paolo
- Gaziano John M.
- Gaziano John M.
- Ghanbari Mohsen
- Ghasemi Sahar
- Giedraitis Vilmantas
- Gieger Christian
- Girotto Giorgia
- Gordon Scott D.
- Gorski Mathias
- Graham Sarah E.
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guilianini Franco
- Guo Feng
- Gögele Martin
- Günther Felix
- Halbritter Jan
- Hallan Stein
- Haller Toomas
- Hamet Pavel
- Hartman Catharina A.
- Hayward Caroline
- Heid Iris M.
- Heng Chew-Kiat
- Hicks Andrew A.
- Ho Kevin
- Ho Kevin
- Hofer Edith
- Holm Hilma
- Hoppmann Anselm
- Horn Katrin
- Huang Wei
- Hung Adriana M.
- Hung Adriana M.
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Shih-Jen
- Ikram M. Arfan
- Ising Marcus
- Jaddoe Vincent W. V.
- Jakobsdottir Johanna
- Jonas Jost B.
- Joshi Peter K.
- Josyula Navya Shilpa
- Josyula Navya Shilpa
- Jung Bettina
- Kamatani Yoichiro
- Kammerer Candace M.
- Kanai Masahiro
- Kastarinen Mika
- Kavousi Maryam
- Kerr Shona M.
- Khor Chiea-Chuen
- Kiess Wieland
- Kirsten Holger
- Klaric Lucija
- Kleber Marcus E.
- Koenig Wolfgang
- Kooner Jaspal S.
- Kovacs Peter
- Kramer Holly
- Kronenberg Florian
- Krämer Bernhard K.
- Kubo Michiaki
- Kuokkanen Mikko
- Kuusisto Johanna
- Kähönen Mika
- Körner Antje
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langefeld Carl D.
- Lanzani Chiara
- Launer Lenore J.
- Lee Jeannette Jen-Mai
- Lehtimäki Terho
- Li Hengtong
- Li Man
- Li Yong
- Lieb Wolfgang
- Lim Su-Chi
- Lind Lars
- Lindgren Cecilia M.
- Liu Jianjun
- Loeffler Markus
- Loos Ruth J. F.
- Lucae Susanne
- Lukas Mary Ann
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- Manunta Paolo
- Marten Jonathan
- Martin Nicholas G.
- Martins Jade
- Mascalzoni Deborah
- Matsuda Koichi
- Meitinger Thomas
- Melander Olle
- Metspalu Andres
- Milaneschi Yuri
- Miliku Kozeta
- Mishra Pashupati P.
- Mohlke Karen L.
- Mononen Nina
- Montgomery Grant W.
- Mook-Kanamori Dennis O.
- Morgan Anna
- Morris Andrew P.
- Mychaleckyj Josyf C.
- Mägi Reedik
- März Winfried
- Nadkarni Girish N.
- Nalls Mike A.
- Nauck Matthias
- Nikus Kjell
- Ning Boting
- Nolte Ilja M.
- Noordam Raymond
- Nutile Teresa
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Orho-Melander Marju
- O’Connell Jeffrey
- O’Donoghue Michelle L.
- Padmanabhan Sandosh
- Palmer Nicholette D.
- Parsa Afshin
- Patil Snehal B.
- Pattaro Cristian
- Pendergrass Sarah A.
- Pendergrass Sarah A.
- Penninx Brenda W. J. H.
- Perola Markus
- Peters Annette
- Phillips Lawrence S.
- Phillips Lawrence S.
- Pirastu Nicola
- Piratsu Mario
- Pistis Giorgio
- Podgornaia Anna I.
- Polasek Ozren
- Pontali Giulia
- Ponte Belen
- Porteous David J.
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Rabelink Ton J.
- Raffield Laura M.
- Raitakari Olli T.
- Rasheed Humaira
- Reilly Dermot F.
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rizzi Federica
- Robinson-Cohen Cassianne
- Robinson-Cohen Cassianne
- Rosenkranz Alexander R.
- Rossing Peter
- Rotter Jerome I.
- Rowan Bryce X.
- Rowan Bryce X.
- Rudan Igor
- Rueedi Rico
- Ruggiero Daniela
- Ryan Kathleen A.
- Sabanayagam Charumathi
- Salomaa Veikko
- Salvi Erika
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulz Christina-Alexandra
- Schupf Nicole
- Schöttker Ben
- Sedaghat Sanaz
- Shaffer Christian M.
- Sieber Karsten B.
- Sim Ralene Z. H.
- Sim Xueling
- Smith Albert V.
- Smith Blair H.
- Snieder Harold
- Spedicati Beatrice
- Spracklen Cassandra N.
- Stanzick Kira J.
- Stark Klaus J.
- Stefansson Kari
- Strauch Konstantin
- Stringham Heather M.
- Stumvoll Michael
- Sulem Patrick
- Sveinbjornsson Gardar
- Svensson Per O.
- Tai E-Shyong
- Tan Nicholas Y. Q.
- Tao Ran
- Tao Ran
- Taylor Kent D.
- Tayo Bamidele
- Teren Andrej
- Teumer Alexander
- Tham Yih-Chung
- Thiery Joachim
- Thio Chris H. L.
- Thio Chris H. L.
- Thomas Laurent F.
- Thorsteinsdottir Unnur
- Tin Adrienne
- Toniolo Daniela
- Tremblay Johanne
- Tzoulaki Ioanna
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Most Peter J.
- van der Most Peter J.
- Vanderwerff Brett R.
- Verweij Niek
- Vitart Veronique
- Vogelezang Suzanne
- Vollenweider Peter
- Völker Uwe
- Waeber Gerard
- Waldenberger Melanie
- Wallentin Lars
- Wang Chaolong
- Wang Ya Xing
- Waterworth Dawn M.
- Wei Wen Bin
- White Harvey D.
- Whitfield John B.
- Willer Cristen J.
- Wilson James F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Tien-Yin
- Wuttke Matthias
- Xu Jie
- Yang Qiong
- Yasuda Masayuki
- Yerges-Armstrong Laura M.
- Yu Zhi
- Zhang Weihua
- Zonderman Alan B.
- Ärnlöv Johan
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
- Author
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Arnlov Johan
- Asvold Bjorn Olav
- Bakker Stephan J. L.
- Banas Bernhard
- Bansal Nisha
- Bergler Tobias
- Bergmann Sven
- Biggs Mary L.
- Biino Ginevra
- Bochud Murielle
- Boeger Carsten A.
- Boehnke Michael
- Boerwinkle Eric
- Bottinger Erwin P.
- Boutin Thibaud S.
- Brenner Hermann
- Brumpton Ben
- Burkhardt Ralph
- Campbell Archie
- Campbell Harry
- Carroll Robert J.
- Catamo Eulalia
- Chai Jin-Fang
- Chambers John C.
- Chasman Daniel, I
- Chee Miao-Li
- Chee Miao-Ling
- Cheng Ching-Yu
- Christensen Kaare
- Chu Audrey Y.
- Citterio Lorena
- Ciullo Marina
- Cocca Massimiliano
- Concas Maria Pina
- Cook James P.
- Coresh Josef
- Corre Tanguy
- Correa Adolfo
- Cusi Daniele
- Czamara Darina
- Daw E. Warwick
- de Borst Martin H.
- De Grandi Alessandro
- de Mutsert Renee
- de Vries Aiko P. J.
- Dehghan Abbas
- Delgado Graciela E.
- Devuyst Olivier
- Dittrich Katalin
- Divers Jasmin
- Dorajoo Rajkumar
- Eckardt Kai-Uwe
- Ehret Georg
- Elliott Paul
- Endlich Karlhans
- Esko Tonu
- Evans Michele K.
- Feitosa Mary F.
- Felicita Sala Cinzia
- Felix Janine F.
- Feresin Agnese
- Foo Valencia Hui Xian
- Francescatto Margherita
- Franke Andre
- Freedman Barry, I
- Freitag-Wolf Sandra
- Friedlander Yechiel
- Fuchsberger Christian
- Gansevoort Ron T.
- Gao He
- Gao Xin
- Gasparini Paolo
- Gaziano John M.
- Ghanbari Mohsen
- Ghasemi Sahar
- Giedraitis Vilmantas
- Gieger Christian
- Girotto Giorgia
- Gogele Martin
- Gordon Scott D.
- Gorski Mathias
- Graham Sarah E.
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guenther Felix
- Guilianini Franco
- Guo Feng
- Halbritter Jan
- Hallan Stein
- Haller Toomas
- Hamet Pavel
- Hartman Catharina A.
- Hayward Caroline
- Heid Iris M.
- Heng Chew-Kiat
- Hicks Andrew A.
- Ho Kevin
- Hofer Edith
- Holm Hilma
- Hoppmann Anselm
- Horn Katrin
- Huang Wei
- Hung Adriana M.
- Hutri-Kahonen Nina
- Hveem Kristian
- Hwang Shih-Jen
- Ikram M. Arfan
- Ising Marcus
- Jaddoe Vincent W. V.
- Jakobsdottir Johanna
- Jonas Jost B.
- Joshi Peter K.
- Josyula Navya Shilpa
- Jung Bettina
- Kahonen Mika
- Kamatani Yoichiro
- Kammerer Candace M.
- Kanai Masahiro
- Kastarinen Mika
- Kavousi Maryam
- Kerr Shona M.
- Khor Chiea-Chuen
- Kiess Wieland
- Kirsten Holgen
- Klaric Lucija
- Kleber Marcus E.
- Koenig Wolfgang
- Koerner Antje
- Koettgen Anna
- Kooner Jaspal S.
- Kovacs Peter
- Kraemer Bernhard K.
- Kramer Holly
- Kronenberg Florian
- Kubo Michiaki
- Kuokkanen Mikko
- Kuusisto Johanna
- La Bianca Martina
- Laakso Markku
- Lange Leslie A.
- Langefeld Carl D.
- Lanzani Chiara
- Launer Lenore J.
- Lee Jeannette Jen-Mai
- Lehtimaki Terho
- Li Hengtong
- Li Man
- Li Yong
- Lieb Wolfgang
- Lim Su-Chi
- Lind Lars
- Lindgren Cecilia M.
- Liu Jianjun
- Loeffler Markus
- Loos Ruth J. F.
- Lucae Susanne
- Lukas Mary Ann
- Lyytikainen Leo-Pekka
- Magi Reedik
- Magnusson Patrik K. E.
- Mahajan Anubha
- Manunta Paolo
- Marten Jonathan
- Martin Nicholas G.
- Martins Jade
- Marz Winfried
- Mascalzoni Deborah
- Matsuda Koichi
- Meitinger Thomas
- Melander Olle
- Metspalu Andres
- Milaneschi Yuri
- Miliku Kozeta
- Mishra Pashupati P.
- Mohlke Karen L.
- Mononen Nina
- Montgomery Grant W.
- Mook-Kanamori Dennis O.
- Morgan Anna
- Morris Andrew P.
- Mychaleckyj Josyf C.
- Nadkarni Girish N.
- Nalls Mike A.
- Nauck Matthias
- Nikus Kjell
- Ning Boting
- Nolte Ilja M.
- Noordam Raymond
- Nutile Teresa
- O'Connell Jeffrey
- O'Donoghue Michelle L.
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Orho-Melander Marju
- Padmanabhan Sandosh
- Palmer Nicholette D.
- Parsa Afshin
- Patil Snehal B.
- Pattaro Cristian
- Pendergrass Sarah A.
- Penninx Brenda W. J. H.
- Perola Markus
- Peters Annette
- Phillips Lawrence S.
- Pirastu Nicola
- Piratsu Mario
- Pistis Giorgio
- Podgornaia Anna, I
- Polasek Ozren
- Pontali Giulia
- Ponte Belen
- Porteous David J.
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Rabelink Ton J.
- Raffield Laura M.
- Raitakari Olli T.
- Rasheed Humaira
- Reilly Dermot F.
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rizzi Federica
- Robinson-Cohen Cassianne
- Rosenkranz Alexander R.
- Rossing Peter
- Rotter Jerome, I
- Rowan Bryce X.
- Rudan Igor
- Rueedi Rico
- Ruggiero Daniela
- Ryan Kathleen A.
- Sabanayagam Charumathi
- Salomaa Veikko
- Salvi Erika
- Schmidt Helena
- Schmidt Reinhold
- Schoettker Ben
- Scholz Markus
- Schulz Christina-Alexandra
- Schupf Nicole
- Sedaghat Sanaz
- Shaffer Christian M.
- Sieber Karsten B.
- Sim Ralene Z. H.
- Sim Xueling
- Smith Albert, V
- Smith Blair H.
- Snieder Harold
- Spedicati Beatrice
- Spracklen Cassandra N.
- Stanzick Kira J.
- Stark Klaus J.
- Stefansson Kari
- Strauch Konstantin
- Stringham Heather M.
- Stumvoll Michael
- Sulem Patrick
- Sveinbjornsson Gardar
- Svensson Per O.
- Tai E-Shyong
- Tan Nicholas Y. Q.
- Tao Ran
- Taylor Kent D.
- Tayo Bamidele
- Teren Andrej
- Teumer Alexander
- Tham Yih-Chung
- Thiery Joachim
- Thio Chris H. L.
- Thomas Laurent F.
- Thorsteinsdottir Unnur
- Tin Adrienne
- Toenjes Anke
- Toniolo Daniela
- Tremblay Johanne
- Tzoulaki Ioanna
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Most Peter J.
- Vanderwerff Brett R.
- Verweij Niek
- Vitart Veronique
- Voelker Uwe
- Vogelezang Suzanne
- Vollenweider Peter
- Waeber Gerard
- Waldenberger Melanie
- Wallentin Lars
- Wang Chaolong
- Wang Ya Xing
- Waterworth Dawn M.
- Wei Wen Bin
- White Harvey D.
- Whitfield John B.
- Willer Cristen J.
- Wilson James F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Tien-Yin
- Wuttke Matthias
- Xu Jie
- Yang Qiong
- Yasuda Masayuki
- Yerges-Armstrong Laura M.
- Yu Zhi
- Zhang Weihua
- Zonderman Alan B.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study