An OPC UA-based industrial Big Data architecture

Industry 4.0 factories are complex and data-driven. Data is yielded from many sources, including sensors, PLCs, and other devices, but also from IT, like ERP or CRM systems. We ask how to collect and process this data in a way, such that it includes metadata and can be used for industrial analytics or to derive intelligent support systems. This paper describes a new, query model based approach, which uses a big data architecture to capture data from various sources using OPC UA as a foundation. It buffers and preprocesses the information for the purpose of harmonizing and providing a holistic state space of a factory, as well as mappings to the current state of a production site. That information can be made available to multiple processing sinks, decoupled from the data sources, which enables them to work with the information without interfering with devices of the production, disturbing the network devices they are working in, or influencing the production process negatively. Metadata and connected semantic information is kept throughout the process, allowing to feed algorithms with meaningful data, so that it can be accessed in its entirety to perform time series analysis, machine learning or similar evaluations as well as replaying the data from the buffer for repeatable simulations

A multa tributária e o princípio constitucional da proporcionalidade

A limitação constitucional ao poder de tributar está expresso na Constituição Federal em diferentes normas e princípios constitucionais. O Supremo Tribunal Federal, ao limitar o valor da multa tributária ao valor do tributo, pela via reflexa, impõe a correção proporcional dos valores devidos a título de multa

Competência Social, Inclusão Escolar e Autismo:: Um Estudo de Caso Comparativo

The aim of this study was to investigate the social competence ((SC) profile) of a child with autism in a regular in school, comparing it with a typically developing child and to investigate the influence of the school context (classroom or playground) on their SC profile. The social interactions with their peers were recorded at school and an independent judge coded the videos. The adapted version of the Q-Sort SC scale was used. The results demonstrated that while the SC profile of the typically developing child practically did not vary between contexts, the child with autism demonstrated a higher frequency of cooperation and social assertion behavior and a lower frequency of aggression and disorganization of the self in the playground.A literatura sobre autismo enfatiza os prejuízos no desenvolvimento de habilidades interativas e da competência social (CS) dessas crianças, colocando em dúvida a educabilidade desses sujeitos no ensino comum. O objetivo deste estudo foi investigar o perfil de CS de uma criança pré-escolar com autismo (AU), em inclusão escolar, comparado a uma criança com desenvolvimento típico (DT) e investigar a influência do ambiente escolar (sala de aula ou pátio) no perfil de CS de ambas. Foi realizada observação sistemática das interações na escola. A codificação das imagens foi realizada por um avaliador independente. Utilizou-se como instrumento a versão adaptada da Escala Q-sort de CS. Os resultados demonstraram diferenças e semelhanças no perfil de CS das duas crianças, nos dois contextos

Diagnosis and its implications in the acceptance process of the child with disability: a qualitative study

Quando nasce uma criança com deficiência, o discurso do profissional da saúde no momento do diagnóstico assume um papel importante na forma como os pais irão lidar com essa nova e indesejada situação de vida. O presente trabalho teve por meta verificar as implicações do modo como é dado o diagnóstico médico e as orientações aos pais de crianças com deficiência, no seu processo de aceitação. Os dados foram coletados através de entrevistas individuais com oito pais de crianças com deficiência. As entrevistas foram transcritas e submetidas à análise de conteúdo. As cinco categorias identificadas demonstram que o diagnóstico é um momento importante para o processo de aceitação da criança com deficiência e para sua inclusão na família e na sociedade.   Palavras-chave: saúde; diagnóstico; criança com deficiência.When a child is born with a disability, the speech of the health professional at the moment of diagnosis has an important role in the way that parents deal with this new and unexpected life situation. This paper aimed to verify the implications of the way that the diagnosis is given and provide guidance to parents of children with disabilities in their acceptance process. Data were collected through individual interviews with eight parents of children with disabilities and submitted to a content analysis. The Five identified categories indicated that diagnosis was an important moment for the parent’s acceptance process and for the child’s inclusion in the family and society.   Keywords: health; diagnosis; children with disabilities

Mulheres gestoras: características na gestão de cooperativas no estado do Rio Grande do Sul

This paper aims to identify and understand the characteristics of four women managers of cooperatives of different branches in the state of Rio Grande do Sul, comparing it with the model proposed by Cursino and Neto (2015). It is a qualitative and descriptive study based on a case study. For data collection we used the interview and as a form of data analysis, content analysis. As for the results, it was possible to make some relevant observations. About the categories of analysis: analytical; competitive; emotive; hardworking; intuitive; loyal; multifunctional; weighted; Concerned and sensitive, all interviewees affirmed with greater intensity the presence of these characteristics in their professional profiles regarding their applicability in their management activities. The characteristics less present in their profiles were: anxious; centralizing; insecure; conservative and dedicated. Finally, the present work achieved the proposed objectives.Este trabalho tem o objetivo de identificar e compreender as características de quatro mulheres gestoras de cooperativas de diferentes ramos no estado do Rio Grande do Sul, comparando-o com o modelo proposto por Cursino e Neto (2015). É um estudo de natureza qualitativa e descritiva, com base num estudo de caso. Para a coleta dos dados utilizou-se a entrevista e como forma de análise de dados, a análise de conteúdo. Quanto aos resultados, foi possível fazer algumas observações relevantes. Sobre as categorias de análise: analítica; competitiva; emotiva; esforçada; intuitiva; leal; multifuncional; ponderada; preocupada e sensível, todas entrevistadas afirmaram com maior intensidade a presença dessas características em seus perfis profissionais em se tratando de sua aplicabilidade em suas atividades de gestão. As características menos presentes em seus perfis foram: ansiosa; centralizadora; insegura; conservadora e dedicada. Por fim, o presente trabalho alcançou os objetivos propostos

Percutaneous coronary revascularization in patients with formerly "refractory angina pectoris in end-stage coronary artery disease" – Not "end-stage" after all

<p>Abstract</p> <p>Background</p> <p>Patients with refractory angina pectoris in end-stage coronary artery disease represent a severe condition with a higher reduction of life-expectancy and quality of life as compared to patients with stable coronary artery disease. It was the purpose of this study to invasively re-evaluate highly symptomatic patients with formerly diagnosed refractory angina pectoris in end-stage coronary artery disease for feasible options of myocardial revascularization.</p> <p>Methods</p> <p>Thirty-four Patients formerly characterized as having end stage coronary artery disease with refractory angina pectoris were retrospectively followed for coronary interventions.</p> <p>Results</p> <p>Of those 34 patients 21 (61.8%) were eventually revascularized with percutaneous interventional revascularization (PCI). Due to complex coronary morphology (angulation, chronic total occlusion) PCI demanded an above-average amount of time (66 ± 42 minutes, range 25–206 minutes) and materials (contrast media 247 ± 209 ml, range 50–750 ml; PCI guiding wires 2.0 ± 1.4, range 1–6 wires). Of PCI patients 7 (33.3%) showed a new lesion as a sign of progression of atherosclerosis. Clinical success rate with a reduction to angina class II or lower was 71.4% at 30 days. Surgery was performed in a total of8 (23.5%) patients with a clinical success rate of 62.5%. Based on an intention-to-treat 2 patients of originally 8 (25%) demonstrated clinical success. Mortality during follow-up (1–18 months) was 4.8% in patients who underwent PCI, 25% in patients treated surgically and 25% in those only treated medically.</p> <p>Conclusion</p> <p>The majority of patients with end-stage coronary artery disease can be treated effectively with conventional invasive treatment modalities. Therefore even though it is challenging and demanding PCI should be considered as a first choice before experimental interventions are considered.</p

Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins

BACKGROUND: The HIV epidemic is a major threat to health in the developing and western worlds. A modality that targets and kills HIV-1-infected cells could have a major impact on the treatment of acute exposure and the elimination of persistent reservoirs of infected cells. The aim of this proof-of-principle study was to demonstrate the efficacy of a therapeutic strategy of targeting and eliminating HIV-1-infected cells with radiolabeled antibodies specific to viral proteins in vitro and in vivo. METHODS AND FINDINGS: Antibodies to HIV-1 envelope glycoproteins gp120 and gp41 labeled with radioisotopes bismuth 213 ((213)Bi) and rhenium 188 ((188)Re) selectively killed chronically HIV-1-infected human T cells and acutely HIV-1-infected human peripheral blood mononuclear cells (hPBMCs) in vitro. Treatment of severe combined immunodeficiency (SCID) mice harboring HIV-1-infected hPBMCs in their spleens with a (213)Bi- or (188)Re-labeled monoclonal antibody (mAb) to gp41 resulted in a 57% injected dose per gram uptake of radiolabeled mAb in the infected spleens and in a greater than 99% elimination of HIV-1-infected cells in a dose-dependent manner. The number of HIV-1-infected thymocytes decreased 2.5-fold in the human thymic implant grafts of SCID mice treated with the (188)Re-labeled antibody to gp41 compared with those treated with the (188)Re-control mAb. The treatment did not cause acute hematologic toxicity in the treated mice. CONCLUSIONS: The current study demonstrates the effectiveness of HIV-targeted radioimmunotherapy and may provide a novel treatment option in combination with highly active antiretroviral therapy for the eradication of HIV

Restoring tibiofemoral alignment during ACL reconstruction results in better knee biomechanics

"Published online: 24 October 2017"PURPOSE: Anterior cruciate ligament (ACL) reconstruction (ACLR) aims to restore normal knee joint function, stability and biomechanics and in the long term avoid joint degeneration. The purpose of this study is to present the anatomic single bundle (SB) ACLR that emphasizes intraoperative correction of tibiofemoral subluxation that occurs after ACL injury. It was hypothesized that this technique leads to optimal outcomes and better restoration of pathological tibiofemoral joint movement that results from ACL deficiency (ACLD). METHODS: Thirteen men with unilateral ACLD were prospectively evaluated before and at a mean follow-up of 14.9 (SD = 1.8) months after anatomic SB ACLR with bone patellar tendon bone autograft. The anatomic ACLR replicated the native ACL attachment site anatomy and graft orientation. Emphasis was placed on intraoperative correction of tibiofemoral subluxation by reducing anterior tibial translation (ATT) and internal tibial rotation. Function was measured with IKDC, Lysholm and the Tegner activity scale, ATT was measured with the KT-1000 arthrometer and tibial rotation (TR) kinematics were measured with 3Dmotion analysis during a high-demand pivoting task. RESULTS: The results showed significantly higher TR of the ACL-deficient knee when compared to the intact knee prior to surgery (12.2° ± 3.7° and 10.7° ± 2.6° respectively, P = 0.014). Postoperatively, the ACLR knee showed significantly lower TR as compared to the ACL-deficient knee (9.6°±3.1°, P = 0.001) but no difference as compared to the control knee (n.s.). All functional scores were significantly improved and ATT was restored within normal values (P < 0.001). CONCLUSIONS: Intraoperative correction of tibiofemoral subluxation that results after ACL injury is an important step during anatomic SB ACLR. The intraoperative correction of tibiofemoral subluxation along with the replication of native ACL anatomy results in restoration of rotational kinematics of ACLD patients to normal levels that are comparable to the control knee. These results indicate that the reestablishment of tibiofemoral alignment during ACLR may be an important step that facilitates normal knee kinematics postoperatively. LEVEL OF EVIDENCE: Level II, prospective cohort study.The authors gratefully acknowledge the funding support from the Hellenic Association of Orthopaedic Surgery and Traumatology (HAOST-EEXOT)info:eu-repo/semantics/publishedVersio