1,068 research outputs found
Inference and Evaluation of the Multinomial Mixture Model for Text Clustering
In this article, we investigate the use of a probabilistic model for
unsupervised clustering in text collections. Unsupervised clustering has become
a basic module for many intelligent text processing applications, such as
information retrieval, text classification or information extraction. The model
considered in this contribution consists of a mixture of multinomial
distributions over the word counts, each component corresponding to a different
theme. We present and contrast various estimation procedures, which apply both
in supervised and unsupervised contexts. In supervised learning, this work
suggests a criterion for evaluating the posterior odds of new documents which
is more statistically sound than the "naive Bayes" approach. In an unsupervised
context, we propose measures to set up a systematic evaluation framework and
start with examining the Expectation-Maximization (EM) algorithm as the basic
tool for inference. We discuss the importance of initialization and the
influence of other features such as the smoothing strategy or the size of the
vocabulary, thereby illustrating the difficulties incurred by the high
dimensionality of the parameter space. We also propose a heuristic algorithm
based on iterative EM with vocabulary reduction to solve this problem. Using
the fact that the latent variables can be analytically integrated out, we
finally show that Gibbs sampling algorithm is tractable and compares favorably
to the basic expectation maximization approach
Spontaneous Symmetry Breaking with Abnormal Number of Nambu-Goldstone Bosons and Kaon Condensate
We describe a class of relativistic models incorporating finite density of
matter in which spontaneous breakdown of continuous symmetries leads to a
lesser number of Nambu-Goldstone bosons than that required by the Goldstone
theorem. This class, in particular, describes the dynamics of the kaon
condensate in the color-flavor locked phase of high density QCD. We describe
the spectrum of low energy excitations in this dynamics and show that, despite
the presence of a condensate and gapless excitations, this system is not a
superfluid.Comment: 5 pages, 1 figure, REVTeX. Minor revisions made and 2 new references
added. To appear in Phys. Rev. Let
Spin-wave Scattering in the Effective Lagrangian Perspective
Nonrelativistic systems exhibiting collective magnetic behavior are analyzed
in the framework of effective Lagrangians. The method, formulating the dynamics
in terms of Goldstone bosons, allows to investigate the consequences of
spontaneous symmetry breaking from a unified point of view. Low energy theorems
concerning spin-wave scattering in ferro- and antiferromagnets are established,
emphasizing the simplicity of actual calculations. The present work includes
approximate symmetries and discusses the modification of the low energy
structure imposed by an external magnetic and an anisotropy field,
respectively. Throughout the paper, analogies between condensed matter physics
and Lorentz-invariant theories are pointed out, demonstrating the universal
feature of the effective Lagrangian technique.Comment: Published versio
Operator Product Expansion and Quark-Hadron Duality: Facts and Riddles
We review the status of the practical operator product expansion (OPE), when
applied to two-point correlators of QCD currents which interpolate to mesonic
resonances, in view of the violations of local quark-hadron duality. Covered
topics are: a mini-review of mesonic QCD sum rules in vacuum, at finite
temperature, or at finite baryon density, a comparison of model calculations of
current-current correlation functions in 2D and 4D with the OPE expression, a
discussion of meson distribution amplitudes in the light of nonperturbatively
nonlocal modifications of the OPE, and a reorganization of the OPE which
(partially) resums powers of covariant derivatives.Comment: now 68 pages, 29 figures (1 figure added), habilitation thesis, mild
restructuring, typos corrected, about 30 references and corresponding text
added, version to be published in Prog. Part. Nucl. Phy
Determination of the Michel Parameters rho, xi, and delta in tau-Lepton Decays with tau --> rho nu Tags
Using the ARGUS detector at the storage ring DORIS II, we have
measured the Michel parameters , , and for
decays in -pair events produced at
center of mass energies in the region of the resonances. Using
as spin analyzing tags, we find , , , , and . In addition, we report
the combined ARGUS results on , , and using this work
und previous measurements.Comment: 10 pages, well formatted postscript can be found at
http://pktw06.phy.tu-dresden.de/iktp/pub/desy97-194.p
Super-resolution lightwave tomography of electronic bands in quantum materials
Searching for quantum functionalities requires access to the electronic structure, constituting the foundation of exquisite spin-valley-electronic, topological, and many-body effects. All-optical band-structure reconstruction could directly connect electronic structure with the coveted quantum phenomena if strong lightwaves transported localized electrons within preselected bands. Here, we demonstrate that harmonic sideband (HSB) generation in monolayer tungsten diselenide creates distinct electronic interference combs in momentum space. Locating these momentum combs in spectroscopy enables super-resolution tomography of key band-structure details in situ. We experimentally tuned the optical-driver frequency by a full octave and show that the predicted super-resolution manifests in a critical intensity and frequency dependence of HSBs. Our concept offers a practical, all-optical, fully three-dimensional tomography of electronic structure even in microscopically small quantum materials, band by band
New World Health Organization Treatment Recommendations for Multidrug-Resistant Tuberculosis: Are We Well Enough Prepared?
Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development
Introduction
Genome-wide association studies have led to numerous genetic loci associated with Alzheimer's disease (AD). Whole-genome sequencing (WGS) now permits genome-wide analyses to identify rare variants contributing to AD risk.
Methods
We performed single-variant and spatial clustering–based testing on rare variants (minor allele frequency [MAF] ≤1%) in a family-based WGS-based association study of 2247 subjects from 605 multiplex AD families, followed by replication in 1669 unrelated individuals.
Results
We identified 13 new AD candidate loci that yielded consistent rare-variant signals in discovery and replication cohorts (4 from single-variant, 9 from spatial-clustering), implicating these genes: FNBP1L, SEL1L, LINC00298, PRKCH, C15ORF41, C2CD3, KIF2A, APC, LHX9, NALCN, CTNNA2, SYTL3, and CLSTN2.
Discussion
Downstream analyses of these novel loci highlight synaptic function, in contrast to common AD-associated variants, which implicate innate immunity and amyloid processing. These loci have not been associated previously with AD, emphasizing the ability of WGS to identify AD-associated rare variants, particularly outside of the exome
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