An Obsession Matched Intervention Improves the Facial/Emotional Recognition Deficit in Children with Asperger’s Syndrome

Asperger’s Syndrome (AS) falls on the high-functioning end of the Autism Spectrum. AS is often characterized by a deficit in social/emotional/facial processing, resistance to change, and routine and repetitive behaviors and interests. Prior research has uncovered that AS individuals process faces in a detail-oriented piecemeal fashion, rather than holistically. They are also found to pay less visual attention to faces and social stimuli. Theoretical explanations that account for this particular functioning and processing style include Weak Central Coherence Theory (WCC) and Hyper-Systemizing Theory. WCC implies that AS individuals do not process instances within context, which contributes to their inability to process many aspects involved with socialization. Hyper-Systemizing Theory implies that AS individuals have a systemization mechanism that is set too high. This hyper-systemization lends itself to a reliance upon predictable systems, which leaves no room for the unpredictable and highly variable nature of socialization. AS individuals also demonstrate devout attention and obsession-like qualities towards their specific object of interest. The content of their obsession often falls under the domain of folk physics: an interest and understanding in how the physical world works. All of these qualities suggest the need for an individualized facial/emotional recognition intervention. Implications regarding well-being and daily functioning are discussed. This study proposes that an obsession-matched intervention will improve AS participant’s scores on a facial/emotional recognition test (Cambridge Mindreading Face-Voice Battery Test for Children [CAM-C]), as well as capture their attention. Participants include 80 AS male children between the ages of 6 and 11, who are obsessed with either clocks or trains. Participants view either an obsession-specific intervention or a non-obsession specific intervention, once a week, for 16 weeks. Eye-tracking technology is used during viewing periods to capture their fixation durations, which is quantified as attention. This intervention is an altered version of the highly efficient “The Transporters” intervention (Baron-Cohen, Golan, & Ashwin, 2009). Scores on the CAM-C are recorded pre and post intervention viewing period. Proposed results reveal that participants who were in the obsession-specific intervention had significantly higher post intervention CAM-C scores, than their pre intervention scores (p Key words: autism, asperger’s syndrome, intervention, obsessions, circumscribed interests, facial recognition, emotion recognition, socialization

Mono Lake or Laschamp geomagnetic event recorded from lava flows in Amsterdam Island (southeastern Indian Ocean)

We report a survey carried out on basalt flows from Amsterdam Island in order to check the presence of intermediate directions interpreted to belong to a geomagnetic field excursion within the Brunhes epoch, completing this paleomagnetic record with paleointensity determinations and radiometric dating. The directional results corroborate the findings by Watkins and Nougier (1973) : normal polarity is found for two units and an intermediate direction, with associated VGPs close to the equator, for the other two units. A notable result is that these volcanic rocks are well suited for absolute paleointensity determinations. Fifty percent of the samples yields reliable intensity values with high quality factors. An original element of this study is that we made use of the PTRM-tail test of Shcherbakova et al. (2000) to help in the interpretation of the paleointensity measurements. Doing thus, only the high temperature intervals, beyond 400 degres C, were retained to obtain the most reliable estimate of the strength of the ancient magnetic field. The normal units yield Virtual Dipole Moments (VDM) of 6.2 and 7.7 10e22 Am2 and the excursional units yield values of 3.7 and 3.4 10e22 Am2. These results are quite consistent with the other Thellier determinations from Brunhes excursion records, all characterized by a decrease of the VDM as VGP latitude decreases. 40Ar/39Ar isotopic age determinations provide an estimate of 26+-15 Kyr and 18+-9 Kyr for the transitional lava flows, which could correspond to the Mono Lake excursion. However, the large error bars associated with these ages do not exclude the hypothesis that this event is the Laschamp

Recent trends in the climate of Namaqualand, a megadiverse arid region of South Africa

Abstract Namaqualand is especially vulnerable to future climate change impacts. Using a high-resolution (0.5°x0.5°) gridded data set (CRU TS 3.1) and individual weather station data, we demonstrated that temperatures as well as frequency of hot extremes have increased across this region. Specifically, minimum temperatures have increased by 1.4 °C and maximum temperatures by 1.1 °C over the last century. Of the five weather stations analysed, two showed evidence of a significant increase in the duration of warm spells of up to 5 days per decade and a reduction in the number of cool days (TX10P) by up to 3 days per decade. In terms of rainfall, we found no clear evidence for a significant change in annual totals or the frequency or intensity of rainfall events. Seasonal trends in rainfall did, however, demonstrate some spatial variability across the region. Spatial trends in evapotranspiration obtained from the 8-day MOD16 ET product were characterised by a steepening inland-coastal gradient where areas along the coastline showed a significant increase in evapotranspiration of up to 30 mm per decade, most notably in spring and summer. The increase in temperature linked with the increases in evapotranspiration pose significant challenges for water availability in the region, but further research into changes in coastal fog is required in order for a more reliable assessment to be made. Overall, the results presented in this study provide evidence-based information for the management of climate change impacts as well as the development of appropriate adaptation responses at a local scale

Portable Sensory Room for the West Orange County Consortium for Special Education

This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose them to new stimuli to explore and learn in a calm and non-threatening environment. There are three different Special Needs classrooms that the Portable Sensory Room will be moved between in a single day. The teachers at Newland Elementary also desired a swing element and a pressure applying device. Both of these components are used regularly in Occupational Therapy with children with autism and have been proven to help children develop necessary skills in life. The design of the Portable Sensory Room, which was composed of several brainstorming sessions and decision matrices, lasted several months from Fall 2015 to midway through the Winter 2016 quarter. The final design consists of seven different components - five of the components act as the structure of the room and can easily connect to one another to achieve a uniform enclosure and two are separate from the room structure. All of these components have interactions on their faces that either comfort or challenge the children and all contribute to a calming sea theme throughout. The components are all on locking casters which makes transportation of the assembly easy. The five components of the room structure are: the tactile wall, the bookshelf, the tactile station, the fabric panels, and the LED panels. The tactile wall focuses on helping the children gain fine motor skills by use of tracks that the children can move fish along, a moveable gear set, and a whiteboard. The bookshelf is filled with activities for fine motor skills as well, and provides extra storage for the teachers to arrange according to their desires. The tactile station is a dresser with calming light effects at the top. The drawers can be completely removed and put on the floor, where the children can play with tactile interactions in an enclosed space to avoid a mess. The fabric panels provide tactile sensations using several swatches of fabric that range from calming to challenging. The LED panels have a calming ocean mural and also allow children to observe the notion of cause-and-effect via a control box that changes the light display. The other two components are the swing structure and the pressure applicator, which can either be used in the room or separately from the room depending on the teachers’ preferences. The swing structure was purchased from Amazon and allows for a 360 degree rotation. The pressure applicator was built by the team and is comprised of two horizontal rollers that the child can slide in between. The addition of rubber bands allows the child/teacher to choose how much pressure will be exerted on the child. The build phase of the project lasted from the end of Winter 2016 quarter to the end of Spring 2016 quarter. All of the components were made from lumber and sanded down in order to avoid any sharp edges. Testing was performed to verify that the teachers would not have to exert an enormous effort to move all of the components, as well as to determine the tipping loads for each of the components. The tipping loads were below the desired specification; in order to mitigate this, two adults will be required to move each component. When the room is assembled together, the entire structure is quite stable and does not pose a tipping hazard. The final product will be delivered to Newland Elementary School on June 17th, 2016

Movement patterns and activity levels are shaped by the neonatal environment in Antarctic fur seal pups

This research was funded by the German Research Foundation (DFG) as part of the SFB TRR 212 (NC3)—Project Numbers 316099922, 396774617, and 396782756. It was also supported by core funding from the Natural Environment Research Council to the British Antarctic Survey’s Ecosystems Program.Tracking studies of juveniles are rare compared to those of adults, and consequently little is known about the influence of intrinsic and extrinsic factors on activity during this critical life stage. We used hourly GPS data, collected from 66 Antarctic fur seal pups from birth until moulting, to investigate the explanatory power of multiple individual-based and environmental variables on activity levels. Pups were sampled from two nearby breeding colonies of contrasting density during two subsequent years, and a two-state hidden Markov model was used to identify modalities in their movement behaviour, specifically 'active' and 'inactive' states. We found that movement was typified by central place exploration, with active movement away from and subsequent return to a location of inactivity. The probability of such directed exploration was unaffected by several factors known to influence marine mammal movement including sex, body condition, and temperature. Compared to pups born at the high-density colony, pups at low-density were more active, increased their activity with age, and transitioned earlier into the tussock grass, which offers protection from predators and extreme weather. Our study illustrates the importance of extrinsic factors, such as colony of birth, to early-life activity patterns and highlights the adaptive potential of movement.Publisher PDFPeer reviewe

Differential effects of RGS proteins on Gαq and Gα11 activity

Heterotrimeric G proteins play a pivotal role in GPCR signalling; they link receptors to intracellular effectors and their inactivation by RGS proteins is a key factor in resetting the pathway following stimulation. The precise GPCR:G protein:RGS combination determines the nature and duration of the response. Investigating the activity of particular combinations is difficult in cells which contain multiples of each component. We have therefore utilised a previously characterised yeast system to express mammalian proteins in isolation. Human Gαq and Gα11 spontaneously activated the yeast pheromone-response pathway by a mechanism which required the formation of Gα-GTP. This provided an assay for the specific activity of human RGS proteins. RGS1, RGS2, RGS3 and RGS4 inhibited the spontaneous activity of both Gαq and Gα11 but, in contrast, RGS5 and RGS16 were much less effective against Gα11 than Gαq. Interestingly, RGS2 and RGS3 were able to inhibit signalling from the constitutively active Gαq QL/Gα11 QL mutants, confirming the GAP-independent activity of these RGS proteins. To determine if the RGS-Gα specificity was maintained under conditions of GPCR stimulation, minor modifications to the C-terminus of Gαq/Gα11 enabled coupling to an endogenous receptor. RGS2 and RGS3 were effective inhibitors of both Gα subunits even at high levels of receptor stimulation, emphasising their GAP-independent activity. At low levels of stimulation RGS5 and RGS16 retained their differential Gα activity, further highlighting that RGS proteins can discriminate between two very closely related Gα subunits

High glucose up-regulates ENaC and SGK1 expression in HCD-cells

Background/Aim: Diabetic nephropathy is associated with progressive renal damage, leading to impaired function and end-stage renal failure. Secondary hypertension stems from a deranged ability of cells within the kidney to resolve and appropriately regulate sodium resorption in response to hyperglycaemia. However, the mechanisms by which glucose alters sodium re-uptake have not been fully characterised. Methods: Here we present RT-PCR, western blot and immunocytochemistry data confirming mRNA and protein expression of the serum and glucocorticoid inducible kinase (SGK1) and the a conducting subunit of the epithelial sodium channel (ENaC) in a model in vitro system of the human cortical collecting duct (HCD). We examined changes in expression of these elements in response to glucose challenge, designed to mimic hyperglycaemia associated with type 2 diabetes mellitus. Changes in Na+ concentration were assessed using single-cell microfluorimetry. Results: Incubation with glucose, the Ca2+-ionophore ionomycin and the cytokine TGF-beta 1 were all found to evoke significant and time-dependent increases in both SGK1 and alpha ENaC protein expression. These molecular changes were correlated to an increase in Na+-uptake at the single-cell level. Conclusion: Together these data offer a potential explanation for glucose-evoked Na+-resorption and a potential contributory role of SGK1 and ENaCs in development of secondary hypertension, commonly linked to diabetic nephropathy

Life-history stage influences immune investment and oxidative stress in response to environmental heterogeneity in Antarctic fur seals

Immune defenses are crucial for survival but costly to develop and maintain. Increased immune investment is therefore hypothesized to trade-off with other life-history traits. Here, we examined innate and adaptive immune responses to environmental heterogeneity in wild Antarctic fur seals. In a fully crossed, repeated measures design, we sampled 100 pups and their mothers from colonies of contrasting density during seasons of contrasting food availability. Biometric and cortisol data as well as blood for the analysis of 13 immune and oxidative status markers were collected at two key life-history stages. We show that immune responses of pups are more responsive than adults to variation in food availability, but not population density, and are modulated by cortisol and condition. Immune investment is associated with different oxidative status markers in pups and mothers. Our results suggest that early life stages show greater sensitivity to extrinsic and intrinsic effectors, and that immunity may be a strong target for natural selection even in low-pathogen environments such as Antarctica.</p

Social Determinants of Health in Dunn, NC - Advocacy Toolkit

This folder contains a public health advocacy toolkit created by the Southern Oral History Program (SOHP)’s 2020-2021 Capstone Team at University of North Carolina Gillings School of Global Public Health. The 2020-2021 SOHP Capstone team worked on the ongoing SOHP Stories to Save Lives project, which collected a series of oral histories from rural North Carolinians about their experiences living, working, and receiving and providing healthcare. The team analyzed 38 unique oral histories that had been collected from patients and providers at a Federally Qualified Health Center (FQHC) based in Dunn, NC between 2018 and 2019. Based on these histories, the team assembled these products to advocate for change and improvements to social determinants of health that had affected the narrators of these oral histories

Life-history stage influences immune investment and oxidative stress in response to environmental heterogeneity in Antarctic fur seals

Immune defenses are crucial for survival but costly to develop and maintain. Increased immune investment is therefore hypothesized to trade-off with other life-history traits. Here, we examined innate and adaptive immune responses to environmental heterogeneity in wild Antarctic fur seals. In a fully crossed, repeated measures design, we sampled 100 pups and their mothers from colonies of contrasting density during seasons of contrasting food availability. Biometric and cortisol data as well as blood for the analysis of 13 immune and oxidative status markers were collected at two key life-history stages. We show that immune responses of pups are more responsive than adults to variation in food availability, but not population density, and are modulated by cortisol and condition. Immune investment is associated with different oxidative status markers in pups and mothers. Our results suggest that early life stages show greater sensitivity to extrinsic and intrinsic effectors, and that immunity may be a strong target for natural selection even in low-pathogen environments such as Antarctica.</p