Letter from Ripley Hitchcock to John Muir, 1893 Mar 8.

D. APPLETON & CO.,1. 3 & 5 BOND STREET, NEW YORK.March 8,1893John Muir, Esq.,Martinez, Cal. Dear Sir:I beg to acknowledge your letter of March 2, and I should like to say that we are very glad indeed to find that the suggestion of the book on mountaineering in the West strikes you favorably. It seems to me that there is a place for a book written by an authority, but at the same time popular rather than scientific, and dealing with actual experiences in mountain climbing. Our idea would be that the book should not be a very large one. On the basis of a 12mo. it should not contain more than 350 or 400 pages. I think the illustrations could be made satisfactory to you. No doubt you have a considerable number of photographs, and these would be very carefully reproduced. We should endeavor to make the book in the best possible manner.As regards terms, we should offer you 10% of the retail price of all copies sold, the payment beginning when the book had met the expense of manufacturing, and then including all copies sold. For example, if the sale of 1000 copies was necessary to meet the cost of plates, etc., we should pay you the royalty on the 1000 copies as soon as this number was sold. The idea is that the publisher and author should become partners, and inasmuch as the publisher invests a considerable amount in the manufacture of the book it seems fair that the cost of manufacture should be recovered before he pays out an additional amount in royalties. I think that this book ought to prove a permanent one, and the results in the long run I trust will be satisfactory. We should probably make a book which would be uniform in size with Darwin\u27s Voyages, or possibly01437 J. M. 2 3/8/93with Wright\u27s Ice Age, although of course our idea would be that the book should be more popular in character.I am obliged to outline this general plan somewhat hastily, but I trust the suggestion will meet with your acceptance, and I shall be very glad indeed to hear from you on the subject at your convenience.Yours very truly,Repley Hitchcock0143

Letter from Ripley Hitchcock [D. Appleton & Co.] to John Muir, 1893 Feb 21.

D. APPLETON & CO.,1,3, & 5 BOND STREET,NEW YORK.Feb. 21,1893John Muir, Esq.,Martinez, Contra Costa Co., Cal, Dear Sir:I shall take the liberty of introducing myself and of addressing you directly as the literary adviser of D. Appleton & Co I have been a reader of your articles in the Century and elsewhere, and I also happen to have a more extensive knowledge of the west, derived from personal observation, than is the case perhaps with most eastern people. You will pardon this personal preamble to the suggestion which I have been very anxious to make, which is this: It seems to me that a book upon American mountains and mountaineering, dealing with the great peaks of the west, and perhaps of Alaska, might be written in a way to attract popular interest. Of course it is a popular rather than a scientific book which I have in mind, but at the same time such a book to possess any weight should be written by an authority like yourself. Every year sees several books added to the mass of Alpine literature, and I see no reason why our own great mountains are not worthy of a volume which would make Americans better acquainted with the magnificent scenery of their own country. I feel that there is no one better qualified than yourself to write a standard book on the great mountains of the west, dealing not only with scenery, but with mountaineering experiences, and with the animal life of the mountains, and I hope very earnestly that you may be induced to consider this suggestion. Of course it will be possible[illegible]to illustrate such a book in a very beautiful manner. May I ask you to consider this suggestion at your convenience? I trust that your reply may not be altogether01431 J.M. 2 2/21/93unfavorable.With best wishes, I amYours very truly,[illegible

The Role of Inflammatory Mediators in the Pathogenesis of Otitis Media and Sequelae

This review deals with the characteristics of various inflammatory mediators identified in the middle ear during otitis media and in cholesteatoma. The role of each inflammatory mediator in the pathogenesis of otitis media and cholesteatoma has been discussed. Further, the relation of each inflammatory mediator to the pathophysiology of the middle and inner ear along with its mechanisms of pathological change has been described. The mechanisms of hearing loss including sensorineural hearing loss (SNHL) as a sequela of otitis media are also discussed. The passage of inflammatory mediators through the round window membrane into the scala tympani is indicated. In an experimental animal model, an application of cytokines and lipopolysaccharide (LPS), a bacterial toxin, on the round window membrane induced sensorineural hearing loss as identified through auditory brainstem response threshold shifts. An increase in permeability of the blood-labyrinth barrier (BLB) was observed following application of these inflammatory mediators and LPS. The leakage of the blood components into the lateral wall of the cochlea through an increase in BLB permeability appears to be related to the sensorineural hearing loss by hindering K+ recycling through the lateral wall disrupting the ion homeostasis of the endolymph. Further studies on the roles of various inflammatory mediators and bacterial toxins in inducing the sensorineumral hearing loss in otitis media should be pursued

Letter from Ripley Hitchcock to John Muir, 1893 Mar 8.

D. APPLETON & CO.,1. 3 & 5 BOND STREET, NEW YORK.March 8,1893John Muir, Esq.,Martinez, Cal. Dear Sir:I beg to acknowledge your letter of March 2, and I should like to say that we are very glad indeed to find that the suggestion of the book on mountaineering in the West strikes you favorably. It seems to me that there is a place for a book written by an authority, but at the same time popular rather than scientific, and dealing with actual experiences in mountain climbing. Our idea would be that the book should not be a very large one. On the basis of a 12mo. it should not contain more than 350 or 400 pages. I think the illustrations could be made satisfactory to you. No doubt you have a considerable number of photographs, and these would be very carefully reproduced. We should endeavor to make the book in the best possible manner.As regards terms, we should offer you 10% of the retail price of all copies sold, the payment beginning when the book had met the expense of manufacturing, and then including all copies sold. For example, if the sale of 1000 copies was necessary to meet the cost of plates, etc., we should pay you the royalty on the 1000 copies as soon as this number was sold. The idea is that the publisher and author should become partners, and inasmuch as the publisher invests a considerable amount in the manufacture of the book it seems fair that the cost of manufacture should be recovered before he pays out an additional amount in royalties. I think that this book ought to prove a permanent one, and the results in the long run I trust will be satisfactory. We should probably make a book which would be uniform in size with Darwin\u27s Voyages, or possibly01437https://scholarlycommons.pacific.edu/jmcl/39096/thumbnail.jp

Letter from Ripley Hitchcock to John Muir, 1893 Mar 8.

J. M. 2 3/8/93with Wright\u27s Ice Age, although of course our idea would be that the book should be more popular in character.I am obliged to outline this general plan somewhat hastily, but I trust the suggestion will meet with your acceptance, and I shall be very glad indeed to hear from you on the subject at your convenience.Yours very truly,Repley Hitchcock01437https://scholarlycommons.pacific.edu/jmcl/39097/thumbnail.jp

Letter from Ripley Hitchcock to John Muir, 1893 Mar 8.

D. APPLETON & CO.,1. 3 & 5 BOND STREET, NEW YORK.March 8,1893John Muir, Esq.,Martinez, Cal. Dear Sir:I beg to acknowledge your letter of March 2, and I should like to say that we are very glad indeed to find that the suggestion of the book on mountaineering in the West strikes you favorably. It seems to me that there is a place for a book written by an authority, but at the same time popular rather than scientific, and dealing with actual experiences in mountain climbing. Our idea would be that the book should not be a very large one. On the basis of a 12mo. it should not contain more than 350 or 400 pages. I think the illustrations could be made satisfactory to you. No doubt you have a considerable number of photographs, and these would be very carefully reproduced. We should endeavor to make the book in the best possible manner.As regards terms, we should offer you 10% of the retail price of all copies sold, the payment beginning when the book had met the expense of manufacturing, and then including all copies sold. For example, if the sale of 1000 copies was necessary to meet the cost of plates, etc., we should pay you the royalty on the 1000 copies as soon as this number was sold. The idea is that the publisher and author should become partners, and inasmuch as the publisher invests a considerable amount in the manufacture of the book it seems fair that the cost of manufacture should be recovered before he pays out an additional amount in royalties. I think that this book ought to prove a permanent one, and the results in the long run I trust will be satisfactory. We should probably make a book which would be uniform in size with Darwin\u27s Voyages, or possibly01437 J. M. 2 3/8/93with Wright\u27s Ice Age, although of course our idea would be that the book should be more popular in character.I am obliged to outline this general plan somewhat hastily, but I trust the suggestion will meet with your acceptance, and I shall be very glad indeed to hear from you on the subject at your convenience.Yours very truly,Repley Hitchcock0143

Letter from Ripley Hitchcock to John Muir, 1893 Mar 8.

J. M. 2 3/8/93with Wright\u27s Ice Age, although of course our idea would be that the book should be more popular in character.I am obliged to outline this general plan somewhat hastily, but I trust the suggestion will meet with your acceptance, and I shall be very glad indeed to hear from you on the subject at your convenience.Yours very truly,Repley Hitchcock01437https://scholarlycommons.pacific.edu/jmcl/39097/thumbnail.jp

Letter from Ripley Hitchcock [D. Appleton & Co.] to John Muir, 1893 Feb 21.

D. APPLETON & CO.,1,3, & 5 BOND STREET,NEW YORK.Feb. 21,1893John Muir, Esq.,Martinez, Contra Costa Co., Cal, Dear Sir:I shall take the liberty of introducing myself and of addressing you directly as the literary adviser of D. Appleton & Co I have been a reader of your articles in the Century and elsewhere, and I also happen to have a more extensive knowledge of the west, derived from personal observation, than is the case perhaps with most eastern people. You will pardon this personal preamble to the suggestion which I have been very anxious to make, which is this: It seems to me that a book upon American mountains and mountaineering, dealing with the great peaks of the west, and perhaps of Alaska, might be written in a way to attract popular interest. Of course it is a popular rather than a scientific book which I have in mind, but at the same time such a book to possess any weight should be written by an authority like yourself. Every year sees several books added to the mass of Alpine literature, and I see no reason why our own great mountains are not worthy of a volume which would make Americans better acquainted with the magnificent scenery of their own country. I feel that there is no one better qualified than yourself to write a standard book on the great mountains of the west, dealing not only with scenery, but with mountaineering experiences, and with the animal life of the mountains, and I hope very earnestly that you may be induced to consider this suggestion. Of course it will be possible[illegible]to illustrate such a book in a very beautiful manner. May I ask you to consider this suggestion at your convenience? I trust that your reply may not be altogether01431 J.M. 2 2/21/93unfavorable.With best wishes, I amYours very truly,[illegible

Letter from Ripley Hitchcock to John Muir, 1893 Mar 8.

D. APPLETON & CO.,1. 3 & 5 BOND STREET, NEW YORK.March 8,1893John Muir, Esq.,Martinez, Cal. Dear Sir:I beg to acknowledge your letter of March 2, and I should like to say that we are very glad indeed to find that the suggestion of the book on mountaineering in the West strikes you favorably. It seems to me that there is a place for a book written by an authority, but at the same time popular rather than scientific, and dealing with actual experiences in mountain climbing. Our idea would be that the book should not be a very large one. On the basis of a 12mo. it should not contain more than 350 or 400 pages. I think the illustrations could be made satisfactory to you. No doubt you have a considerable number of photographs, and these would be very carefully reproduced. We should endeavor to make the book in the best possible manner.As regards terms, we should offer you 10% of the retail price of all copies sold, the payment beginning when the book had met the expense of manufacturing, and then including all copies sold. For example, if the sale of 1000 copies was necessary to meet the cost of plates, etc., we should pay you the royalty on the 1000 copies as soon as this number was sold. The idea is that the publisher and author should become partners, and inasmuch as the publisher invests a considerable amount in the manufacture of the book it seems fair that the cost of manufacture should be recovered before he pays out an additional amount in royalties. I think that this book ought to prove a permanent one, and the results in the long run I trust will be satisfactory. We should probably make a book which would be uniform in size with Darwin\u27s Voyages, or possibly01437https://scholarlycommons.pacific.edu/jmcl/39096/thumbnail.jp