Strategic investment of embodied energy during the architectural planning process

Building industry impacts natural cycles and has potential for optimization. While impairment on nature reached a new dimension already some three centuries ago the building industry started to realize the dependency in the second half of the 20th century. With LCA method all life cycle phases can be monitored and the environmental impact of each can be quantified. The energy consuming and emission generating components in the building context can be distinguished in the groups transport, operation and material. An architect deals with the operational energy and the building substance. With nearly zero (not renewable) energy for operation an ecological building is defined by the building substance. Evaluation of the building substance While the building structure accounts for the highest share of embodied energy and GWP, the facade offers high potential for optimisation. This potential is even higher when considering a long (50-100 years) usage life span; the building structure remains while the (non load-bearing) facade is object to exchange cycles. Findings and their integration into the architectural planning process The city is a depot for resources and we (it involves a variety of professions) need to learn how to organize it. Modularity, light construction, the use of renewable materials and mono materials are also interesting fields which are looked at from a different point of view. They are relevant for all building elements. Although they are not initially invented to reduce the ecological impact of the built environment, they show potential to do so. The facade is the essential parameter for the resource-efficiency of a building as it is exchanged and binds relevant amounts of material. Impact can be made within this element due to its high variation in construction and materialization. The material cycles need to become smaller and the gaps – landfill or downcycling need to be closed. The use of resources will increasingly develop impact on architecture and by that resource efficiency is a successor of energy efficiency

Comparative Overview on LCA Software Programs for Application in the Façade Design Process

Façades impact the environmental performance of a building by their passive contribution to operational energy demand and by embodied energy and emissions during each life cycle phase. LCA is a method widely used to quantify the environmental contribution. The use of LCA software programs in façade planning can guide design decisions and contribute to environmental optimisation. A large amount of LCA software programs have been developed so far, all of which differ in their focus and requirements. This paper aims to address these differences and investigate the capability and suitability of these programs for façade design. It is structured in four sections. The first part introduces LCA in the building and façade design context. The second part introduces categories to understand the different capabilities of LCA software products. Hereafter, eleven products are evaluated based on these categories. The fourth part focuses on the suitability of software products for simple or complex façades. The study concludes that there are different software choices available for almost every level of user knowledge. While Gabi, Simapro, and Umberto require users to work to a high level of proficiency, software programs like eLCA, CAALA, and 360 Optimi do not require much user knowledge over LCA, but provide a range of other opportunities

sustainable and resilient building design:

The challenges to which contemporary building design needs to respond grow steadily. They originate from the influence of changing environmental conditions on buildings, as well as from the need to reduce the impact of buildings on the environment. The increasing complexity requires the continual revision of design principles and their harmonisation with current scientific findings, technological development, and environmental, social, and economic factors. It is precisely these issues that form the backbone of the thematic book, Sustainable and Resilient Building Design: Approaches, Methods, and Tools. The purpose of this book is to present ongoing research from the universities involved in the project Creating the Network of Knowledge Labs for Sustainable and Resilient Environments (KLABS). The book starts with the exploration of the origin, development, and the state-of-the-art notions of environmental design and resource efficiency. Subsequently, climate change complexity and dynamics are studied, and the design strategy for climate-proof buildings is articulated. The investigation into the resilience of buildings is further deepened by examining a case study of fire protection. The book then investigates interrelations between sustainable and resilient building design, compares their key postulates and objectives, and searches for the possibilities of their integration into an outreaching approach. The fifth article in the book deals with potentials and constraints in relation to the assessment of the sustainability (and resilience) of buildings. It critically analyses different existing building certification models, their development paths, systems, and processes, and compares them with the general objectives of building ratings. The subsequent paper outlines the basis and the meaning of the risk and its management system, and provides an overview of different visual, auxiliary, and statistical risk assessment methods and tools. Following the studies of the meanings of sustainable and resilient buildings, the book focuses on the aspects of building components and materials. Here, the life cycle assessment (LCA) method for quantifying the environmental impact of building products is introduced and analysed in detail, followed by a comprehensive comparative overview of the LCA-based software and databases that enable both individual assessment and the comparison of different design alternatives. The impact of climate and pollution on the resilience of building materials is analysed using the examples of stone, wood, concrete, and ceramic materials. Accordingly, the contribution of traditional and alternative building materials to the reduction of negative environmental impact is discussed and depicted through different examples. The book subsequently addresses existing building stock, in which environmental, social, and economic benefits of building refurbishment are outlined by different case studies. Further on, a method for the upgrade of existing buildings, described as ‘integrated rehabilitation’, is deliberated and supported by best practice examples of exoskeleton architectural prosthesis. The final paper reflects on the principles of regenerative design, reveals the significance of biological entities, and recognises the need to assign to buildings and their elements a more advanced role towards natural systems in human environments

Generation of a human induced pluripotent stem cell line from urinary cells of a healthy donor using integration free Sendai virus technology

We have generated a human induced pluripotent stem cell (iPSC) line derived from urinary cells of a 28 year old healthy female donor. The cells were reprogrammed using a non-integrating viral vector and have shown full differentiation potential. Together with the iPSC line, the donor provided blood cells for the study of immunological effects of the iPSC line and its derivatives in autologous and allogeneic settings. The line is available and registered in the human pluripotent stem cell registry as BCRTi005-A

Spitzer Mid-Infrared Spectroscopy of Infrared Luminous Galaxies at z~2 III: Far-IR to Radio Properties and Optical Spectral Diagnostics

We present the far-IR, millimeter, and radio photometry as well as optical and near-IR spectroscopy of a sample of 48 z~1-3 Spitzer-selected ULIRGs with IRS mid-IR spectra. Our goals are to compute their bolometric emission, and to determine both the presence and relative strength of their AGN and starburst components. We find that strong-PAH sources tend to have higher 160um and 1.2mm fluxes than weak-PAH sources. The depth of the 9.7um silicate feature does not affect MAMBO detectability. We fit the far-IR SEDs of our sample and find an average ~7x10^{12}Lsun for our z>1.5 sources. Spectral decomposition suggests that strong-PAH sources typically have ~20-30% AGN fractions. Weak-PAH sources by contrast tend to have >~70% AGN fractions, with a few sources having comparable contributions of AGN and starbursts. The optical line diagnostics support the presence of AGN in the bulk of the weak-PAH sources. With one exception, our sources are narrow-line sources, show no obvious correspondence between the optical extinction and the silicate feature depth, and, in two cases, show evidence for outflows. Radio AGN are present in both strong-PAH and weak-PAH sources. This is supported by our sample's far-IR-to-radio ratios (q) being consistently below the average value of 2.34 for local star-forming galaxies. We use survival analysis to include the lower-limits given by the radio-undetected sources, arriving at =2.07+/-0.01 for our z>1.5 sample. In total, radio and, where available, optical line diagnostics support the presence of AGN in 57% of the z>1.5 sources, independent of IR-based diagnostics. For higher-z sources, the AGN luminosities alone are estimated to be >10^{12}Lsun, which, supported by the [OIII] luminosities, implies that the bulk of our sources host obscured quasars.Comment: 22 pages, 14 figures, accepted for publication in Ap

HIV and adolescents: focus on young key populations

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138345/1/jia20076.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138345/2/jia20076-sup-0001.pd

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.

BACKGROUND: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant data meta-analyses of prospective studies of body-mass index (BMI), limiting confounding and reverse causality by restricting analyses to never-smokers and excluding pre-existing disease and the first 5 years of follow-up. METHODS: Of 10 625 411 participants in Asia, Australia and New Zealand, Europe, and North America from 239 prospective studies (median follow-up 13·7 years, IQR 11·4-14·7), 3 951 455 people in 189 studies were never-smokers without chronic diseases at recruitment who survived 5 years, of whom 385 879 died. The primary analyses are of these deaths, and study, age, and sex adjusted hazard ratios (HRs), relative to BMI 22·5-<25·0 kg/m(2). FINDINGS: All-cause mortality was minimal at 20·0-25·0 kg/m(2) (HR 1·00, 95% CI 0·98-1·02 for BMI 20·0-<22·5 kg/m(2); 1·00, 0·99-1·01 for BMI 22·5-<25·0 kg/m(2)), and increased significantly both just below this range (1·13, 1·09-1·17 for BMI 18·5-<20·0 kg/m(2); 1·51, 1·43-1·59 for BMI 15·0-<18·5) and throughout the overweight range (1·07, 1·07-1·08 for BMI 25·0-<27·5 kg/m(2); 1·20, 1·18-1·22 for BMI 27·5-<30·0 kg/m(2)). The HR for obesity grade 1 (BMI 30·0-<35·0 kg/m(2)) was 1·45, 95% CI 1·41-1·48; the HR for obesity grade 2 (35·0-<40·0 kg/m(2)) was 1·94, 1·87-2·01; and the HR for obesity grade 3 (40·0-<60·0 kg/m(2)) was 2·76, 2·60-2·92. For BMI over 25·0 kg/m(2), mortality increased approximately log-linearly with BMI; the HR per 5 kg/m(2) units higher BMI was 1·39 (1·34-1·43) in Europe, 1·29 (1·26-1·32) in North America, 1·39 (1·34-1·44) in east Asia, and 1·31 (1·27-1·35) in Australia and New Zealand. This HR per 5 kg/m(2) units higher BMI (for BMI over 25 kg/m(2)) was greater in younger than older people (1·52, 95% CI 1·47-1·56, for BMI measured at 35-49 years vs 1·21, 1·17-1·25, for BMI measured at 70-89 years; pheterogeneity<0·0001), greater in men than women (1·51, 1·46-1·56, vs 1·30, 1·26-1·33; pheterogeneity<0·0001), but similar in studies with self-reported and measured BMI. INTERPRETATION: The associations of both overweight and obesity with higher all-cause mortality were broadly consistent in four continents. This finding supports strategies to combat the entire spectrum of excess adiposity in many populations. FUNDING: UK Medical Research Council, British Heart Foundation, National Institute for Health Research, US National Institutes of Health.UK MRC, BHF, NIHR; US NIHThis is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/S0140-6736(16)30175-

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead