221 research outputs found

    PCN14 COST IMPLICATIONS OF ORAL TREATMENT OF COLORECTAL CANCER IN GERMANY

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    Statistical properties of a free-electron laser revealed by the Hanbury Brown and Twiss interferometry

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    We present a comprehensive experimental analysis of statistical properties of the self-amplified spontaneous emission (SASE) free-electron laser (FEL) FLASH at DESY in Hamburg by means of Hanbury Brown and Twiss (HBT) interferometry. The experiments were performed at the FEL wavelengths of 5.5 nm, 13.4 nm, and 20.8 nm. We determined the 2-nd order intensity correlation function for all wavelengths and different operation conditions of FLASH. In all experiments a high degree of spatial coherence (above 50%) was obtained. Our analysis performed in spatial and spectral domains provided us with the independent measurements of an average pulse duration of the FEL that were below 60 fs. To explain complicated behaviour of the 2-nd order intensity correlation function we developed advanced theoretical model that includes the presence of multiple beams and external positional jitter of the FEL pulses. By this analysis we determined that in most experiments several beams were present in radiating field and in one of the experiments external positional jitter was about 25% of the beam size. We envision that methods developed in our study will be used widely for analysis and diagnostics of the FEL radiation.Comment: 29 pages, 14 figures, 3 table

    Two-phase transverse flux machine with disc rotor for high torque low speed application

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    This paper presents a special two-phase transverse flux machine with disc rotor. Because of the noncomplex construction and by using simple 2D flux path and 3D printing methods the manufacturing costs are hold low. A design criterion is proposed for maximizing the torque density in the low speed range. To prove the concept and analyse the potential of this construction a first direct driven prototype was built. The experimental results confirm the viability of this proposal and provide the required information for further enhancements

    Prevalence of Nutrition and Health-Related Claims on Pre-Packaged Foods: A Five-Country Study in Europe

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    This study is part of the research undertaken in the EU funded project CLYMBOL (“Role of health-related CLaims and sYMBOLs in consumer behaviour”). The first phase of this project consisted of mapping the prevalence of symbolic and non-symbolic nutrition and health-related claims (NHC) on foods and non-alcoholic beverages in five European countries. Pre-packaged foods and drinks were sampled based on a standardized sampling protocol, using store lists or a store floor plan. Data collection took place across five countries, in three types of stores. A total of 2034 foods and drinks were sampled and packaging information was analyzed. At least one claim was identified for 26% (95% CI (24.0%–27.9%)) of all foods and drinks sampled. Six percent of these claims were symbolic. The majority of the claims were nutrition claims (64%), followed by health claims (29%) and health-related ingredient claims (6%). The most common health claims were nutrient and other function claims (47% of all claims), followed by disease risk reduction claims (5%). Eight percent of the health claims were children’s development and health claims but these were only observed on less than 1% (0.4%–1.1%) of the foods. The category of foods for specific dietary use had the highest proportion of NHC (70% of foods carried a claim). The prevalence of symbolic and non-symbolic NHC varies across European countries and between different food categories. This study provides baseline data for policy makers and the food industry to monitor and evaluate the use of claims on food packaging

    A concise revised myeloma comorbidity index as a valid prognostic instrument in a large cohort of 801 multiple myeloma patients

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    With growing numbers of elderly multiple myeloma patients, reliable tools to assess their vulnerability are required. The objective of the analysis herein was to develop and validate an easy to use myeloma risk score (revised Myeloma Comorbidity Index) that allows for risk prediction of overall survival and progression-free survival differences in a large patient cohort. We conducted a comprehensive comorbidity, frailty and disability evaluation in 801 consecutive myeloma patients, including comorbidity risks obtained at diagnosis. The cohort was examined within a training and validation set. Multivariate analysis determined renal, lung and Karnofsky Performance Status impairment, frailty and age as significant risks for overall survival. These were combined in a weighted revised Myeloma Comorbidity Index, allowing for the identification of fit (revised Myeloma Comorbidity Index ≤3 [n=247, 30.8%]), intermediate-fit (revised Myeloma Comorbidity Index 4-6 [n=446, 55.7%]) and frail patients (revised Myeloma Comorbidity Index >6 [n=108, 13.5%]): these subgroups, confirmed via validation analysis, showed median overall survival rates of 10.1, 4.4 and 1.2 years, respectively. The revised Myeloma Comorbidity Index was compared to other commonly used comorbidity indices (Charlson Comorbidity Index, Hematopoietic Cell Transplantation-Specific Comorbidity Index, Kaplan-Feinstein Index): if each were divided in risk groups based on 25% and 75% quartiles, highest hazard ratios, best prediction and Brier scores were achieved with the revised Myeloma Comorbidity Index. The advantages of the revised Myeloma Comorbidity Index include its accurate assessment of patients' physical conditions and simple clinical applicability. We propose the revised Myeloma Comorbidity Index to be tested with the “reference” International Myeloma Working Group frailty score in multicenter analyses and future clinical trials

    Action-related information trumps system information: influencing consumers’ intention to reduce food waste

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    In order to substantially reduce food waste at the household level, it is essential to change consumer behavior. Informing consumers about the food waste issue is a promising means of bringing about behavior change: research confirms that information can increase food waste reduction behavior. However, it has yet to be determined what kind of information is most effective and exactly how that information affects consumer food waste behavior. This study compares the effects of system vs. action-related information (i.e., knowing what impacts specific actions entail vs. knowing how specific actions can help to accomplish a goal) on behavioral intention towards food waste. That is, the study focuses on the effect of information on the role of food waste in the food system versus information of actions that can be taken to avoid it. Moreover, an adapted model of the Theory of Planned Behavior is used to assess how these information effects are mediated by consumers’ attitude, norms, and perceived behavioral control. Results from an online experiment with a between-subjects design (N = 2,248) show that action-related information significantly increases respondents’ intention to reduce food waste while system information has no significant effect. The change in behavioral intention in the action-related information group is ascribed to greater personal norm activation, more favorable attitudes towards food waste reduction, and higher perceived behavioral control of food waste behaviors. Even though system information does not significantly increase intention to reduce food waste, it results in more favorable attitudes towards food waste reduction. The findings provide insights for policy makers and NGOs on what type of information to consider when designing effective food waste reduction campaigns targeted at consumers, with action-related information supporting the opportunity for consumer behavior change

    Source of the 1693 Catania earthquake and tsunami (southern Italy): New evidence from tsunami modeling of a locked subduction fault plane,

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    The 1693 Catania earthquake, which caused 60000 deaths in eastern Sicily and generated a 5–10 m high tsunami, is investigated. GPS data indicate ESE‐WNW convergence in the Calabrian arc at 4–5 mm/yr. New high‐resolution seismic data image active compression at the toe of the accretionary wedge. The lack of instrumentally recorded thrust earthquakes suggests the presence of a locked subduction fault plane. Thermal modeling is applied to calculate the limits of the seismogenic zone. Tsunami modeling is performed to test the hypothesis that the 1693 earthquake occurred on the subduction fault plane (160 × 120 km in size) with 2 m of mean co‐seismic slip. This source successfully reproduces historical observations with regard to polarity and predicts 1–3 m high amplitudes. It is likely that only the SW segment of the subduction fault plane ruptured in 1693 and 1169, implying a recurrence interval of roughly 500 years for similar events

    Room-Temperature Ballistic Transport in III-Nitride Heterostructures

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    Room-temperature (RT) ballistic transport of electrons is experimentally observed and theoretically investigated in III-nitrides. This has been largely investigated at low temperatures in low band gap III–V materials due to their high electron mobilities. However, their application to RT ballistic devices is limited by their low optical phonon energies, close to KT at 300 K. In addition, the short electron mean-free-path at RT requires nanoscale devices for which surface effects are a limitation in these materials. We explore the unique properties of wide band-gap III-nitride semiconductors to demonstrate RT ballistic devices. A theoretical model is proposed to corroborate experimentally their optical phonon energy of 92 meV, which is ∼4× larger than in other III–V semiconductors. This allows RT ballistic devices operating at larger voltages and currents. An additional model is described to determine experimentally a characteristic dimension for ballistic transport of 188 nm. Another remarkable property is their short carrier depletion at device sidewalls, down to 13 nm, which allows top-down nanofabrication of very narrow ballistic devices. These results open a wealth of new systems and basic transport studies possible at RT.United States. Defense Advanced Research Projects Agency. Nitride Electronic NeXt-Generation Technology (NEXT) ProgramUnited States. Office of Naval Research. Young Investigator Progra

    Strong Influence of Coadsorbate Interaction on CO Desorption Dynamics on Ru(0001) Probed by Ultrafast X-Ray Spectroscopy and \u3cem\u3eAb Initio\u3c/em\u3e Simulations

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    We show that coadsorbed oxygen atoms have a dramatic influence on the CO desorption dynamics from Ru(0001). In contrast to the precursor-mediated desorption mechanism on Ru(0001), the presence of surface oxygen modifies the electronic structure of Ru atoms such that CO desorption occurs predominantly via the direct pathway. This phenomenon is directly observed in an ultrafast pump-probe experiment using a soft x-ray free-electron laser to monitor the dynamic evolution of the valence electronic structure of the surface species. This is supported with the potential of mean force along the CO desorption path obtained from density-functional theory calculations. Charge density distribution and frozen-orbital analysis suggest that the oxygen-induced reduction of the Pauli repulsion, and consequent increase of the dative interaction between the CO 5σ and the charged Ru atom, is the electronic origin of the distinct desorption dynamics. Ab initio molecular dynamics simulations of CO desorption from Ru(0001) and oxygen-coadsorbed Ru(0001) provide further insights into the surface bond-breaking process
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