Clinical symptoms, paraclinical tests and histopathological results in children with acute appendicitis in Zabol southeast of Iran: a cross-sectional study

Background: This article aimed to assessment clinical signs and symptoms, paraclinical tests and histopathological results in children with acute appendicitis.Methods: A cross-sectional study conducted on 100 children with acute appendicitis in an urban hospital in southeast of Iran from January to December 2016. Participants were selected by simple random sampling method. Clinical signs and symptoms, paraclinical tests and histopathological results recorded in checklists. The data were analyzed using SPSS 22.Results: Mean age of the patients was 10.26±3.25, fourthly-eight of patients (58.5%) were males and 34 patients (41.5%) were females. The most frequent clinical signs and symptoms were acute suppurative appendicitis with peri appendicitis (45.83%) and acute suppurative appendicitis (39.58%). The most frequent results in ultrasound reports were Intestinal loop thickness greater than 6 mm without peristalsis (positive report) (46.34%) and Invisible appendix (nega Hesaraki tive report) (13.41%).Conclusions: The results of this study showed that abdominal pain and RLQ tenderness were the most common signs and symptoms and WBC left-shift was the most common laboratory finding. Since the rate of negative appendectomy in this study was consistent with surgical results and other articles, it is concluded that diagnostic accuracy of preoperative appendectomy was acceptable and most children with acute appendicitis underwent appendectomy

A comparison of serum and transcutaneous methods for diagnosis of neonatal hyperbilirubinemia

Background: Bili-Check is a simple test for non-invasive, quick, and painless estimation of the total serum bilirubin. This research aimed to compare serum and transcutaneous methods for the diagnosis of neonatal hyperbilirubinemia.Methods: In this descriptive study, a sample of 120 neonates diagnosed with hyperbilirubinemia was selected using convenience non-probability. They were hospitalized in Amir Al-Momemin Hospital of Zabol, Iran in 2013. The extent of neonatal bilirubin was measured by NINGBO DAVID and lab test. Then, they were compared. The data were analyzed using correlation and t-test in SPSS 22.Results: In this descriptive study, a sample of 120 neonates diagnosed with hyperbilirubinemia was selected using convenience non-probability. They were hospitalized in Amir Al-Momemin Hospital of Zabol, Iran in 2013. The extent of neonatal bilirubin was measured by NINGBO DAVID and lab test. Then, they were compared. The data were analysed using correlation and t-test in SPSS 22.Conclusions: The results showed that Bili-Check can be recommended as an appropriate tool for screening and monitoring phototherapy process. The serum method can be replaced by Bili-check

Effect of probiotic supplement (kidilact) on prevention of acute diarrhea in children: a double-blind randomized clinical trial

Background: Acute viral diarrhea is one of the most common diseases in children, which is associated with high risk of mortality. The present study aimed to determine the effect of Kidilact on the treatment of children with acute diarrhea.Methods: This double-blind randomized clinical trial was conducted on 84 children aged 6-60 months with diarrhea, hospitalized in pediatric ward of Amir al-Mu'minin hospital of Zabol, Iran. The patients who met the inclusion criteria were included and assigned to the control and treatment groups (42 patients in each group). Data collection instruments included clinical examination of participants in terms of gender, medication, diet, stool test, weight, average heart rate, average respiratory rate, average body temperature, and average frequency of defecation Data was analyzed with descriptive and analytical tests (chi-square, Fisher's exact test, t-test, etc.) in SPSS-21.Results: Body temperature, heart rate, and frequency of defecation significantly reduced in the intervention group after three days (p<0.05). In addition, weight gain presented an improving trend in the intervention group, but not significantly different from the control group (p<0.05).Conclusions: Findings indicated that the use of Kidilact may be helpful in the treatment of acute viral diarrhea in children and play a key role in early recovery, reduction of disease severity, and improvement of vital signs in these patients

Comparaisons d'un modèle de transport d'aérosols avec une analyse de 4 ans de mesures estivales d’épaisseur optique d'aérosols dans l'Arctique canadien

Abstract : This is a study concerning comparisons between the Dubovik Aerosol optical depth (AOD) retrievals from AEROCAN (ARONET) stations and AOD estimates from simulations provided by a chemical transport model (GEOS-Chem : Goddard Earth Observing System Chemistry). The AOD products associated with the Dubovik product are divided into total, fine and coarse mode components. The retrieval period is from January 2009 to January 2013 for 5 Arctic stations (Barrow, Alaska; Resolute Bay, Nunavut; 0PAL and PEARL (Eureka), Nunavut; and Thule, Greenland). We also employed AOD retrievals from 10 other mid-latitude Canadian stations for comparisons with the Arctic stations. The results of our investigation were submitted to Atmosphere-Ocean. To briefly summarize those results, the model generally but not always tended to underestimate the (monthly) averaged AOD and its components. We found that the subdivision into fine and coarse mode components could provide unique signatures of particular events (Asian dust) and that the means of characterizing the statistics (log-normal frequency distributions versus normal distributions) was an attribute that was common to both the retrievals and the model.Résumé : Cette étude compare des épaisseurs optiques d’aérosols (AOD) à 5 stations arctiques d’AEROCAN (AERONET), obtenues d’une part à l’aide de l’algorithme d'inversion de Dubovik appliqué à des mesures in situ, et d’autre part du modèle de transport chimique (GEOS-Chem : Goddard Earth Observing Système Chemistry). Les produits d’AOD associés à l’algorithme d’inversion sont divisés en composantes totales, fines et grossières. Pour chacune des 5 stations (Barrow, Alaska, Resolute Bay, au Nunavut, 0PAL et PEARL (Eureka), Nunavut, et Thulé, au Groenland), la période de récupération est de janvier 2009 à janvier 2013. Nous avons également utilisé les mesureurs d’AOD de dix autres stations canadiennes de latitudes moyennes, à des fins de comparaison. Les résultats de l’étude ont été soumis à la revue Atmosphere-Ocean. Pour résumer brièvement ces résultats, le modèle a généralement, mais pas toujours, eu tendance à sous-estimer l'AOD moyenne et de ses composantes. Nous avons constaté que la subdivision en composantes fine et grossière pourrait fournir des signatures uniques d'événements particuliers (poussière asiatique) et que les moyens de caractériser des statistiques (les distributions de fréquence log-normale versus les distributions normales) était un attribut qui était commun aux deux les mesureurs et le modèle

Remedial action schemes for power system performance enhancement using protective relaying

Nowadays, according to the improvement of industries, and the growth of the population, the need for high-quality energy is felt more and more. One of the significant challenges in designing distributed power networks is providing reliable protection with the target of decreasing blackouts. This goal can be achieved by detecting faults in the power system and action to correct or remove the faults. In most cases, taking correct and quick remedial action to protect the power system is done by tripping. Generally, the protective relaying equipment is responsible for tripping in a power system. In this thesis, various types of remedial action schemes for power system performance enhancement using protective relaying are studied in detail. The concept of power system protection consists of protection components, and their functionality is illustrated. Furthermore, several types of protective relays, and their general operating and design considerations are briefly investigated. Several protective relays such as analog overcurrent relay, digital overcurrent relay, and digital under-over frequency relay are investigated, modeled, and simulated in this thesis. To study the power system frequency response, the System Frequency Response (SFR) model is derived and simulated in MATLAB Simulink environment, and the effect of some parameters of a generator on the system’s frequency response is examined. Additionally, a new method to model power system frequency response is proposed based on the factorial design method using the Design of Expert. The actual system and the final model are simulated, compared, and validated. The result shows that the model based on the proposed method can be used to estimate the system frequency response. The concept of load curtailment (load shedding) and its different methods are discussed. A conventional underfrequency load shedding relay is simulated in MATLAB software to show how load shedding relays can enhance power system performance. The significant factors which affect power system stability are identified. To show the effect of significant factors on power system stability, a standard IEEE 9-Bus and the IEEE 10-Generator 39-Bus New England Test System are simulated in the PowerWorld. Finally, the concept of autoreclosing is studied in detail. An autorecloser relay is designed, simulated, and examined in MATLAB Simulink, and the proposed relay’s units are explained. Optimal autoreclosing methods are also presented in this thesis

Experimental study of energy performance in low-temperature hydronic heating systems

Energy consumption, thermal environment and environmental impacts were analytically and experimentally studied for different types of heat emitters. The heat emitters studied were conventional radiator, ventilation radiator, and floor heating with medium-, low-, and very-low-temperature supply, respectively. The ventilation system in the lab room was a mechanical exhaust ventilation system that provided one air change per hour of fresh air through the opening in the external wall with a constant temperature of 5 °C, which is the mean winter temperature in Copenhagen. The parameters studied in the climate chamber were supply and return water temperature from the heat emitters, indoor temperature, and heat emitter surface temperature. Experiments showed that the mean supply water temperature for floor heating was the lowest, i.e. 30 °C, but it was close to the ventilation radiator, i.e. 33 °C. The supply water temperature in all measurements for conventional radiator was significantly higher than ventilation radiator and floor heating; namely, 45 °C. Experimental results indicated that the mean indoor temperature was close to the acceptable level of 22 °C in all cases. For energy calculations, it was assumed that all heat emitters were connected to a ground-source heat pump. Analytical calculations showed that using ventilation radiator and floor heating instead of conventional radiator resulted in a saving of 17% and 22% in heat pump's electricity consumption, respectively. This would reduce the CO2 emission from the building's heating system by 21 % for the floor heating and by 18% for the ventilation radiator compared to the conventional radiator.QC 20160128</p

Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

The present study was designed to evaluate the in vivo effect of Allium sativum (garlic) hydroalcoholic extract on wound healing in rats. For this purpose, 72 mature Wistar rats were divided into four groups (n=18/each) to receive no treatment, placebo, Cicalfate(r), or 2% Allium sativum (AS) extract, administered topically to the wound area, for 21 days. Following the experimental period, tissue samples were dissected out and underwent to histopathological analyses. Fibroblasts, fibrocytes, mast cells, intra-cytoplasmic carbohydrate ratio, neovascularization, collagen deposition, and re-epithelialization were analyzed in all groups. Animals in the treated groups showed significant enhancement in fibroblast, fibrocyte, and mast-cell distribution. Significantly higher neovascularization was observed on day 3 after wound induction in AS-treated animals versus those in the placebo, Cicalfate, and untreated groups (

Приоритетные направления разработки курса дистанционного обучения в высшей медицинской школе

ИНФОРМАЦИОННЫЕ СИСТЕМЫОБРАЗОВАНИЕ ДИСТАНЦИОННОЕДИСТАНЦИОННЫЕ ТЕЛЕКОНСУЛЬТАЦИИОБРАЗОВАНИЕ МЕДИЦИНСКОЕОБРАЗОВАНИЯ ТЕХНОЛОГИЯМУЛЬТИМЕДИ

Physicochemical Properties and Cellular Responses of Strontium-Doped Gypsum Biomaterials

This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19–2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one

Optimization of expression, extraction & purification of the N-terminal region of ipaD gene in Shigella dysenteriae by proteomics analysis

زمینه و هدف: باکتری شیگلا دیسانتری یکی از عوامل پاتوژن مهم است که علی‌رغم تلاش‌های چندین ساله برای تهیه واکسن علیه آن هنوز مطالعات گسترده پیرامون آن ادامه دارد. محصولات پلاسمید تهاجمی شیگلا (Ipa) نقش مهمی در تهاجم باکتری ایفا می‌کنند. پروتئین IpaD یکی از اعضای این خانواده است که به عنوان کاندید واکسن شیگلا مطرح می‌باشد. مطالعات متعدد بر روی این پروتئین نشان داده که ناحیه N- ترمینال آن نقش مهمی در فرآیند تهاجمی باکتری دارد. این مطالعه با هدف بهینه سازی بیان N- ترمینال ژن IpaD به منظور افزایش تولید پروتئین نو ترکیب انجام شد. روش بررسی: در این مطالعه تجربی-آزمایشگاهی باکتری E. coli BL21(DE3) حامل پلاسمید pET-28a که ژن ناحیه N- ترمینال IpaD در آن همسانه سازی شده بود جهت مطالعات مورد استفاده قرار گرفت. پس از کشت باکتری، تاثیر سه فاکتور زمان القا، دما و غلظت ماده القا کننده ایزو-پروپیل-تایوبتا دی گالاکتوپیرانوزید (IPTG) بر میزان بیان، با استفاده از ژل سدیم دو دسیل سولفات-پلی آکریل آمید (SDS-PAGE) به صورت کیفی بررسی گردید. با استفاده از تصاویر دو بعدی تهیه شده از ژل‌ها با کمک نرم افزار آنالیز ژل‌های دو بعدی بررسی کمی بیان پروتئین صورت پذیرفت. مراحل استخراج و تخلیص پروتئین نوترکیب با کمک روش شیب اوره آغاز و با عبور نمونه‌ها از ستون کروماتوگرافی پایان یافت. یافته‌ها: نتایج بر روی ژل‌های SDS-PAGE نشان داد که میزان تقریبا مشابهی از تولید پروتئین نوترکیب در زمان‌ القا، دما و غلظت های مختلف IPTG بیان وجود دارد، اما یافته‌های نرم افزاری نشان داد بهترین شرایط بیان ناحیه N- ترمینال پروتئین IpaD در وکتور pET-28a دمای 37 درجه سانتی‌گراد، غلظت 7/0 میلی مولار IPTG و زمان 3 ساعت بعد از القا می‌باشد. نتیجه‌گیری: بر اساس نتایج این مطالعـــه هر پروتئین بعد از فرآیند همسانه سازی شرایط بیان مخصوص به خود را دارا می‌باشد که شرایط دمایی و طول زمان القا سلول‌ها در مقدار تولید پروتئین موثرتر می‌باشند