Handedness as a marker of cerebral lateralization in children with and without autism

We employed a multiple case studies approach to investigate lateralization of hand actions in typically and atypically developing children between 4 and 5 years of age. We report on a detailed set of over 1200 hand actions made by four typically developing boys and four boys with autism. Participants were assessed for unimanual hand actions to both objects and the self (self-directed behaviors). Individual and group analyses suggest that typically developing children have a right hand dominance for hand actions to objects and a left hand dominance for hand actions for self-directed behaviors, revealing a possible dissociation for functional specialization of the left and right hemispheres respectively. Children with autism demonstrated mixed-handedness for both target conditions, consistent with the hypothesis that there is reduced cerebral specialization in these children. The findings are consistent with the view that observed lateralized motor action can serve as an indirect behavioral marker for evidence of cerebral lateralization

Contributions of the French Institut Géographique National (IGN) to the International DORIS Service

International audienceDORIS is one of the four geodetic space techniques participating to the Global Geodetic Observing System (GGOS). Since the early development of this system, the Institut Géographique National played a specific and active role. Within, the International DORIS Service (IDS), IGN is in a particular position. While it is responsible for the installation and the maintenance of the DORIS ground tracking stations, it also handles one of the two IDS data center delivering DORIS data and products and has been an IDS Analysis Center for years, providing all possible IDS products, in particular the latest ignwd08 time series in preparation of ITRF2008. This paper explains the different aspects of the IGN contribution to IDS from an historical point of view, presents current activities and scientific results and provides a perspective for future activities. Recent DORIS results show a 10 mm precision or better when more than four DORIS satellites are available. Comparisons between recent DORIS solutions (ign07d02 and ign09d02) and past ITRF realizations show that errors are shared between the DORIS and the ITRF realizations. Some problems related to DORIS data processing are also discussed and possible ways to solve them in the future are discussed. In particular, we can now reject the tropospheric origin of the problem detected in the Envisat data after the software upload of October 12, 2004. A few applications in geodesy (terrestrial reference frame, Earth’s polar motion) and geophysics are also discussed as a natural extension of these service-type activities

Arabidopsis Histone Deacetylase HDA6 Is Required for Maintenance of Transcriptional Gene Silencing and Determines Nuclear Organization of rDNA Repeats

Histone acetylation and deacetylation are connected with transcriptional activation and silencing in many eukaryotic organisms. Gene families for enzymes that accomplish these modifications show a surprising multiplicity in sequence and expression levels, suggesting a high specificity for different targets. We show that mutations in Arabidopsis (Arabidopsis thaliana) HDA6, a putative class I histone deacetylase gene, result in loss of transcriptional silencing from several repetitive transgenic and endogenous templates. Surprisingly, total levels of histone H4 acetylation are only slightly affected, whereas significant hyperacetylation is restricted to the nucleolus organizer regions that contain the rDNA repeats. This switch coincides with an increase of histone 3 methylation at Lys residue 4, a modified DNA methylation pattern, and a concomitant decondensation of the chromatin. These results indicate that HDA6 might play a role in regulating activity of rRNA genes, and this control might be functionally linked to silencing of other repetitive templates and to its previously assigned role in RNA-directed DNA methylation

The International DORIS Service (IDS): Toward maturity

International audienceDORIS is one of the four space-geodetic techniques participating in the Global Geodetic Observing System (GGOS), particularly to maintain and disseminate the Terrestrial Reference Frame as determined by International Earth rotation and Reference frame Service (IERS). A few years ago, under the umbrella of the International Association of Geodesy, a DORIS International Service (IDS) was created in order to foster international cooperation and to provide new scientific products. This paper addresses the organizational aspects of the IDS and presents some recent DORIS scientific results. It is for the first time that, in preparation of the ITRF2008, seven Analysis Centers (AC’s) contributed to derive long-term time series of DORIS stations positions. These solutions were then combined into a homogeneous time series IDS-2 for which a precision of less than 10 mm was obtained. Orbit comparisons between the various AC’s showed an excellent agreement in the radial component, both for the SPOT satellites (e.g. 0.5-2.1 cm RMS for SPOT-2) and Envisat (0.9-2.1 cm RMS), using different software packages, models, corrections and analysis strategies. There is now a wide international participation within IDS that should lead to future improvements in DORIS analysis strategies and DORIS-derived geodetic products

Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort.: Response to raltegravir in heavily pre-treated patients

International audienceBACKGROUND: The efficacy of raltegravir plus optimized background therapy (OBT) has been demonstrated for antiretroviral (ARV)-experienced HIV-1-infected patients in randomized clinical trials. We studied viro-immunological response, pharmacokinetic parameters and genotypic test results in an observational cohort of multiple ARV class-experienced patients starting a raltegravir-based regimen. METHODS: Already enrolled ANRS CO3 Aquitaine Cohort patients with virological failure were included in this study after starting a raltegravir-based regimen (400 mg twice a day, week 0). Virological success was defined by the plasma HIV-1 RNA level [viral load (VL)] or =1 and or =2 (P = 0.02), respectively. Raltegravir-related mutations emerged in 9 of 11 failing patients (82%): Q148H/R (n = 5), N155S/H (n = 3) and S230N (n = 1). Median CD4 increases from week 0 to week 4 and week 24 were 28 (-4, 85) and 57 (0, 156) cells/mm(3), respectively. A poor immune response was independently associated with a lower VL decline (week 0 to week 12) [odds ratio (OR): 3.5, 95% confidence interval (CI): 1.4, 8.4, for 1 log(10) less] and CD4+% at baseline (OR: 2.6, 95% CI: 0.97, 8.3, for 10% lower). CONCLUSIONS: Raltegravir plus OBT provided a good virological success rate in highly pre-treated patients under clinical routine conditions