XSEDE Publication Initiative

The eXtreme Science and Engineering Discovery Environment (XSEDE) proposes the following program-wide Publication Initiative as a strategy to document and share XSEDE work experiences, innovative activities, lessons learned, and best practices. One of XSEDE’s goals is to “Sustain the Ecosystem,” measured by the following metric: number of staff publications which fulfills the subgoal of how to “Operate an innovative and virtual organization.” The metric also feeds upward into a Key Performance Indicator (KPI) for the entire project. Tracking the number of staff publications produced shows that XSEDE staff are involved in novel activities including those that achieve peer-reviewed publication. For PY7, the target metric will be 30 staff publications posted in the XSEDE User Portal for that Program Year. Historically, XSEDE has periodically emphasized staff entering previous and currently-published works with inconsistent diligence. In response to NSF encouragement, XSEDE will build on what we have been doing and what we have learned as a project and expand by identifying opportunities for both what content we would share with the community and the vehicles for doing so. In order to foster broad representation of XSEDE to the advanced computing community, XSEDE will build into the PY8 plan time for staff to write peer-reviewed papers, technical reports, white papers, and present from these publications derived from their work on XSEDE.Ope

University of Illinois Year of Cyberinfrastructure Final Report

The University of Illinois at Urbana-Champaign is a leader in computing and information technology (IT). Our leadership role has both produced and been produced by a culture of innovation. Many efforts have arisen over the years that have been the product of this culture. While the university’s commitment to developing digital infrastructure, resources, and support services has served campus researchers well, it has become clear that a more coherent and unified approach to assessing and addressing the IT services and support needs of campus researchers is imperative. With the support of the Vice Chancellor for Research and the Chief Information Officer, we embarked on the Year of Cyberinfrastructure (Year of CI). Through this effort, we engaged researchers across disciplines to gain an understanding of the challenges they face in order to inform how we, as a campus, should move together to address these needs. We confirmed that researchers tend to assemble needed resources and services on their own, often out of necessity. While this practice has allowed those with the ambition or, more frequently, the absolute need, to advance their fields, it has primarily benefitted only those researchers and their collaborators. Providers of resources and services have brought value to the research process, but this value has been accrued in a largely disjointed manner that has tended to favor the power users of technology. The Year of CI effort has made clear that our research support landscape is not only lacking coherence but is also very uneven across academic and research units. To support modern research practices and to be competitive and preeminent in the academic community and the world, the 21st century research university must provide a foundation of research IT infrastructure and services that are accessible by all disciplines. Our campus needs a strong vision for how IT supports research, along with the ability to realize and evolve that vision in lockstep with the changing needs of the research community and the technologies available to meet those needs. Though Illinois faces significant financial challenges, it is time to be bold and make an investment to allow the university to emerge from these challenges as the premier destination for faculty, postdocs, graduate students, undergraduate students, and research staff who seek to work in a world-class modern research environment. It is time to provide the infrastructure that will grow the campus research portfolio to new heights. The Year of CI has provided the initial assessment of the campus and indicates the steps we must take to develop the digital support ecosystem that will allow the campus to realize its vision of preeminence in research.Ope

Cancer centre supportive oncology service: health economic evaluation

Objectives: There have been many models of providing oncology and palliative care to hospitals. Many patients will use the hospital non-electively or semielectively, and a large proportion are likely to be in the last years of life. We describe our multidisciplinary service to treatable but not curable cancer patients at University Hospitals Sussex. The team was a mixture of clinical nurse specialists and a clinical fellow supported by dedicated palliative medicine consultant time and oncology expertise. / Methods: We identified patients with cancer who had identifiable supportive care needs and record activity with clinical coding. We used a baseline 2019/2020 dataset of national (secondary uses service) data with discharge code 79 (patients who died during that year) to compare a dataset of patients seen by the service between September 2020 and September 2021 in order to compare outcomes. While this was during COVID-19 this was when the funding was available. / Results: We demonstrated a reduction in length of stay by an average of 1.43 days per admission and a reduction of 0.95 episodes of readmission rates. However, the costs of those admissions were found to be marginally higher. Even with the costs of the service, there is a clear return on investment with a benefit cost ratio of 1.4. / Conclusions: A supportive oncology service alongside or allied to acute oncology but in conjunction with palliative care is feasible and cost-effective. This would support investment in such a service and should be nationally commissioned in conjunction with palliative care services seeing all conditions

Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters

Objectives Antiviral interventions are required to complement vaccination programmes and reduce the global burden of COVID-19. Prior to initiation of large-scale clinical trials, robust preclinical data to support candidate plausibility are required. This work sought to further investigate the putative antiviral activity of probenecid against SARS-CoV-2. Methods Vero E6 cells were preincubated with probenecid, or control media for 2 h before infection (SARS-CoV-2/Human/Liverpool/REMRQ0001/2020). Probenecid or control media was reapplied, plates reincubated and cytopathic activity quantified by spectrophotometry after 48 h. In vitro human airway epithelial cell (HAEC) assays were performed for probenecid against SARS-CoV-2-VoC-B.1.1.7 (hCoV-19/Belgium/rega-12211513/2020; EPI_ISL_791333, 2020-12-21) using an optimized cell model for antiviral testing. Syrian golden hamsters were intranasally inoculated (SARS-CoV-2 Delta B.1.617.2) 24 h prior to treatment with probenecid or vehicle for four twice-daily doses. Results No observable antiviral activity for probenecid was evident in Vero E6 or HAEC assays. No reduction in total or subgenomic RNA was observed in terminal lung samples (P > 0.05) from hamsters. Body weight of uninfected hamsters remained stable whereas both probenecid- and vehicle-treated infected hamsters lost body weight (P > 0.5). Conclusions These data do not support probenecid as a SARS-CoV-2 antiviral drug

Tiny Medicine: Nanomaterial-Based Biosensors

Tiny medicine refers to the development of small easy to use devices that can help in the early diagnosis and treatment of disease. Early diagnosis is the key to successfully treating many diseases. Nanomaterial-based biosensors utilize the unique properties of biological and physical nanomaterials to recognize a target molecule and effect transduction of an electronic signal. In general, the advantages of nanomaterial-based biosensors are fast response, small size, high sensitivity, and portability compared to existing large electrodes and sensors. Systems integration is the core technology that enables tiny medicine. Integration of nanomaterials, microfluidics, automatic samplers, and transduction devices on a single chip provides many advantages for point of care devices such as biosensors. Biosensors are also being used as new analytical tools to study medicine. Thus this paper reviews how nanomaterials can be used to build biosensors and how these biosensors can help now and in the future to detect disease and monitor therapies

XSEDE Annual​ ​Process: Planning,​ ​Reporting,​ ​and​ ​Review

Document describes the XSEDE annual planning, reporting, surveying, and review processOpe

XSEDE Annual​ ​Process: Planning,​ ​Reporting,​ ​and​ ​Review

Document describes the XSEDE annual planning, reporting, surveying, and review processOpe

Laura Herriott Interview

Interview with Laura Herriott, owner and operator of Wilma\u27s Cottage Bed and Breakfast and a caterer. The interview takes place at Wilma\u27s Cottage before she serves lunch. Herriott remembers growing up on Sandy Island and the types of food that would be grown on the island. She grew up going to Gordon Chapel United Methodist Church with her grandmother, Georgie Brown Herriott. She describes the seeking ritual that she went through as a child before joining the Methodist church, where she was paired with a spiritual mother (the deaconess of the church). Crawford asks Herriott about songs that were performed by her mother and grandmother, who were both in the choir. She recalls the long walk from Georgia Hill (at the north end of the community) to the Sandy Island School (near the Mount Arena community). Herriott discusses the types of materials used at the Sandy Island School, and what children would do as part of their work

Laura Herriott Interview, April 2017

An interview with Laura Herriott at her bed and breakfast on Sandy Island, Wilma\u27s cottage. She is interviewed by Quentin Ameris, Eric Crawford, and Brooks Liebee. She discusses her and her children\u27s schooling. Her cottage bed and breakfast, Wilma\u27s Cottage, attracts visitors from all over the nation to see Sandy Island, and sometimes they stay on the island and sometimes they just come to go on a tour and eat. She discusses the dishes that she cooks, including string beans, rice, chicken, and more regional dishes. The interviewees and interviewers talk through the various fundraisers the island does, as well as the business outlets she has at farmers\u27 markets for her cooking

ACCESS Resource Allocation Marketplace and Platform Services (RAMPS) PY1 Annual Report

The Carnegie Mellon University led team provides Allocation Services as part of the NSF-funded Advanced Cyberinfrastructure Coordination Ecosystem: Services & Support (ACCESS) program. This report details the team's progress in Project Year 1 from May 1, 2022 to March 31, 2023 along with data related to the current status of the ACCESS ecosystem. </p